M100907, a selective 5-HT(2A) receptor antagonist, attenuates phencyclidine-induced Fos expression in discrete regions of rat brain.
European journal of pharmacology April 13, 2001 T Habara, T Hamamura, M Miki et al.
The selective 5-HT2A receptor antagonist M100907 attenuates phencyclidine (PCP)-induced Fos expression in specific rat brain regions. PCP (5 mg/kg) induced Fos expression in the cingulate cortex area 3, agranular insular cortex, piriform cortex, nucleus accumbens, anterior paraventricular thalamic nucleus, and ventral lateral septal nucleus. Pretreatment with M100907 (0.5 mg/kg) reduced Fos expression in the nucleus accumbens core and shell, agranular insular cortex, and piriform cortex, but not in other regions. M100907 alone did not induce Fos expression in any region, including the dorsolateral caudate/putamen. These results indicate that 5-HT2A receptor antagonism attenuates Fos expression in a regionally specific manner in the PCP model of psychosis.