Differential effects of amphetamine and phencyclidine on the expression of growth-associated protein GAP-43.
Neuroscience research June 1, 2001 S Vukosavic, S Ruzdijic, R Veskov et al.
Chronic treatment with amphetamine reduced GAP-43 mRNA expression in rats, an effect that persisted for up to 14 days after the last dose, suggesting a neurotoxic effect. In contrast, phencyclidine increased GAP-43 mRNA expression, detectable from early treatment until 21 days after the last dose, indicating activation of pathways involved in remodeling. Haloperidol did not significantly change GAP-43 mRNA expression.