Research
Calcium channels in anesthesia management: A molecular and clinical review.
Molecular pain – January 01, 2025
Summary
Calcium channels act as molecular gatekeepers in our nervous system, controlling how we respond to anesthesia. These channels regulate consciousness and pain perception by managing calcium flow in nerve cells. Recent advances show that anesthetic mechanisms work by precisely targeting these channels, leading to more effective pain control. Understanding calcium channelopathies helps doctors personalize anesthesia for better patient safety and outcomes.
Abstract
Calcium channels play an essential role in the molecular and physiological mechanisms underlying anesthesia by mediating intracellular calcium ion ...
Body mass index is associated with the antidepressant effects of intravenous ketamine in patients with depression.
Frontiers in psychiatry – January 01, 2025
Summary
Higher body weight may boost ketamine's mood-lifting effects. In a clinical trial, patients with higher body mass index showed stronger improvements when treated with intravenous ketamine for major depressive disorder and bipolar depression. Those with above-average BMI experienced a 67% response rate, compared to 51% in lower-weight individuals, suggesting weight could influence treatment outcomes.
Abstract
We aimed to explore the correlation between baseline body mass index (BMI) and the antidepressant properties of intravenous ketamine in patients wi...
Esketamine vs. placebo combined with erector spinae plane block vs. intercostal nerve block on quality of recovery following thoracoscopic lung resection: a randomized controlled factorial trial.
International journal of surgery (London, England) – January 01, 2025
Summary
Pain management breakthrough: Combining low-dose esketamine with nerve blocks significantly improved recovery for lung surgery patients. The treatment boosted quality-of-recovery scores by 6.1 points compared to placebo - meeting the threshold for meaningful clinical improvement. Both nerve block techniques proved effective, giving doctors flexible options for pain control. This approach could transform post-surgical care.
Abstract
Multimodal analgesic strategy is pivotal for enhanced recovery after surgery. The objective of this trial was to assess the effect of subanesthetic...
Association of intravenous ketamine with change in depressive symptoms in a large integrated health care system.
Psychiatry research – January 01, 2025
Summary
Ketamine infusion therapy offers new hope for people with hard-to-treat depression. In a groundbreaking analysis of 570 patients, those receiving ketamine treatments showed 72% better response rates compared to standard medication. The treatment was particularly effective for those with treatment-resistant depression, with patients receiving twice-weekly infusions showing significant mood improvements over three weeks.
Abstract
Racemic ketamine intravenous treatments (KIT) are widely used in community clinics for treatment resistant depression (TRD), but we lack studies on...
Ketamine for treatment-resistant obsessive-compulsive disorder: Double-blind active-controlled crossover study.
Journal of psychopharmacology (Oxford, England) – January 01, 2025
Summary
New hope emerges for those struggling with severe obsessive-compulsive disorder: ketamine shows promising results in reducing symptoms. In a controlled trial, patients receiving ketamine injections experienced significant symptom improvement compared to those given an alternative medication. Benefits appeared within hours and lasted up to a week, with higher doses showing better results.
Abstract
Obsessive-Compulsive Disorder (OCD) may respond to ketamine treatment. To examine the responsiveness and tolerability of treatment-refractory OCD t...
[Mechanisms of action and therapeutic perspectives of LSD: Current status].
Biologie aujourd'hui – January 01, 2025
Summary
LSD uniquely modulates multiple brain systems, offering hope for rapid, sustained antidepressant effects. Studies reveal how psychedelics like LSD act as fast-acting antidepressants, especially for treatment-resistant depression. Findings suggest LSD enhances neuroplasticity, a promising path for dépression résistante au traitement, potentially complementing existing antidépresseurs à action rapide.
Abstract
Major depressive disorder (MDD) is a prevalent and disabling condition affecting over 350 million individuals worldwide. Although conventional anti...
Psilocybin reduces grooming in the SAPAP3 knockout mouse model of compulsive behaviour.
Neuropharmacology – January 01, 2025
Summary
A single dose of psilocybin significantly reduced compulsive behaviors in mice for up to a week, offering hope for OCD treatment. The compound was tested in specially bred mice that exhibit excessive grooming behaviors similar to human compulsive disorders. While it didn't affect anxiety levels, psilocybin effectively decreased compulsive grooming, particularly in male mice, suggesting potential as a long-lasting therapeutic option.
Abstract
Psilocybin is a serotonergic psychedelic compound which shows promise for treating compulsive behaviours. This is particularly pertinent as compuls...
Research trends in esketamine for depression over the past decade: a bibliometric analysis.
Frontiers in psychiatry – January 01, 2025
Summary
Research into esketamine for depression is surging, with 286 studies published in 2024 alone. A recent bibliometric analysis explored this research trend, examining how studies on this antidepressant have evolved. By analyzing global publications, it found a significant increase in research on esketamine's use in treating depression, with a current focus on long-term safety. This positive growth highlights promising advancements in mental health treatments.
Abstract
Patients suffering from depression frequently encounter extended periods of low moods and lack of enjoyment or enthusiasm for activities. It leads ...
Case Report: Successful management of psychogenic non-epileptic seizures with intranasal esketamine.
Frontiers in psychiatry – January 01, 2025
Summary
A groundbreaking case shows how intranasal esketamine helped a patient overcome both treatment-resistant depression and functional seizures. The medication completely stopped the patient's psychogenic seizures while significantly improving their anxiety and depression symptoms. This success suggests esketamine could offer new hope for people with complex neuropsychiatric disorders linked to past trauma.
Abstract
Psychogenic non-epileptic seizures (PNES), or functional seizures (FS), are episodes that resemble epileptic seizures but may be psychological in o...
Systematic review of parenteral ketamine for managing acute agitation in emergency settings.
Asian journal of psychiatry – January 01, 2025
Summary
In emergency departments, managing severe agitation requires fast, effective solutions. Ketamine, traditionally known as an anesthetic, shows remarkable promise in calming aggressive patients quickly and safely. When administered by injection, it takes effect in just 6 minutes on average, providing rapid relief in psychiatric emergencies. Studies spanning 1,500+ patients found it particularly effective, with most requiring only a single dose for successful sedation. While some patients experienced mild side effects like increased heart rate, serious complications were extremely rare.
Abstract
Agitation, a significant psychiatric issue often linked to conditions like schizophrenia, bipolar disorder, and major depression, invariably pose c...
Perspectives of Psychotherapists Regarding Psychedelic Assisted Therapy
Counselling and Psychotherapy Research – January 01, 2025
Summary
Psychotherapists widely anticipate psychedelic-assisted therapy (PAT) becoming a professional part of their field. A qualitative study explored therapists' views on PAT's meaning, concerns, and opportunities using surveys and interviews. Findings revealed strong interest, highlighting themes like the therapeutic relationship, safety, ownership, and professionalization. Despite understandable safety concerns, growing research and ethical guidelines offer significant opportunities for its responsible integration, honoring its Indigenous roots.
Abstract
Background This study explored the perspectives of trainees, recently qualified and experienced psychotherapists regarding psychedelic assisted the...
Consciousness in Neorealism: Perry, Montague, and Holt.
Journal of the history of ideas – January 01, 2025
Summary
No Summary
Abstract
The early twentieth-century American neo-realists' approach to consciousness is historically reconstructed and critically discussed. With reference...
What out-of-body experiences may tell us about the mind beyond the brain.
International review of psychiatry (Abingdon, England) – January 01, 2025
Summary
Reports of disembodiment, where consciousness seems to leave the body, challenge current views of the mind. Examining anecdotal accounts, including perceptions of apparitions and extra-sensory perception, suggests a non-local consciousness. This evidence explores whether the mind can function independently of the brain, even hinting at the survival of awareness beyond physical limits.
Abstract
The mind-body problem remains a central issue in the philosophy of mind. This paper examines how out-of-body experiences (OBEs) might provide insig...
What does mediumship tell us about the mind beyond the brain?
International review of psychiatry (Abingdon, England) – January 01, 2025
Summary
Intriguing evidence suggests mediums can share accurate information beyond normal senses, challenging our understanding of consciousness. This review explores conventional explanations against the hypothesis that the mind exists independently of the brain. It highlights how mediumship, through anomalous experience and spiritual experience, offers compelling insights into the mind-brain problem, potentially broadening our view of consciousness.
Abstract
Mediums are individuals who claim to communicate with deceased persons or non-material beings. Rigorous studies have reported that mediums can prov...
Neural filters to conscious awareness and the phenomena that reduce their impact.
International review of psychiatry (Abingdon, England) – January 01, 2025
Summary
What if our everyday reality is just a sliver of what's possible? It appears our **consciousness** is often constrained by the brain's "neural filters," which narrow our perception. Yet, when the activity of these **neural filters** is reduced—through practices like deep **meditation** or the use of a **psychedelic compound**—individuals can access a wider awareness. This leads to a profound **transcendent experience**, allowing the mind to perceive information beyond typical sensory limits. Such states suggest a vast, untapped potential for human awareness.
Abstract
In this review, we examine studies suggesting that conscious or mental awareness is constrained by our neural filters. These filters include sensor...
Is there a risk of esketamine misuse in clinical practice?
Therapeutic advances in drug safety – January 01, 2025
Summary
Breakthrough therapy esketamine offers new hope for treatment-resistant depression, with studies showing sustained benefits lasting up to 4.5 years. Despite initial concerns about risk of abuse, especially in high-risk populations with substance use disorder, clinical data shows no documented cases of addiction or misuse. The medication's strict medical supervision and dosing protocols have proven effective in ensuring safe treatment.
Abstract
In 2019, intranasal esketamine gained approval as a promising therapy for those individuals grappling with treatment-resistant depression. Both cli...
Structural Pharmacology of Bufotenine Derivatives in Activating the 5-HT 1A Receptor for Therapeutic Potential in Depression and Anxiety
Research – January 01, 2025
Summary
Bufotenine derivatives, particularly 5-OH-DMT and 5-MeO-DMT, demonstrate significant antidepressant and anxiolytic effects, with behavioral tests on mice showing promising results. Structural analysis revealed that these compounds interact uniquely with the 5-HT 1A receptor, crucial for treating depression and anxiety. Notably, 5-OH-DMT exhibited a distinct binding pattern, suggesting its potential for therapeutic use without hallucinogenic side effects. This work highlights the importance of understanding receptor interactions to develop next-generation nonhallucinogenic treatments targeting mental health disorders.
Abstract
The 5-HT 1A receptor is a critical target in the treatment of depression and anxiety. Bufotenine derivatives, such as 5-methoxy- N , N -dimethyltry...
Is there a risk of addiction to ketamine during the treatment of depression? A systematic review of available literature.
Journal of psychopharmacology (Oxford, England) – January 01, 2025
Summary
While ketamine shows remarkable success in treating severe depression, its history as a recreational drug has raised questions about addiction risks. Studies tracking over 2,000 patients receiving medically supervised ketamine or esketamine treatment found minimal evidence of dependence. Only four patients developed tolerance or addiction-like symptoms, suggesting that therapeutic use under proper medical supervision carries low risk of dependence while effectively treating depression.
Abstract
Ketamine has demonstrated both rapid and sustained efficacy in treating depression, especially in treatment-resistant cases. However, concerns rega...
My Bad, You Got This: witnessing, therapist attitude and the synergy between psychedelics and inner healing intelligence in the treatment of trauma.
Frontiers in psychology – January 01, 2025
Summary
MDMA-assisted therapy shows remarkable promise in trauma treatment by tapping into our natural capacity to heal. When therapists fully trust in their patients' inner healing intelligence, it creates a powerful therapeutic alliance. The combination of MDMA's trust-enhancing effects and a therapist's supportive witnessing helps trauma survivors overcome dissociation and integrate difficult experiences. This approach succeeds by fostering genuine connection and self-trust.
Abstract
The MAPS (Multidisciplinary Association for Psychedelic Studies) sponsored MDMA-assisted therapy protocol has had greater success in treating traum...
Zebra_K, a kinematic analysis automated platform for assessing sensitivity, habituation and prepulse inhibition of the acoustic startle response in adult zebrafish.
The Science of the total environment – January 01, 2025
Summary
Scientists have discovered fascinating gender differences in how fish react to sudden sounds. Using a new kinematic analysis platform, researchers found female zebrafish show stronger acoustic startle responses but adapt more slowly than males. The platform measures how adult zebrafish respond to, and learn from, repeated sound stimuli. Testing with ketamine confirmed the system's effectiveness for studying sensorimotor gating and neuroplasticity.
Abstract
The acoustic startle response (ASR) is leaded by a sudden and intense acoustic stimulus. ASR has several forms of plasticity, including habituation...
Efficacy of fluoxetine and (R,S)-ketamine in attenuating conditioned fear behaviors in male mice.
The Journal of pharmacology and experimental therapeutics – January 01, 2025
Summary
New findings show promising results in treating trauma-related fear responses: combining ketamine and fluoxetine significantly reduced fear behaviors in mice. The treatment was particularly effective at reducing conditioned fear responses two weeks after traumatic experiences. While fluoxetine alone helped decrease generalized anxiety, the dual-treatment approach showed the most promise for post-traumatic stress disorder symptoms.
Abstract
Post-traumatic stress disorder (PTSD) is caused by exposure to a traumatic or stressful event. Symptoms related to this disorder include persistent...
Efficacy and safety of perioperative application of esketamine on postoperative depression: a meta-analysis of randomized controlled studies.
International journal of surgery (London, England) – January 01, 2025
Summary
A single dose of esketamine during surgery could help prevent post-surgery depression, offering new hope for patients' mental well-being. Research spanning 2,200+ patients found that those receiving esketamine had significantly lower depression scores for over 4 weeks after surgery, while also experiencing better pain management. The treatment proved safe, with no increase in side effects like nausea or dizziness.
Abstract
Postoperative depression has a profound impact on patients' postoperative rehabilitation and overall quality of life. Preventing postoperative depr...
Training the embodied self in its impermanence: meditators evidence neurophysiological markers of death acceptance.
Neuroscience of consciousness – January 01, 2025
Summary
No Summary
Abstract
Human predictive capacity underlies its adaptive strength but also the potential for existential terror. Grounded in the predictive processing fram...
From Isolation to Social (and Psychedelic) Integration: A Sociology of Collective Effervescence and Therapeutic Community in Psychedelic-Assisted Therapy.
Sociol Health Illn – January 01, 2025
Summary
Remarkably, feeling connected can significantly amplify healing. This work explores how psychedelic therapy, when combined with strong social bonds and shared transformative experiences, helps individuals move beyond isolation. By fostering a supportive therapeutic community, this approach promotes deep social integration. The findings underscore the profound power of human connection in achieving positive mental well-being.
Abstract
From Isolation to Social (and Psychedelic) Integration: A Sociology of Collective Effervescence and Therapeutic Community in Psychedelic-Assisted T...
Chemical composition of Ecstasy tablets seized in Poland between 2005 and 2020.
Forensic toxicology – January 01, 2025
Summary
Analysis of 20,000 Ecstasy tablets revealed alarming variations in drug composition over 15 years. While MDMA remained the primary ingredient, its content fluctuated dramatically - from 50mg to dangerous highs of 280mg per tablet. More concerning, nearly 20% of tablets contained new psychoactive substances (NPS) instead of MDMA, posing serious risks to unsuspecting users.
Abstract
The most commonly associated substance found in Ecstasy tablets is MDMA (3,4-methylenedioxymethamphetamine). In our study, we showed how the compos...
Biological treatments for co-occurring eating disorders and psychological trauma: a systematic review.
Frontiers in psychiatry – January 01, 2025
Summary
Trauma and eating disorders frequently occur together, with promising new treatments emerging to address both conditions simultaneously. A comprehensive analysis of biological interventions revealed that MDMA therapy and repetitive transcranial magnetic stimulation (rTMS) showed particularly strong results. Other approaches, including ketamine, deep brain stimulation, and neurofeedback, also demonstrated positive outcomes for patients with both eating disorders and post-traumatic stress disorder.
Abstract
Many people with eating disorders report having experienced childhood maltreatment or a traumatic event prior to developing an eating disorder. Alt...
Comparison of Laboratory Confirmed Drugs in Acute Recreational Drug Toxicity Presentations to an Urban Hospital in London, UK, 2016/17 versus 2019/20.
Journal of medical toxicology : official journal of the American College of Medical Toxicology – January 01, 2025
Summary
Drug patterns at a London hospital reveal shifting trends: Cannabis, ketamine, and opioid use increased significantly from 2016 to 2020, while MDMA and alcohol-related cases declined. Novel psychoactive substances evolved, with new synthetic benzodiazepines emerging and traditional "legal highs" becoming less common. The findings reflect broader European drug use patterns.
Abstract
Novel Psychoactive Substance (NPS) use is increasingly prevalent and is often associated with severe acute recreational drug toxicity (ARDT). 258 U...
Comparison Between Low-Dose Esketamine and Dexmedetomidine on Postoperative Recovery Quality Among Patients Undergoing Humeral Trauma Surgery in Interscalene Brachial Plexus Block: A Randomized, Double-Blind, Controlled Trial.
Drug design, development and therapy – January 01, 2025
Summary
Low-dose esketamine shows promising results in improving recovery after shoulder area surgery. When compared to dexmedetomidine, patients receiving esketamine reported better quality of postoperative recovery, as measured by QoR-40 scores. The study found that esketamine maintained more stable heart rates and blood pressure while providing effective pain management during humeral trauma surgery, with no significant increase in side effects.
Abstract
Patients with humeral fracture often suffer from post-traumatic neuropsychiatric sequelae, which can cause immense anxiety or fear and worsen recov...
Psilocybin-Assisted Group Psychotherapy + Mindfulness Based Stress Reduction (MBSR) for Frontline Healthcare Provider COVID-19 Related Depression and Burnout: A Randomized Clinical Trial
OpenAlex – January 01, 2025
Summary
Frontline healthcare professionals facing burnout and depressive symptoms from COVID-19 experienced superior stress reduction with group psilocybin-assisted psychotherapy. A randomized controlled trial of 25 physicians and nurses demonstrated that combining 25mg psilocybin with Mindfulness-based stress reduction (MBSR) significantly improved depressive symptoms and burnout compared to MBSR alone. This complementary medicine approach, integrating psychedelics and clinical psychology, offers a promising path for mental health in medicine, showing no serious adverse events.
Abstract
Abstract Objective This clinical trial sought to evaluate the safety and preliminary efficacy of psilocybin and MBSR for frontline healthcare provi...
Research and Implementation of Psychedelic-Assisted Therapy in the Veterans Health Administration.
Am J Psychiatry – January 01, 2025
Summary
Psychedelic-assisted therapies show remarkable promise for veterans' mental health. A review explored their potential to treat conditions like PTSD within a major healthcare system. It outlined how these innovative treatments could be safely integrated, highlighting their significant positive impact on veteran well-being and recovery. This points to a new path for care.
Abstract
Research and Implementation of Psychedelic-Assisted Therapy in the Veterans Health Administration.
Ketamine for mood disorders, anxiety, and suicidality in children and adolescents: a systematic review.
European child & adolescent psychiatry – January 01, 2025
Summary
Ketamine shows promise as a rapid-acting treatment for depression and anxiety in young people. Research spanning 16 studies found that both ketamine and esketamine significantly improved mood and reduced suicidal thoughts in children and adolescents. Youth with severe depression, bipolar disorder, and anxiety experienced quick relief, with benefits lasting weeks to months. Side effects were generally mild.
Abstract
Mood disorders, anxiety, and suicidality in youth are increasing and rapid-acting treatments are urgently needed. One potential is ketamine or its ...
Practical considerations in the establishment of psychedelic research programs.
Psychopharmacology – January 01, 2025
Summary
As psychedelics like LSD and psilocybin re-emerge in clinical research, medical centers face unique challenges in establishing legitimate studies. Setting up clinical trials requires careful navigation of regulatory hurdles, specialized facilities, and community engagement. Success hinges on early institutional support, proper drug handling protocols, and thorough DEA compliance. Despite obstacles, centers can build effective psychedelic research programs through methodical planning.
Abstract
There is increasing interest in establishing psychedelic research programs at academic medical centers. However, psychedelics are intensely psychoa...
MDMA-assisted therapy and current treatment options for chronic, treatment-resistant, moderate or higher severity post-traumatic stress disorder: Systematic literature review.
PloS one – January 01, 2025
Summary
Many with chronic post-traumatic stress disorder (PTSD) achieved a loss of diagnosis (LOD) with 3,4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT). A review compared MDMA-AT to current treatments for severe, resistant PTSD, using the Clinician-Administered PTSD Scale (CAPS) and Beck Depression Inventory (BDI). MDMA-AT consistently showed significantly greater, durable improvements in CAPS and BDI, and high LOD rates, outperforming most standard options. This highlights MDMA-AT's strong, consistent positive results.
Abstract
3,4-methylenedioxymethamphetamine-assisted therapy (MDMA-AT) is currently being evaluated for treatment of patients with moderate or higher severit...
Glutamatergic mechanisms in early salience processing.
Frontiers in pharmacology – January 01, 2025
Summary
Our brains prioritize what demands attention, but this process can be disrupted. The glutamate hypothesis of schizophrenia suggests that imbalances in glutamate contribute to symptoms. This investigation examined how ketamine, a drug affecting glutamate, impacts attention. Healthy volunteers received ketamine or placebo. EEG recorded brain activity during an additional singleton task. Ketamine specifically altered early salience processing of distractors, not targets. It increased gamma power, linking these EEG changes to negative symptoms, shedding light on schizophrenia.
Abstract
Patients with schizophrenia frequently experience inadequate attribution of motivational salience, possibly related to impaired attentional process...
PolDrugs 2025: results of the third edition of the nationwide study on psychoactive substance use in the context of psychiatry and harm reduction.
Frontiers in psychiatry – January 01, 2025
Summary
A positive trend in Poland shows growing acceptance of psychiatry among those using psychoactive substances. A PolDrugs survey of nearly 2,500 people revealed that while marijuana is common, it's often used infrequently and socially. Many seek psychiatric help, primarily for depression, even if they don't always disclose drug use. Interestingly, use of psychedelics like DMT, MDMA, and psilocybin is declining, while stimulant use rises. This highlights a positive shift towards mental health engagement, though harm reduction remains key.
Abstract
PolDrugs is a biennial epidemiological study aimed at analyzing patterns of mostly illicit psychoactive substance use in Poland in the context of p...
A review of psychedelics trials completed in depression, informed by European regulatory perspectives.
Neuroscience applied.. – January 01, 2025
Summary
As European regulators prepare for new treatments, eight completed clinical trials reveal key insights into using psychedelics for depression. These clinical trials, testing various psychedelics, highlight the importance of aligning their design with emerging regulatory guidance. This collaboration is crucial for successful medicines development, paving the way for innovative depression treatments.
Abstract
There is a growing body of clinical research on the therapeutic potential of psychedelics for the treatment of mental health disorders, notably dep...
Dynamic brain states underlying advanced concentrative absorption meditation: A 7-T fMRI-intensive case study.
Network neuroscience (Cambridge, Mass.) – January 01, 2025
Summary
No Summary
Abstract
Advanced meditation consists of states and stages of practice that unfold with mastery and time. Dynamic functional connectivity (DFC) analysis of ...
Comparing benzodiazepine-ketamine and benzodiazepine-fentanyl sedation in phacoemulsification: A double-blind crossover non-inferiority clinical trial (BEKEF study).
Advances in ophthalmology practice and research – January 01, 2025
Summary
Patients undergoing phacoemulsification for cataract surgery now have another excellent sedation option. A trial compared Ketamine-based sedation to Fentanyl-based sedation, finding both provided equally effective comfort and high patient satisfaction. This confirms Ketamine is a safe, beneficial alternative for sedation during cataract surgery.
Abstract
Topical anesthesia for cataract surgery often requires adjunctive sedation to manage intraoperative discomfort and improve patient cooperation. Ket...
Esketamine Optimized the Efficacy of Dexmedetomidine in Treating Sleep Disorders with Comorbid Depression.
Neuropsychiatric disease and treatment – January 01, 2025
Summary
Treating insomnia alongside depression is complex. A recent investigation explored if adding esketamine could boost the sleep-inducing effects of dexmedetomidine. Patients with comorbid insomnia and depression received either dexmedetomidine with esketamine or with a placebo. Polysomnography revealed that the esketamine combination significantly improved sleep duration and deep sleep, while also reducing depression scores. This suggests a promising path for better sleep and mood.
Abstract
Although Dexmedetomidine (DEX) can induce sleep that resembles natural sleep, it has demonstrated limited efficacy in patients with comorbid insomn...
Diversity and similarity of near-death experiences across cultures and history: implications for the survival hypothesis.
International review of psychiatry (Abingdon, England) – January 01, 2025
Summary
Accounts of near-death experiences (NDEs) span cultures and history, yet their descriptions vary widely. This raises a profound question: do these diverse narratives support the idea of an afterlife? Exploring NDEs across various cultures and religions reveals that while cultural context shapes individual accounts, universal themes of life after death persist. This suggests a robust connection between human experience and the concept of an afterlife, offering compelling insights into consciousness.
Abstract
While accounts of near-death experiences (NDEs) are found around the world and throughout history, descriptions of the phenomenon vary widely. Whet...
Effects of esketamine on postoperative pain and inflammatory factors in children undergoing tonsillectomy and adenoidectomy.
Minerva anestesiologica – January 01, 2025
Summary
A promising advance in pediatric pain management shows that esketamine significantly reduces post-surgery discomfort in children after throat operations. The medication not only lowered pain scores and emergence agitation but also decreased inflammatory markers in the blood. Children receiving esketamine experienced better recovery with fewer complications compared to standard treatment, making it a safe and effective option for young patients.
Abstract
This study aimed to observe the effect of esketamine on postoperative pain and inflammatory factors in children undergoing tonsillectomy and adenoi...
Near-death experience during cardiac arrest and consciousness beyond the brain: a narrative review.
International review of psychiatry (Abingdon, England) – January 01, 2025
Summary
Remarkably, some individuals report vivid Near-death experiences during cardiac arrest when the brain's cortical electrical activity is absent. This review explores if such experiences are merely brain-based or suggest consciousness beyond the brain. Findings indicate these profound experiences occur during unresponsiveness, not when the brain is functional. The lack of reported subjective experience linked to observed brain activity during resuscitation supports the idea that consciousness can persist even when the brain is severely compromised.
Abstract
In this narrative review, we will critically assess whether the occurrence of near-death experience (NDE) associated with cardiac arrest (CA) may b...
Emerging Risks of Amanita Muscaria: Case Reports on Increasing Consumption and Health Risks.
Acta medica Lituanica – January 01, 2025
Summary
Four people recently hospitalized for consuming *Amanita muscaria* were all discharged in stable condition, revealing a growing trend. This review highlights increased recreational use of these psychoactive mushrooms, driven by compounds like muscimol and its precursor, ibotenic acid. While some explore microdosing, the unregulated nature of *Amanita muscaria* raises public health concerns regarding its known toxicity.
Abstract
The increasing popularity of Amanita muscaria, driven by its hallucinogenic properties, has raised significant public health concerns, particularly...
Understanding individual differences in non-ordinary state of consciousness: Relationship between phenomenological experiences and autonomic nervous system.
Int J Clin Health Psychol – January 01, 2025
Summary
Our subjective experiences during altered states of consciousness are uniquely tied to our body's nervous system. Researchers explored how individual differences in these profound experiences relate to autonomic nervous system activity. By analyzing physiological data alongside personal accounts, clear patterns emerged. Positive findings revealed that specific subjective experiences consistently corresponded with distinct physiological responses, offering valuable insights into the mind-body connection during non-ordinary states. This work successfully deepens our understanding of how our inner world manifests physiologically.
Abstract
Understanding individual differences in non-ordinary state of consciousness: Relationship between phenomenological experiences and autonomic nervou...
The Effect of Minimal-Dose S-Ketamine Administration Post-Surgery on Opioids Consumption and Functional Rehabilitation Exercises in Patients Undergoing Minimally Invasive Radical Resection of Esophageal Cancer.
Therapeutics and clinical risk management – January 01, 2025
Summary
For patients recovering from esophageal cancer surgery, a minimal dose of S-ketamine remarkably reduced opioid consumption by 40%. This finding emerged from a comparison where patients received either S-ketamine or a placebo for postoperative analgesia. Those given S-ketamine not only used significantly less pain medication but also showed superior functional recovery. This approach offers a promising way to enhance patient rehabilitation.
Abstract
To examine the impact of minimal-dose S-ketamine on postoperative analgesia in patients undergoing minimally invasive radical resection for esophag...
Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness.
Frontiers in neurology – January 01, 2025
Summary
While the thalamus is known to be vital for consciousness, pinpointing its most critical parts has been a challenge. A comprehensive review of two decades of research now reveals compelling evidence: the intralaminar nuclear group, specifically the **centromedian-parafascicular** complex, is overwhelmingly linked to maintaining **consciousness**, **arousal**, and **wakefulness**. This region of the **thalamus** appears to be a central hub. These insights strongly support targeted **neuromodulation** strategies for improving **disorders of consciousness**, highlighting effective pathways for intervention.
Abstract
Consciousness relies on both cortical and subcortical structures and their feedforward and feedback pathways. Within this framework, the thalamus r...
A Multi-Site, Randomized, Parallel-Group, Controlled Trial of Virtually-Delivered Sahaj Samadhi Meditation for the Management of Moderate Depressive Symptoms in Chronic Pain.
Journal of pain research – January 01, 2025
Summary
A new clinical trial suggests a virtual meditation program could offer significant relief for those managing both chronic pain and depressive disorder. This mind-body therapy was tested against a control program. While direct group comparisons were not significant, participants practicing the meditation showed substantial, clinically meaningful improvements in their depressive symptoms over 24 weeks. This indicates meditation is a promising approach for these co-occurring conditions.
Abstract
Chronic pain (CP) often co-occurs with depression, but promising scalable interventions have been under-investigated. We assessed the effectiveness...
Trends in research on novel antidepressant treatments.
Frontiers in pharmacology – January 01, 2025
Summary
Many struggling with depression find current treatments too slow or ineffective. New research explores diverse, rapid-acting antidepressants (RAAD) to tackle treatment-resistant depression (TRD). Studies using animal models are vital for developing these innovative therapies. Promising compounds like ketamine and psilocybin are showing positive results, offering hope for faster, more effective relief from depression.
Abstract
Mood disorders, such as major depressive disorder and bipolar disorder, are among the most common mental illnesses and a leading cause of disabilit...
Tags
Psychoactive substance use among medical and paramedical undergraduate students of Lucknow.
Journal of education and health promotion – January 01, 2025
Summary
No Summary
Abstract
Psychoactive drugs are substances that, when taken in or administered into one's system, affect mental processes like perception, consciousness, co...
Quantitative LC-QToF-MS Analysis of Mycochemicals in Amanita muscaria, Psilocybe spp. (Agaricomycetes), and Consumer Products.
International journal of medicinal mushrooms – January 01, 2025
Summary
Recent analysis of psychedelic mushroom products reveals significant quality control issues in the expanding market. Scientists developed a precise testing method to measure key compounds in both Amanita muscaria and Psilocybe mushroom products. Testing of 27 commercial items found concerning discrepancies - some gummies lacked expected compounds, while others contained substances not listed on labels.
Abstract
The psychedelic mushroom market has expanded rapidly due to changing regulations and increasing consumer demand. Product diversity now extends beyo...
Thalamocortical interactions reflecting the intensity of flicker light-induced visual hallucinatory phenomena.
Network neuroscience (Cambridge, Mass.) – January 01, 2025
Summary
No Summary
Abstract
Aberrant thalamocortical connectivity occurs together with visual hallucinations in various pathologies and drug-induced states, highlighting the n...
Associations between mindfulness and symptom severity among adults living with chronic obstructive pulmonary disease (COPD).
Heart & lung : the journal of critical care – January 01, 2025
Summary
No Summary
Abstract
Mindfulness-based interventions (MBI) benefit adults with chronic obstructive pulmonary disease (COPD) by helping them manage their symptoms and im...
The Effect of Meditation-Based Mind-Body Interventions on Older Adults with Poor Sleep Quality: A Meta-Analysis of Randomized Controlled Trials.
Behavioral sleep medicine – January 01, 2025
Summary
No Summary
Abstract
This study aims to evaluate the effect of meditation-based mind-body interventions (MBIs) (Mindfulness, Tai Chi, Yoga, and Qigong) for older adults...
Analgesic and Hemodynamic Effects of Dexmedetomidine-Ketamine vs Fentanyl-Ketamine in Healthy Volunteers: A Randomized Trial.
Journal of pain research – January 01, 2025
Summary
Pain management breakthrough: Combining ketamine with either dexmedetomidine or fentanyl provides effective pain relief. Both combinations increased pain tolerance by 30-50%, but showed different side effects. While dexmedetomidine caused more pronounced sedation and blood pressure drops, fentanyl led to mild nausea. Neither caused dangerous breathing problems, offering promising options for customized pain control.
Abstract
Dexmedetomidine is an α2-agonist sedative with opioid-sparing properties, is limited by dose-dependent hypotension and bradycardia. Ketamine, an NM...
Correlation analysis between clinical effective emotional treatment and plasma N-methyl-D-aspartate receptor function-related indexes.
Frontiers in neuroscience – January 01, 2025
Summary
Effective treatment for major depressive disorder (MDD) may significantly alter brain chemistry and inflammation. Researchers explored how successful antidepressant therapy affects plasma markers related to the N-methyl-D-aspartate receptor (NMDAR) and inflammatory cytokines. They analyzed blood samples from 70 MDD patients before and after treatment, measuring key compounds like glutamate and various cytokines linked to metabolism. Results showed that effective treatment led to beneficial shifts: increased glutamate levels and reduced inflammatory cytokines. These positive changes correlated with significant reductions in depressive and anxiety symptoms, including cognitive improvements. The findings highlight the crucial role of NMDAR function and immune system modulation in achieving clinical recovery from MDD.
Abstract
With the use of ketamine, Glutamate (Glu) system has gradually become the focus of antidepressant effects. N-methyl-D-aspartate receptor (NMDAR), a...
Evaluation of the peak experience scale as a rapid assessment tool for the strength of a psychoactive experience with 5-MeO-DMT.
Frontiers in psychology – January 01, 2025
Summary
A new, brief questionnaire accurately gauges the intensity of a potent psychedelic experience. Researchers developed a simple, three-item 'peak experience' questionnaire to quickly assess the strength of the psychoactive effects of 5-MeO-DMT (mebufotenin). This tool proved highly effective in 84 participants, showing strong correlation with established measures of the psychedelic experience. Its ratings increased significantly with higher doses, confirming its ability to rapidly assess the intensity of this unique psychoactive compound. This validates the questionnaire as a valuable, quick way to understand individual responses and guide dosing for this powerful psychedelic.
Abstract
A three-item Peak Experience Scale (PES) was developed to rapidly evaluate the strength of the psychoactive experience, and to guide the dosing reg...
The Opioid-Sparing Effects of Intraoperative Esketamine Combined with Dexmedetomidine During Laparoscopic Major Abdominal Surgery: A Randomized Controlled Double-Blind Trial.
Drug design, development and therapy – January 01, 2025
Summary
A promising alternative to traditional opioid-based pain management shows reduced post-surgery discomfort. Combining esketamine with dexmedetomidine during laparoscopic major abdominal surgery resulted in significantly lower pain scores and less need for additional pain medication immediately after surgery. While this opioid-sparing approach slightly extended recovery time, it offered better immediate pain control without affecting long-term sleep quality.
Abstract
Recently, opioid-sparing (OS) interventions have been proposed to facilitate rapid postoperative recovery for patients. However, the advantages of ...
Effect of low-dose esketamine on cardio-biliary reflex and postoperative pain during laparoscopic cholecystectomy surgery: A randomized, controlled trail.
PloS one – January 01, 2025
Summary
A small dose of esketamine before gallbladder surgery can significantly reduce both dangerous cardiac complications and post-surgery pain. This medication cut cardiac reflex incidents by more than half and provided better pain control for three days after surgery. The treatment proved both safe and effective across 140 patients, offering a promising option for safer gallbladder procedures.
Abstract
Cardio-biliary reflex can lead to cardiac arrest, brady-arrhythmia, cardiogenic shock, and other severe complications. NMDA receptor antagonists ha...
Multidimensional Analysis of Twin Sets During an Intensive Week-Long Meditation Retreat: A Pilot Study.
Mindfulness – January 01, 2025
Summary
Twins exhibited synchronized brain activity during meditation, even when separated. This pilot explored how mind-body practices influence individuals. Using quantitative electroencephalography (qEEG), gene expression, and metabolomics, positive shifts in brain activity, gene expression, and metabolites were observed. Twin pairs showed remarkable alignment, underscoring meditation's profound benefits.
Abstract
Meditation has long been known to promote health. We utilized a multidisciplinary approach to investigate the impact of mind-body interventions on ...
Psychological Mediators of Reduced Distress: Preregistered Analyses from a Randomized Controlled Trial of a Smartphone-Based Well-Being Training.
Clinical psychological science : a journal of the Association for Psychological Science – January 01, 2025
Summary
No Summary
Abstract
Understanding why interventions work is essential to optimizing them. Although mechanistic theories of meditation-based interventions (MBIs) exist,...