Effects of repeated phencyclidine administration on adult hippocampal neurogenesis in the rat.
Synapse (New York, N.Y.) July 1, 2006 Juan Liu, Toshihito Suzuki, Tatsunori Seki et al.
Repeated injections of phencyclidine (PCP, 7.5 mg/kg) in rats cause a 23% decrease in the number of newly born cells in the dentate gyrus of the hippocampus 24 hours after the last injection, but cell counts return to normal within one week. The survival of cells already formed is not affected. PCP also produces stereotyped behaviors that increase with repeated doses, while ataxia and backpedaling behaviors decrease. These transient disruptions in cell proliferation may relate to behavioral abnormalities induced by PCP, though whether they contribute to behavioral sensitization or result from adaptation to the drug's effects remains unclear.