A Sliding Time-Window ICA Reveals Spatial Variability of the Default Mode Network in Time
Brain Connectivity October 1, 2011 Vesa Kiviniemi, Tapani Vire, Jukka Remes et al. 268 citations
The spatial layout of the brain's default mode network (DMN) fluctuates over time, even when a person is at rest. Using a sliding time window analysis of functional connectivity MRI data from 12 participants, the authors found that the spatial similarity of successive DMN maps varied at low frequencies and followed a 1/f power spectral pattern. A single voxel appeared within a group DMN map in at most 82% of time windows, indicating marked temporal variation. Incidental connectivity increased centrifugally toward brain areas outside the DMN core. The method, SliTICA, captures this spatial variance and may provide a more complete measure of a network's functional activity.