Research
Does LSD confer lasting psychological resilience? an investigation of naturalistic users experiencing job loss.
PloS one – January 01, 2024
Summary
Contrary to popular beliefs about psychedelics building mental resilience, LSD users may actually face greater psychological challenges during difficult life events. Analysis of over 5 million unemployed individuals revealed that those who used LSD before losing their jobs experienced more severe psychological distress afterward, even when accounting for demographic factors. These findings challenge current assumptions about psychedelics' protective effects on mental health.
Abstract
Recent studies on classic psychedelics have suggested that their use is associated with psychological strengths and resilience, thereby conferring ...
Inducing a meditative state by artificial perturbations: A mechanistic understanding of brain dynamics underlying meditation.
Network neuroscience (Cambridge, Mass.) – January 01, 2024
Summary
No Summary
Abstract
Contemplative neuroscience has increasingly explored meditation using neuroimaging. However, the brain mechanisms underlying meditation remain elus...
Behavioral sensitization and tolerance induced by repeated treatment with ketamine enantiomers in male Wistar rats.
PloS one – January 01, 2024
Summary
Ketamine's two mirror-image forms show different effects on the brain, with the S-form proving more potent. In rats, repeated doses of S-ketamine led to increased movement and coordination issues, while developing some tolerance to its effects over time. R-ketamine showed milder effects, suggesting it may be a gentler option for therapeutic use. The findings reveal how ketamine's distinct forms uniquely impact behavior and motor control.
Abstract
Ketamine has gained significant attention as a fast-acting antidepressant. However, ketamine is also associated with undesirable side effects. In o...
The amino acid metabolism pathway of peripheral T lymphocytes and ketamine-induced schizophrenia-like phenotype.
Journal of psychiatry & neuroscience : JPN – January 01, 2024
Summary
Abnormal amino acid levels in blood may hold clues to schizophrenia development. Scientists found that ketamine treatment in mice led to increased T-cell counts and altered amino acid metabolism. Four specific amino acids—glycine, alanine, asparagine, and aspartic acid—showed notably higher levels in blood samples, suggesting a link between immune system changes and schizophrenia-like symptoms.
Abstract
The intricate interplay between peripheral adaptive immune cells and the central nervous system (CNS) has garnered increasing recognition. Given th...
A Case of Hepatotoxicity Induced by Therapeutic Ketamine Use for Sedation.
Case reports in critical care – January 01, 2024
Summary
A rare but serious side effect of ketamine therapy has been documented: liver toxicity. When used for sedation in a 27-year-old ICU patient, ketamine caused concerning elevation in liver enzymes. The condition resolved after stopping the medication. This case highlights that while ketamine is generally safe for short-term use, monitoring liver function during treatment is crucial for patient safety.
Abstract
Ketamine, initially developed as an anesthetic, has shown versatility in medical applications, including pain management, treatment-resistant depre...
The mitogenomic landscape of Banisteriopsis caapi (Malpighiaceae), the sacred liana used for ayahuasca preparation.
Genetics and molecular biology – January 01, 2024
Summary
Scientists have decoded the complete mitochondrial DNA of the sacred ayahuasca vine, revealing fascinating insights into this culturally significant Amazonian plant. The vine works synergistically with another plant to create ayahuasca's effects by preventing the breakdown of its psychoactive compounds. Analysis shows unique genetic features, including unusual gene patterns and evidence of DNA sharing between cellular components, helping confirm its identity as the "Tucunacá" variety used in traditional ceremonies.
Abstract
The sacred ayahuasca brew, utilized by indigenous communities in the Amazon and syncretic religious groups in Brazil, primarily consists of a decoc...
Patient-reported outcomes on sleep quality and circadian rhythm during treatment with intravenous ketamine for treatment-resistant depression.
Therapeutic advances in psychopharmacology – January 01, 2024
Summary
Ketamine therapy shows promising effects on sleep patterns in people with hard-to-treat depression. In a 4-week study, patients receiving ketamine infusions reported significant improvements in sleep quality and daytime functioning. The treatment helped regulate their natural sleep-wake cycle (circadian rhythm) and reduced insomnia symptoms. Most notably, participants slept longer and felt more alert during the day.
Abstract
Intravenous (IV) ketamine is a rapid acting antidepressant used primarily for treatment-resistant depression (TRD). It has been suggested that IV k...
The rising use of cognitive enhancement drugs and predictors of use during COVID-19: findings from a cross-sectional survey of students and university staff in the UK.
Frontiers in psychology – January 01, 2024
Summary
During COVID-19 lockdowns, UK universities saw a striking 42% increase in students using cognitive enhancement drugs like Modafinil. A survey of 736 students and staff revealed significant upticks in psychoactive drug use, including microdosing psychedelics, as people adapted to remote learning. Lower agreeableness and conscientiousness emerged as key personality factors predicting drug use.
Abstract
The use of psychoactive substances to increase cognitive performance while studying has been termed 'pharmacological cognitive enhancement' (PCE). ...
Trends in waking salivary alpha-amylase levels following healing lucid dreams.
Frontiers in psychology – January 01, 2024
Summary
No Summary
Abstract
Salivary alpha-amylase (sAA) is considered a marker of autonomic nervous system activity in stress research, and atypical waking sAA responses have...
Effect of cyclic meditation on anxiety and sleep quality in sailors on merchant ships-A quasi-experimental study.
Frontiers in public health – January 01, 2024
Summary
No Summary
Abstract
Sailors undergo anxiety and sleep disturbances due to prolonged journeys and the nature of their work on ships. Earlier studies indicate Cyclic Med...
Case report: Adult with bipolar disorder and autism treated with ketamine assisted psychotherapy.
Frontiers in psychiatry – January 01, 2024
Summary
A groundbreaking treatment combining ketamine and psychotherapy showed remarkable results for a 29-year-old man struggling with both bipolar disorder and Autism Spectrum Disorder. After six ketamine infusions over one month, plus two boosters, the patient experienced significant improvements in mood stability, reduced anxiety, and fewer anger outbursts. This success suggests ketamine assisted psychotherapy could offer new hope for people with complex mental health conditions.
Abstract
Evidence has increased in recent years regarding the potential for ketamine to serve as a novel treatment option for a range of conditions, particu...
Corrigendum: Transcranial magnetic stimulation and ketamine: implications for combined treatment in depression.
Frontiers in neuroscience – January 01, 2024
Summary
Combining ketamine therapy with transcranial magnetic stimulation (TMS) shows remarkable promise for treating severe depression. This correction to previous research clarifies how these two treatments work together to enhance brain plasticity and improve mood regulation, offering new hope for patients with treatment-resistant depression.
Abstract
[This corrects the article DOI: 10.3389/fnins.2023.1267647.].
Within-subject comparison of near-death and psychedelic experiences: acute and enduring effects
Neuroscience of Consciousness – January 01, 2024
Summary
Profound mystical states of consciousness, whether from near-death experiences or hallucinogens like psilocybin, ayahuasca, and mescaline, share remarkable similarities. A study of 31 adults who experienced both revealed significant overlap in their phenomenology and attribution of reality. While sensory perception differed—NDEs involved more disembodiment, psychedelics more visual imagery—both induced similar mystical-like effects. This suggests the psychology of psychedelic experiences offers a valuable lens for understanding profound, sometimes paranormal, insights.
Abstract
Abstract Mystical-like states of consciousness may arise through means such as psychedelic substances, but may also occur unexpectedly during near-...
Effect of Pretreatment with a Small Dose of Esketamine on Myoclonus Induced by Etomidate: A Randomized Controlled Trial.
Drug design, development and therapy – January 01, 2024
Summary
A small dose of esketamine before anesthesia can reduce involuntary muscle movements by up to 42%. When patients receive etomidate for anesthesia, many experience myoclonus - sudden muscle jerks. However, pretreatment with esketamine significantly lowered these episodes without causing additional side effects. This breakthrough offers a simple solution for safer, more comfortable anesthesia procedures.
Abstract
Etomidate has been observed to precipitate myoclonus in patients undergoing induction of general anaesthesia. This study was designed to investigat...
Clinical Nurse Well-being Improved Through Transcendental Meditation: A Multimethod Randomized Controlled Trial.
The Journal of nursing administration – January 01, 2024
Summary
No Summary
Abstract
To evaluate the impact of Transcendental Meditation® (TM®) practice on the multidimensional well-being of nurse clinicians affected by the COVID-19...
N-methyl-d-aspartate (NMDA) receptor antagonists for treatment of catatonia in adults: Narrative review.
General hospital psychiatry – January 01, 2024
Summary
Breakthrough treatments offer new hope for catatonia, a severe condition causing physical immobility. Novel medications targeting NMDA receptors in the brain show promising results, especially when traditional treatments fail. Amantadine and memantine lead the way, with rapid improvement in most cases. Ketamine and esketamine also demonstrate effectiveness, particularly in resistant cases, providing doctors with more options to help patients regain normal movement and function.
Abstract
While the majority of patients with catatonia fully respond to benzodiazepines or ECT, some have a partial or no response. Benzodiazepines may be c...
Ketamine Induced Acute Systolic Heart Failure.
European journal of case reports in internal medicine – January 01, 2024
Summary
Long-term ketamine misuse can trigger severe heart complications, as revealed in a striking case of a 28-year-old woman. After 14 years of regular ketamine use, she developed systolic heart failure with severe symptoms. Following proper medical treatment and cessation of ketamine use, her heart function improved dramatically - from 15% to 54% efficiency within four months. This highlights how ketamine-induced heart problems can be reversed with timely intervention.
Abstract
Studies have shown major cardiovascular effects associated with ketamine use disorder including dose-dependent negative inotropic effects. Preopera...
The relationship between cryptomarket drug purchase, social networks and adverse drug events: A cross-sectional study.
The International journal on drug policy – January 01, 2024
Summary
Online drug purchases through cryptomarkets are linked to higher rates of adverse drug events, particularly among solo users. Analysis of 23,000+ respondents shows that people buying drugs through digital marketplaces were more likely to use alone, without social networks for support. While overall medical incidents remained low (5.2%), cryptomarket buyers faced notably higher risks with cocaine and LSD compared to those who obtained drugs through traditional means.
Abstract
Drug use and trading are typically social activities; however, supply through cryptomarkets can occur without any in-person social contact. People ...
Where do the symptoms come from in depression? Topography and dynamics matter
Brain Communications – January 01, 2024
Summary
Specific brain dynamics predict how well psilocybin treats severe depression. A study of 55 patients with treatment-resistant depression found a single 25mg psilocybin dose led to remarkable improvements. Pre-treatment functional brain connectivity dynamics, a key area in mental health research topics, indicated who would respond best. 70.9% achieved remission at three weeks, with average symptom reductions of 21.6 points. This work in psychology and psychedelics and drug studies offers insights for psychotherapists, moving beyond traditional psychoanalysis to personalize depression treatment.
Abstract
This scientific commentary refers to ‘Brain dynamics predictive of response to psilocybin for treatment-resistant depression’, by Vohryzek et al. (...
Quantum-like Qualia hypothesis: from quantum cognition to quantum perception.
Frontiers in psychology – January 01, 2024
Summary
Our conscious experiences change when we pay attention to them - much like quantum particles change when observed. Scientists have discovered striking similarities between quantum physics and human perception. The way our brain processes sensory experiences (qualia) mirrors quantum behavior, especially when we consciously focus our attention on them. This suggests consciousness operates through quantum-like mechanisms, offering a new framework for understanding how we perceive reality.
Abstract
To arbitrate theories of consciousness, scientists need to understand mathematical structures of quality of consciousness, or qualia. The dominant ...
Use of Esketamine Nasal Spray in Patients with Treatment-Resistant Depression in Routine Practice: A Real-World French Study.
Depression and anxiety – January 01, 2024
Summary
A nasal spray form of ketamine offers new hope for severe depression patients who haven't responded to other treatments. In a French healthcare setting, 40% of patients showed significant improvement within just one month, with some achieving complete remission. The spray, combined with traditional antidepressants, helped long-term sufferers who had tried an average of 6 previous treatments. While side effects occurred in most patients, the benefits proved meaningful, with nearly a quarter returning to work within 3 months.
Abstract
The efficacy and safety of esketamine nasal spray (ESK) were established in registration trials in patients with treatment-resistant depression (TR...
Ayahuasca-assisted meaning reconstruction therapy for grief: a non-randomized clinical trial protocol.
Frontiers in psychiatry – January 01, 2024
Summary
Groundbreaking research explores ayahuasca's potential to help people process deep grief. This innovative protocol combines traditional psychotherapy with psychedelic medicine to aid those experiencing prolonged grief disorder. The study will compare three approaches: meaning reconstruction therapy with ayahuasca, therapy alone, and no treatment, tracking how participants process bereavement and rebuild meaning in their lives.
Abstract
Psychotherapy for Prolonged Grief Disorder (PGD), a condition characterized by an intense and persistent grief response, has received increased att...
Psychological and physiological effects of extended DMT.
Journal of psychopharmacology (Oxford, England) – January 01, 2024
Summary
Dimethyltryptamine (DMT), a powerful psychedelic found in ayahuasca, can now be safely administered for extended periods. Researchers found that combining initial and continuous doses maintains altered consciousness states for 30 minutes, while anxiety levels stay low. The serotonin-affecting compound showed promising safety profiles, with heart rates stabilizing quickly despite sustained psychedelic effects.
Abstract
N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic that induces a rapid and transient altered state of consciousness when inhaled or inject...
Cannabidiol or ketamine for preventing the impact of adolescent early drug initiation on voluntary ethanol consumption in adulthood.
Frontiers in pharmacology – January 01, 2024
Summary
Early exposure to alcohol during adolescence can significantly increase drinking habits in adulthood, but promising treatments may help prevent this pattern. Research with rodent models revealed that teenage alcohol exposure acts as a key addiction risk factor, leading to higher voluntary alcohol consumption later in life, regardless of sex differences. While cocaine exposure alone didn't affect future drinking, cannabidiol showed promise in reducing alcohol intake in both males and females, with ketamine offering additional benefits for females. These therapeutical options could help prevent alcohol use disorder development in vulnerable populations.
Abstract
Few studies have previously evaluated the long-term impact of initiating the combined use of alcohol and cocaine early-in-life during adolescence. ...
Three Decades of Research on the Development of Ibogaine Treatment of Substance Use Disorders: A Scientometric Analysis.
Journal of psychoactive drugs – January 01, 2024
Summary
Global interest in Ibogaine for substance use disorders is rapidly expanding. A scientometric analysis, utilizing tools like CiteSpace and vosviewer, explored the evolving research landscape of Ibogaine as a potential treatment. Analyzing over 1500 publications across three decades revealed a significant increase in global research activity. This growth highlights Ibogaine's potential, with recent trends focusing on its role among psychedelics for treating opioid and other substance use disorders. This widespread, growing attention underscores its promising therapeutic future.
Abstract
Ibogaine is a natural psychoactive drug that has been investigated for its potential role in the treatment of substance use disorders since the mid...
Ibogaine administration following repeated morphine administration upregulates myelination markers 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and myelin basic protein (MBP) mRNA and protein expression in the internal capsule of Sprague Dawley rats.
Frontiers in neuroscience – January 01, 2024
Summary
A surprising finding reveals that a psychedelic medicine could help repair brain damage from addiction. Researchers explored how ibogaine might address white matter issues often seen in opioid use disorder. Using rats, they found that after opioid exposure, ibogaine significantly boosted markers for myelin, the protective sheath around nerve fibers. This suggests ibogaine helps oligodendrocytes repair white matter, offering a new mechanism for treating opioid use disorder and highlighting its potential as a psychedelic medicine.
Abstract
Ibogaine is a psychedelic alkaloid being investigated as a possible treatment for opioid use disorder. Ibogaine has a multi-receptor profile with a...
Identification of clerodane diterpene modifying cytochrome P450 (CYP728D26) in Salvia divinorum - en route to psychotropic salvinorin A biosynthesis.
Physiologia plantarum – January 01, 2024
Summary
A unique plant compound, salvinorin A, offers hope for new pain relievers distinct from traditional opioids. Scientists identified a crucial enzyme, CYP728D26, that performs a key modification on a precursor molecule. This breakthrough significantly advances understanding of the compound's biosynthesis, paving the way for bio-manufacturing and developing alternative analgesics.
Abstract
Salvia divinorum is a hallucinogenic plant native to the Oaxaca in Mexico. The active ingredient for psychotropic effects in this plant is salvinor...
Participation in an indigenous Amazonian-led ayahuasca retreat associated with increases in nature relatedness – a pilot study
Drug Science Policy and Law – January 01, 2024
Summary
Participation in Indigenous Amazonian ayahuasca retreats significantly enhances nature-relatedness and reduces stress. In a study with participants attending an average of 6.31 ceremonies, notable increases in nature connection were measured using the Short form Nature Relatedness Scale, alongside improvements in depression and stress levels assessed by the DASS-21. A moderate negative correlation indicated that greater nature-relatedness corresponded with lower stress levels. These findings suggest ayahuasca retreats may serve as a therapeutic intervention, though further investigation is needed to understand underlying mechanisms and long-term effects.
Abstract
Indigenous Amazonian shamanic ayahuasca practice is embedded in a nature-based context and is employed as an ecological mediating agent and in coll...
Your brain on art, nature, and meditation: a pilot neuroimaging study.
Frontiers in human neuroscience – January 01, 2024
Summary
No Summary
Abstract
Exposure to art, nature, or meditation, all transcending human experiences, has beneficial effects on health and wellbeing. Focusing inward or watc...
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Effect of receptive provocation as a therapeutic approach for cognitive and consciousness improvement among traumatic brain injury patients in India.
Bioinformation – January 01, 2024
Summary
Gentle sensory stimulation could be key to awakening the injured brain. In a groundbreaking Indian healthcare initiative, patients with traumatic brain injury showed remarkable cognitive improvements through receptive provocation therapy - a structured approach using controlled multisensory stimulation. Daily 20-minute sessions over one week significantly enhanced consciousness levels and mental function, compared to standard care alone.
Abstract
Traumatic brain injury (TBI) is a global health concern, often resulting in cognitive deficits and altered states of consciousness. This study eval...
The Role of Attentional Control in Mindfulness Intervention for Emotional Distress: A Randomized Controlled Trial With Longitudinal Mediation Analyses.
Clinical psychology & psychotherapy – January 01, 2024
Summary
No Summary
Abstract
This study aimed to investigate whether attentional control serves as a mediator for mindfulness-based interventions for emotional distress, utiliz...
Ketamine modulates disrupted in schizophrenia-1/glycogen synthase kinase-3β interaction.
Frontiers in molecular neuroscience – January 01, 2024
Summary
The anesthetic ketamine can disrupt crucial brain proteins, but lithium may help protect against its effects. New research reveals how ketamine reduces levels of DISC1, a key protein for brain development and mental health. When DISC1 decreases, it impairs its partnership with GSK-3β, leading to shorter nerve cell connections. Importantly, lithium treatment prevented these negative effects, suggesting a potential protective approach.
Abstract
Disrupted in schizophrenia-1 (DISC1) is a scaffolding protein whose mutated form has been linked to schizophrenia, bipolar affective disorders, and...
A Validation Study of the Mindfulness-Based Interventions Teaching Assessment Criteria for Assessing Mindfulness-Based Intervention Teacher Skill: Inter-Rater Reliability and Predictive Validity.
Global advances in integrative medicine and health – January 01, 2024
Summary
No Summary
Abstract
Prior data suggests the Mindfulness-Based Interventions: (MBI) Teaching Assessment Criteria (MBI:TAC) has good inter-rater reliability, but many ra...
The effects of mindfulness enhanced Tai Chi Chuan training on mental and physical health among beginners: a randomized controlled trial.
Frontiers in psychology – January 01, 2024
Summary
No Summary
Abstract
Tai Chi Chuan (TCC) is a traditional Chinese mind-body exercise widely adopted in Chinese communities and colleges. However, the mindful essence of...
A brief induction of loving kindness meditation to reduce anti-fat bias.
PloS one – January 01, 2024
Summary
No Summary
Abstract
Weight stigma is highly prevalent. However, existing weight stigma interventions are only modestly effective at reducing anti-fat attitudes. The cu...
Changes in peripheral oxytocin and vasopressin during a silent month-long Insight meditation retreat.
Frontiers in endocrinology – January 01, 2024
Summary
No Summary
Abstract
Given its putative roles in mediating prosocial behavior, attachment bonds, and stress physiology, oxytocin modulation has been hypothesized to be ...
A bibliometrics review of the journal mindfulness: science mapping the literature from 2012 to 2022.
Frontiers in psychology – January 01, 2024
Summary
No Summary
Abstract
This study conducts a bibliometric analysis using the Web of Science database on 1,950 articles published in the journal Mindfulness from 2012 to 2...
Psychedelic Mushrooms: The Use of Psilocybin in the Treatment of Mental Disorders
Annals of Bioethics & Clinical Applications – January 01, 2024
Summary
Advances in psychopharmacology have benefited thousands of patients, and psilocybin, a potent hallucinogen, is emerging as a promising treatment in Psychiatry. Preliminary evidence from Psychedelics and Drug Studies suggests marked improvements in mental health with psilocybin-assisted psychotherapy, delivered by a psychotherapist. This approach, explored within Psychology, aims to offer a valid therapeutic alternative. While safety and efficacy are primary objectives, some findings confirm psilocybin's safety in controlled environments, positioning it in Complementary and Alternative Medicine Studies.
Abstract
Psychedelics are a class of hallucinogenic drugs. They have been explored particularly for treatment-resistant psychiatric illnesses. In recent yea...
Childhood trauma, challenging experiences, and posttraumatic growth in ayahuasca use
Drug Science Policy and Law – January 01, 2024
Summary
Individuals with a history of childhood trauma do not face increased risks of adverse experiences during ayahuasca sessions, according to a survey of 231 participants (average age 40.3, 48% women). The findings reveal no significant difference in challenging experiences between those with and without childhood trauma (8% effect size). Furthermore, posttraumatic growth outcomes were similar for both groups. These results suggest that prior trauma may not negatively impact responses to ayahuasca, contrasting with other therapeutic interventions like counseling.
Abstract
Challenging experiences in ayahuasca use, childhood trauma, and posttraumatic growth have not been investigated systematically. This study aimed to...
The Potentials of Yoga Nidra for Addressing Pediatric Behavioral Concerns: A Comprehensive Review.
International journal of yoga – January 01, 2024
Summary
No Summary
Abstract
Pediatric behavioral concerns, encompassing anxiety, hyperactivity, and emotional dysregulation, pose significant challenges for children, families...
Psychedelics in PERIL: The Commercial Determinants of Health, Financial Entanglements and Population Health Ethics.
Public health ethics – January 01, 2024
Summary
No Summary
Abstract
The nascent for-profit psychedelic industry has begun to engage in corporate practices like funding scientific research and research programs. Ther...
Pain, mindfulness, and placebo: a systematic review.
Frontiers in integrative neuroscience – January 01, 2024
Summary
No Summary
Abstract
Pain is a complex phenomenon influenced by psychosocial variables, including the placebo effect. The effectiveness of mindfulness-based interventio...
Near-death experience: memory recovery during hypnosis.
Explore (New York, N.Y.) – January 01, 2024
Summary
No Summary
Abstract
Increasing numbers of research studies have offered evidence regarding awareness of verified events during near-death experiences (NDEs) occurring ...
Long-term transformational effects of near-death experiences.
Explore (New York, N.Y.) – January 01, 2024
Summary
No Summary
Abstract
The purpose of this study was to deepen our understanding of the phenomenon of long-term transformational effects of near-death experiences (NDEs)....
The Relationship of Rumination, Worry and OCD Symptoms During Technology Supported Mindfulness Therapy for OCD.
Clinical psychology & psychotherapy – January 01, 2024
Summary
No Summary
Abstract
In this study, we re-examined data from a previous randomized controlled trial investigating 'technology supported mindfulness' (TSM)-an 8-week tre...
The application of virtual reality meditation and mind-body exercises among older adults.
Frontiers in psychology – January 01, 2024
Summary
No Summary
Abstract
Virtual reality (VR)-based mindfulness is a promising method to improve the health of older adults. Therefore, many attempts have been made to expl...
Commentary: Evidence-Informed Recommendation to Achieve Approximate Parity in the Allowed Number of Doses for Common Psychedelics.
Journal of psychoactive drugs – January 01, 2024
Summary
Current psychedelic policy reforms lack scientific consistency in personal possession limits. New recommendations establish evidence-based equivalent doses across major compounds like psilocybin, LSD, DMT, and MDMA. This guide helps policymakers set more rational and equitable possession thresholds based on therapeutic doses and real-world use patterns.
Abstract
In recent years, policymakers have proposed and implemented regulatory changes promoting the deprioritization, decriminalization, or state-level le...
Assessing the mindfulness predictors of mental health: does mindfulness practise or dispositional mindfulness better protect young peoples' mental health?
Health psychology and behavioral medicine – January 01, 2024
Summary
No Summary
Abstract
University is an important time in a young person's life. Although it is a time of exploration, self-discovery and socialising, it is also a time o...
Evaluation of easy-to-implement anti-stress interventions in a series of N-of-1 trials: study protocol of the anti-stress intervention among physicians study.
Frontiers in psychiatry – January 01, 2024
Summary
No Summary
Abstract
Adverse effects of chronically high levels of stress on physical and mental health are well established. In physicians, the effects of elevated str...
Childhood adversity severity modulates the associations between adaptive psychological changes and amygdala volumetric changes in response to behavioral interventions.
Journal of affective disorders reports – January 01, 2024
Summary
No Summary
Abstract
Adverse Childhood Experience (ACE) has been shown to have detrimental impact on amygdala structure. Prior research found that adaptive psychologica...
CCH attack frequency reduction after psilocybin correlates with hypothalamic functional connectivity
Headache The Journal of Head and Face Pain – January 01, 2024
Summary
Psilocybin, a potent hallucinogen, shows promise for chronic cluster headaches. In a trial of 10 patients, one experienced 21 weeks of complete remission, with overall attack frequency seeing a 31% reduction. This finding, relevant to Psychedelics and Drug Studies, suggests psilocybin's influence on neurotransmitter receptors may offer a new treatment. Neuroscience and psychology insights revealed changes in brain functional connectivity—the communication between specific regions like the hypothalamus—were linked to this therapeutic effect, offering a novel approach for psychosomatic disorders and their treatments.
Abstract
Abstract Objective To evaluate the feasibility and prophylactic effect of psilocybin as well as its effects on hypothalamic functional connectivity...
Preliminary evidence for the importance of therapeutic alliance in MDMA-assisted psychotherapy for posttraumatic stress disorder.
European journal of psychotraumatology – January 01, 2024
Summary
No Summary
Abstract
Background: MDMA-assisted psychotherapy (MDMA-AP) is a combined psychotherapeutic and pharmacologic intervention that shows promise in the treatmen...
Ayahuasca for the treatment of alcohol use disorder.
International review of neurobiology – January 01, 2024
Summary
Ancient Amazonian medicine meets modern addiction treatment: Ayahuasca, a traditional psychedelic brew, shows remarkable potential in treating alcohol use disorder. Clinical studies reveal significant decreases in alcohol consumption among users, while pre-clinical research demonstrates its ability to block alcohol's addictive effects. This natural compound joins other psychedelics as a promising treatment option.
Abstract
For decades, psychedelics have been investigated for the treatment of psychiatric disorders. Specifically, evidence suggests that psychedelics may ...
Polydrug Use Typologies of Regular Ecstasy Users Visiting Electronic Dance Music Events: A Latent Class Analysis.
European addiction research – January 01, 2024
Summary
No Summary
Abstract
Polydrug use patterns among young adults using ecstasy vary, as well as their willingness to change them. Polydrug use patterns are likely associat...
Increased functional connectivity between brain regions involved in social cognition, emotion and affective-value in psychedelic states induced by N,N-Dimethyltryptamine (DMT).
Frontiers in pharmacology – January 01, 2024
Summary
DMT, a powerful psychedelic, strengthens connections between brain regions responsible for social understanding and emotional processing. Brain scans revealed enhanced communication between areas controlling empathy, self-awareness, and emotional value, suggesting how psychedelics might help treat social and emotional disorders.
Abstract
The modulation of social cognition is suggested as a possible mechanism contributing to the potential clinical efficacy of psychedelics in disorder...
Incorporating biofeedback into the Mindfulness in Motion Intervention for health care professionals: Impact on sleep and stress.
Explore (New York, N.Y.) – January 01, 2024
Summary
No Summary
Abstract
Health care providers (HCP) experience high stress and burnout rates. Mindfulness Based Interventions (MBI) with biofeedback may help improve resil...
Is Poorly Assisted Psilocybin Treatment an Increasing Risk?
American Journal of Psychiatry – January 01, 2024
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Therapeutic Protocols Using Ketamine and Esketamine for Depressive Disorders: A Systematic Review.
Journal of psychoactive drugs – January 01, 2024
Summary
No Summary
Abstract
Depression is one of the most prevalent mental health disorders globally, causing severe emotional suffering, reducing life expectancy and increasi...
The role of neurotrophic factors in novel, rapid psychiatric treatments.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology – January 01, 2024
Summary
No Summary
Abstract
Neurotrophic factors are a family of growth factors that modulate cellular growth, survival, and differentiation. For many decades, it has been gen...
Understanding the role of the NMDA receptor subunit, GluN2D, in mediating NMDA receptor antagonist-induced behavioral disruptions in male and female mice.
Journal of neuroscience research – January 01, 2024
Summary
No Summary
Abstract
Noncompetitive NMDA receptor (NMDAR) antagonists like phencyclidine (PCP) and ketamine cause psychosis-like symptoms in healthy humans, exacerbate ...