Persisting changes in brain glucose uptake following neurotoxic doses of phencyclidine which mirror the acute effects of the drug.
Psychopharmacology August 1, 1996 G D Ellison, A S Keys
Phencyclidine (PCP) can cause a psychosis resembling schizophrenia and dementia that sometimes persists long after the drug is stopped. In rats, a five-day continuous 'binge' of PCP caused lasting increases in brain glucose metabolism, especially in limbic regions (retrosplenial, piriform, and entorhinal cortex, hippocampus, and olfactory tubercle). These increases were still present 10 days after the drug was removed, indicating that the metabolic changes persist. The findings suggest a brain basis for the prolonged psychosis that can follow PCP use.