Oxidation of 5-methoxy-N,N-diisopropyltryptamine in rat liver microsomes and recombinant cytochrome P450 enzymes.
Biochemical pharmacology February 1, 2008 Shizuo Narimatsu, Rei Yonemoto, Kazufumi Masuda et al.
The designer drug 5-MeO-DIPT (Foxy) is metabolized differently in rats than in humans. In rat liver, the main metabolic pathway is side-chain N-deisopropylation, with a smaller amount of aromatic ring O-demethylation, the opposite of human metabolism where O-demethylation dominates. Specific rat cytochrome P450 enzymes (CYP2C11, CYP3A2, CYP2D2, CYP2C6) are responsible for these reactions. Pretreatment with beta-naphthoflavone produced an additional 6-hydroxylated metabolite. These findings clarify the metabolic fate of 5-MeO-DIPT in rats, aiding toxicological studies.