Effects of haloperidol on the delta-9-tetrahydrocannabinol response in humans: a responder analysis.
Psychopharmacology September 1, 2019 Swapnil Gupta, Joao P De Aquino, Deepak C D'Souza et al.
In healthy individuals who respond to THC, pre-treatment with the antipsychotic haloperidol reduces the psychosis-like effects of THC. Among 10 THC responders, THC-induced increases in positive symptoms (measured by the PANSS) were lower after haloperidol (average increase of 1.1 points) than after placebo (average increase of 2.9 points). This suggests that dopamine signaling may play a role in the psychosis-like effects of cannabinoids.