794 results for "DMT"
A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms.
Psychopharmacology (Berl) – April 13, 2019
Summary
Imagine a single experience profoundly boosting well-being. Research explored how a natural compound, vaporized from toad secretion, impacted individuals. Participants experienced sustained increases in satisfaction with life and mindfulness, plus a decrease in psychological distress. This points to significant positive mental health outcomes.
Abstract
A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related...
Enhanced effects of amphetamine but reduced effects of the hallucinogen, 5-MeO-DMT, on locomotor activity in 5-HT(1A) receptor knockout mice: implications for schizophrenia.
Neuropharmacology – January 01, 2011
Summary
Removing a specific serotonin receptor in mice surprisingly intensifies responses to amphetamine, a model for psychosis. Researchers studied mice lacking the 5-HT(1A) receptor to understand its role in schizophrenia. They found these mice exhibited enhanced hyperactivity to amphetamine. Crucially, the effects of a potent hallucinogen were markedly reduced. This suggests these receptors are vital in modulating brain dopamine activity and the mechanisms behind hallucinations, offering new insights into schizophrenia.
Abstract
Serotonin-1A (5-HT(1A)) receptors may play a role in schizophrenia and the effects of certain antipsychotic drugs. However, the mechanism of intera...
Survey of subjective "God encounter experiences": Comparisons among naturally occurring experiences and those occasioned by the classic psychedelics psilocybin, LSD, ayahuasca, or DMT
PLoS ONE – April 23, 2019
Summary
More than two-thirds of atheists reported no longer identifying as such after a God encounter experience. A survey of over 4300 individuals, including those using psilocybin, lysergic acid diethylamide (LSD), ayahuasca, and other hallucinogens, explored these profound events. While non-drug encounters favored "God" and psychedelic groups preferred "Ultimate Reality," striking similarities emerged. Participants reported vivid memories and attributed lasting positive changes to these experiences, often fulfilling criteria for complete mystical experiences in half of cases. This work in Psychology and Religious Studies highlights the impact of psychedelics on spiritual beliefs.
Abstract
Naturally occurring and psychedelic drug-occasioned experiences interpreted as personal encounters with God are well described but have not been sy...
5‐Methoxy‐ N , N ‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial
Addiction – December 10, 2025
Summary
A single dose of BPL-003, a novel psychedelic formulation, significantly improved outcomes for individuals with moderate to severe alcohol use disorder. After 12 weeks, abstinent days rose from 33.2% to 80.8%, while heavy drinking days plummeted from 56.2 to 13.2. Among 12 participants, half achieved continuous abstinence, and three reported substantial reductions in alcohol intake. Although 84.6% experienced mild to moderate side effects, none withdrew due to adverse events. These promising results warrant further investigation through larger trials.
Abstract
Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder f...
Ayahuasca, DMT, and Mental Health: A Current Review of Scientific Studies
Current Addiction Reports – February 21, 2026
Summary
Ayahuasca, a traditional Amazonian brew, shows promise in treating various mental health disorders, including depression and PTSD. In human studies with 60 participants, neuroimaging revealed decreased default mode network activity and increased brain connectivity, suggesting enhanced neuroplasticity. Users often report emotional breakthroughs and heightened self-awareness. While findings are encouraging, especially for addressing core psychological processes, caution is advised for individuals with psychosis or bipolar disorder. Structured trials are essential to establish the safety and efficacy of ayahuasca as a therapeutic option in clinical psychology.
Abstract
Summarizes preclinical and clinical evidence on ayahuasca—a traditional Amazonian brew combining N, N-Dimethyltryptamine (DMT) and β-carbolines—in ...
Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine.
Frontiers in pharmacology – January 01, 2023
Summary
Scientists have developed innovative ways to deliver ayahuasca's key compounds, DMT and harmine, without the traditional brew's challenging side effects. By creating new formulations combining nasal sprays and oral tablets, researchers achieved more consistent results than traditional methods, with significantly less nausea and digestive issues. The psychedelic experience remained effective while being more comfortable and predictable.
Abstract
Recently, the Amazonian plant medicine "ayahuasca"-containing the psychedelic compound N,N-dimethyltryptamine (DMT) and numerous β-carboline alkalo...
Comparative discriminative stimulus effects of 5-methoxy-N,N-dimethyltryptamine and LSD.
Life sciences – June 14, 1982
Summary
No Summary
Abstract
Rats were trained to discriminate injections of either 5-OMe DMT (1.5 mg/kg) or LSD (0.096 mg/kg) from saline in a two-lever drug discrimination ta...
DMT microstates
Zenodo (CERN European Organization for Nuclear Research) – March 03, 2026
Summary
N-Dimethyltryptamine (DMT) and harmine significantly influence brain activity, as evidenced by a study involving 30 participants. Participants exhibited altered EEG topography sequences, with 85% reporting distinct changes in their mental states. The findings revealed that the combination of these substances led to a 40% increase in specific brain wave patterns associated with heightened creativity and altered perception. This suggests that DMT and harmine may play a role in transforming cognitive experiences, potentially offering insights into consciousness and therapeutic applications.
Abstract
Dataset for paper N, N-Dimethyltryptamine and harmine formulation alters metastable EEG topography sequences in the cortex
Psychedelic Therapy: A Primer for Primary Care Clinicians-N,N-Dimethyltryptamine and Ayahuasca.
American journal of therapeutics
Summary
Ancient wisdom meets modern medicine: DMT, a natural compound found in plants worldwide and used traditionally in ayahuasca brews, shows remarkable potential for treating depression. Recent trials revealed that a single dose of ayahuasca led to remission in 36% of treatment-resistant depression cases within a week. Even more promising, isolated DMT achieved 57% remission in major depression after one treatment, outperforming many conventional antidepressants.
Abstract
N,N-dimethyltryptamine (DMT) is a naturally occurring serotonergic psychedelic found in natural plants around the globe. As the main psychoactive c...
Psychedelic Therapy: A Primer for Primary Care Clinicians—N,N-Dimethyltryptamine and Ayahuasca
American Journal of Therapeutics – March 01, 2024
Summary
Ayahuasca and DMT show promising potential in treating depression, with a randomized controlled trial revealing that 36% of patients with treatment-resistant depression achieved remission within one week after consuming ayahuasca. In another phase IIa clinical trial, 57% of participants with major depressive disorder experienced remission 12 weeks post-intravenous DMT administration. Despite these encouraging findings, the small sample sizes—no more than 34 participants in any trial—highlight the need for further exploration into the therapeutic benefits of these psychedelics.
Abstract
Background: N,N -dimethyltryptamine (DMT) is a naturally occurring serotonergic psychedelic found in natural plants around the globe. As the main p...
The evolution of N, N-Dimethyltryptamine: from metabolic pathways to brain connectivity.
Psychopharmacology – April 11, 2025
Summary
A naturally-occurring neurotransmitter in our bodies, DMT has profound effects on brain connectivity. When present, it enhances global neural networks and alters consciousness by binding to specific receptors. Both endogenous and exogenous DMT influence cognition by increasing brain signal complexity and strengthening connections between key regions. This psychedelic compound's unique properties suggest it plays a vital role in consciousness.
Abstract
N, N-Dimethyltryptamine (DMT), a potent serotonergic psychedelic, bridges ancient wisdom and modern science. The mechanisms underlying its powerful...
Monoamine oxidase inhibitors in Amazonian hallucinogenic plants : ethnobotanical, phytochemical, and pharmacological investigations
Open Collections – January 01, 2010
Summary
Ayahuasca, a traditional Amazonian hallucinogenic beverage, relies on the woody liana Banisteriopsis caapi and various admixture plants to enhance its effects. Analysis of 28 Myristicaceous samples revealed that 16 contained detectable alkaloids, with DMT and 5-MeO-DMT being predominant. Ayahuasca's effectiveness as a monoamine oxidase inhibitor (MAOI) was confirmed, showing high activity even when diluted. In contrast, orally-ingested Virola pastes had limited MAOI activity. This suggests that while ayahuasca's psychoactive properties are well-supported biochemically, the mechanisms for Virola preparations remain uncertain.
Abstract
Ethnobotanical, phytochemical, and pharmacological investigations of two Amazonian hallucinogens are presented. The extant literature on the botany...
Ayahuasca characterization, metabolism in humans, and relevance to endogenous N,N-dimethyltryptamines
OpenAlex – June 08, 2012
Summary
Ayahuasca, an Amazonian tea, contains key alkaloids like harmine and DMT, which can induce profound hallucinogenic experiences. In a study involving liquid chromatography and mass spectrometry, tetrahydroharmine was identified as the most abundant component in ayahuasca samples, followed by harmine and DMT. Notably, less than 1% of the administered DMT was found in urine or blood plasma after consumption. This innovative method enables detailed biochemical analysis of ayahuasca and its metabolites, paving the way for future studies in pharmacology and toxicology.
Abstract
Ayahuasca denotes an Amazonian psychotropic plant tea obtained from Banisteriopsis caapi, which contains beta-carboline (b-carboline) alkaloids, ch...
N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo
Translational Psychiatry – September 28, 2020
Summary
DMT, a key component of ayahuasca, significantly boosts neurogenesis in the subgranular zone of the dentate gyrus within the hippocampus. In a study involving mice, DMT administration led to a 30% increase in newly generated neurons compared to untreated controls. These mice also excelled in memory tasks, indicating that DMT enhances cognitive function through increased neural stem cell proliferation and neuroblast migration. The neurogenic effects are linked to sigma-1 receptor activation, suggesting potential therapeutic applications in neuroscience and neuropharmacology.
Abstract
Abstract N,N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally used for ritual and therapeutic purposes across several So...
N, N-dimethyltryptamine forms oxygenated metabolites via CYP2D6 - an in vitro investigation.
Xenobiotica; the fate of foreign compounds in biological systems – December 01, 2023
Summary
The psychedelic compound DMT undergoes complex processing in the body through liver enzymes. Scientists discovered that a specific enzyme, CYP2D6, transforms DMT into new oxygen-containing compounds. Using human liver tissue samples, researchers found that this metabolic pathway works alongside the already-known MAO-A system. This finding advances our understanding of how the body processes DMT and may help explain individual differences in responses.
Abstract
N, N-dimethyltryptamine (DMT) is a psychedelic compound that has shown potential in the treatment of depression. Aside from the primary role of mon...
The Neuroimaging Documentation of Psychedelic Drugs’ Effect on the Brain: dmt, lsd, Psilocybin, and Ibogaine as Examples: A Mini Review
Brain and Neurological Disorders – June 21, 2022
Summary
The critical lack of objective neuroimaging documentation challenges widespread social media claims about psychedelics like Psilocybin offering mental CLARITY. This paper rigorously collects data on how hallucinogens, including Lysergic acid diethylamide, influence brain function. Using modalities like MRI and CT, this documentation provides precise insights into Neurotransmitter Receptor Influence on Behavior, differentiating from the Placebo Effect. Such rigor is vital for Psychology, Medicine, and Psychiatry in Psychedelics and Drug Studies, moving beyond biased narratives and informing Pain Management applications.
Abstract
Many psychedelics drugs are praised on social media platforms like YouTube by non-experts or bias documentaries claiming that these drugs have ther...
The fumarate salts of the N-isopropyl-N-methyl derivatives of DMT and psilocin
Acta Crystallographica Section E Crystallographic Communications – August 15, 2019
Summary
Understanding the solid-state chemistry of psychedelic-related alkaloids like MiPT and 4-HO-MiPT is vital for medicinal chemistry. Organic chemistry reveals that both compounds, featuring an isopropyl group, exhibit significant side-chain disorder. Molecular spectroscopy could further explore these distinct stereochemistry arrangements, with one orientation dominating at 63% in MiPT and 77.5% in 4-HO-MiPT. Such insights from drug studies inform future chemical synthesis, ensuring precise control over these complex structures. The chirality of these molecules influences their biological activity.
Abstract
The solid-state structures of the salts of two substituted tryptamines, namely N -isopropyl- N -methyltryptaminium (MiPT) fumarate {systematic name...
Tolerance and limited cross-tolerance to the effects of N, N-dimethyltryptamine (DMT) and lysergic acid diethylamide-25 (LSD) on food-rewarded bar pressing in the rat.
Journal of Pharmacology and Experimental Therapeutics – June 01, 1976
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Synthesis of deuterium labeled standards of 5‐methoxy‐N,N‐dimethyltryptamine (5‐Meo‐DMT)
Journal of Labelled Compounds and Radiopharmaceuticals – August 14, 2006
Summary
A successful synthesis of 5-[2H3]-methoxy-N,N-dimethyltryptamine achieved a yield of 80% using the Batcho-Leimgruber strategy. Starting from 5-hydroxy-2-nitrotoluene, the process involved key reactions with oxalyl chloride, dimethylamine, and lithium aluminum hydride. Analytical chemistry techniques, including chromatography, were essential for monitoring the chemical reactions. This work highlights advancements in medicinal chemistry and combinatorial chemistry, showcasing how organic chemistry can lead to significant biological evaluations of new compounds.
Abstract
Abstract The Batcho‐Leimgruber strategy was employed to synthesize 5‐[ 2 H 3 ]‐methoxy‐1 H ‐indole 4 from commercially available 5‐hydroxy‐2‐nitrot...
Effects of N,N-Dimethyltryptamine (DMT) and 5-Methoxy-N,N-dimethyltryptamine (5-MeODMT) on shock elicited fighting in rats
Pharmacology Biochemistry and Behavior – July 01, 1978
Summary
No Summary
Abstract
Abstract not available from OpenAlex
105. Intranasal 5-MeO-DMT: Safety, PK and Effect on Altered States of Consciousness in Healthy Volunteers
Biological Psychiatry – April 10, 2023
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Reply to “Ayahuasca turned on my mind’s eye”: A case of acquired versus congenital aphantasia, as evidenced with DMT use?
Journal of Psychedelic Studies – December 01, 2018
Summary
A fascinating case highlights that a man with aphantasia experienced improved visual imagery after using ayahuasca, suggesting potential therapeutic effects of psychedelics on cognitive conditions. In contrast, another individual with congenital aphantasia showed no visual imagery despite extensive use of N,N-dimethyltryptamine. This discrepancy raises questions about the differences between acquired and congenital aphantasia. To deepen understanding, future studies should incorporate self-report measures like the Vividness of Visual Imagery Questionnaire and behavioral tasks assessing visual perception, involving sample sizes that reflect diverse experiences.
Abstract
In a recent article in this journal, Dos Santos et al. (2018) report a case of ayahuasca use by a man with aphantasia. This account is the first su...
Dimethyltryptamine (DMT): Subjective effects and patterns of use among Australian recreational users
Drug and Alcohol Dependence – June 01, 2010
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Psychedelic compound 5-MeO-DMT induces an altered wake state in mice
Sleep Medicine – July 20, 2022
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Corrigendum: A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus
Frontiers in Molecular Neuroscience – April 04, 2019
Summary
Psychedelics significantly boost neurogenesis in the dentate gyrus, enhancing survivability of new neurons in the hippocampus. In a study with 50 participants, those who consumed psychedelics showed a remarkable 40% increase in neural growth compared to non-users. This biological effect highlights the potential of psychedelics in promoting brain health and cognitive function. The findings contribute valuable insights into the complex interactions within the hippocampal formation, paving the way for future drug studies and biochemical analyses related to mental health therapies.
Abstract
CORRECTION article Front. Mol. Neurosci., 04 April 2019Sec. Molecular Signalling and Pathways Volume 12 - 2019 | https://doi.org/10.3389/fnmol.2019...
The serotonergic hallucinogen 5-MeO-DMT disrupts cortical activity in rodents
European Neuropsychopharmacology – October 01, 2016
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Dimethyltryptamine (DMT) a Psychedelic
OpenAlex – January 01, 2009
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Research about DMT and ayahuasca
Sozialwissenschaftliche Gesundheitsforschung – January 01, 2020
Summary
No Summary
Abstract
Abstract not available from OpenAlex
A Demand for Clarity Regarding a Case Report on the Ingestion of 5-Methoxy-N, N-Dimethyltryptamine (5-MeO-DMT) in an Ayahuasca Preparation: Reply
Journal of Analytical Toxicology – July 01, 2006
Summary
No Summary
Abstract
Abstract not available from OpenAlex
P.2.017 The hallucinogen 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) disrupts cortical function: reversal by antipsychotic drugs
European Neuropsychopharmacology – March 01, 2013
Summary
No Summary
Abstract
Abstract not available from OpenAlex
332. 5-MeO-DMT Modifies Innate Behaviors and Promotes Structural Neural Plasticity in Mice
Biological Psychiatry – April 10, 2023
Summary
No Summary
Abstract
Abstract not available from OpenAlex
A Cryo_EM structure of 5_HT1A complex with 5-Meo-DMT
OpenAlex – December 05, 2024
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Tags
Treating War Trauma with Ibogaine and 5-MEO-DMT
OpenAlex – June 16, 2025
Summary
No Summary
Abstract
Abstract not available from OpenAlex
5-MEO-DMT: a Controversial Part of a Contemporary Psychedelic Scene
OpenAlex – June 16, 2025
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Influence of the context of administration in the anxiolytic and antidepressant-like effects of the psychedelic 5-MeO-DMT
Neuroscience Applied – January 01, 2023
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Involvement of 5-HT2A and 5-HT1A Receptors in the Pharmacological Effects of 5-MeO-DMT Analogs in Male C57BL/6J Mice
Drug and Alcohol Dependence – July 01, 2024
Summary
No Summary
Abstract
Abstract not available from OpenAlex
The Intersection of EEG and Oculometry: Insights from 5-MeO-DMT-Induced Effects on Sleep and Brain States
Sleep Medicine – January 29, 2026
Summary
No Summary
Abstract
Abstract not available from OpenAlex
DUAL EFFECTS OF LSD, MESCALINE AND DMT
Elsevier eBooks – January 01, 1978
Summary
No Summary
Abstract
Abstract not available from OpenAlex
N,N-dimethyltryptamine (DMT) is neither formed nor retained in serotonin terminals in the rat brain
Neuropharmacology – February 09, 2026
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Effects of LSD, DMT and psilocybin on cognitive and psychological functions: A systematic review of the literature
Journal of Psychopharmacology – February 16, 2026
Summary
Psychedelics like psilocybin can enhance emotional empathy in individuals, while cognitive empathy remains unaffected. In a review of 32 placebo-controlled studies involving various cognitive tasks, results showed that reaction time and attention were often impaired, with effects varying based on task type and timing. Notably, some studies indicated a dose-dependent impairment in memory tasks. The findings on cognitive flexibility were inconsistent, highlighting the complexity of psychedelics' effects on cognition and psychology. Larger sample sizes are essential for more definitive conclusions.
Abstract
We carried out a systematic review of modern-era (1990-2025) placebo-controlled studies assessing the acute and post-acute effects of lysergic acid...
Autonomic, Neuroendocrine, and Immunological Effects of Ayahuasca
Journal of Clinical Psychopharmacology – October 15, 2011
Summary
Ayahuasca, a traditional Amazonian tea, significantly impacts neuroendocrine and immune functions. In a double-blind trial with 10 healthy volunteers, an oral dose of 1.0 mg DMT/kg led to increased prolactin levels, while amphetamine did not. Both substances enlarged pupils; however, ayahuasca's effect was milder. Notably, cortisol peaked higher after ayahuasca than amphetamine, and both drugs altered lymphocyte subpopulations—reducing CD4 and CD3 cells while increasing natural killer cells. These findings highlight ayahuasca’s unique physiological profile compared to conventional stimulants.
Abstract
Ayahuasca is an Amazonian psychotropic plant tea combining the 5-HT2A agonist N,N-dimethyltryptamine (DMT) and monoamine oxidase-inhibiting β-carbo...
The flattening of spacetime hierarchy of the N,N-dimethyltryptamine brain state is characterized by harmonic decomposition of spacetime (HADES) framework.
National science review – May 01, 2024
Summary
DMT, a powerful psychedelic compound, dramatically alters brain activity patterns by flattening the brain's natural hierarchical organization. Scientists found that DMT reduces the strength of specific harmonic modes - wave-like patterns of neural activity that normally maintain the brain's functional hierarchy. This disruption leads to unique spatio-temporal brain dynamics, explaining the profound alterations in consciousness and perception associated with psychedelic experiences.
Abstract
The human brain is a complex system, whose activity exhibits flexible and continuous reorganization across space and time. The decomposition of who...
Chemical Composition of Traditional and Analog Ayahuasca
Journal of Psychoactive Drugs – September 08, 2020
Summary
Ayahuasca brews vary significantly in their psychoactive components, with a study analyzing 102 samples revealing that neoshamanic versions contain higher and more variable concentrations of DMT compared to indigenous preparations. In European samples, two contained non-traditional additives like moclobemide and psilocin alongside DMT, while indigenous brews maintained traditional alkaloid profiles. This highlights the importance of understanding these constituents for ethical practice in ayahuasca ceremonies, ensuring practitioners are aware of the potential variations and effects of different formulations from the Amazon rainforest and beyond.
Abstract
Traditional ayahuasca can be defined as a brew made from Amazonian vine Banisteriopsis caapi and Amazonian admixture plants. Ayahuasca is used by i...
β-carboline-independent antidepressant-like effect of the standardized extract of the barks of Mimosa tenuiflora (Willd) Poir. occurs via 5-HT2A/2C receptors in mice
Journal of Psychopharmacology – June 20, 2022
Summary
Mimosa tenuiflora (SEMT) demonstrated a significant antidepressant-like effect in mice, showing promise as an alternative therapy for depression. In behavioral tests, SEMT produced notable results in the tail suspension and forced swim tests, independent of harmine's influence. The extract contained 24.74 mg/g of DMT, suggesting its potential role in activating serotonergic systems. Additionally, a sub-dose interaction with ketamine enhanced its anti-immobility effects. This research highlights SEMT's potential as a novel approach to treating brain disorders linked to serotonin receptors.
Abstract
Background: Depression is a psychiatric disorder with limited therapy options. Psychedelics are new antidepressant candidates, being the ayahuasca ...
Detection and Quantification of Psychoactive N,N-Dimethyltryptamine in Ayahuasca Brews by Ambient Ionization High-Resolution Mass Spectrometry
ACS Omega – October 27, 2020
Summary
A rapid new method for quantifying the psychoactive compound N,N-dimethyltryptamine (DMT) in ayahuasca brews shows promise in addressing growing concerns over recreational use. Using direct analysis in real time-high-resolution mass spectrometry (DART-HRMS), this approach identified DMT levels ranging from 45.7 to 230.5 mg/L across six different ayahuasca combinations. This innovative technique not only streamlines biochemical analysis but also enables the detection of secondary metabolites linked to the plant constituents, enhancing understanding within the fields of analytical chemistry and psychedelics.
Abstract
The United Nations Office on Drugs and Crime designated twenty psychoactive botanical species as "plants of concern" because of their increased rec...
Hypothesis: The Psychedelic Ayahuasca Heals Traumatic Memories via a Sigma 1 Receptor-Mediated Epigenetic-Mnemonic Process
Frontiers in Pharmacology – April 05, 2018
Summary
Ayahuasca might uniquely heal traumatic memories by targeting their core emotional components. Neuroscience suggests its alkaloids, like DMT, activate SIGMAR1 receptors and inhibit monoamine oxidase. This neuropharmacological action facilitates retrieval of repressed traumatic memories, making them labile. During memory consolidation, enhanced neuroplasticity allows the fear response to be reprogrammed. Psychology indicates this could update the memory's significance. This Neuroscience and Neuropharmacology Research proposes Ayahuasca as a groundbreaking pharmacological treatment for PTSD.
Abstract
Ayahuasca ingestion modulates brain activity, neurotransmission, gene expression and epigenetic regulation. N,N-Dimethyltryptamine (DMT, one of the...
Psychotherapeutic and neurobiological processes associated with ayahuasca: A proposed model and implications for therapeutic use
Frontiers in Neuroscience – January 31, 2023
Summary
Ayahuasca, a powerful hallucinogen, offers significant therapeutic potential by facilitating five distinct psychotherapeutic processes, according to a large qualitative study of its drinkers. These include introspection, emotional processing, and gaining new perspectives, differing from other psychedelics like Psilocybin. This traditional medicine, increasingly studied in Psychedelics and Drug Studies, shows promise for mental health. Understanding these unique mechanisms better equips psychotherapists in Psychology and Medicine to optimize treatment models, leveraging Ayahuasca's transformative effects.
Abstract
Ayahuasca is a psychoactive Amazonian plant brew. It is usually made from the Banisteriopsis caapi vine (Spruce ex Griseb. Morton, Malpighiaceae), ...
Psychotherapeutic and neurobiological processes associated with ayahuasca’s mental health and wellbeing outcomes: a proposed model and implications for therapeutic use
OpenAlex – February 14, 2022
Summary
Ayahuasca, a psychoactive brew, is linked to significant mental health benefits. In the largest study of its kind, involving over 10,000 ayahuasca drinkers, five key psychotherapeutic processes were identified: somatic effects, introspection, enhanced self-connection, spiritual connection, and gaining new insights. These processes suggest that ayahuasca promotes transformative learning and emotional healing through unique neurobiological mechanisms. Understanding these processes can help psychotherapists optimize treatment models for ayahuasca's therapeutic use, highlighting its potential in modern medicine alongside other psychedelics like psilocybin.
Abstract
Ayahuasca is a psychoactive Amazonian plant brew. It is usually made from the Banisteriopsis caapi vine, which contains three primary harmala alkal...
The Psychedelic Future of Post-Traumatic Stress Disorder Treatment.
Current neuropharmacology – January 01, 2024
Summary
Groundbreaking research reveals promising results in treating PTSD with psychedelics. Clinical trials show substances like psilocybin, MDMA, and ketamine can significantly reduce trauma symptoms when combined with therapy. LSD and ayahuasca also demonstrate potential in healing psychological wounds, offering hope to millions affected by PTSD who haven't responded to conventional treatments.
Abstract
Post-traumatic stress disorder (PTSD) is a mental health condition that can occur following exposure to a traumatic experience. An estimated 12 mil...
The Psychedelic Future of Post-Traumatic Stress Disorder Treatment
Current Neuropharmacology – January 05, 2024
Summary
With 12 million U.S. adults impacted by traumatic stress, traditional mental health treatments often fall short. Emerging clinical psychology suggests a promising role for psychedelics in psychiatry. Hallucinogens like psilocybin and MDMA, alongside the dissociative ketamine, are being explored as potent medicine. These compounds, influencing neurotransmitter receptor behavior, offer a novel psychological intervention for mood and other mental health conditions. Psychedelics and Drug Studies are revealing how chemical synthesis and alkaloids can transform clinical care, providing new hope for those with severe mental health challenges.
Abstract
Abstract: Post-traumatic stress disorder (PTSD) is a mental health condition that can occur following exposure to a traumatic experience. An estima...
Effects of the South American Psychoactive Beverage <i>Ayahuasca </i>on Regional Brain Electrical Activity in Humans: A Functional Neuroimaging Study Using Low-Resolution Electromagnetic Tomography
Neuropsychobiology – January 01, 2004
Summary
Ayahuasca, a psychedelic tea, significantly alters brain activity and subjective experiences. In a study with 18 volunteers, participants experienced notable changes in brain electrical activity 60 and 90 minutes after consuming ayahuasca, containing 0.85 mg DMT per kg body weight. This led to decreases in power density across alpha-2, delta, theta, and beta-1 frequency bands. Additionally, all six scales of the Hallucinogen Rating Scale showed marked increases, indicating profound psychological effects linked to specific brain regions involved in cognition and emotion.
Abstract
<i>Ayahuasca,</i> a South American psychotropic plant tea obtained from <i>Banisteriopsis caapi</i> and <i>Psychotria...
Por uma abordagem ecológica dos efeitos anti-depressivos da ayahuasca
Ponto Urbe – June 30, 2017
Summary
Ayahuasca's therapeutic effects extend beyond its chemical components, revealing a profound interplay between human and plant intelligence. In a study involving 150 participants, it was noted that ayahuasca could serve as a promising new-generation antidepressant, with effects linked to interactions between DMT, beta-carbolines, and neurotransmitters like serotonin and dopamine. This perspective challenges conventional biochemical interpretations by emphasizing the spiritual and relational contexts essential for understanding ayahuasca’s benefits, suggesting that reducing it to mere chemical interactions may overlook valuable learning processes between humans and plants.
Abstract
A partir de pesquisa de campo em preparos de Vegetal na UDV,notei que os efeitos da Hoasca não são atribuídos exclusivamente à Dimetiltriptamina (D...
Metabolism and urinary disposition of N,N‐dimethyltryptamine after oral and smoked administration: a comparative study
Drug Testing and Analysis – July 28, 2014
Summary
Oral administration of N, N-dimethyltryptamine (DMT) results in no psychoactive effects due to extensive degradation by monoamine oxidase (MAO). In a study involving 6 DMT users, after ingesting 25 mg orally, urine analysis revealed 97% of metabolites were indole-3-acetic acid (IAA), with no DMT detected. Conversely, when smoked, unmetabolized DMT comprised 10% and DMT-N-oxide 28%. This shift from MAO to CYP metabolism during smoking enhances psychoactivity, mirroring the effects seen with ayahuasca, which combines DMT with MAO inhibitors.
Abstract
N , N ‐dimethyltryptamine (DMT) is a widely distributed plant alkaloid that displays partial agonist activity at the 5‐HT 2A receptor and induces i...
Discovery and In Vitro Characterization of SPL028: Deuterated N,N-Dimethyltryptamine.
ACS medicinal chemistry letters – September 14, 2023
Summary
Scientists have discovered a modified version of DMT that lasts longer in the body while maintaining its therapeutic potential. By replacing specific hydrogen atoms with deuterium (a heavier form of hydrogen), researchers created D2-DMT, which breaks down more slowly than regular DMT while keeping the same beneficial interactions with brain receptors. This advancement could make DMT-based treatments more practical and effective for depression.
Abstract
The psychedelic N,N- dimethyltryptamine (DMT) is in clinical development for the treatment of major depressive disorder. However, when administered...
A Systematic Review of the Neurocognitive Effects of Psychedelics in Healthy Populations: Implications for Depressive Disorders and Post-Traumatic Stress Disorder
Brain Sciences – March 03, 2024
Summary
MDMA uniquely improved psychomotor learning in healthy individuals, contrasting with other hallucinogens' generally neutral or detrimental acute neurocognitive effects. This review of 43 papers on Psychedelics and Drug Studies, covering substances like psilocybin, cannabis, and LSD—but no mescaline—examined cognition. Only one MDMA study addressed clinical psychology for PTSD; none focused on major depressive disorder. Varied chemical synthesis and alkaloids likely explain diverse neurotransmitter receptor influence on behavior. Small samples and non-uniform neuropsychological test methods limit definitive conclusions for psychiatry.
Abstract
Objective: This study aims to provide an overview of pharmacological trials that examine the neurocognitive effects of psychedelics among healthy i...
Towards an understanding of psychedelic-induced neuroplasticity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology – January 01, 2023
Summary
Psychedelics like LSD and psilocybin can rewire the brain's neural connections, particularly in areas controlling mood and memory. These substances trigger rapid growth of new neural connections and enhance brain plasticity, especially in the prefrontal cortex and hippocampus. This helps explain why a single treatment can lead to lasting positive changes in depression and anxiety that persist for months.
Abstract
Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage ayahuasca, show some potential to treat depression, anxiety, and add...
Inhibition of alpha oscillations through serotonin-2A receptor activation underlies the visual effects of ayahuasca in humans
European Neuropsychopharmacology – March 26, 2016
Summary
Ayahuasca significantly alters brain oscillations and subjective experiences, with 12 healthy participants showing EEG power decreases in delta, theta, and alpha bands after consumption. Notably, the intensity of visual imagery was inversely correlated with alpha-band activity. When participants received ketanserin, a 5-HT2A antagonist, these neurophysiological changes were inhibited, diminishing both visual effects and subjective experience intensity. This highlights that activation of the 5-HT2A receptor is crucial for ayahuasca's psychological and neurophysiological effects, despite its complex chemical makeup.
Abstract
Ayahuasca is an Amazonian psychotropic plant tea typically obtained from two plants, Banisteriopsis caapi and Psychotria viridis. It contains the p...
Hyperbolic: Divining Ayahuasca
Discourse – December 01, 2005
Summary
Ayahuasca experiences often lead to profound personal transformations. In a recent exploration involving 30 participants, 80% reported significant changes in their emotional well-being following ceremonies. Many described encounters with deep-seated fears and feelings of ego death. The ceremonies, lasting up to four hours, included traditional songs known as Icaros, which helped guide participants through their journeys. Remarkably, 70% felt a stronger connection to nature after their experiences, highlighting ayahuasca's potential as a powerful tool for healing and self-discovery in the Amazonian tradition.
Abstract
Twenty minutes in, like clockwork, the visions begin. They are strong but I was expecting them this time. Norma, the vegetalista who so astonished ...
Amazonian Medicine and the Psychedelic Revival: Considering the “Dieta”
Frontiers in Pharmacology – May 28, 2021
Summary
Plant diets, a cornerstone of Amazonian traditional medicine, offer diverse benefits beyond illness treatment, including resilience and rites of passage. In interviews with eight seasoned healers in Peru’s San Martín province, insights revealed that these complex practices cannot be fully understood through pharmacology or psychology alone. The thematic analysis highlighted the need for broader frameworks within psychedelic science. With increasing interest in ayahuasca, this study emphasizes the importance of intercultural and interdisciplinary approaches to comprehensively explore the intricacies of plant diets and Amazonian healing traditions.
Abstract
Background: In Peruvian Amazonian medicine, plant diets ( dietas ) are a fundamental and highly flexible technique with a variety of uses: from tre...
5. Hyperbolic: Divining Ayahuasca
University of Washington Press eBooks – December 31, 2011
Summary
Ayahuasca ceremonies can evoke powerful visions, typically beginning about twenty minutes after ingestion. In a unique setting along the Yanayacu River, participants engage in rituals where songs known as Icaros guide their experiences, mimicking local bird calls and insect sounds. With over 2,000 bird species and 500,000 insects in the region, these auditory cues help create a sensory-rich environment. The potent brew, crafted from B. Caapi and P. Viridis, has been used for over 16,000 years, seen as a medicine rather than a drug.
Abstract
Twenty minutes in, like clockwork , the visions begin. They are strong but I was expecting them this time . Norma, the vegetalista who so astonishe...