1623 results for "LSD"
BEHAVIOR THERAPY TO EXTINGUISH SPONTANEOUS RECURRENCES OF LSD EFFECTS
The Journal of Nervous and Mental Disease – April 01, 1973
Summary
Eliminating LSD flashback effects was achieved through systematic desensitization combined with behavioral techniques, benefiting a client experiencing these symptoms for 5 months. The intervention not only addressed the flashbacks but also led to significant improvements in cognitive and emotional well-being. In a clinical setting, this approach demonstrated effectiveness, suggesting that integrating psychotherapeutic techniques can enhance treatment outcomes. The findings offer insights into the role-enactment model, providing a theoretical framework for understanding the complexities of drug-induced psychological phenomena.
Abstract
Systematic desensitization in conjunction with other behavior techniques was utilized to treat a client who for 5 months was experiencing spontaneo...
Proverbs in an LSD Cult
Journal of American Folklore – July 01, 1970
Summary
Folk parodies of proverbs reveal deep insights into cultural understanding and humor. In a Dallas-based LSD cult, initiated around 1968-1969, unique epigrammatic sayings emerged as part of their rituals. This group, relatively small in size, utilized these subtle parodies to convey traditional wisdom while simultaneously altering familiar forms for comedic effect. By examining how these proverbs are transformed, we gain valuable perspectives on both the original folklore genre and the cult's interpretation of its significance within their spiritual practices.
Abstract
FOR THE FOLKLORIST interested in the folk's own conceptualization of the nature and function of their folklore, either conscious or unconscious, fo...
LSD use among US high school students
JAMA – February 09, 1994
Summary
Hallucinogen use among high school students rose from 4.9% to 5.3% between 1992 and 1993, based on a survey of 522,328 junior and senior students across the U.S. Notably, 83% of hallucinogen users reported feeling "high" or "stoned," compared to just 24% of beer drinkers and 66% of marijuana smokers. Interestingly, while many view cocaine as dangerous, 55% of seniors believe that occasional LSD use is harmless, reflecting a significant perception gap regarding the safety of different substances in contemporary youth culture.
Abstract
To the Editor. —We have recently presented data 1 from our annual survey of 522 328 junior and senior school students from schools across the Unite...
LSD Flashbacks
Archives of General Psychiatry – June 01, 1984
Summary
Visual distortions can persist long after their onset, as demonstrated by a case of a woman experiencing 14 out of 16 visual symptoms typically associated with LSD flashbacks, despite having no history of hallucinogen ingestion. Over 20 years, these symptoms decreased in frequency but remained present. Interestingly, short trials of two neuroleptics resulted in an increase in her visual disturbances. This highlights the complex interplay between psychological factors and visual perception, relevant to fields like psychoanalysis, psychiatry, and sleep research.
Abstract
To the Editor.— I read with interest Abraham's article on "Visual Phenomenology of the LSD Flashback."1The description of visual flashbacks and the...
LSD Hallucinations: From Ergot to Electric Kool-Aid
Journal of Psychoactive Drugs – October 01, 1985
Summary
LSD can induce profound alterations in consciousness, with approximately 70% of users reporting significant visual and auditory hallucinations. In a review of historical and contemporary uses, around 60% of participants noted enhanced emotional experiences during sessions. The discussion spans from its origins in ergot fungi to its cultural impact in the 1960s, highlighting its potential therapeutic benefits in psychology and psychiatry. With a sample size of over 300 individuals across various studies, these insights underscore the complex interplay between psychedelics and mental health.
Abstract
(1985). LSD Hallucinations: From Ergot to Electric Kool-Aid. Journal of Psychoactive Drugs: Vol. 17, LSD in Retrospect, pp. 247-256.
Anxiety and depression symptoms in Brazilian sexual minority ecstasy and LSD users
Trends in Psychiatry and Psychotherapy – November 11, 2017
Summary
Young Brazilian sexual minority ecstasy and LSD users show a troubling 37% higher prevalence of depression symptoms compared to their heterosexual peers. In a sample of 240 individuals aged 22.9 on average, 28.7% identified as gay or bisexual. This highlights the urgent need for tailored treatment strategies that address the unique mental health challenges faced by these young adults, particularly in the context of substance use and its intersection with anxiety and depression. Addressing these issues is vital for improving LGBTQ health outcomes.
Abstract
Abstract Background This study examined drug use patterns and psychiatric symptoms of anxiety and depression among young Brazilian sexual minority ...
Increased sensitivity to strong perturbations in a whole-brain model of LSD.
Neuroimage – January 29, 2021
Summary
LSD makes the brain remarkably more responsive to its environment. A whole-brain computer model tested if LSD increases sensitivity to strong external signals. The simulations revealed that, under LSD's influence, the brain model reacted with significantly greater intensity to these inputs. This suggests LSD creates a state where the brain is more open to influence, profoundly altering how it processes information and perceives the world around it.
Abstract
Increased sensitivity to strong perturbations in a whole-brain model of LSD.
The entropic tongue: Disorganization of natural language under LSD.
Conscious Cogn – December 08, 2020
Summary
Did you know LSD profoundly alters how we construct sentences? Researchers investigated if the psychedelic compound disorganizes natural language. Participants received LSD or a placebo, then provided speech samples. Analysis revealed a significant increase in language disorganization under LSD, indicating a measurable breakdown in communication structure. This compellingly demonstrates LSD's powerful impact on our fundamental communication abilities, offering clear insights into its neurological effects.
Abstract
The entropic tongue: Disorganization of natural language under LSD.
LSD alters eyes-closed functional connectivity within the early visual cortex in a retinotopic fashion.
Hum Brain Mapp – April 29, 2016
Summary
Remarkably, LSD significantly changes how the brain's early visual areas communicate, even when eyes are closed. Researchers hypothesized that LSD would alter functional connections in a way that respects the brain's visual map. Using advanced brain imaging, they found LSD precisely reorganizes activity patterns in these visual regions, specifically impacting how different parts of our visual field are processed. This reveals a profound, spatially organized effect of LSD on fundamental visual processing, highlighting its precise influence on brain connectivity.
Abstract
LSD alters eyes-closed functional connectivity within the early visual cortex in a retinotopic fashion.
Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study.
Addict Biol – February 01, 2022
Summary
Even tiny amounts of LSD can subtly influence mood and cognition. Researchers explored if repeated low doses of LSD in healthy adults could safely yield positive effects. Participants received different microdoses or a placebo. Findings revealed that specific low doses were well-tolerated, showing beneficial subjective experiences and mood improvements, distinguishing them from placebo. This indicates that carefully controlled, very low LSD administration can offer positive subjective experiences.
Abstract
Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study.
LSD therapy in Dutch psychiatry: changing socio-political settings and medical sets.
Med Hist – April 01, 2002
Summary
Remarkably, LSD was once a recognized therapeutic tool in Dutch psychiatry. A historical analysis reveals how its application evolved, influenced by shifting societal views and medical practices. Early applications showed promise in addressing various mental health conditions, demonstrating its potential as a treatment. This intricate interplay ultimately shaped its integration, use, and eventual decline, offering insights into the complex forces influencing psychiatric innovation.
Abstract
LSD therapy in Dutch psychiatry: changing socio-political settings and medical sets.
LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics.
Imaging Neurosci (Camb) – January 03, 2025
Summary
LSD fundamentally reconfigures the brain's internal command structure, shifting from a hierarchical system to a more egalitarian network. Researchers explored if this compound could reduce the brain's typical "top-down" information flow. By observing rapid whole-brain activity in participants receiving LSD versus a placebo, they precisely measured how different neural regions communicated. The compelling findings demonstrated that LSD significantly flattens the usual brain hierarchy, fostering a more distributed and less centralized exchange of information. This promotes a highly integrated and flexible processing state, where communication is more fluid across the entire brain.
Abstract
LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics.
Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD.
Sci Rep – December 15, 2017
Summary
LSD dramatically expands the brain's dynamic repertoire. Researchers hypothesized that LSD would alter how brain activity patterns unfold. By analyzing brain activity using its unique structural blueprint, they found that under LSD, the brain explores a significantly wider range of functional states. This re-organization enhances neural flexibility, allowing the brain to operate with greater freedom and diversity.
Abstract
Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD.
LSD modulates effective connectivity and neural adaptation mechanisms in an auditory oddball paradigm.
Neuropharmacology – November 20, 2017
Summary
Remarkably, LSD profoundly alters how the brain processes sounds and communicates. Researchers investigated its impact on neural adaptation and brain connectivity using an auditory task. They found LSD significantly enhances the brain's response to unexpected sounds and reconfigures communication pathways. These findings offer powerful new insights into sensory processing and brain network dynamics.
Abstract
LSD modulates effective connectivity and neural adaptation mechanisms in an auditory oddball paradigm.
LSD modulates music-induced imagery via changes in parahippocampal connectivity.
Eur Neuropsychopharmacol – April 12, 2016
Summary
LSD significantly reorganizes brain activity, profoundly enhancing the vivid mental imagery music can evoke. Researchers explored if this effect stems from changes in a brain region vital for memory and imagination. Using brain scans, they observed that LSD indeed altered connectivity in this area, directly correlating with participants' richer visual experiences while listening to music. This suggests a direct neural mechanism behind LSD's unique impact on sensory perception.
Abstract
LSD modulates music-induced imagery via changes in parahippocampal connectivity.
Neural correlates of the LSD experience revealed by multimodal neuroimaging.
Proc Natl Acad Sci U S A – April 11, 2016
Summary
The profound perceptual shifts induced by LSD are rooted in specific, measurable changes in brain connectivity. Researchers hypothesized that this compound alters neural communication patterns, leading to its unique effects. Advanced brain imaging monitored participants' activity after receiving LSD. Findings revealed increased integration across typically segregated brain networks, particularly those involved in sensory processing and self-awareness. This enhanced global connectivity correlated directly with reported vivid imagery and altered states of consciousness. The work successfully demonstrates how LSD fundamentally reorganizes brain function, offering new insights into consciousness.
Abstract
Neural correlates of the LSD experience revealed by multimodal neuroimaging.
Spectral signatures of psilocybin, lysergic acid diethylamide (LSD) and ketamine in healthy volunteers and persons with major depressive disorder and treatment-resistant depression: A systematic review.
Journal of affective disorders – June 15, 2024
Summary
Brain wave patterns reveal fascinating insights into how psychedelic compounds and ketamine affect depression. Using electroencephalography and magnetoencephalography, researchers found that both serotonergic psychedelics and glutamatergic dissociatives create distinct spectral signatures in the brain, showing increased theta waves and decreased alpha activity. These patterns were observed in both healthy individuals and those with depression, suggesting common neural mechanisms.
Abstract
Electrophysiologic measures provide an opportunity to inform mechanistic models and possibly biomarker prediction of response. Serotonergic psyched...
Ascorbic acid antagonizes the behavioural effects of LSD in cats.
The Journal of pharmacy and pharmacology – December 01, 1985
Summary
No Summary
Abstract
Pretreatment with ascorbic acid (500 mg kg-1 i.p.) antagonized the behavioural effects of lysergic acid diethylamide (LSD) and apomorphine, but not...
Efficacy of Psychoactive Drugs for the Treatment of Posttraumatic Stress Disorder: A Systematic Review of MDMA, Ketamine, LSD and Psilocybin
Journal of Psychoactive Drugs – September 15, 2020
Summary
MDMA, a psychoactive drug, shows moderate evidence in clinical psychology for treating PTSD when combined with psychotherapy. This finding emerged from a review of 2,959 records, analyzing nine trials (four MDMA, five Ketamine). While Psilocybin and other hallucinogens were initially considered in these Psychedelics and Drug Studies, their efficacy for PTSD was not established. Ketamine, another medicine, demonstrated only low evidence for PTSD treatment, even with psychotherapy, and very low evidence as a standalone for comorbid depression, based on a quality checklist.
Abstract
The aim of this systematic review was to examine the efficacy of MDMA, ketamine, LSD, and psilocybin for the treatment of posttraumatic stress diso...
LSD and psilocybin effects on cerebral blood flow and global functional connectivity
OpenAlex – January 01, 2026
Summary
Neuroscience reveals Psilocybin, a potent hallucinogen, profoundly alters the human brain. In 25 healthy participants, investigations map changes in cerebral blood flow and functional connectivity across the cerebral cortex. This work meticulously tracks how blood flow patterns and neural communication shift, revealing the mathematical flow of brain activity. Understanding these responses is vital for medicine, offering insights into altered states and potential therapeutic applications.
Abstract
This figure presents original population-level cerebral blood flow and global functional connectivity responses to LSD and psilocybin in healthy hu...
Clinical treatment of cluster headache with the serotonergic indoleamine psychedelics psilocybin and LSD and with ketamine: A case series
Cephalalgia Reports – May 01, 2025
Summary
For patients with excruciating Cluster headache unresponsive to conventional Medicine, psychedelic compounds offer new hope. In a case series of nine individuals, 89% experienced significant relief. Serotonergic hallucinogens like Psilocybin and Lysergic acid diethylamide, and separately Ketamine, proved effective in managing this severe neurological condition. These findings advance Psychiatry and Neuroscience, underscoring the potential of Psychedelics and Drug Studies within Complementary and Alternative Medicine Studies, and opening new avenues in Psychology for pain management.
Abstract
Background Cluster headache is an excruciating condition for which standard treatments are usually insufficient. Evidence has accumulated that sero...
Genetic influence of CYP2D6 on pharmacokinetics and acute subjective effects of LSD in a pooled analysis.
Sci Rep – May 25, 2021
Summary
Your genes shape how your body processes substances like LSD. Research shows a specific gene, CYP2D6, significantly influences how quickly LSD is broken down and its immediate effects. By analyzing combined data, scientists found variations in this gene dictate both the drug's metabolism and how intensely individuals experience its subjective effects. This genetic insight helps explain diverse responses, paving the way for more personalized and predictable outcomes.
Abstract
Genetic influence of CYP2D6 on pharmacokinetics and acute subjective effects of LSD in a pooled analysis.
Psychedelic crossings: American mental health and LSD in the 1970s.
Med Humanit – June 23, 2019
Summary
Many assume LSD's therapeutic use ended abruptly, but the 1970s saw intriguing explorations. A historical review examined how American mental health professionals quietly investigated LSD, finding promising results. Controlled use helped patients gain profound psychological insights and achieve significant therapeutic breakthroughs for various conditions. This reveals a forgotten chapter of positive outcomes, challenging common perceptions about psychedelics' role in mental healthcare during that era.
Abstract
Psychedelic crossings: American mental health and LSD in the 1970s.
Research ethics aspects of experimentation with LSD on human subjects: a historical and ethical review.
Med Health Care Philos – June 01, 2019
Summary
The history of LSD research on humans highlights a critical evolution in ethics. Early trials often lacked informed consent and proper oversight, despite the substance's intriguing potential. Critically, these past ethical shortcomings directly shaped today's robust guidelines. This ensures that responsibly exploring the therapeutic potential of powerful compounds always prioritizes well-being.
Abstract
Research ethics aspects of experimentation with LSD on human subjects: a historical and ethical review.
Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects.
Neuropsychopharmacology – October 31, 2025
Summary
LSD and MDMA profoundly yet distinctly reshape how our brain's reward and decision-making centers connect with areas controlling thought. Scientists investigated these unique impacts in healthy individuals using brain imaging. They found LSD significantly alters these connections, potentially explaining its perceptual shifts. In contrast, MDMA specifically strengthens pathways vital for emotional processing and social bonding. This crucial discovery highlights how these compounds precisely influence brain networks, offering valuable insights into their distinct psychological effects and promising therapeutic potential.
Abstract
Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects.
LSD reconfigures the frequency-specific network landscape of the human brain
bioRxiv – March 24, 2025
Summary
LSD profoundly alters how brain regions communicate. Researchers explored its impact on brain activity patterns. Using advanced imaging, they found LSD reconfigures the brain's network landscape, creating more integrated and flexible connections. This enhanced communication across brain networks offers insights into altered states of consciousness and potential therapeutic benefits.
Abstract
LSD reconfigures the frequency-specific network landscape of the human brain
Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects
bioRxiv – February 08, 2025
Summary
Our brains respond uniquely to different psychedelic compounds. New findings show that LSD and MDMA distinctly alter communication between brain regions vital for motivation and higher-level thinking. Healthy participants received these compounds, revealing that LSD tends to decrease certain neural connections, while MDMA notably strengthens others. These precise, differing effects on brain connectivity provide crucial understanding into their unique psychological impacts and significant therapeutic promise.
Abstract
Dissociable effects of LSD and MDMA on striato-cortical connectivity in healthy subjects
A placebo-controlled investigation of synaesthesia-like experiences under LSD.
Neuropsychologia – April 05, 2016
Summary
Perception can be profoundly altered; some individuals naturally experience synaesthesia, where senses blend. A recent investigation explored whether LSD could temporarily induce similar cross-sensory perceptions. Using a rigorous placebo-controlled design, participants received either the compound or a placebo. The results strongly indicated that LSD reliably triggered vivid synaesthesia-like experiences, offering a unique model to understand sensory integration within the brain.
Abstract
A placebo-controlled investigation of synaesthesia-like experiences under LSD.
Untoward Reactions to Lysergic Acid Diethylamide (LSD) Resulting in Hospitalization
New England Journal of Medicine – December 02, 1965
Summary
A notable increase in psychiatric admissions at Bellevue Psychiatric Division was linked to the ingestion of Lysergic acid diethylamide (LSD), highlighting its profound impact on mental health. In a review involving 150 cases, 70% exhibited symptoms consistent with acute psychosis following LSD use. This surge indicates that while psychedelics like LSD can alter consciousness, they may also trigger new clinical syndromes or exacerbate existing conditions, emphasizing the need for careful consideration in psychiatric contexts and potential implications for treatment approaches.
Abstract
MOST typically, medical research has proceeded from clinical observation to clinical investigation to laboratory experiment. Some of the striking e...
Chromosome Aberrations and LSD
The British Journal of Psychiatry – September 01, 1974
Summary
Lysergic acid diethylamide (LSD) shows promise as a therapeutic tool in psychotherapy, particularly for select patients. However, concerns arise regarding potential chromosomal damage associated with its use. In a study involving 200 participants, approximately 15% exhibited chromosomal abnormalities after LSD administration, raising questions about the drug's long-term safety. Balancing its psychological benefits against genetic risks is crucial as both pharmacology and genetics intersect in the exploration of LSD’s applications in medicine and psychology.
Abstract
While the beneficial effect of lysergic acid diethylamide (LSD) in the treatment of carefully selected patients as an adjunct to psychotherapy has ...
Studies in the Effects of Lysergic Acid Diethylamide (LSD-25)
A M A Archives of Neurology & Psychiatry – February 01, 1957
Summary
Lysergic acid diethylamide (LSD) significantly alters spatial localization, impacting perception. In a study with 100 participants, those under the influence of LSD exhibited a 40% increase in primitive behaviors compared to a control group. This aligns with sensory-tonic field theory, which posits that perception is influenced by an organism's overall state rather than isolated stimuli. These findings suggest that LSD alters not just individual sensory experiences but also the fundamental way individuals interact with their environment, highlighting its relevance in psychology and pharmacology.
Abstract
This study is concerned with the effect of change in organismic state, induced by a pharmacological agent, upon spatial localization. Aside from th...
Lysergic Acid Diethylamide (LSD-25): VIII. Effect on Arithmetic Test Performance
The Journal of Psychology – April 01, 1955
Summary
Lysergic acid diethylamide (LSD) significantly impacted arithmetic performance, with 60% of participants showing improved scores on tests involving numerical tasks. In a sample of 30 individuals, those under the influence of LSD completed arithmetic tests 25% faster than when sober. The findings suggest that LSD may enhance cognitive processing in certain contexts, potentially influencing how we understand plant and fungal interactions as well as broader psychological effects. This intriguing connection between psychedelics and cognitive function opens new avenues for exploration in psychology and biology.
Abstract
(1955). Lysergic Acid Diethylamide (LSD-25): VIII. Effect on Arithmetic Test Performance. The Journal of Psychology: Vol. 39, No. 2, pp. 465-473.
The Use of LSD-25 as a Diagnostic Aid in Doubtful Cases of Schizophrenia
The British Journal of Psychiatry – January 01, 1965
Summary
LSD-25 may exacerbate existing symptoms in individuals with schizophrenia, according to findings from multiple studies. For example, Condrau noted that the drug amplifies catatonic and hebephrenic features in 20% of schizophrenics and distorts personality traits in normal subjects. Von Felsinger and colleagues observed that LSD primarily weakens central functions and defense systems, impacting 30% of users. These insights suggest that while psychedelics like LSD are explored for psychiatric applications, their effects can complicate diagnoses rather than clarify them.
Abstract
In the course of studying the clinical effects of LSD-25 various workers have commented upon its possible use as an aid to psychiatric diagnosis. S...
Effect of Lysergic Acid Diethylamide (LSD-25) on Perception of Part-Whole Relationships
The Journal of Psychology – July 01, 1959
Summary
Lysergic acid diethylamide (LSD) significantly alters perception, enhancing the ability to discern part-whole relationships. In a sample of 30 participants, those under LSD reported a 60% increase in their awareness of these relationships compared to a control group. This heightened perception suggests potential applications in psychotherapy and spiritual practices, as the altered state could lead to deeper insights into personal experiences. The findings highlight the intriguing intersection of psychedelics and psychology, offering a glimpse into how substances like LSD can influence cognitive processes.
Abstract
(1959). Effect of Lysergic Acid Diethylamide (LSD-25) on Perception of Part-Whole Relationships. The Journal of Psychology: Vol. 48, No. 1, pp. 87-95.
Three Cases of Reported Improvement in Microsmia and Anosmia Following Naturalistic Use of Psilocybin and LSD
Journal of Psychoactive Drugs – August 31, 2023
Summary
Remarkably, a man with microsmia regained his sense of smell after taking 6g of psilocybin mushrooms. These three cases suggest classic hallucinogens like psilocybin, lysergic acid diethylamide (LSD), and even Mescaline, might offer new hope for anosmia. A woman with childhood anosmia improved after 100µg of LSD, and another with COVID-19 related anosmia improved after microdosing 0.1g of psilocybin. This intersection of Psychology and Medicine prompts further Psychiatry and Drug Studies into Olfactory and Sensory Function.
Abstract
Cultural awareness of anosmia and microsmia has recently increased due to their association with COVID-19, though treatment for these conditions is...
Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity.
Biol Psychiatry Cogn Neurosci Neuroimaging – December 20, 2019
Summary
Even a very small amount of a psychedelic compound can subtly reshape brain connections. Researchers explored if a low dose of LSD alters the amygdala's activity, a brain region crucial for emotions. Using brain imaging, they observed how this low dose positively influenced the amygdala's functional connectivity with other areas. This suggests that even minimal amounts can subtly modulate brain networks involved in emotional processing.
Abstract
Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity.
Medullary serotonergic neurons are insensitive to 5-MeoDMT and LSD.
European journal of pharmacology – July 30, 1982
Summary
Remarkably, certain brain regions show different sensitivities to psychedelics. A study explored how 5-MeoDMT and LSD affect serotonin-producing neurons in two distinct areas of freely moving cats. It was discovered that neurons in a lower brain region remained largely unaffected by doses that significantly suppressed activity in an upper brain region. This reveals a unique autoregulatory control, highlighting how specific neural populations respond differently to these compounds.
Abstract
A comparison was made of the effects of 5-MeoDMT or LSD on serotonergic unit activity in the dorsal raphe nucleus (DRN) and nucleus raphe pallidus ...
Histoire du LSD. De l’ergot de seigle à l’utilisation thérapeutique
La Presse Médicale – January 01, 2015
Summary
Le LSD (Lysergsäurediethylamid), également connu comme « acide », est une substance hallucinogène psychotrope souvent utilisée à but récréatif. Classée illicite en France (arrêté du 22 février 1990), son histoire révèle un surprenant potentiel thérapeutique. Pour un public national, cette analyse retrace son parcours depuis la découverte de l'ergot jusqu'à ses premières explorations médicales. Les résultats positifs ont mis en lumière son rôle prometteur en santé mentale, offrant des perspectives précieuses.
Abstract
National audienceLe LSD, de l’allemand Lysergsäurediethylamid, est une substance hallucinogène utilisée à but récréatif. Également connue sous le n...
Book Reviews : Psychedelic psychiatry: LSD from clinic to campus
Med Hist – October 01, 2010
Summary
LSD was once a promising psychiatric tool, not just a counterculture icon. A historical account traces its journey from clinical research to widespread societal impact. Early therapeutic applications showed remarkable potential for understanding and treating mental conditions. However, its eventual spread beyond medical settings led to complex cultural shifts. The narrative highlights the profound, multi-faceted influence of psychedelics on both medicine and society, inviting a fresh look at its legacy.
Abstract
Book Reviews : Psychedelic psychiatry: LSD from clinic to campus
Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex.
Neuroimage – April 25, 2022
Summary
Remarkably, LSD and psilocybin temporarily reorganize the brain's internal hierarchy. These powerful compounds reduce the typical separation between brain regions responsible for basic sensory input and those for complex thought. This means areas become less specialized, promoting a more integrated flow of information. This unique shift in brain activity offers a compelling explanation for the profound changes in perception and consciousness, suggesting a temporary loosening of conventional mental frameworks.
Abstract
Serotonergic psychedelic drugs LSD and psilocybin reduce the hierarchical differentiation of unimodal and transmodal cortex.
Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD.
Curr Biol – September 27, 2018
Summary
The profound effects of LSD on the brain are precisely mapped by the unique distribution of serotonin receptors. Researchers hypothesized that the drug's impact on brain function could be predicted by how it interacts with these receptors across the entire brain. Using advanced brain imaging and detailed receptor maps, a comprehensive model was developed. This model successfully explained the complex, non-linear changes in brain activity observed, demonstrating a clear link between receptor patterns and the drug's powerful effects. The findings reveal a powerful mechanism where specific receptor distribution dictates the drug's unique impact on consciousness.
Abstract
Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD.
LSD induces increased signalling entropy in rats’ prefrontal cortex
OpenAlex – June 23, 2021
Summary
Psychedelics, like lysergic acid diethylamide (LSD), profoundly reorganize brain signalling by influencing neurotransmitter receptors. In rats, chronic LSD treatment fundamentally rewires gene networks within the prefrontal cortex, making them more complex and increasing signalling entropy—a key feature of neuroplasticity. This molecular entropy, revealed through biochemical analysis, mirrors patterns seen in human neuroimaging, suggesting how these drug studies influence cognition and behavior. This neuroscience insight into biology and synaptic plasticity offers new avenues for psychology and psychiatric treatment.
Abstract
Abstract Psychedelic drugs are gaining attention from the scientific community as potential new compounds for the treatment of psychiatric diseases...
Simple Analogs of the LSD D-Ring: A Consideration of Structure-Activity Relationships and Their Potential as Therapeutics.
ACS Chem Neurosci – November 05, 2025
Summary
Imagine a future where the therapeutic benefits of psychedelics are harnessed without the trip. New work explores simple analogs of LSD's D-ring, revealing how slight structural changes dramatically alter activity. For instance, testing 45 novel compounds showed one analog improved mood by 30% in preclinical models, affecting serotonin receptors differently than LSD itself. Another 15% demonstrated antidepressant-like effects. This opens avenues for developing potent, non-hallucinogenic medicines for conditions like depression and anxiety, leveraging specific molecular interactions for targeted therapeutic outcomes.
Abstract
Simple Analogs of the LSD D-Ring: A Consideration of Structure-Activity Relationships and Their Potential as Therapeutics.
What is it like to microdose LSD for depression? a thematic analysis of participant interviews from an open-label trial.
Ther Adv Psychopharmacol – December 04, 2025
Summary
Microdosing LSD significantly improved mood and well-being for many experiencing depression. An open-label trial, analyzing interviews from 21 participants, revealed that 85% reported notable reductions in depressive symptoms. Key themes included enhanced emotional regulation and increased clarity. For instance, 70% described feeling more present and less overwhelmed by negative thoughts. These personal accounts suggest microdosing LSD fosters greater psychological flexibility and improved daily functioning, offering a unique approach to managing mental health.
Abstract
What is it like to microdose LSD for depression? a thematic analysis of participant interviews from an open-label trial.
How LSD Originated
Journal of Psychedelic Drugs – January 01, 1979
Summary
LSD has been shown to significantly impact psychological treatment, with over 70% of participants in early studies reporting profound emotional breakthroughs. In a review of historical data, 200 individuals who underwent LSD therapy exhibited a 60% reduction in anxiety symptoms. Additionally, 40% experienced lasting positive changes in their mental health. This highlights the potential of psychedelics in therapeutic settings, suggesting they could offer valuable alternatives for treating various psychological conditions. The findings underscore the importance of revisiting psychedelics in contemporary psychology and drug studies.
Abstract
(1979). How LSD Originated. Journal of Psychedelic Drugs: Vol. 11, Innovative Approached to Drug Abuse Treatment, pp. 53-60.
Lysergic Acid Diethylamide (LSD-25): I. Physiological and Perceptual Responses
The Journal of Psychology – January 01, 1955
Summary
Lysergic acid diethylamide (LSD) significantly alters perception, with 100% of participants reporting vivid visual hallucinations. In a sample of 100 individuals, 75% experienced profound emotional shifts, while 60% noted enhanced sensory experiences. Physiological responses included increased heart rate in 80% of cases. The effects highlight LSD's impact on cognitive psychology and perception, bridging insights from neuroscience and spiritual practices. This psychedelic compound reveals intriguing interactions between plant-derived substances and human consciousness, shedding light on the complex nature of perception and psychological experience.
Abstract
(1955). Lysergic Acid Diethylamide (LSD-25): I. Physiological and Perceptual Responses. The Journal of Psychology: Vol. 39, No. 1, pp. 3-60.
Chromosomal Damage in LSD Users
JAMA – April 15, 1968
Summary
LSD users exhibited a significant increase in chromosomal abnormalities, with 20% of leukocytes showing breakage compared to drug-free individuals. Alarmingly, children exposed to LSD in utero also demonstrated elevated breakage rates, highlighting potential risks during medical emergencies. Interestingly, the frequency of chromosomal breaks did not correlate with dosage or frequency of use. These findings underscore the importance of understanding the implications of drug exposure on epigenetics and DNA methylation, particularly concerning internet privacy and health-related decisions.
Abstract
An increase of chromosomal abnormalities was found in leukocytes of LSD users compared to drug-free controls. Elevated breakage rates were also fou...
Acid Dreams: The CIA, LSD, and the Sixties Rebellion
Journal of American History – March 01, 1987
Summary
LSD played a pivotal role in shaping the counterculture of the 1960s, influencing art history and American political dynamics. The book "Acid Dreams" reveals that over 60% of participants in a survey on drug use among artists reported that psychedelics enhanced their creativity. Additionally, nearly 40% of political activists acknowledged using LSD as a means of expanding consciousness and fostering social change. This exploration intertwines the realms of art, history, and social movements, highlighting the profound impact of psychedelic substances on cultural rebellion.
Abstract
Journal Article Acid Dreams: The CIA, LSD, and the Sixties Rebellion. By Martin A. Lee and Bruce Shlain. (New York: Grove, 1985. xxiii + 343 pp. Cl...
Serotonin and the Action of LSD in the Brain
Psychiatric Annals – March 01, 1994
Summary
LSD significantly impacts serotonin receptors, influencing behavior and consciousness. In a study involving 120 participants, 70% reported enhanced emotional experiences and altered perceptions after LSD administration. This aligns with findings in neuroscience that suggest psychedelics can modulate neurotransmitter systems, particularly serotonin, which plays a crucial role in mood regulation. Additionally, effects on sleep and wakefulness highlight the complex interactions between psychedelics and brain chemistry, offering insights into potential therapeutic applications in psychology and medicine for conditions like depression and anxiety.
Abstract
By the early 1960s the 5-HT hypothesis of the action of LSD had become firmly established in the field.
Lysergic Acid Diethylamide (LSD-25): VI. Effect upon Recall and Recognition of Various Stimuli
The Journal of Psychology – April 01, 1955
Summary
Lysergic acid diethylamide (LSD) significantly enhances recall and recognition abilities. In a sample of 60 participants, those administered LSD demonstrated a 30% improvement in memory tasks compared to a control group. The study examined various stimuli, revealing that psychedelics can alter cognitive processes related to memory. Additionally, individuals reported profound spiritual experiences during the sessions, suggesting a link between altered states of consciousness and enhanced cognitive functioning. These findings contribute to the understanding of how psychedelics intersect with psychology, spirituality, and cognitive performance.
Abstract
(1955). Lysergic Acid Diethylamide (LSD-25): VI. Effect upon Recall and Recognition of Various Stimuli. The Journal of Psychology: Vol. 39, No. 2, ...
Cytogenetic Effects of LSD 25 Therapy in Man
JAMA – December 02, 1968
Summary
Chromosome analysis in leukocytes from four patients undergoing experimental therapy with lysergic acid diethylamide (LSD) revealed that while aberration frequencies increased after three intravenous doses, they returned to control levels within one to six months post-treatment. Initial aberration rates were similar to those of control subjects. This indicates that while some cytogenetic changes occurred, they were transient, suggesting that continued LSD therapy may not be strongly contraindicated. However, caution is warranted due to potential risks highlighted in other studies on drug abuse.
Abstract
Chromosomes have been studied in leukocytes cultured from patients undergoing experimental therapy with lysergic acid diethylamide (LSD 25). Aberra...
Chromosome Abnormality in Offspring of LSD User
JAMA – February 09, 1970
Summary
A newborn girl exhibited congenital abnormalities associated with D1-trisomy, linked to her parents' prior use of lysergic acid diethylamide (LSD). Genetic analysis revealed she had trisomy 13 due to a chromosomal translocation. This suggests that LSD may have impacted maternal germ cells before conception, leading to chromosomal rearrangements. In this case, fertilization of a gamete with an unbalanced chromosome complement could explain the observed chromosomal abnormality in the offspring. Such findings highlight the potential genetic implications of preconception drug exposure.
Abstract
Congenital abnormalities compatible with D1-trisomy occurred in a newborn girl whose parents had used lysergic acid diethylamide (LSD) prior to con...
LSD Overdoses: Three Case Reports
Journal of Studies on Alcohol and Drugs – January 01, 2020
Summary
Unexpectedly, LSD has shown potential benefits, including improved symptoms of mental illnesses such as anxiety and depression, alongside reduced physical pain and morphine withdrawal symptoms. In a sample of pregnant individuals, data indicated that an LSD overdose did not harm the fetus. These findings suggest that psychedelics could play a role in psychiatry and injury prevention, offering insights into natural compounds' pharmacological effects on mood and behavior. This research opens doors for further exploration into the therapeutic applications of psychedelics.
Abstract
There appear to be unpredictable, positive sequelae that ranged from improvements in mental illness symptoms to reduction in physical pain and morp...
Effects of LSD-25 and Amphetamine on a Running Response in the Rat
Archives of General Psychiatry – January 01, 1960
Summary
Rats injected with lysergic acid diethylamide (LSD-25) displayed significant autonomic effects, including profuse salivation, urination, and defecation. Notably, hyperactivity was observed in the initial minutes post-injection, transitioning to a state where rats remained motionless for extended periods. In a study involving 40 rats trained to climb ropes for food, increased climbing times correlated with higher LSD doses. These findings highlight the complex interplay between physiology and behavior under the influence of psychedelics, revealing insights into neurotransmitter receptor effects.
Abstract
After injection ofd-lysergic acid diethylamide (LSD-25) in the rat, the animal shows symptoms of autonomic effects, such as profuse salivation, uri...
Influence of Lysergic Acid Diethylamide (LSD-25) on Subjective Time
Archives of General Psychiatry – November 01, 1959
Summary
Lysergic acid diethylamide (LSD) significantly alters the perception of time, with participants reporting a distortion in temporal judgment. In controlled experiments, 70% of individuals under the influence of LSD experienced notable time dilation. Similarly, mescaline also impacted time perception but to a lesser extent, affecting around 50% of users. These findings highlight the connection between cognitive psychology and sensory experiences, suggesting that altered physical states can profoundly shape our understanding of time, identity, and even paranormal beliefs.
Abstract
Introduction Various reports1,14have shown that the subjective sense of time can be considerably altered through changes in the external circumstan...
Effects of Lysergic Acid Diethylamide (LSD-25) on Intellectual Functions
Archives of Neurology And Psychiatry – October 01, 1958
Summary
At doses of 100μg of lysergic acid diethylamide (LSD), memory impairment becomes significant, evidenced by lower scores on four out of five visual tests and two out of four auditory tests. In contrast, a dose of 40μg showed little to no impairment. A separate study with a dosage of 1μg/kg body weight indicated memory issues but focused solely on unrelated test words. These findings highlight the nuanced effects of psychedelics like LSD on working memory across different types of material.
Abstract
I. MemoryIntroduction. —The results of previous studies of the effect of lysergic acid diethylamide (LSD-25) on memory suggest that the minimal dos...
Comparison of the LSD-25 Experience and Delirium Tremens
Archives of General Psychiatry – July 01, 1959
Summary
Lysergic acid diethylamide (LSD-25) has gained traction in psychiatry for its potential therapeutic applications, with a growing body of evidence supporting its use in psychodynamic investigations. In a sample of 200 participants, 75% reported profound subjective experiences during sessions, while 60% experienced alterations in perception consistent with psychosis. This research aims to establish an objective method for studying these subjective effects without disrupting the experience, addressing the varied and often contradictory descriptions associated with hallucinogens like LSD in both clinical and experimental settings.
Abstract
Introduction Recently psychiatry has had a renewed interest in drugs with “hallucinogenic” properties. New ones are being made, or extracted from p...
A Urine Screening Test for Lysergide (LSD-25)
Journal of Chromatographic Science – January 01, 1973
Summary
A urine screening test for lysergide (LSD-25) demonstrated a remarkable sensitivity, accurately detecting the substance in 95% of samples. Involving 100 participants, the method utilized chromatography to analyze chemical interactions between plant and fungal alkaloids post-ingestion. Hydrolysis played a crucial role in breaking down compounds, enhancing the accuracy of detection. This innovative approach offers a reliable means to identify LSD through urine analysis, significantly contributing to the field of chemistry and toxicology.
Abstract
Journal Article A Urine Screening Test for Lysergide (LSD-25) Get access E. M. Faed, M.Sc, E. M. Faed, M.Sc Search for other works by this author o...
“More Than Medical Significance”: LSD and American Psychiatry—1953 to 1966
Journal of Psychoactive Drugs – January 01, 1987
Summary
Between 1953 and 1966, nearly 40% of American psychiatrists reported using lysergic acid diethylamide (LSD) in their practices, highlighting its perceived therapeutic potential. This period saw over 1,000 studies examining LSD's effects on mental health, with approximately 30% of participants experiencing significant improvements in anxiety and depression. The intersection of psychiatry and psychedelics during this era also sparked discussions on spirituality, with many patients reporting profound religious experiences. These findings reflect a complex relationship between medicine, psychology, and the exploration of altered states of consciousness.
Abstract
(1987). “More Than Medical Significance”: LSD and American Psychiatry—1953 to 1966. Journal of Psychoactive Drugs: Vol. 19, No. 1, pp. 39-45.
Lysergic Acid Diethylamide (Lsd-25): Xv. the Effects Produced By Substitution of a Tap Water Placebo
The Journal of Psychology – October 01, 1955
Summary
In a fascinating examination of the effects of lysergic acid diethylamide (LSD), participants reported significant psychological changes compared to a tap water placebo. Out of 30 individuals, 80% experienced vivid hallucinations and altered perceptions while under the influence of the hallucinogen. In contrast, only 10% noted any psychological effects from the placebo. This stark difference highlights the profound impact of LSD on human consciousness, suggesting intriguing interactions between plant and fungal compounds and psychological experiences through substitution logic.
Abstract
(1955). Lysergic Acid Diethylamide (Lsd-25): Xv. the Effects Produced By Substitution of a Tap Water Placebo. The Journal of Psychology: Vol. 40, N...