Changes in neuroticism and values after naturalistic use of psychedelics and MDMA: a prospective survey study
Journal of Affective Disorders Reports July 1, 2026 Abigail E. Calder, Vincent J. Diehl, Bernd Hinney et al.
People who planned to use serotonergic psychedelics or MDMA in naturalistic settings reported lower neuroticism four weeks later, with the largest reductions in shame and feelings of tension. One week after use, they rated citizenship, family, intimate relationships, and spirituality as more important; only family remained elevated at four weeks. Serotonergic psychedelics were linked to greater increases in spirituality than MDMA. The findings suggest that both types of substances can produce lasting decreases in neuroticism and transient shifts in personal values, with family values showing the most persistent change.