Effects of lamotrigine on PCP-evoked elevations in monoamine levels in the medial prefrontal cortex of freely moving rats.
Journal of psychopharmacology (Oxford, England) December 1, 2011 Davide Quarta, Charles H Large
Lamotrigine reduced the overflow of dopamine and serotonin in the medial prefrontal cortex of awake rats after administration of phencyclidine (PCP), a drug that mimics psychotic-like behavior. The effect on noradrenaline was not statistically significant. Lamotrigine did not affect PCP-induced hyperactivity, suggesting different brain circuits are involved in these processes. The findings support lamotrigine's potential as an add-on treatment for schizophrenia by preventing neurochemical changes linked to psychotomimetic effects.