Brain changes associated with depression treatment: a meta-analysis
NeuroImage Clinical January 1, 2025 Gianna M. Perez, Benjamin M. Rosenberg, Wenyi Xu et al. 3 citations
A meta-analysis of 18 experiments with 302 depressed patients found that effective depression treatment—whether pharmacology, psychotherapy, electroconvulsive therapy, psilocybin, or ketamine—consistently changes brain activity in the right amygdala. Across studies, activity in this region decreased after treatment. The finding suggests that the right amygdala is a key brain area for tracking depression treatment effects with fMRI, offering a target for future biomarker research.