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P. Nagele

2 papers in the library · publishing 2020-2022

Papers

Nitrous Oxide, a Rapid Antidepressant, Has Ketamine-like Effects on Excitatory Transmission in Adult Hippocampus

Biological Psychiatry June 1, 2022 Y. Izumi, F. Hsu, C. Conway et al.

Nitrous oxide (N2O), like ketamine, produces lasting enhancement of glutamate-mediated synaptic transmission in the hippocampus. In rat hippocampal slices, 30% N2O administered for 15-20 minutes persistently strengthened responses mediated by both AMPA and NMDA receptors, an effect blocked by a competitive NMDA receptor antagonist but not by an AMPA receptor antagonist, unlike ketamine. Both agents required TrkB, mTOR, and nitric oxide synthase, though with some mechanistic differences. N2O potentiation occluded enhancement by ketamine, and prior in vivo N2O exposure prevented further potentiation by either agent. These findings suggest N2O has ketamine-like effects on hippocampal synaptic function at a sub-anesthetic, therapeutically relevant concentration.

DOI: 10.1016/j.biopsych.2022.06.016 Full text Medicine

Prolonged Remission of Major Depressive Disorder After Single Nitrous Oxide Inhalation Treatment

Frontiers in Psychiatry July 17, 2020 P. Nagele, Frank Brown, Victoria Bass et al.

A patient with severe recurrent treatment-resistant major depression experienced full remission lasting more than one month after a single nitrous oxide (laughing gas) inhalation treatment. Previous studies had shown antidepressant effects starting within two hours and lasting up to one week, but it was unknown whether effects could persist longer. This case provides evidence that remission can extend beyond one month.

DOI: 10.3389/fpsyt.2020.00692 Full text Medicine