Repeated low dose of phencyclidine administration impairs spatial learning in mice: blockade by clozapine but not by haloperidol.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology July 1, 2008 Simret Beraki, Alexander Kuzmin, Fadao Tai et al.
Repeated low-dose phencyclidine (PCP) impairs spatial learning and memory in mice without causing sensorimotor deficits, while higher doses produce severe motor disturbances that prevent testing. The atypical antipsychotic clozapine, but not the typical antipsychotic haloperidol, blocks the spatial impairment caused by low-dose PCP. This dissociation may help model declarative memory disturbances in schizophrenia and clarify differences between antipsychotic drug classes.