Subchronic administration of phencyclidine produces hypermethylation in the parvalbumin gene promoter in rat brain.
Epigenomics September 1, 2016 Helene A Fachim, Umarat Srisawat, Caroline F Dalton et al.
Rats given phencyclidine (PCP) for 7 days showed increased DNA methylation at one of two specific sites in the parvalbumin gene promoter in both the prefrontal cortex and hippocampus six weeks later, compared to rats given a vehicle. No change was seen in a global measure of DNA methylation. This hypermethylation may contribute to parvalbumin neuron deficits in this animal model of psychosis, which are also observed in schizophrenia.