Analysis of overall gene expression induced by amphetamine and phencyclidine: novel targets for the treatment of drug psychosis and schizophrenia.
Current pharmaceutical design January 1, 2002 Chihiro Ito
A review suggests that amphetamine and phencyclidine alter the expression of genes related to neurotransmitter systems (dopamine, glutamic acid), transcription factors, cell proliferation, apoptosis, cell adhesion, and synapses in animal models. These changes in gene expression may help identify candidate genes for drug psychosis or schizophrenia and lead to the development of novel antipsychotics.