Early suicidal ideation change and suicidality-associated emergency department utilization after ketamine or esketamine treatment in treatment-resistant depression.
Ther Adv Psychopharmacol May 22, 2026 Liliana Patarroyo-Rodriguez, Vanessa K. Pazdernik, Jennifer L. Vande Voort et al.
Among people with treatment-resistant depression, early changes in suicidal ideation after ketamine or esketamine treatment are linked to later emergency department visits for suicidality. The analysis indicates that reductions in suicidal thoughts during the first few weeks of treatment may lower the risk of subsequent emergency care for suicidality, though the relationship requires further study.