Effects of a non-competitive N-methyl-d-aspartate (NMDA) antagonist, tiletamine, in adult zebrafish.
Neurotoxicology and teratology January 1, 2017 Tatiana O Kolesnikova, Sergey L Khatsko, Vadim A Shevyrin et al.
Tiletamine, a veterinary anesthetic related to ketamine, produces dose-dependent sedative effects in adult zebrafish. Immersion in 1 mg/L caused only reduced top entries in a novel tank test, while 5 and 10 mg/L caused robust sedation and skin darkening. Brain samples confirmed tiletamine presence only at the two higher doses. The results demonstrate potent neurotropic effects of tiletamine in zebrafish and support the use of fish-based aquatic screens for studying NMDA receptor antagonists.