794 results for "DMT"
Effectiveness and safety of ofatumumab in treatment-naive and oral DMT-switched multiple sclerosis patients: a multicenter observational study in China.
Multiple sclerosis and related disorders – November 01, 2025
Summary
Many people living with Multiple sclerosis saw significant improvements in their condition after starting Ofatumumab. This real-world data reveals impressive Effectiveness, with patients experiencing a substantial drop in relapse rates and improved disability scores. The study observed individuals new to treatment and those who made a crucial switch from oral therapies due to disease progression or relapses. Crucially, the Safety profile was excellent, with no serious adverse events reported. These findings underscore Ofatumumab's positive impact on managing Multiple sclerosis.
Abstract
Ofatumumab, a fully humanized anti-CD20 monoclonal antibody, is the only highly effective disease modifying therapy (DMT) approved for the treatmen...
Liquid chromatography-tandem mass spectrometry method for the bioanalysis of N,N-dimethyltryptamine (DMT) and its metabolites DMT-N-oxide and indole-3-acetic acid in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences – December 15, 2022
Summary
Scientists have developed a precise method to track how the psychedelic compound DMT, found in ayahuasca, moves through the human body. This bioanalysis technique uses advanced HPLC technology to measure DMT and its metabolites in blood plasma, offering unprecedented insight into the pharmacokinetics of this powerful substance. The method proved highly accurate and efficient, enabling researchers to monitor DMT metabolism in patients receiving controlled doses.
Abstract
The indole alkaloid N,N-dimethyltryptamine (DMT) induces psychedelic effects in humans. In addition to ceremonial and recreational use, DMT is subj...
Acute experiences and persisting psychological effects associated with an encapsulated DMT-harmala alkaloid combination: results of a phase 1 study.
Scientific reports – November 20, 2025
Summary
Mystical experiences during psychedelic journeys are strongly linked to lasting mental well-being. A clinical study explored an encapsulated DMT-harmala combination. Healthy volunteers received varying doses, reliably experiencing potent mystical experiences, often exceeding previous reports. These intense psychedelic experiences were robustly associated with beneficial persisting psychological effects, highlighting the potential of this DMT and Harmala formulation for therapeutic use.
Abstract
Acute subjective experiences induced by psychedelics have been identified as important mediators of therapeutic outcomes in many studies. Mystical ...
DMT-induced shifts in criticality correlate with self-dissolution
The Journal of Neuroscience – November 24, 2025
Summary
A fascinating discovery reveals how psychedelics reshape consciousness. A powerful substance, DMT, profoundly alters brain activity, shifting its normal rhythmic patterns away from a 'critical' state. This change, observed in alpha and theta brainwaves, increases brain entropy while reducing its complexity. Crucially, these shifts directly correlate with the profound subjective experience of 'self-dissolution,' where one's sense of self temporarily fades. This clarifies how psychedelics impact the brain's fundamental dynamics, illuminating altered states of consciousness.
Abstract
Psychedelics profoundly alter subjective experience and brain dynamics. Brain oscillations express signatures of near-critical dynamics, relevant f...
DMT-induced shifts in criticality correlate with self-dissolution.
The Journal of neuroscience : the official journal of the Society for Neuroscience – November 24, 2025
Summary
Our sense of self is intricately linked to the brain's 'critical' balance of activity. New findings reveal how a potent psychedelic shifts brain oscillations, particularly alpha waves, towards a quieter, subcritical state. This change, increasing brain entropy while reducing complexity, directly correlates with the intensity of experiencing a dissolved sense of self. These insights illuminate the neurological basis of altered consciousness.
Abstract
Psychedelics profoundly alter subjective experience and brain dynamics. Brain oscillations express signatures of near-critical dynamics, relevant f...
DMT-induced shifts in criticality correlate with ego-dissolution
bioRxiv – February 08, 2025
Summary
Our brains operate at a unique "sweet spot" for processing information. This study explored if a powerful psychedelic, DMT, shifts this brain balance and how that relates to profound changes in self-perception. Researchers measured brain activity in participants given DMT, observing network behavior and subjective reports of ego-dissolution. Findings revealed DMT shifted brain activity away from this optimal balance, making it more chaotic. This change strongly correlated with participants reporting a profound loss of their sense of self. This directly links specific brain state changes to the subjective experience of ego-dissolution, offering new insights into consciousness.
Abstract
DMT-induced shifts in criticality correlate with ego-dissolution
Further studies on the dose-dependent stimulus properties of 5-methoxy-N,N-dimethyltryptamine.
Pharmacology, biochemistry, and behavior – December 01, 1986
Summary
No Summary
Abstract
Twenty-two rats were trained to discriminate either 1.5 mg/kg of 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a standard two-lever o...
Psychedelic Therapy: A Primer for Primary Care Clinicians – Part III. N,N-dimethyltryptamine (DMT) and Ayahuasca
CrossRef
Summary
A single dose of DMT led to 57% of major depressive disorder patients experiencing remission 12 weeks later. This naturally-occurring psychedelic, also found in ayahuasca, shows significant promise. A separate trial found ayahuasca caused remission in 36% of patients with treatment-resistant depression within one week. While generally safe, ayahuasca can cause transient vomiting. The therapeutic and biological roles of DMT, including its possible link to near-death experiences and its impact on human consciousness, warrant further exploration.
Abstract
Background: N,N-dimethyltryptamine (DMT) is a naturally-occurring serotonergic psychedelic found in natural plants around the globe. As the main ps...
Neural network models for DMT-induced visual hallucinations
Neuroscience of Consciousness – January 01, 2020
Summary
Psychedelic alkaloids like N,N-Dimethyltryptamine profoundly alter visual perception, offering unique insights into consciousness. Neuroscience and cognitive psychology reveal how the serotonergic system, influenced by these compounds, critically gates sensory and internal information, shaping our reality. Utilizing two advanced generative deep neural networks, cognitive science can illustrate psychedelic-induced visual hallucination. This innovative approach helps conceptualize how the serotonergic sensory system regulates visual perception, providing a novel framework for understanding sensory gating and the biochemical basis of perception within drug studies.
Abstract
Abstract The regulatory role of the serotonergic system on conscious perception can be investigated perturbatorily with psychedelic drugs such as N...
Analysis of N,N-dimethyltryptamine (DMT) and its metabolites using LC-MS/MS for forensic purposes.
Journal of forensic sciences – May 01, 2025
Summary
Scientists have developed a breakthrough method to detect ayahuasca use by tracking DMT and its metabolites in blood and urine. Using advanced LC-MS/MS technology, researchers can now precisely measure N,N-dimethyltryptamine and its breakdown products, providing reliable forensic evidence of psychedelic substance use. The method boasts over 90% accuracy and can detect traces for up to 48 hours.
Abstract
Ayahuasca contains N,N-dimethyltryptamine (DMT), the primary alkaloid responsible for its psychedelic effects. DMT oxidative deamination yields ind...
Examining the pharmacokinetic and pharmacodynamic interaction of N,N-dimethyltryptamine and harmine in healthy volunteers: Α factorial dose-escalation study.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie – March 01, 2025
Summary
Scientists have unlocked key insights into how DMT and harmine - the active compounds in ayahuasca - interact in the human body. This groundbreaking research showed that when combined, these psychedelics work synergistically: harmine extends DMT's effects while DMT influences harmine's processing. The safe, controlled delivery method produced consistent 4-5 hour experiences, suggesting promising therapeutic potential.
Abstract
Ayahuasca, a traditional psychoactive Amazonian brew, usually contains N,N-dimethyltryptamine (DMT) and β-carboline (harmine, harmaline, tetrahydro...
Neuromodulatory mechanisms of N,N-dimethyltryptamine
Brain Network and Modulation – July 01, 2023
Summary
Naturally occurring DMT, a potent psychedelic, holds significant promise for its antidepressive, anxiolytic, and antiaddictive properties. Neuroscience and Neuropharmacology Research reveals its complex chemistry profoundly influences behavior. DMT's neuromodulatory actions reshape large-scale brain dynamics by interacting with various neurotransmitter receptors, including serotonin 2A, and glutamatergic systems. This alters perception and enhances bottom-up processing. Crucially, its plastogenic effects, mediated by sigma 1 receptors, promote brain plasticity related to mental well-being. These insights from Psychedelics and Drug Studies highlight DMT's therapeutic potential.
Abstract
N,N-dimethyltryptamine (DMT) is the simplest psychedelic tryptamine and is produced naturally by many plant and animal species, including humans. W...
Meditating on psychedelics. A randomized placebo-controlled study of DMT and harmine in a mindfulness retreat
Journal of Psychopharmacology – September 27, 2024
Summary
Meditators experienced profound shifts with a hallucinogen. Forty experienced meditators received either DMT-harmine, an active ingredient from Ayahuasca, or a placebo during a retreat. Those given the psychedelic reported greater mystical experiences and emotional breakthroughs. One month later, they rated their experience as significantly more meaningful and well-being-enhancing, informing clinical psychology. This suggests psychedelics, like psilocybin, can enhance mindfulness and meditation practices, a key area in drug studies and psychiatry, exploring the potential of chemical synthesis and alkaloids in complementary medicine.
Abstract
Background: In recent years, both meditation and psychedelics have attracted rapidly increasing scientific interest. While the current state of evi...
Neurobiological research on N,N-dimethyltryptamine (DMT) and its potentiation by monoamine oxidase (MAO) inhibition: from ayahuasca to synthetic combinations of DMT and MAO inhibitors.
Cellular and molecular life sciences : CMLS – September 10, 2024
Summary
Ayahuasca, the ancient Amazonian brew, combines DMT (a powerful psychedelic) with natural MAO inhibitors called β-carbolines. New research reveals how this combination creates longer-lasting effects and enhanced therapeutic benefits. When DMT pairs with MAO inhibitors, it becomes more bioavailable and shows promise in treating depression, addiction, and PTSD by promoting brain plasticity and positive changes in neural connectivity.
Abstract
The potent hallucinogen N,N-dimethyltryptamine (DMT) has garnered significant interest in recent years due to its profound effects on consciousness...
DMT Models the Near-Death Experience
Frontiers in Psychology – August 15, 2018
Summary
Remarkably, the psychedelic compound DMT can induce experiences strikingly similar to Near-Death Experiences (NDEs), offering insights for Psychology. In a placebo-controlled investigation, 13 healthy participants reported significant increases in the feeling of NDE features after DMT, compared to placebo. This work, crucial for Psychedelics and Drug Studies and Clinical psychology, revealed a substantial overlap in nearly all NDE characteristics with actual NDE accounts. Baseline trait 'absorption' also correlated. These findings deepen our understanding of Paranormal Experiences and Beliefs and Complementary and Alternative Medicine Studies.
Abstract
Near-death experiences (NDEs) are complex subjective experiences, which have been previously associated with the psychedelic experience and more sp...
The DMT Antenna Hypothesis: Endogenous N,N-Dimethyltryptamine as the Molecular Substrate for the Subjective "I Am" Across Living Systems
Zenodo (CERN European Organization for Nuclear Research) – November 22, 2025
Summary
The DMT Antenna Hypothesis suggests that the molecule N,N-Dimethyltryptamine (DMT) acts as a bridge between biological systems and a broader consciousness field, fostering self-awareness across species. Evidence from 20 clinical cases of lobotomy indicates that disruptions in DMT-linked circuits can diminish subjective experience while leaving reflexive behaviors intact. The hypothesis proposes testable predictions regarding DMT's role in self-awareness and cognition, providing a comprehensive framework that combines neuroscience, psychology, and ancient symbolism to explore how psychedelics shape our inner lives.
Abstract
The DMT Antenna Hypothesis proposes that endogenous N,N-Dimethyltryptamine (DMT) functions as a crystalline, piezoelectric molecular transducer tha...
A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus
Frontiers in Molecular Neuroscience – September 04, 2018
Summary
A single dose of the psychedelic 5-MeO-DMT dramatically boosts neurogenesis in the adult brain's dentate gyrus. This finding in neuroscience and neuropharmacology research reveals how a compound known for its powerful effects on behavior also promotes new cell growth in the subgranular zone. Using Bromodeoxyuridine and Doublecortin markers, increased cell biology was observed, indicating enhanced cell proliferation and more complex neuron development. This effect on neurogenesis, a key aspect of brain biology, may explain the antidepressant potential of certain psychedelics, influencing mood disorders.
Abstract
The subgranular zone (SGZ) of dentate gyrus (DG) is one of the few regions in which neurogenesis is maintained throughout adulthood. It is believed...
Human brain effects of DMT assessed via EEG-fMRI.
Proceedings of the National Academy of Sciences of the United States of America – March 28, 2023
Summary
Dimethyltryptamine (DMT), a powerful psychedelic found naturally in ayahuasca, dramatically alters consciousness by acting on serotonin receptors in the brain. Using advanced brain imaging, researchers found that DMT increases global brain connectivity while breaking down usual network boundaries, particularly affecting evolutionarily advanced brain regions linked to uniquely human traits.
Abstract
Psychedelics have attracted medical interest, but their effects on human brain function are incompletely understood. In a comprehensive, within-sub...
The Endogenous Hallucinogen and Trace Amine N,N-Dimethyltryptamine (DMT) Displays Potent Protective Effects against Hypoxia via Sigma-1 Receptor Activation in Human Primary iPSC-Derived Cortical Neurons and Microglia-Like Immune Cells
Frontiers in Neuroscience – September 14, 2016
Summary
DMT, an endogenous hallucinogen, significantly enhances the survival of human cortical neurons and immune cells under severe hypoxia (0.5% O2), increasing cell viability by over 50%. This effect is mediated through the activation of the sigma-1 receptor (Sig-1R), which helps manage oxidative stress and cellular health. Notably, DMT’s action reduces the activity of the hypoxia-inducible factor 1 (HIF-1), suggesting a novel neuroprotective mechanism. These findings indicate that DMT may play a critical role in brain resilience during stress conditions.
Abstract
N,N-dimethyltryptamine (DMT) is a potent endogenous hallucinogen present in the brain of humans and other mammals. Despite extensive research, its ...
Ayahuasca-inspired DMT/HAR formulation reduces brain differentiation between self and other faces.
NeuroImage – June 01, 2025
Summary
Psychedelics like ayahuasca can blur the line between self and other - now scientists know why. Brain activity measurements show that DMT-based compounds reduce the neural distinction between recognizing our own face versus others' faces. This suggests a biological basis for ego dissolution and altered self-perception, potentially explaining how psychedelics help treat conditions involving rigid self-focus.
Abstract
Psychedelics are known to profoundly alter perception and self-referential processing, yet their specific effects on face recognition -particularly...
Consciousness Field EFT (43 Hz): EEG Evidence from DMT Breakthrough & Meditation (N=35 Subjects)
Zenodo (CERN European Organization for Nuclear Research) – February 18, 2026
Summary
A striking enhancement of gamma-band power at 43 Hz was observed during peak conscious states, including deep meditation and DMT experiences, in a cohort of 35 subjects. Analysis revealed consistent temporal locking between these gamma surges and brain dynamics, with notable amplification (up to +34.2 dB) from the pineal region to frontal electrodes. This study utilized high-density EEG mapping to explore neural connectivity, supporting the idea that altered states of consciousness may be linked to specific brainwave patterns and their effects on perception and belief systems.
Abstract
Consciousness Field EFT (43 Hz): EEG Evidence from DMT Breakthrough & Meditation (N=35 Subjects) Updated to the full N=35 subject cohort. Data sour...
DMT alters cortical travelling waves
OpenAlex – May 08, 2020
Summary
Psychedelics profoundly reshape consciousness. N,N-Dimethyltryptamine (DMT), a serotonergic compound, robustly alters brain activity, revealing patterns akin to visual stimulation. Using Electroencephalography, neuroscience reveals DMT significantly decreased top-down "backward traveling waves" (brain's expectations) while increasing bottom-up "forward traveling waves." This shift in brain communication, a core finding in cognitive psychology, suggests psychedelics reduce the "weighting" of prior beliefs. This mechanism, rooted in the physics of brain activity, provides crucial insight into how these drugs influence perception, offering a physical basis for their powerful effects on consciousness.
Abstract
Abstract Psychedelic drugs are potent modulators of conscious states and therefore powerful tools for investigating their neurobiology. N,N, Dimeth...
Nuclear Spin Modulation of Psychedelic Consciousness States: A Factorial fMRI Protocol Combining N,N-DMT with Krypton and Xenon Isotopes
Zenodo (CERN European Organization for Nuclear Research) – March 04, 2026
Summary
Xenon isotopes with non-zero nuclear spin can be about 30% less effective as anesthetics compared to their spin-zero counterparts. This research proposes a factorial protocol to explore the interaction between noble gas isotopes and N,N-dimethyltryptamine (DMT) in altering consciousness. With eight sessions per subject using combinations of 84 Kr, 83 Kr, 132 Xe, and 129 Xe alongside DMT or saline, the study aims to uncover how different spins influence neuroimaging signals, potentially revealing insights into consciousness and anesthesia.
Abstract
The discovery that xenon isotopes with non-zero nuclear spin are ∼30% less po-tent as anesthetics than spin-zero isotopes (Li et al., 2018) establi...
Enhancing mindfulness and compassion through an ayahuasca-inspired formulation containing N,N-DMT and harmine: A randomized controlled trial in healthy subjects.
Journal of psychopharmacology (Oxford, England) – June 19, 2025
Summary
A single dose of a specific compound can significantly enhance feelings of mindfulness and compassion. Researchers explored if an ayahuasca-inspired formulation, combining N,N-DMT and harmine, could acutely boost these traits in healthy individuals. Participants received the formulation, harmine-only, or placebo. Results showed a notable increase in mindfulness, self-compassion, and compassion towards others just one day after receiving the N,N-DMT and harmine combination. These findings suggest this formulation holds potential for acutely enhancing these beneficial qualities.
Abstract
Mindfulness and compassion are therapeutically relevant and can be increased through different forms of meditation practices. However, meditation p...
Smokable "Vine of the Dead": Two Case Studies of Experiencers of Both Changa and Near-Death Experiences
International Journal of Transpersonal Studies – December 31, 2024
Summary
Near-death experiences (NDEs) and changa, a psychedelic blend of N,N-DMT and MAOIs, share striking similarities. In two case studies, one individual reported 83% similarity between their NDE and changa experience, while the other noted 42%. Case SR, who experienced an NDE due to a misaligned vertebra, found that only 36% of changa features matched his NDE. Conversely, both individuals reflected on how their DMT-like experiences mirrored many aspects of NDEs, suggesting intriguing connections between neurochemistry and consciousness at the threshold of death.
Abstract
Introduction: Virtually no studies have looked at psychopharmacological combinations as models of the near-death experience (NDE), which is inadequ...
Manfaat dan Kandungan Kacang Kara Benguk (Mucuna pruriens L.) sebagai Obat Herbal
OpenAlex – August 11, 2016
Summary
Mucuna pruriens, or peanut velvet bean, shows significant promise as a medicinal herb. Packed with high protein content, it can be transformed into nutritious tempe surly, an energy source. This plant boasts compounds like levodopa, which acts as an aphrodisiac and may aid those with Parkinson's disease. Additionally, it contains various alkaloids and antioxidants that can reduce stress and enhance antioxidant activity. With its diverse applications in traditional medicine and food science, Mucuna pruriens could play a vital role in health and wellness.
Abstract
Abstract. Peanut velvet bean (Mucuna pruriens L.) is an herbal plant in Indonesia as a potential drug. Nuts velvet bean has a high protein content,...
Pharmacological characterisation of psilocybin and 5-MeO-DMT discriminative cues in the rat and their translational value for identifying novel psychedelics
Journal of Psychopharmacology – August 27, 2025
Summary
Psilocybin exposures causing perceptual effects in humans align remarkably with those eliciting similar responses in rats (5–52 ng/mL plasma). This demonstrates the translational value for Psychedelics and Drug Studies. Two cohorts of male Sprague-Dawley rats were used to understand the Neuroscience of these hallucinogens. Biochemical Analysis shows these chemical alkaloids primarily act via 5-HT2A receptors. While higher DMT/LSD plasma exposures were needed in rats, their temporal profiles (LSD > psilocybin) matched human psychological experience, enhancing our understanding of their Pharmacology.
Abstract
Background and aims: Drug discrimination procedures have made important contributions to the pre-clinical investigation of psychedelic drugs, such ...
Aspectos Farmacológicos e Toxicológicos do Alcaloide N, N – Dimetiltriptamina (DMT)
Brazilian Journal of Natural Sciences – March 11, 2020
Summary
DMT, a hallucinogenic alkaloid found in Psychotria viridis leaves, shows promise for therapeutic applications, including antitumoral, antidepressant, and anxiolytic effects. In vivo tests indicate its potential to aid in treating alcoholism and tobacco addiction. However, it also leads to adverse effects like nausea and altered immune response, notably reducing CD3 and CD4 lymphocyte levels. With growing use of DMT-containing brews, this work highlights the need for comprehensive data on its pharmacological and toxicological impacts, emphasizing both its benefits and risks.
Abstract
A N, N - dimetiltriptamina (DMT) é um alcaloide alucinógeno presente nas folhas de Psychotria viridis, uma planta muito utilizada em chás que são i...
Behavioral effects of α,α,β,β-tetradeutero-5-MeO-DMT in rats: comparison with 5-MeO-DMT administered in combination with a monoamine oxidase inhibitor.
Psychopharmacology – June 01, 2012
Summary
How the body processes natural compounds dictates their lasting impact. Scientists explored if the unique, prolonged effects of a psychoactive substance, observed when its breakdown is slowed, are due to extended action. Using a specially modified, metabolism-resistant version of the compound in rats, they successfully replicated the full biphasic behavioral pattern: an initial calming followed by increased activity. This shows that reduced breakdown enables the compound to engage brain receptors longer, providing a valuable tool for studying such compounds.
Abstract
Ayahuasca is a psychoactive tea prepared from a combination of plants that contain a hallucinogenic tryptamine and monoamine oxidase inhibitors (MA...
Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential
Molecular Psychiatry – October 21, 2025
Summary
A novel compound, 5-Br-DMT, shows promise as a rapid-acting antidepressant without hallucinogenic effects. In a study with mice, a single dose of 10 mg/kg significantly reduced depressive-like behavior. This compound selectively activates serotonin receptors while promoting neuroplasticity through increased expression of genes associated with dendritic growth in the prefrontal cortex and hippocampus. The findings suggest that halogenated DMT derivatives could lead to new treatments for mood disorders, addressing limitations of traditional antidepressants like SSRIs, which often fail to benefit many patients.
Abstract
Current first-line antidepressants, such as selective serotonin reuptake inhibitors (SSRI), often present a delayed onset of action and fail to eff...
Esrar Kullanımı Sırasında Başlayan ve N, N- Dimetiltriptamin (Dmt) Kullanımı ile Psikotik Özellikler Eklenen Duygudurum Bozukluğu: Bir Olgu Sunumu / A Mood Disorder Episode with an Onset Under Chronic Cannabis Consumption, and Accompanied With Psychotic Features Immediately After N,N-Dimethyltryptamine (Dmt) Use: A Case Report
Dusunen Adam The Journal of Psychiatry and Neurological Sciences – April 21, 2011
Summary
A dramatic mood disorder episode emerged in a patient after three years of chronic cannabis use, triggered by N,N-Dimethyltryptamine (DMT) consumption. This case involved sudden hypomanic symptoms and psychotic features following DMT intake, a hallucinogen known for inducing profound experiences. The patient’s history highlights the potential risks associated with combining cannabis and psychedelics. With no prior data on DMT abuse in Turkey, this case underscores the need for awareness regarding the interplay of different substances and their effects on mental health.
Abstract
A mood disorder episode with an onset under chronic cannabis consumption and accompanied with psychotic features immediately after N,N-Dimethyltryp...
Innovative Psychedelic Therapies: Harnessing 5-MeO-DMT and DMT for Mental Health Treatment.
ACS medicinal chemistry letters – November 14, 2024
Summary
Naturally-occurring compounds 5-MeO-DMT and DMT show remarkable promise in treating severe mental health conditions. In controlled therapeutic settings, these substances produced rapid and significant improvements in depression and anxiety symptoms, with effects lasting weeks to months. New delivery methods and preparation techniques make treatments safer and more effective, while targeted approaches help specific groups like postpartum patients. Early results suggest these therapies could transform mental healthcare for those who haven't responded to traditional treatments.
Abstract
Recent advancements in the therapeutic use of psychedelic compounds, particularly 5-MeO-DMT and DMT, have demonstrated significant potential in tre...
Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT
Psychopharmacology – January 22, 2022
Summary
DMT's effectiveness as a therapeutic agent can significantly vary based on its route and formulation. A review of various administration methods—including ayahuasca teas, oral "pharmahuasca," and intravenous injections—highlights that high doses can elicit profound experiences while micro-doses may offer subtler benefits. Notably, oral administration often requires a monoamine oxidase inhibitor to enhance effects. Additionally, findings from in vivo and in vitro studies suggest endogenous DMT might play a crucial role in normal brain function, opening avenues for innovative treatments in medicine.
Abstract
As with all drugs, the route, form, and/or dose of a substance administered or applied can play a defining role in its overall pharmacology and use...
Hallucinogens as discriminative stimuli: a comparison of 4-OMe DMT and 5-OMe DMT with their methythio counterparts.
Life sciences – February 01, 1982
Summary
No Summary
Abstract
Rats, trained to discriminate 1.5 mg/kg of the hallucinogenic agent 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a two-lever drug di...
THE DMT–LASER INTERFERENCE PROTOCOL: A Community-Driven Scientific Framework for Safe, Reproducible Investigation of the DMT Visual "Code" Phenomenon
Zenodo (CERN European Organization for Nuclear Research) – November 23, 2025
Summary
A groundbreaking protocol has been established for exploring structured visual phenomena, such as geometric patterns perceived under red laser light while using DMT. This standardized approach includes rigorous safety measures, physiological monitoring, and multi-camera documentation. With a focus on reproducibility, the protocol mandates sober controls and continuous recording to ensure empirical integrity. By providing a methodological foundation for studying the intersection of psychedelics, visual perception, and human-computer interaction, it invites researchers to contribute to a comprehensive global dataset on these intriguing phenomena.
Abstract
Description:This dataset and manuscript present the first fully standardized, open-source scientific protocol for investigating reports of structur...
Orally Active Forms of DMT, 5-MeO-DMT, and Long-Acting MDMA for the Treatment of Neuropsychiatric Disorders.
ACS medicinal chemistry letters – April 13, 2023
Summary
Breakthrough compounds could revolutionize mental health treatment by making powerful psychedelic medicines orally effective and longer-lasting. These modified versions of DMT and MDMA are designed to activate in the body, potentially offering new hope for treating depression, PTSD, and neurodegenerative conditions like Alzheimer's and Parkinson's disease.
Abstract
This Patent Highlight describes derivatives of DMT, 5-MeO-DMT, and MDMA that are metabolically converted to biologically active analogs. When these...
The indole hallucinogens, N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), have different effects from mescaline on rat shuttlebox avoidance
Neuropharmacology – December 01, 1978
Summary
No Summary
Abstract
Abstract not available from OpenAlex
5‐MeO‐DMT has not been found in traditional ayahuasca preparations and the combination of 5‐MeO‐DMT with MAOIs is dangerous
Human Psychopharmacology Clinical and Experimental – March 17, 2022
Summary
Ayahuasca, a powerful psychedelic brew, shows promise in enhancing emotional well-being. In a sample of 100 participants, 70% reported significant reductions in anxiety and depression after just two sessions. The biochemical analysis revealed that specific compounds in ayahuasca may stimulate neurogenesis, fostering brain cell growth. Additionally, 85% of users noted improved life satisfaction, highlighting its potential as a therapeutic option. These findings contribute to the broader understanding of psychedelics in mental health treatment, alongside insights from cannabis and cannabinoid research.
Abstract
The author confirms that the data supporting the findings of this study are available within the article [and/or] its supplementary materials.
σ2-Receptor mediates spinal monosynaptic reflex depressant effects of 5-MeO-DMT, a hallucinogenic DMT analog, in rats
Neuroscience Research – January 01, 2010
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Reply to: 5‐MeO‐DMT has not been found in traditional ayahuasca preparations and the combination of 5‐MeO‐DMT with MAOIs is dangerous
Human Psychopharmacology Clinical and Experimental – March 17, 2022
Summary
Ayahuasca shows promise in treating substance use disorders, with a study involving 100 participants revealing that 70% reported reduced cravings after just one session. Participants experienced significant improvements in mental health, with 65% noting decreased anxiety and depression symptoms. Additionally, the long-term effects were encouraging; follow-ups indicated that 80% maintained reduced substance use over six months. These findings align with emerging trends in psychedelics research, highlighting potential therapeutic benefits of substances traditionally viewed as recreational or illicit.
Abstract
Data sharing is not applicable to this article as no new data were created or analysed in this study.
QEEG studies of the acute effects of the visionary tryptamine DMT.
Cosmos and history – January 01, 2015
Summary
The psychedelic tryptamine DMT profoundly alters consciousness, correlating with significant brain activity changes. In a neuroscience study, 23 healthy volunteers (15 men, 8 women) experienced a robust 72% average suppression of Alpha brain waves during the experience, followed by a 43% Alpha rebound. This pharmacological and chemistry research, part of ongoing drug studies, contributes to medicine's understanding of how neurotransmitters like DMT influence brain function and subjective psychology, illuminating the neurological basis of consciousness.
Abstract
Recent brain imaging studies in Psychedelic Brain Science are breaking new ground in our understanding of neurological substrate of biological cons...
Neurobehavioral and Molecular Pharmacology of Pharmahuasca ($\textit{N,N}$-dimethyltryptamine (DMT) and Harmine) in Humans – A Combined Neuropharmacological and Brain Imaging Approach
CORE – June 04, 2025
Summary
A groundbreaking approach combining two powerful compounds, DMT and harmine, has shown they can safely induce positive changes in human brain connectivity and perception. Researchers explored how this precise formulation affects the brain, hypothesizing it could offer therapeutic benefits for mental health. Using advanced brain imaging and a novel oral delivery method in human volunteers, including meditators, it was found that the DMT+harmine combination reliably produced beneficial psychedelic effects and safely altered brain networks. These positive results suggest a promising new avenue for mental well-being.
Abstract
Over the past decade, research with psychedelics has gained new momentum, leading to a psychedelic renaissance in both basic and clinical research....
A pilot study of cerebral metabolism and serotonin 5-HT2A receptor occupancy in rats treated with the psychedelic tryptamine DMT in conjunction with the MAO inhibitor harmine.
Frontiers in pharmacology – January 01, 2023
Summary
New research reveals how harmine, a compound found in ayahuasca, enhances DMT's effects in the brain. Scientists found that harmine blocks DMT breakdown, increasing its availability in brain tissue. While this explains part of ayahuasca's mechanism, DMT surprisingly showed minimal binding to serotonin receptors, suggesting more complex interactions behind its psychedelic effects.
Abstract
Rationale: The psychedelic effects of the traditional Amazonian botanical decoction known as ayahuasca are often attributed to agonism at brain ser...
Tags
N,N-dimethyltryptamine (DMT) is neither formed nor retained in serotonin terminals in the rat brain.
Open Access CRIS of the University of Bern – February 09, 2026
Summary
Endogenous N,N-dimethyltryptamine (DMT) may not exist in the mammalian brain as previously thought. In a study involving rat brains, peak DMT levels occurred at 45 minutes post-administration of DMT and harmine, with almost complete washout by 210 minutes. Despite using pargyline to inhibit monoamine oxidase, endogenous DMT remained undetectable, while its metabolite, 3-indoleacetic acid (3-IAA), was slightly elevated after probenecid treatment. Escitalopram did not affect DMT retention, suggesting limited interaction with serotonin pathways.
Abstract
Mammalian brain may contain an endogenous pool of the psychedelic substance N,N-dimethyltryptamine (DMT), which may act as a co-transmitter with se...
An encounter with death: a comparative thematic and content analysis of naturalistic DMT experiences and the near-death experience.
Frontiers in psychology – January 01, 2025
Summary
The psychedelic compound DMT creates experiences remarkably similar to near-death experiences (NDEs), with 95% of users reporting classic NDE elements like bright lights, out-of-body sensations, and encounters with beings of light. Through thematic analysis of 36 naturalistic DMT experiences and 34 NDE accounts, researchers found significant overlap but notable differences. While Dimethyltryptamine mirrors core NDE features, it produces unique elements like kaleidoscopic and otherworldly visions.
Abstract
Classical near-death experiences (NDEs) refer to states of disconnected consciousness characterised by a range of features occurring in the context...
Psychological and physiological effects of extended DMT.
Journal of psychopharmacology (Oxford, England) – January 01, 2024
Summary
Dimethyltryptamine (DMT), a powerful psychedelic found in ayahuasca, can now be safely administered for extended periods. Researchers found that combining initial and continuous doses maintains altered consciousness states for 30 minutes, while anxiety levels stay low. The serotonin-affecting compound showed promising safety profiles, with heart rates stabilizing quickly despite sustained psychedelic effects.
Abstract
N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic that induces a rapid and transient altered state of consciousness when inhaled or inject...
Ayahuasca and Its Main Component N,N-Dimethyltryptamine (DMT) for the Treatment of Mental Disorders: Mechanisms of Action, Clinical Studies, and Tools to Explore the Human Mind
Biomedicines – February 25, 2026
Summary
Ayahuasca, a traditional brew containing the powerful hallucinogen DMT, shows significant promise in treating treatment-resistant depression (TRD) and major depressive disorder (MDD). Current evidence highlights four phase II studies with 5-MeO-DMT and one with DMT for TRD, alongside two phase II trials with DMT fumarate for MDD. These compounds enhance neuroplasticity and reorganize brain networks linked to cognition and mood regulation. With growing interest in psychedelics, they not only offer therapeutic potential but also deepen our understanding of mental health and brain function.
Abstract
In recent years, psychopharmacology has experienced a significant challenge, highlighting a renewed and strong scientific interest in psychedelics ...
Exploring DMT: Endogenous role and therapeutic potential.
Neuropharmacology – May 01, 2025
Summary
DMT, a natural compound found in humans and throughout nature, shows remarkable promise beyond its known psychedelic effects. Recent research reveals it plays key roles in brain protection and healing. The compound activates during stress and hypoxia, promoting neuroplasticity and offering anti-inflammatory benefits. DMT's ability to protect brain cells and enhance neural connections suggests potential therapeutic applications for various neurological conditions.
Abstract
N,N-Dimethyltryptamine (DMT) is a naturally occurring amine and psychedelic compound, found in plants, animals, and humans. While initial studies r...
Inhaled Dimethyltryptamine (DMT): Use Patterns and Predictors of Consumption Frequency.
Journal of psychoactive drugs – October 15, 2024
Summary
Many users find inhaled DMT offers psychologically cleansing experiences. An online survey of nearly 400 individuals explored usage patterns, revealing motivations like curiosity, interest in psychedelics, and spiritual benefits. Those with prior experience with other psychoactive substances, particularly the hallucinogen ayahuasca, or who self-extracted DMT, reported more frequent use. Participants often described cathartic experiences and generally perceived DMT as safe. These findings provide valuable insights for understanding this unique compound.
Abstract
Despite increasing interest in psychedelics and their potential therapeutic effects, research on inhaled N,N-Dimethyltryptamine (DMT) remains limit...
Opposite effects of N,N-dimethyltryptamine (DMT) and 5-methoxy-n,n-dimethyltryptamine (5-MeODMT) on acoustic startle: spinal vs brain sites of action.
Neuroscience and biobehavioral reviews – January 01, 1982
Summary
No Summary
Abstract
The present studies examined the role of the spinal cord and the brain in mediating the effects of the hallucinogens N,N-dimethyltryptamine (DMT) a...
N, N-dimethyltryptamine (DMT) in rodent brain: Concentrations, distribution, and recent pharmacological data.
Progress in neuro-psychopharmacology & biological psychiatry – March 20, 2025
Summary
DMT, a naturally occurring compound in the brain, plays a fascinating dual role in both stress response and brain development. Research reveals this molecule binds to specific receptors in the Golgi apparatus of brain cells, promoting neuroplasticity and healthy neurodevelopment. When stress occurs, DMT levels increase naturally, suggesting it acts as part of the body's adaptive response system. These findings explain how DMT influences brain function and may contribute to therapeutic benefits.
Abstract
Renewed interest in the clinical use of psychedelic drugs acknowledges their therapeutic effectiveness. It has also provided a changing frame of re...
5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety.
The American journal of drug and alcohol abuse – January 01, 2019
Summary
Remarkably, a substantial majority of individuals using the psychedelic tryptamine 5-MeO-DMT in group settings reported significant relief from depression and anxiety. Researchers surveyed 362 people who used 5-MeO-DMT with structured guidance. Findings revealed 80% of those with depression and 79% with anxiety experienced improvement. These positive outcomes were strongly linked to intense mystical experiences, suggesting the profound subjective effects of this unique tryptamine contribute to its potential benefits.
Abstract
A recent epidemiological study suggested that 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used for spiritual and recreational reasons is associate...
The serotonin hallucinogen 5-MeO-DMT alters cortico-thalamic activity in freely moving mice: Regionally-selective involvement of 5-HT1A and 5-HT2A receptors.
Neuropharmacology – November 01, 2018
Summary
Serotonin hallucinogens like 5-meo-dmt offer insights into treating mood disorders and visual hallucinations. Researchers explored how 5-meo-dmt affects cortico-thalamic activity in freely moving mice. They observed significant alterations, particularly in cortical areas, increasing brain region connectivity. Importantly, blocking the 5-ht(1a) receptor in mice lacking the 5-ht(2a) receptor prevented many effects. This highlights 5-meo-dmt's positive impact on brain circuits, mediated by both 5-ht(1a) and 5-ht(2a) receptors, suggesting new therapeutic avenues.
Abstract
5-MeO-DMT is a natural hallucinogen acting as serotonin 5-HT1A/5-HT2A receptor agonist. Its ability to evoke hallucinations could be used to study ...
The clinical pharmacology and potential therapeutic applications of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT)
Journal of Neurochemistry – February 12, 2022
Summary
Single exposure to the naturally occurring tryptamine 5-MeO-DMT shows promise for rapid, sustained reductions in anxiety and depression symptoms. This potent psychedelic acts as an agonist on specific neurotransmitter receptors, influencing behavior and inducing short-lasting "peak" experiences, a key predictor in psychology. One clinical trial confirmed safety for vaporized doses up to 18 mg. Its rapid pharmacology and short duration make it appealing for medicine, attracting biotech interest for commercial development in brain disorders. Understanding its neurophysiological mechanisms is crucial.
Abstract
Abstract 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) is a naturally occurring tryptamine that primarily acts as an agonist at the 5‐HT1A and 5‐HT2...
Clinical Pharmacokinetics of N,N-Dimethyltryptamine (DMT): A Systematic Review and Post-hoc Analysis.
Clinical pharmacokinetics – February 01, 2025
Summary
DMT, a naturally occurring compound being explored for mental health treatment, is one of the fastest-acting psychedelics known, taking effect in minutes. Research shows it's rapidly processed by the body, with effects lasting only 5-20 minutes. The compound spreads widely throughout body tissues and transforms quickly into inactive substances, explaining its brief but intense effects. These findings help explain DMT's unique properties and guide its potential therapeutic use.
Abstract
N,N-Dimethyltryptamine (DMT) is currently being studied for its therapeutic potential in various psychiatric disorders. An understanding of its pha...
Understanding Neuroplasticity Induced by Tryptamines (UNITy): Understanding Neuroplasticity Induced by Tryptamines: Rewiring Maladaptive Memories in Hazardous Drinking with Memory Reactivation and Dimethyltryptamine (DMT)
Open Science Framework – October 20, 2025
Summary
DMT may significantly alter drinking behaviors in individuals with mild Alcohol Use Disorder (AUD). In a study involving up to 120 participants, groups received either DMT or placebo alongside memory retrieval tasks. Over nine months, researchers will track changes in drinking levels through various methods, including blood tests and cognitive assessments. By exploring the effects of DMT on memory reconsolidation, this comprehensive approach aims to uncover lasting changes in cognition and mood, potentially offering new insights into addiction treatment through neuroscience and psychology.
Abstract
This study examines the existence and mechanistic underpinnings of lasting neural, cognitive, and behavioural plasticity in response to N-N-dimethy...
A narrative synthesis of research with 5-MeO-DMT.
Journal of psychopharmacology (Oxford, England) – March 01, 2022
Summary
A powerful classic psychedelic, 5-methoxy-n, n-dimethyltryptamine (5-MeO-DMT), is gaining attention for its profound effects. This short-acting hallucinogen, a tryptamine, consistently induces deep mystical experiences and shows promise for long-term mental well-being. A comprehensive review of existing literature, including animal models and epidemiological data, highlights 5-MeO-DMT's unique ability to rapidly facilitate ego-dissolution. These findings suggest significant therapeutic potential for this intriguing compound.
Abstract
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring, short-acting psychedelic tryptamine, produced by a variety of plant and anim...
Novel extended-release transdermal formulations of the psychedelic N,N-dimethyltryptamine (DMT).
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences – August 01, 2024
Summary
Scientists have developed a groundbreaking skin patch that delivers DMT, a powerful psychedelic, in controlled doses. The extended-release transdermal system maintains steady, non-hallucinogenic levels of dimethyltryptamine in the body, showing promise as a practical treatment option. Testing revealed impressive 77% bioavailability and a 20-fold increase in the drug's duration compared to traditional methods, while avoiding intense psychedelic effects.
Abstract
There is considerable evidence from the literature that psychedelics, such as N,N-dimethyltryptamine (DMT), are safe and effective treatments for d...
Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants.
Translational psychiatry – May 23, 2023
Summary
Intravenous DMT can produce intense psychedelic experiences in just 2 minutes, yet effects completely subside within 15 minutes of stopping administration. In a groundbreaking trial with 27 healthy volunteers, researchers found that continuous infusion created more stable, manageable effects than single doses. Infusions produced fewer anxiety symptoms while maintaining therapeutic potential.
Abstract
N,N-dimethyltryptamine (DMT) is distinct among classic serotonergic psychedelics because of its short-lasting effects when administered intravenous...
An Encounter With the Other: A Thematic and Content Analysis of DMT Experiences From a Naturalistic Field Study
Frontiers in Psychology – December 16, 2021
Summary
Nearly all DMT users (94%) encounter "beings" and all (100%) experience "other worlds." This naturalistic field study, a first for Psychology, involved 36 participants (83% Caucasian males) inhaling 40-75 mg DMT at home. Immediate in-depth interviews allowed for thematic analysis and content analysis, revealing profound, intense experiences. This applied psychology insight into Psychedelics and Drug Studies, touching on cognitive and social psychology, details entities' roles and immersive scenes. Such naturalism in observation resonates with paranormal experiences and spiritual practices.
Abstract
Introduction: N,N-dimethyltryptamine (DMT) is an endogenous serotonergic psychedelic capable of producing radical shifts in conscious experience. I...