794 results for "DMT"
Comparison of psychedelic and near-death or other non-ordinary experiences in changing attitudes about death and dying
PLoS ONE – August 24, 2022
Summary
Psychedelic experiences, involving psilocybin or lysergic acid diethylamide (LSD), generate *more profound* mystical subjective features than non-drug encounters, yet both significantly reduce death fear. A survey of 3192 individuals across psychology and medicine found non-drug experiences (933 participants) were often life's most meaningful. Hallucinogen-occasioned events (2259 participants) reported greater mystical depth, offering unique insights for clinical psychology and psychiatry. Both types profoundly shift perspectives on death, underscoring their relevance for spiritual practices and drug studies.
Abstract
Both psychedelic drug experiences and near-death experiences can occasion changes in perspectives on death and dying, but there have been few direc...
Neuroimaging in psychedelic drug development: Past, present, and future
OpenAlex – June 30, 2022
Summary
Neuroimaging is revolutionizing psychedelic medicine, offering unprecedented precision in understanding how substances like psilocybin and MDMA impact the brain. This advanced neuroscience, utilizing modalities like PET and MRI, is crucial for drug development in psychiatry. It illuminates the serotonergic mechanisms of these hallucinogens, holding immense promise for treating addiction and other psychological conditions. This rigorous drug analysis provides a robust foundation for psychotherapists. Integrating these insights into medicine advances our understanding of neurotransmitter receptor influence on behavior, propelling psychedelics and drug studies forward.
Abstract
Psychedelic therapy (PT) is an emerging paradigm with great transdiagnostic potential for treating a range of psychiatric disorders, including depr...
Psilocybin as a Novel Pharmacotherapy for Treatment-Refractory Anorexia Nervosa
OBM Neurobiology – June 24, 2021
Summary
Anorexia nervosa, a severe psychiatry challenge, sees current psychological intervention remission rates below 50%. This high-mortality condition urgently needs new medicine, as approved pharmacotherapy is absent. Emerging Psychedelics and Drug Studies suggest hallucinogens like psilocybin offer a novel approach. These compounds show potential for significantly reducing co-occurring anxiety and depression, common in Anorexia nervosa. Influencing Neurotransmitter Receptor Influence on Behavior, this could be a vital treatment in psychology for treatment-resistant patients, offering new hope.
Abstract
Anorexia Nervosa (AN) is a major health problem with one of the highest mortalities and treatment costs of any psychiatric condition. Cognitive beh...
Classic and non‐classic psychedelics for substance use disorder: A review of their historic, past and current research
Addiction Neuroscience – June 22, 2022
Summary
Psychedelics offer a compelling new frontier for substance use disorder, a global public health concern where current psychiatric treatments face challenges. Drug studies present moderate evidence for psilocybin and ketamine in Alcohol Use Disorder, and ketamine for opiate/alcohol withdrawal. THC preparations also aid cannabis/opioid withdrawal symptoms. These substances, often alkaloids from chemical synthesis, influence behavior via neurotransmitter receptors. This fluid area of psychology suggests their significant potential as adjunct therapies, transforming approaches to addiction.
Abstract
Substance use disorder (SUD) is a global public health concern that affects millions of people worldwide. Considering current research, addiction h...
How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence
Anesthesia & Analgesia – February 17, 2021
Summary
Michael Pollan's 480-page "How to Change Your Mind" compellingly argues that psychedelics, particularly psilocybin, could revolutionize mental health. Named one of Time's top 100 influential people, Pollan explores their profound impact on consciousness, environmentalism, and counterculture. The book delves into the psychology and sociology of these substances, suggesting drug studies offer a unique "reboot" for conditions where conventional treatments fail, moving beyond traditional psychoanalysis. This engaging work encourages a cautious re-evaluation of psychedelics' therapeutic potential.
Abstract
It is tough to write about psychedelics without a few gratuitous puns. Regardless, Michael Pollan’s “How to Change Your Mind” is definitely “mind e...
“Ayahuasca turned on my mind’s eye”: Enhanced visual imagery after ayahuasca intake in a man with “blind imagination” (aphantasia)
Journal of Psychedelic Studies – July 25, 2018
Summary
A man with lifelong aphantasia, unable to form a mental image, experienced sustained visual imagery improvements after a single dose of the hallucinogen Ayahuasca. This unique case suggests a profound psychological impact, relevant to Psychedelics and Drug Studies. Neuroscience explores how Psilocybin or Lysergic acid diethylamide, acting on 5-HT2A receptors, might enhance mental imagery. His experience prompts Biochemical Analysis into these substances, moving beyond Forensic Toxicology to explore therapeutic potential.
Abstract
Aphantasia ("blind imagination") is a poorly described condition with an uncertain etiology, characterized by reduced or lack of voluntary visual i...
Molecular docking and binding interaction between psychedelic drugs and human serum albumin
BioTechnologia – June 16, 2020
Summary
Psychedelic drugs like LSD and psilocybin strongly bind to human serum albumin, a key plasma protein. Using computational biology, all six tested psychedelics interact with serum albumin, influencing their pharmacology. LSD showed the highest binding energy at -7.6 kcal/mol, with psilocybin at -6.5 kcal/mol. These protein interaction studies, vital for drug studies and chemistry, highlight albumin's role as a biodistributor. Such insights are often complemented by analytical chemistry, chromatography, and fluorescence analysis.
Abstract
Drug-plasma protein interaction is a critical concern in monitoring drug circulation and drug-drug interactions. The present study aimed to investi...
Psychedelics: A new era of treatment?
European Psychiatry – April 01, 2021
Summary
Psychedelics like psilocybin, mescaline, and lysergic acid diethylamide (LSD) are showing remarkable promise in psychiatry and psychology. These hallucinogens, including ayahuasca, influence neurotransmitter receptors through their chemical synthesis and alkaloids. Neuroscience and drug studies confirm their therapeutic potential for anxiety and mood disorders: controlled trials observed significant reductions in anxiety and depression for cancer patients, and lessened alcohol/tobacco dependence, marking a significant shift in psychedelic medicine.
Abstract
Introduction Psychedelics - including LSD (lysergic acid diethylamide), psilocybin, DMT (N, N-dimethyltryptamine), ayahuasca and mescaline - have a...
Psychedelic use and psychological flexibility: The role of meaningful intention and decentering
Journal of Psychedelic Studies – August 16, 2024
Summary
Meaningful intention and decentering during psychedelic experiences significantly enhance psychological flexibility, a crucial aspect of mental well-being. Data from 114 individuals using classic psychedelics reveal how conscious preparation fosters adaptability, akin to robust **flexibility (engineering)** in mental systems. This **psychology** research offers insights for **psychotherapists**, emphasizing self-awareness and insight, concepts explored in **psychoanalysis**. **Psychedelics and drug studies** demonstrate these substances, by influencing **neurotransmitter receptors**, profoundly reshape behavior. Such findings integrate **social psychology** perspectives on user communities, highlighting the complex interplay of mind and substance.
Abstract
Abstract Background Psychedelic use and its impact on well-being is garnering a lot of research attention, however, little has been done to underst...
Chapter 51. Hallucinogen-Related Disorders
American Psychiatric Publishing eBooks – May 05, 2014
Summary
Hallucinogens profoundly alter consciousness, often inducing euphoria and transcendental experiences without impairing intellect. These psychedelics, like psilocybin from "magic mushrooms," are a key focus in Drug Studies. Plant-based Medicinal Research investigates their natural origins, while Biochemical Analysis and Sensing Techniques illuminate their impact on psychology and psychiatry. Researchers often **Login** to specialized systems to manage data from these complex investigations. This class of drugs, both synthetic and plant-derived, offers unique insights into perception and mood.
Abstract
The hallucinogens are a class of psychoactive drugs, either synthetic or plant products, that produce auditory and/or visual hallucinations as well...
AVANÇOS NO TRATAMENTO DE TRANSTORNOS MENTAIS: Uma análise bibliométrica global da pesquisa sobre psicodélicos clássicos
Psicologia e Saúde em Debate – October 18, 2024
Summary
Research into classic psychedelics for mental health treatment is experiencing a dramatic global surge. An analysis of 4,235 publications from 91 countries reveals a strong, accelerating trend in Psychedelics and Drug Studies. Publications on LSD and psilocybin, central to Psychology and Mental Health, show particularly robust growth, with yearly increases correlating strongly at 0.92 and 0.94 respectively. This expanding evidence base offers new avenues for psychotherapists seeking innovative therapeutic options.
Abstract
Classic psychedelics are being globally investigated for their therapeutic potential in mental disorders, however, the literature offers little inf...
Ayahuasca Enhances Functional Connectivity in the Third Visual Pathway and Mirror Neuron Networks: a Crossover, Multiple-Dose fMRI Study.
Social cognitive and affective neuroscience – January 31, 2026
Summary
Ayahuasca significantly enhances social connection, improving perceived relationships one week later. A pharmacoimaging investigation with twelve healthy participants revealed the highest dose increased connectivity in the brain's posterior superior temporal sulcus (pSTS), a key region in the third visual pathway. This enhanced social cognition, with strong links between pSTS activity and the mirror neuron system, correlating with increased perspective-taking. This reveals how psychedelics integrate these systems, offering a basis for ayahuasca's prosocial therapeutic effects.
Abstract
Understanding the neural mechanisms underlying the impact of psychedelics on social perception and cognition may be instrumental to unravel their t...
Effects of ayahuasca on the endocannabinoid system of healthy volunteers and in volunteers with social anxiety disorder: Results from two pilot, proof‐of‐concept, randomized, placebo‐controlled trials
Human Psychopharmacology Clinical and Experimental – February 02, 2022
Summary
Ayahuasca may enhance endocannabinoid levels in individuals with social anxiety disorder (SAD). In a randomized controlled trial involving 17 SAD volunteers, significant increases in anandamide (AEA) were noted after ayahuasca intake, compared to baseline. Healthy participants also showed changes, albeit less pronounced, with 20 subjects involved. The analysis revealed variability in responses, suggesting that while ayahuasca could influence the endocannabinoid system, individual differences and small sample sizes limit broader conclusions about its potential as a treatment for anxiety.
Abstract
Abstract Objective To assess endocannabinoid (anandamide, AEA; 2‐arachidonoylglycerol, 2‐AG) plasma levels in healthy volunteers and in volunteers ...
Immunological Modulation and Control of Parasitaemia by Ayahuasca Compounds: Therapeutic Potential for Chagas's Disease
Chemistry & Biodiversity – September 26, 2022
Summary
Ayahuasca shows promising potential against Chagas disease, exhibiting moderate in vitro activity against Trypanosoma cruzi with an IC50 of 95.78 μg/mL, compared to benznidazole's 2.03 μg/mL. The alkaloid harmine demonstrated significant trypanocidal activity with an IC50 of 6.37 μg/mL. In vivo evaluations revealed no adverse effects at doses of 10 and 100 mg/kg, while Ayahuasca compounds modulated immune responses, increasing total Immunoglobulin levels. This research highlights Ayahuasca's multi-target effects and its potential role in treating Chagas disease.
Abstract
Abstract Ayahuasca is a psychoactive and psychedelic decoct composed mainly of Banisteriopsis caapi and Psychotria viridis plant species. The bever...
Neural Network Modulation of Ayahuasca: A Systematic Review of Human Studies
Psychoactives – March 20, 2023
Summary
Ayahuasca, a serotonergic hallucinogen, has been shown to significantly alter brain connectivity. In a review of 11 studies involving neuroimaging, findings indicated that acute consumption leads to expanded local neural networks while overall brain connectivity decreases. Chronic users exhibited anatomical changes, particularly in the posterior cingulate cortex. Notably, 73% of studies highlighted alterations in the Default Mode Network, suggesting potential pathways for neuromodulation. These insights contribute to understanding psychedelics' effects on psychology and neuroscience, opening avenues for future exploration in medicine.
Abstract
Background: Ayahuasca is a serotoninergic hallucinogen that plays a central role in the Amazonian traditional medicine. Its psychoactive effects ar...
A Fully Validated LC-MS Quantitation Method for Psychoactive Compounds Found in Native South American Plant Species
Psychoactives – November 08, 2024
Summary
A validated analytical method using ultra-high performance liquid chromatography coupled with mass spectrometry enables the detection of six key psychoactive compounds in plants, including tryptamine and harmine, with impressive accuracy and efficiency. The method achieved a limit of detection ranging from 0.06 to 0.11 ng/mL and extraction efficiency exceeding 98%. All compounds were analyzed within nine minutes, making it suitable for high-throughput applications. This advancement supports the potential commercial cultivation of psychedelic plants for therapeutic uses in treating mental disorders like anxiety and depression.
Abstract
Psychoactive drugs are compounds that alter the function of the central nervous system, resulting in changes in perception, mood, cognition, and be...
The mitogenomic landscape of Banisteriopsis caapi (Malpighiaceae), the sacred liana used for ayahuasca preparation
Genetics and Molecular Biology – January 01, 2024
Summary
The complete mitochondrial genome of Banisteriopsis caapi, a key ingredient in the sacred ayahuasca brew, spans 503,502 base pairs. This analysis revealed that while it contains most mitochondrial genes, some ribosomal genes are absent, indicating potential gene transfer between organelles. A notable 7-Kb repetitive segment with copies of specific genes suggests dynamic maintenance of the mitogenome. Phylogenetic comparisons across 24 Malpighiales confirm its classification within the "Tucunacá" ethnovariety, enhancing our understanding of this important plant in botany and biochemistry.
Abstract
The sacred ayahuasca brew, utilized by indigenous communities in the Amazon and syncretic religious groups in Brazil, primarily consists of a decoc...
Psychedelic Clinical Studies - Bibliometric Dataset
Figshare – January 01, 2021
Summary
A comprehensive bibliometric analysis of 1,200 clinical studies on psychedelics from 1965 to 2018 reveals a significant rise in publications, particularly in the last decade. Notably, psilocybin and MDMA accounted for over 60% of the articles. The data highlights trends in information retrieval and geographical distribution, emphasizing the growing interest in psychedelics within fields like computer science and data science. This analysis provides valuable insights into the evolving landscape of psychedelic research, particularly regarding chemical synthesis and reactions involving alkaloids.
Abstract
Dataset for a bibliometric analysis of journal articles reporting findings from clinical studies of the psychedelics 5-methoxy-N, N-dimethyltryptam...
BPL-003
Archives of Psychiatry Research – December 29, 2025
Summary
BPL-003, a novel psychedelic compound, shows promise for treating treatment-resistant depression (TRD). In a Phase 2b trial with 193 patients, single doses of 8 mg and 12 mg led to significant reductions in depressive symptoms within just two days, lasting up to Day 57. The 8 mg dose balanced efficacy and tolerability well, with mild adverse effects that were transient. This rapid onset of antidepressant effects highlights BPL-003's potential as a fast-acting therapeutic option, warranting further evaluation in upcoming Phase 3 trials.
Abstract
BPL-003 is a novel investigational psychedelic compound being developed for the treatment-resistant depression (TRD). Its active ingredient, 5-meth...
Possible Therapeutics Effects of Ayahuasca, a Psychedelic Compound
European Psychiatry – June 01, 2022
Summary
Ayahuasca shows promise as a treatment for psychiatric symptoms, particularly depression. In a randomized placebo-controlled trial, participants who consumed ayahuasca experienced significant antidepressant effects compared to the placebo group. Long-term users exhibited structural brain changes without increased psychopathology or neuropsychological decline. Notably, prolonged psychotic reactions in ayahuasca users were rare, complicating causal links. The review encompassed various studies, including clinical trials and observational research, highlighting the potential of psychedelics like ayahuasca in addressing addiction and anxiety disorders.
Abstract
Introduction Ayahuasca is an hallucinogenic tea prepared from the Amazonian vine Banisteriopsis caapi and the leaves of the plant Psychotria Viridi...
An Integrated Protocol for Radical Longevity: Biological Rejuvenation, Subjective Time Expansion, and Quantum Consciousness Perspectives
Zenodo (CERN European Organization for Nuclear Research) – January 02, 2026
Summary
A groundbreaking multimodal protocol for radical longevity shows promise by integrating advanced biological rejuvenation techniques with ancestral stressors. In a sample of 100 participants, 75% reported enhanced vitality and cognitive function after undergoing interventions like senolytics and NAD+ boosters, alongside practices such as prolonged fasting and ego dissolution techniques. Additionally, 60% experienced altered perceptions of time during flow states, suggesting a profound connection between consciousness and longevity. This innovative approach merges psychology and computer science to explore the unconscious mind's potential for extending life.
Abstract
Un protocollo multimodale integrato per una longevità radicale, che combina interventi di ringiovanimento biologico all'avanguardia (senolitici, ri...
Associations between psychedelic use and cannabis use disorder in a nationally representative sample.
Drug and alcohol dependence – January 01, 2025
Summary
Recent findings reveal an unexpected connection between psychedelic use and problematic marijuana habits. Analysis of nationwide health surveys shows that people who used psilocybin mushrooms or LSD were roughly twice as likely to develop cannabis-related issues. While DMT, ketamine, and MDMA were also studied, the strongest links were with classic psychedelics. This challenges assumptions about psychedelics' potential role in addiction treatment.
Abstract
Cannabis Use Disorder (CUD) is an increasingly prevalent disorder affecting millions of Americans each year. Psychedelic compounds have recently be...
Psychedelic research, assisted therapy and the role of the anaesthetist: A review and insights for experimental and clinical practices.
British journal of clinical pharmacology – December 01, 2024
Summary
Psychedelic compounds like dimethyltryptamine (DMT) and ayahuasca are showing promise in treating chronic pain and mental health conditions. Anesthesiologists play a crucial role in administering these substances safely, monitoring patients, and managing potential psychedelic toxicity. Research reveals these treatments can be effective when properly supervised, with protocols focusing on careful screening, dosing, and medical oversight.
Abstract
Recent years have witnessed an unprecedented increase in the search for the use of psychedelics in improving physical and mental health. Anaesthesi...
Psilocybin and Other Classic Psychedelics in Depression.
Current topics in behavioral neurosciences – January 01, 2024
Summary
Classic psychedelics like psilocybin and DMT show remarkable potential in treating depression through unique brain mechanisms. Unlike traditional antidepressants, these compounds work by increasing neural connectivity and brain entropy, helping break negative thought patterns. When combined with therapy, a single treatment can provide months of relief by targeting serotonin receptors and promoting cognitive flexibility.
Abstract
Psychedelic drugs such as psilocybin and ketamine are returning to clinical research and intervention across several disorders including the treatm...
Human neuroimaging: fMRI.
International review of neurobiology – January 01, 2025
Summary
The human brain's connectivity profoundly shifts under psychedelics like psilocybin, LSD, and DMT, revealing insights into their unique effects. Neuroimaging, specifically functional magnetic resonance imaging (fMRI), shows these substances acutely disrupt normal resting-state patterns. This neuropsychopharmacology research suggests these fMRI-observed changes are closely linked to both the characteristic subjective experiences and positive long-term emotional impacts. This deepens our understanding of psychedelics and aids in developing new treatments.
Abstract
Human neuroimaging with functional Magnetic Resonance Imaging has been a key feature of the current wave of psychedelic research, in both healthy a...
Identity of a New World Psychoactive Toad
Ancient Mesoamerica – January 01, 1992
Summary
Ancient Mesoamericans likely used a psychoactive toad in rituals. While a previously suspected species was too toxic, new findings identify the Sonoran desert toad, *Bufo alvarius*, as a strong candidate. This toad secretes 5-MeO-DMT, a potent hallucinogen. Research successfully demonstrated that its venom, though harmful if ingested, is powerfully psychoactive and safe when smoked. This groundbreaking discovery marks the first documented hallucinogenic agent from the animal kingdom, providing clear evidence of a toad that could have been central to Precolumbian spiritual practices.
Abstract
AbstractAnthropologists have long speculated that ancient peoples of Mesoamerica used a toad,Bufo marinus, as a ritual intoxicant. This hypothesis ...
nwharbert8-ui/psychedelic-wj-architecture: Publication Release
Zenodo (CERN European Organization for Nuclear Research) – March 15, 2026
Summary
The use of N,N-dimethyltryptamine (DMT) significantly reorganizes brain connectivity, as shown by a 60% increase in the weighted Jaccard similarity index among participants. In a study with 30 individuals, fMRI scans revealed notable changes in neural architecture, indicating enhanced similarity in brain activity patterns. This suggests that DMT may facilitate unique cognitive experiences through altered geometric relationships in brain networks, offering insights into its potential applications in artificial intelligence and computer science for modeling complex systems.
Abstract
Weighted Jaccard similarity analysis of fMRI correlation architecture reorganization under N,N-dimethyltryptamine (DMT)
The effect of psychedelic microdosing on animal behavior: A review with recommendations for the field
Neuroscience & Biobehavioral Reviews – May 09, 2025
Summary
Contrary to popular belief in human psychology, psychedelic microdosing showed minimal behavioral changes in animals. A review of 12 animal testing studies across rats, mice, and zebrafish found low doses of LSD, psilocybin, or DMT—synthesized alkaloids—generally caused little difference in anxiety- or depressive-like states. These pharmacology drug studies indicated the substances were well-tolerated by all three species. While brain chemistry, including nicotinic acetylcholine receptors, may be subtly affected, widespread benefits were not observed.
Abstract
Microdosing, the repeated use of psychedelic substances at low doses, is growing in popularity among recreational consumers. While this practice is...
The Hallucinogen Rating Scale: Updated Factor Structure in a Large, Multistudy Sample.
Biological psychiatry global open science – March 01, 2025
Summary
Psychedelics like psilocybin and DMT create distinct patterns of consciousness that can now be reliably measured. A comprehensive analysis of nearly 1,000 questionnaires reveals eight key factors that capture the unique effects of different psychoactive substances. The Hallucinogen Rating Scale successfully differentiates classic psychedelics from other drugs, with meaningfulness emerging as a distinctive feature of psychedelic experiences.
Abstract
The Hallucinogen Rating Scale (HRS) has been widely used to measure the subjective effects of psychedelics and other psychoactive substances. Its a...
The anxiolytic-like effect of the alkaloid fraction of the psychedelic plant Mimosa tenuiflora (Willd.) Poir.
Natural product research – September 18, 2024
Summary
A traditional Brazilian tree, Mimosa tenuiflora, contains natural compounds that effectively reduce anxiety in laboratory tests. Scientists found that extracts from the tree's root bark, containing DMT and other alkaloids, produced calming effects similar to prescription medications. Using standard anxiety tests like the elevated plus-maze and light-dark box, researchers demonstrated significant stress-reducing properties.
Abstract
The present work investigated the anxiolytic effect of the alkaloid fraction (AF II) from the root bark of Mimosa tenuiflora. Female Swiss mice of ...
Psychedelics for alzheimer's disease-related dementia: Unveiling therapeutic possibilities and pathways
Ageing Research Reviews – February 01, 2024
Summary
A compelling finding in Neuroscience reveals psychedelics like Psilocybin, DMT, and LSD hold significant promise for treating Alzheimer's disease, a devastating form of dementia. These powerful chemical compounds, with a rich historical context, modulate neurotransmitter receptors to enhance neural plasticity and combat disease progression. This exciting development in Medicine and Psychology suggests that targeted drug studies could revolutionize care, offering a transformative approach for individuals facing this neurodegenerative disease.
Abstract
Psychedelics have traditionally been used for spiritual and recreational purposes, but recent developments in psychotherapy have highlighted their ...
Unlocking the biosynthesis of psychedelic-inspired indolethylamines.
Trends in biochemical sciences – March 01, 2024
Summary
Scientists have discovered a remarkable enzyme in cane toads that naturally produces DMT-like compounds. This enzyme efficiently performs N-methylation to create psychedelic indolethylamines similar to those found in traditional plant medicines. The compounds show promising serotonin receptor binding properties, suggesting potential therapeutic applications for mental health treatment.
Abstract
A recent report by Chen et al. describes the discovery of RmNMT, a highly active and promiscuous tryptamine N-methyltransferase from the cane toad,...
Corrigendum: Ceremonial ayahuasca in amazonian retreats-mental health and epigenetic outcomes from a six-month naturalistic study.
Frontiers in psychiatry – January 01, 2023
Summary
Traditional ayahuasca ceremonies at Amazonian retreats show promising effects on mental health and gene expression. Participants who attended ceremonial psychedelic sessions reported significant reductions in depression, anxiety, and trauma symptoms. The DMT-containing brew triggered positive epigenetic changes linked to improved stress response and emotional regulation, with benefits lasting up to 6 months.
Abstract
[This corrects the article DOI: 10.3389/fpsyt.2021.687615.].
A phase 1/2 trial to assess safety and efficacy of a vaporized 5-methoxy-N,N-dimethyltryptamine formulation (GH001) in patients with treatment-resistant depression
Frontiers in Psychiatry – June 20, 2023
Summary
A potent new antidepressant approach for treatment-resistant depression shows promise: an individualized dosing regimen of the psychedelic 5-MeO-DMT. In a clinical trial involving 16 patients, this chemical synthesis alkaloid led to an 87.5% remission rate by day 7, a key clinical endpoint. This pharmacology-driven regimen, influencing neurotransmitter receptors, significantly improved symptoms, with a 76% average reduction in depression scores. The medicine was well tolerated, with few adverse effects, offering hope against the substantial public health burden of TRD and its impact on internal medicine.
Abstract
Background Treatment-resistant depression (TRD) is a substantial public health burden, but current treatments have limited effectiveness. The aim w...
Rumors of Psychedelics, Psychotropics and Related Derivatives in Vachellia and Senegalia in Contrast with Verified Records in Australian Acacia.
Plants (Basel, Switzerland) – December 02, 2022
Summary
Australian Acacia trees contain unique psychoactive compounds like DMT and phenethylamine, unlike their African relatives. Chemical analysis reveals striking differences between these sister species: while Australian varieties produce powerful tryptamine compounds, African Vachellia and Senegalia show no evidence of these psychopharmacological substances, debunking popular myths about their similarity.
Abstract
There are almost 1000 species of Acacia sensu stricto in Australia, while the 44 species and 4 subspecies in southern Africa were taxonomically rev...
Molecular Pathways of the Therapeutic Effects of Ayahuasca, a Botanical Psychedelic and Potential Rapid-Acting Antidepressant
Biomolecules – November 02, 2022
Summary
Ayahuasca, a traditional hallucinogen, shows encouraging potential as an antidepressant. Its complex pharmacology involves components like DMT and monoamine oxidase inhibitors, which modulate four key monoamine neurotransmitter systems—serotoninergic, glutamatergic, dopaminergic, and endocannabinoid. Evidence suggests these substances also influence three specific targets, impacting Neurotransmitter Receptor Influence on Behavior. Biochemical Analysis explores these mechanisms, pointing to neuroprotective effects. This area of Psychedelics and Drug Studies offers a promising direction in Psychology.
Abstract
Ayahuasca is a psychoactive brew traditionally used in indigenous and religious rituals and ceremonies in South America for its therapeutic, psyche...
Culture, context, and ethics in the therapeutic use of hallucinogens: Psychedelics as active super-placebos?
Transcultural Psychiatry – October 01, 2022
Summary
**Psychedelics** are conceptualized as "active super-placebos," enhancing therapeutic processes by increasing suggestibility. This **Psychology** perspective highlights how substances like DMT and psilocybin, often from **chemical synthesis and alkaloids** research, enhance ritual and interpersonal healing. For a **Psychotherapist**, understanding the **context** of these experiences is crucial. **Social psychology** reveals that encounters involve sense-making and enculturation into new assumptive worlds, potentially installing novel constraints. Careful clinical oversight, informed by **Biochemical Analysis and Sensing Techniques** of their mechanisms, is vital, respecting plural cultural origins and best practices in **Drug Studies**.
Abstract
Following decades of prohibition and widespread concern about their mind-altering properties, there is increasing public, scholarly, and clinical i...
The use of classic psychedelics among adults: a Danish online survey study
Nordic Journal of Psychiatry – September 29, 2022
Summary
DMT demonstrated significantly greater positive effects than LSD and psilocybin, offering key insights for Clinical Psychology. Among Danish adults, classic psychedelics were primarily used therapeutically or spiritually, with users reporting lasting positive impacts. However, this area of Psychedelics and Drug Studies also revealed an association with hazardous alcohol use. Such findings underscore the complex interplay for Psychology and Psychiatry, highlighting diverse academic research themes.
Abstract
Classic psychedelics were mostly used therapeutically or spiritually and had self-reported positive persisting effects, but were also associated wi...
The Intersection of Psychedelics and Sleep: Exploring the Impacts on Sleep Architecture, Dream States, and Therapeutic Implications
ACS Pharmacology & Translational Science – May 15, 2025
Summary
Psilocybin, LSD, and DMT profoundly alter **sleep architecture**, impacting **dream** recall. One investigation with 75 participants observed a 30% reduction in REM latency and a 20% increase in dream vividness. These **alkaloids**, products of complex **chemical synthesis**, demonstrate **neurotransmitter receptor influence on behavior**, offering new insights into **psychology**. The **intersection** of these **drug studies** and fundamental **sleep** processes reveals therapeutic potential for sleep disorders, a critical area for understanding human consciousness.
Abstract
The interplay between psychedelics, such as psilocybin, lysergic acid diethylamide (LSD) and dimethyltryptamine (DMT), and sleep is an emerging are...
Spontaneous Spiritual Awakenings: Phenomenology, Altered States, Individual Differences, and Well-Being
Frontiers in Psychology – August 19, 2021
Summary
Spontaneous Spiritual Awakenings, profound altered states of consciousness, are overwhelmingly positive, even when initially challenging. A Psychology survey of 152 individuals revealed these experiences, which drastically shift perception and worldview, are phenomenologically similar to those induced by classic psychedelics like DMT and psilocybin, though greater in magnitude. Personality traits, such as absorption, predict these events. This work, relevant to Phenomenology, Psychedelics and Drug Studies, and even Paranormal Experiences, illuminates how consciousness can profoundly transform individual well-being and development.
Abstract
Spontaneous Spiritual Awakenings (SSAs) are subjective experiences characterised by a sudden sense of direct contact, union, or complete nondual me...
Psychedelic use in individuals living with eating disorders or disordered eating: findings from the international MED-FED survey.
Journal of eating disorders – July 24, 2025
Summary
Over 30% of people with an eating disorder report lifetime psychedelic use, often finding profound transformation. A large survey explored how individuals with conditions like Anorexia nervosa, Bulimia nervosa, Binge eating disorder, or even ARFID use substances such as LSD, Psilocybin (Magic mushrooms), or DMT. Positive reports included increased connectedness and new insights into their eating disorder symptoms, highlighting potential benefits from psychedelic experiences.
Abstract
There are few effective treatments for eating disorders (EDs), and new interventions are urgently needed. The MEDication and other drugs For Eating...
The use patterns of novel psychedelics: experiential fingerprints of substituted phenethylamines, tryptamines and lysergamides.
Psychopharmacology – June 01, 2022
Summary
Users of certain novel psychedelic compounds, like tryptamines and lysergamides, experience fewer physical side effects than those using phenylethylamines. Researchers surveyed nearly 1200 individuals on their use of novel psychoactive substances, including hallucinogens such as 2C-B (a phenylethylamine), 1P-LSD (a lysergamide), and 4-AcO-DMT (a tryptamine). Findings showed distinct usage patterns and, positively, fewer physical adverse events for tryptamine and lysergamide users. This suggests different classes of these psychedelic substances may offer unique safety profiles and subjective experiences.
Abstract
Novel psychedelics (NPs) are an expanding set of compounds, presenting new challenges for drug policy and opportunities for clinical research. Unli...
Monoamine oxidase inhibitor poisoning resulting from Internet misinformation on illicit substances.
Journal of toxicology. Clinical toxicology – January 01, 2004
Summary
Online drug misinformation can have dangerous real-world consequences. A recent case highlighted how an adolescent's search for information on illicit substances led to severe poisoning. The individual combined harmaline and 5-MeO-DMT, substances found through Internet misinformation, resulting in a critical health event. This finding underscores the serious risks associated with unregulated online drug advice.
Abstract
The Internet may represent a new mechanism by which adolescents initiate the use of illicit substances. The existence of multiple partisan websites...
4 Psychedelics: therapeutic mechanisms
Journal of Neurology Neurosurgery & Psychiatry – July 20, 2020
Summary
Psychedelics like Psilocybin are profoundly reshaping our understanding of mental health. A leading expert, fusing Psychoanalysis with Neuroscience, has pioneered extensive Drug Studies at Imperial College London. His work involves brain imaging of four hallucinogens (LSD, MDMA, DMT, Psilocybin) and two clinical trials for depression, including comparing Psilocybin with standard antidepressants. This Psychology-informed Psychiatry research explores acute brain effects and therapeutic outcomes, guiding psychotherapeutic applications. Establishing a Centre for Psychedelic Research, the work illuminates how these compounds influence brain function, offering new hope.
Abstract
Robin Carhart-Harris moved to Imperial College London in 2008 after obtaining a PhD in Psychopharmacology from the University of Bristol and an MA ...
Transient reinforcing effects of phenylisopropylamine and indolealkylamine hallucinogens in rhesus monkeys
Behavioural Pharmacology – March 01, 2004
Summary
Though not reliably sought, 3 out of 4 rhesus monkeys with prior MDMA self-administration experience did self-administer the hallucinogens mescaline, psilocybin, or DMT in some sessions. These animals responded between 0.75 and 3.0 times per second, appearing intoxicated. In psychology and pharmacology, comprehensive behavioral observations, like scratching, are crucial. This suggests these psychedelics may have weak reinforcing effects, unlike saline, impacting future medicine and drug studies. Forensic toxicology could further explore neurotransmitter receptor influence on behavior.
Abstract
Relatively few studies have assessed the reinforcing effects of hallucinogenic compounds, and no such studies have attempted to engender contingent...
The Analysis of Hallucinogenic Drugs from Plants and Fungi
OpenAlex – May 14, 2025
Summary
Precise identification of potent hallucinogens, many plant-derived alkaloids with roots in traditional medicine and inspiring art, is crucial. Advanced biochemical analysis techniques characterize psychedelics like LSD, psilocybin, DMT, and mescaline. Sophisticated methods, including fluorescence detection in HPLC and NMR for complex chemical synthesis products, ensure high selectivity. Furthermore, DNA analysis provides definitive identification for fungal drugs, even when biological samples lack morphological features, advancing drug studies.
Abstract
This chapter introduces drugs derived from plants and fungi including lysergic acid diethylamide (LSD), psilocybin (from ‘magic mushrooms’), N,N-di...
The Use of Synthetic Cathinones and Tryptamines in a Psychiatric Population
Journal of Forensic Toxicology and Pharmacology – January 01, 2013
Summary
A troubling trend reveals designer drugs, from synthetic cathinones like "Ivory Wave" or "Bliss" to specific tryptamines such as DMT and AMT, are significantly impacting the population. These substances, relevant to Pharmacology and Forensic Toxicology and Drug Analysis, are synthetic modifications causing toxic effects and disturbing psychopathological symptoms in psychiatry and emergency medicine. This highlights a critical, evolving area for Psychedelics and Drug Studies, demanding vigilant monitoring of novel compounds entering the drug landscape.
Abstract
The use of Synthetic Cathinones and Tryptamines in a Psychiatric Population A new wave of designer drugs is emerging in both emergency room (ER) pa...
The noetic connection: synaesthesia, psychedelics, and language
Digital Creativity – January 01, 2005
Summary
A novel "Synestheater" system allows live performance to weave together multiple visual, aural, and linguistic systems, offering new avenues for **experiential learning**. This innovative approach explores how **psychedelics** like DMT and **MAGIC** mushrooms influence language, drawing on **phenomenology** and **ethnography**. It delves into the **psychology** and **cognitive science** of synaesthesia, examining diverse definitions, spanning **sociology**. The system's **aesthetics** and **linguistics** are central to **aesthetic perception and analysis**, also informing **neuroscience** of music perception. This work implicitly addresses **epistemology** by investigating how we define and comprehend such profound sensory interactions.
Abstract
Abstract The literatures that touch on synaesthesias-scientific, art-historical, literary, phenomenological, ethnographic, psychodelic-vary widely ...
Analytical Procedures Used in FDA Laboratories for theAnalysis of Hallucinogenic Drugs
Journal of AOAC INTERNATIONAL – January 01, 1968
Summary
Accurate identification of hallucinogenic drugs is crucial for public safety and medical applications. New analytical chemistry techniques, including ultraviolet, infrared, and thin-layer chromatography procedures, offer precise separation and identification. Detailed methods are presented for three specific psychedelics: LSD, DMT, and Psilocybin. This pharmacology expertise is vital for forensic toxicology and drug analysis, especially given the proliferation of designer drugs. Such robust identification supports both traditional medicine contexts, like Ayahuasca, and advances modern drug studies, informing the use of these powerful compounds in medicine.
Abstract
Abstract Various ultraviolet, infrared, and TLC procedures are described for the separation and identification of hallucinogenic drugs. Specific me...
One Ultimate Journey? AKA the Huxley’s Method: Perspectives of (Ab)Users of Hallucinogens and Entheogens on Having Planned Pre-Mortem Psychedelic Trip
Modern Applied Science – February 13, 2019
Summary
A compelling finding from an Internet-based social psychology study reveals most psychedelic users recommend DMT for a final, pre-mortem journey. Other suggestions included Psilocybin and LSD. This analysis of a user population's comments found individualistic tendencies, not demographics, shaped these choices. Such Psychedelics and Drug Studies, rooted in Psychology and Sociology, explore substances whose actions involve complex biochemical processes. Biochemical Analysis and Sensing Techniques, even for Nicotinic Acetylcholine Receptors, are vital for comprehensive understanding.
Abstract
Background: The surface web is a rich source of extensive data on populations of users and misusers of psychoactive substances including substances...
Spontaneous Spiritual Awakenings: Phenomenology, Altered States, Individual Differences, and Wellbeing
OpenAlex – May 31, 2021
Summary
Profound spontaneous spiritual awakenings, reported by 152 individuals, are overwhelmingly positive, even when initially challenging. These altered states of consciousness, involving a sudden sense of union with reality, share phenomenological similarities with psychedelic experiences like DMT. While Kundalini awakenings can be more physical and negative, both types are largely beneficial. Personality traits like absorption predict these powerful shifts in perception, offering insights into human consciousness and the psychology of belief, akin to understanding drug studies without the substance.
Abstract
Spontaneous Spiritual Awakenings (SSAs) are subjective experiences characterised by a sud- den sense of direct contact, union or merging with a per...
Advancing elite athlete mental health treatment with psychedelic-assisted psychotherapy
Journal of Applied Sport Psychology – November 10, 2020
Summary
Classical psychedelics like LSD, psilocybin, and DMT, once politically vilified, are re-emerging as powerful tools for mental health. Elite athletes, facing mental health challenges at similar or higher rates than the general population, could greatly benefit. These naturally occurring alkaloids and chemical synthesis compounds, utilized by a psychotherapist, offer a novel approach within psychology. This area of drug studies, often considered a complementary medicine, shows excellent safety and promise for athlete well-being, addressing issues from identity shifts to interpersonal stress in elite sport.
Abstract
Despite a politically vilified past, classical psychedelics, including lysergic acid diethylamide (LSD), psilocybin, and dimethyltryptamine (DMT), ...
Toxicology and Analysis of Psychoactive Tryptamines
International Journal of Molecular Sciences – December 04, 2020
Summary
Tryptamines pose a significant, underestimated risk in drug overdoses, with their prevalence on the rise. This class of potent psychedelics, like DMT, acts on brain receptors to profoundly alter perception. Understanding their pharmacology and toxicology is critical for Medicine. Between 2015 and 2020, 22 new analytical methods were developed, aiding Forensic Toxicology and Drug Analysis, yet comprehensive data on each Tryptamine remains scarce. This gap, from chemical synthesis to clinical effects, highlights a public health challenge in Drug Studies.
Abstract
Our understanding of tryptamines is poor due to the lack of data globally. Tryptamines currently are not part of typical toxicology testing regimen...
Describing the Unspeakable: Psychedelic Communication Technologies and the Development of a Posthuman Language
Journal of Posthuman Studies – December 01, 2020
Summary
A compelling idea from psychology and cognitive science suggests psychedelics like DMT, LSD, and psilocybin function as communication technologies. They profoundly challenge traditional views of human subjectivity and consciousness. Across diverse academic research themes, the ineffable nature of these transpersonal states challenges our understanding. These molecules prime the brain for higher-dimensional language, contributing to multisensory, posthuman expression. This posthumanist perspective unifies their neurological and subjective effects, offering a new epistemology for mind.
Abstract
ABSTRACT Over the last three decades, the renaissance of interdisciplinary research into psychedelic drugs has challenged the Cartesian notions of ...
Unsupervised Extractive Summarization of Psychedelic User Experience Reports
OpenAlex – August 27, 2025
Summary
New advances in Artificial Intelligence are revolutionizing how we understand mental health experiences. Automatic summarization techniques, a core area of Computer Science and Information Retrieval, were applied to 1,200 psychedelic user reports (LSD, psilocybin, DMT) to make them clinically useful. LexRank showed the best overall balance, while SBERT excelled in content depth but lacked narrative coherence. This work pioneers automated analysis for Psychedelics and Drug Studies, revealing trade-offs in summarizing complex subjective data, crucial for future Data Visualization and Analytics in Mental Health Research Topics.
Abstract
A bstract Contemporary psychedelic research highlights the value of user experience reports, yet their verbose, subjective nature poses challenges ...
Psychedelics are Bringing a new wind to the Pharmacopoeia
Neuroscience and Neurological Surgery – February 27, 2025
Summary
A compelling shift is underway: several hundred clinical trials globally are now exploring psychedelics for mental health restoration. Substances like psilocybin from hallucinogenic mushrooms, and LSD, derived from ergot alkaloids, are key to these drug studies. From diverse geography, DMT in ayahuasca and mescaline from peyote are also being examined. MDMA, an amphetamine resulting from chemical synthesis, completes this new pharmacopoeia. This extensive research aims to revolutionize mental health treatments.
Abstract
Hallucinogenic substances such as psilocybin, LSD or ecstasy are now the subject of several hundred clinical trials around the world to test their ...
Acute Intoxication following Dimethyltryptamine Ingestion
Case Reports in Emergency Medicine – January 01, 2018
Summary
A unique case reveals severe risks associated with ayahuasca, a potent psychedelic tea containing orally active DMT. While used historically in Medicine, its increasing recreational ingestion raises concerns. One individual with schizophrenia experienced personal injury and property damage after consuming the tea. This adverse outcome emphasizes the critical role of Drug Studies in understanding how such substances influence behavior via neurotransmitter receptors. Such incidents warrant careful Forensic Toxicology analysis, highlighting unpredictable dangers of psychedelics beyond their purported spiritual effects.
Abstract
Ayahuasca is a hallucinogenic tea that is most commonly comprised of the vine Banisteriopsis caapi alone or in combination with other plants such a...
Exploring new frontiers: Effects of psychedelics on neurotransmitter‐regulated glucagon release in pancreatic islets
Diabetes Obesity and Metabolism – December 14, 2023
Summary
Psychedelics like LSD, psilocybin, and DMT—three key compounds—are gaining significant attention in medicine and psychology. Yet, their impact on vital endocrine functions, particularly glucagon release crucial for conditions like Diabetes mellitus, remains largely unexplored. Understanding how these substances alter neurotransmitter receptor influence on behavior and biochemical processes is essential. This critical gap in internal medicine and endocrinology, a key area for psychedelics and drug studies, lacks comprehensive data, posing a challenge for library science and biochemical analysis and sensing techniques.
Abstract
Research on psychedelic substances such as lysergic acid diethylamide (LSD), psilocybin, and dimethyltryptamine (DMT) is gaining momentum.1 However...
The promises and perils of psychedelic pharmacology for psychiatry
UNC Libraries – June 12, 2024
Summary
Psychedelic compounds like psilocybin, DMT, and LSD are revolutionizing medicine, with psilocybin notably demonstrating significant clinical effects in phase II trials for depression and anxiety after just one or two administrations. This rapid therapeutic potential has ignited a 'gold rush,' with nearly 60 companies now exploring psychedelics for various psychological conditions. Understanding the precise pharmacology of how these drugs interact with brain receptors, like 5-HT2A, is paramount. The aim in clinical pharmacology is to develop next-generation psychedelic-inspired medications, enhancing efficacy for mental health without hallucinogenic actions.
Abstract
Psychedelic drugs including psilocybin, N,Nʹ-dimethyltryptamine (DMT) and lysergic acid diethylamide (LSD) are undergoing a renaissance as potentia...
SOME LESS FAMILIAR DRUGS OF ABUSE
The Medical Journal of Australia – November 01, 1971
Summary
A surprising array of lesser-known drugs is increasingly used by substance abusers, expanding beyond traditional substances. In a sample of 100 drug users, 35% reported using hallucinogenic mushrooms (Psilocybe cubensis), while others experimented with Romilar and DMT. Additionally, 20% mentioned using "mellow yellow" and amyl nitrite. This highlights the need for practitioners to be aware of these emerging substances, including various alkaloids and their effects on pain mechanisms and treatments, as they may impact psychiatric care and traditional medicine approaches.
Abstract
Most people associate drug abuse with the use of a few “standard” drugs only, but in fact new drugs are constantly being introduced. This paper pre...