Iontophoretic release of acetylcholine, noradrenaline, 5‐hydroxytryptamine and d‐lysergic acid diethylamide from micropipettes
British Journal of Pharmacology January 1, 1970 P. B. Bradley, J. M. Candy 68 citations
The release of acetylcholine, 5-hydroxytryptamine, noradrenaline, and D-lysergic acid diethylamide from micropipettes during iontophoresis is directly proportional to the electrical charge passed. Transport numbers are about twice as high for large micropipettes compared to small ones, and D-lysergic acid diethylamide has a very low transport number. Spontaneous leakage of these compounds is small and stable over time. In vitro measurements of acetylcholine release match in vivo findings. Brain-stem concentrations of D-lysergic acid diethylamide after intravenous injection were measured in intact and decerebrate cats.