Specificity of phencyclidine-like drugs and benzomorphan opiates for two high affinity phencyclidine binding sites in guinea pig brain.
Neuropharmacology September 1, 1990 A A Reid, M V Mattson, B R De Costa et al.
Phencyclidine (PCP) and its analog TCP bind non-selectively to two high-affinity binding sites in guinea pig brain: one coupled to the NMDA glutamate receptor (site 1) and the other associated with the dopamine reuptake carrier (site 2). The compound (+)MK801 is highly selective for site 1 and produces minimal psychotomimetic effects in humans at doses that reduce seizures, whereas PCP produces psychotomimetic effects. This suggests that (+)MK801 can serve as a marker for site 1 and that PCP's psychotomimetic effects may be mediated by site 2.