A Physician’s Attempt to Self-Medicate Bipolar Depression with N,N-Dimethyltryptamine (DMT)
Journal of Psychoactive Drugs August 8, 2017 Tanida Brown, Wanda Shao, Shehzad Ayub et al. 21 citations
A physician with refractory bipolar depression chronically self-medicated with N,N-dimethyltryptamine (DMT) augmented with phenelzine, leading to altered mental status, mania, and psychosis. The case explores DMT's potential therapeutic and recreational uses, its theorized mechanism involving agonist activity at 5-HT1A, 5-HT2A, and 5-HT2C receptors, and the risks of self-medication, especially among physicians.