What are the psychological effects of using synthetic cannabinoids? A systematic review
Journal of Psychopharmacology February 21, 2019 Hina Akram, Claire Mokrysz, H. Valerie Curran 57 citations
Synthetic cannabinoids are more potent than natural cannabis because they fully activate the CB1 receptor, potentially causing more serious psychological effects. A review of 17 studies found that acute use impairs cognitive functioning and alters subjective psychological ratings compared to placebo. Non-intoxicated users show lower cognitive performance and elevated symptoms like paranoia compared to natural cannabis users and non-users. Methodological limitations across studies hinder conclusions about how dose, frequency, or type of synthetic cannabinoid influences outcomes. More research is urgently needed as use increases in at-risk populations.