Antipsychotic Drugs Efficacy in Dextromethorphan-Induced Psychosis.
Biomedicines January 3, 2023 Malgorzata Zaremba, Pawel Serafin, Patrycja Kleczkowska
Dextromethorphan (DXM), a common cough suppressant that is not a controlled substance in the US, can induce psychosis characterized by disorganized behavior, thinking, and perception. Management of DXM-related psychosis depends on the type of symptoms. Atypical neuroleptics such as olanzapine, risperidone, and quetiapine, as well as typical haloperidol, are used for symptomatic treatment, particularly for positive symptoms like hallucinations and delusions. Atypical antipsychotics are preferred over haloperidol due to their better efficacy and safety profile in the short term. This review summarizes current knowledge on DXM's psychotic potential and the management of DXM-related psychoses, focusing on atypical antipsychotic drugs.