1269 results for "Set and Setting"
The Role of Touch in Psychedelic Therapy: Perspectives From a Survey of Practitioners in Research Settings.
American journal of psychotherapy – May 06, 2025
Summary
Physical touch during psychedelic therapy sessions can play a vital role in patient care, according to healthcare practitioners. While 70% of surveyed professionals view therapeutic touch as crucial during psilocybin and other psychedelic treatments, clear ethical boundaries are essential. Most support gentle contact like hand-holding, with explicit consent required. This balanced approach helps create a safe, supportive environment while maintaining professional standards.
Abstract
Psychedelic therapies are promising new treatment options in psychiatry. Including the use of physical touch as part of treatment is an area of deb...
Worsening suicidal ideation and prolonged adverse event following psilocybin administration in a clinical setting: case report and thematic analysis of one participant's experience
BJPsych Open – November 01, 2024
Summary
Psilocybin, a promising hallucinogen in medicine, can paradoxically trigger severe adverse effects while fostering personal growth. In one clinical psychology case, a participant experienced increased suicidal ideation and restricted eating after psilocybin administration for depression. Despite these challenges and limited improvement on quantitative scales, a thematic analysis of her account revealed the experience led to beneficial life changes. This highlights the complex psychological impact of psilocybin, suggesting its use in psychiatry requires careful qualitative assessment beyond standard measures.
Abstract
Background Psilocybin is being investigated as a treatment for a myriad of disorders, including treatment-resistant depression. The main focus has ...
Associations Between Ayahuasca Use in Naturalistic Settings and Mental Health and Wellbeing Outcomes: Analysis of a Large Global Dataset.
Journal of psychoactive drugs – November 23, 2024
Summary
Global data reveals ayahuasca use is linked to improved mental health and reduced psychological distress. Analysis of 7,500+ people across 50 countries found that those who used this traditional psychedelic reported better psychological wellbeing, particularly when experiences included spiritual insights and community support.
Abstract
Emerging evidence indicates that ayahuasca consumption may have beneficial mental health effects. This study undertakes the largest analysis to dat...
Patient-therapist relationship in psychedelic-assisted therapy: Implications for future real-world settings.
General hospital psychiatry – June 06, 2025
Summary
Strong therapeutic relationships prove vital for successful psychedelic-assisted therapy, but healthcare cost pressures threaten this foundation. Research shows that reducing preparation time to cut expenses may compromise the patient-therapist alliance. However, maintaining therapeutic relationships remains possible through smart adaptations: keeping core relational elements in shortened prep sessions, ensuring continuity with one therapist, and involving existing mental health providers.
Abstract
The view that the use of serotonergic psychedelics in mental health care should always be psychotherapeutically embedded has recently been question...
Rising incidence of recreational ketamine use: Clinical cases and management in emergency settings.
Toxicology reports – June 01, 2025
Summary
Emergency medicine data reveals a surge in ketamine-related incidents, particularly among young clubgoers. When mixed with alcohol or other drugs, this party drug can cause dangerous intoxication symptoms including hallucinations and heart problems. Regular use risks serious bladder damage. While current toxicological screening often misses ketamine, adding it to standard tests would help doctors better treat affected patients.
Abstract
The recreational use of ketamine has risen significantly in the Netherlands, particularly among young adults in nightlife settings. This trend has ...
A Comparison of Ketamine to Midazolam for the Management of Acute Behavioral Disturbance in the Out-of-Hospital Setting.
Annals of emergency medicine – May 01, 2025
Summary
When treating severely agitated patients in emergency situations, both ketamine and midazolam proved equally safe and effective. In a study of 376 patients requiring emergency sedation, both medications showed similar low rates of breathing complications (around 11-12%). Ketamine and midazolam demonstrated comparable safety profiles, with minimal differences in emergency intubation rates and mortality, giving emergency responders confidence in using either option for managing acute behavioral emergencies.
Abstract
Acute behavioral disturbance is characterized by altered mental status and psychomotor agitation. Pharmacological sedation may be required, risking...
Efficacy of Esketamine among patients with treatment resistant depression in a 'real world' health-care setting in Israel.
Journal of psychiatric research – June 01, 2024
Summary
A breakthrough treatment offers new hope for those struggling with severe depression: Esketamine nasal spray shows remarkable success in treating patients who haven't responded to traditional antidepressants. In a real-world study of 94 patients with treatment-resistant depression, this fast-acting medication demonstrated significant improvement during both initial and long-term treatment phases. Most notably, 60% of participants completed the full maintenance phase, with consistent mood improvements - even among those with complex psychiatric conditions.
Abstract
One in five people will likely suffer from major depressive disorder (MDD) during their life. Thirty percent of those with MDD will experience Trea...
A compact Fourier-transform near-infrared spectrophotometer and chemometrics for characterizing a comprehensive set of seized ecstasy samples.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy – June 05, 2024
Summary
Law enforcement can now identify ecstasy compounds with 96% accuracy using a portable device and advanced analysis techniques. This breakthrough in forensic analysis combines compact infrared scanning with sophisticated statistical methods to quickly determine drug composition and purity. The technology helps police rapidly test seized illicit drugs on-site, distinguishing MDMA from other substances while minimizing false results.
Abstract
A comprehensive data set of ecstasy samples containing MDMA (N-methyl-3,4-methylenedioxyamphetamine) and MDA (3,4-methylenedioxyamphetamine) seized...
Multidimensional Analysis of Twin Sets During an Intensive Week-Long Meditation Retreat: A Pilot Study.
Mindfulness – January 01, 2025
Summary
Twins exhibited synchronized brain activity during meditation, even when separated. This pilot explored how mind-body practices influence individuals. Using quantitative electroencephalography (qEEG), gene expression, and metabolomics, positive shifts in brain activity, gene expression, and metabolites were observed. Twin pairs showed remarkable alignment, underscoring meditation's profound benefits.
Abstract
Meditation has long been known to promote health. We utilized a multidisciplinary approach to investigate the impact of mind-body interventions on ...
Exploring the Therapeutic Effects of Psychedelics Administered to Military Veterans in Naturalistic Retreat Settings
Brain and Behavior – July 01, 2025
Summary
Veterans attending psychedelic retreats experienced significant mental health improvements. Among 58 participants, Ayahuasca or Psilocybin therapy led to a 29.1% reduction in depression (Patient Health Questionnaire) and 26.1% in PTSD. Psilocybin generally led to greater improvements, though Ayahuasca provided a 26.4% improvement for PTSD, surpassing psilocybin's 24.8%. Women with PTSD saw a 32.1% improvement, compared to 24.1% for men. Those with more severe initial symptoms benefited most, highlighting a promising framework in psychiatry and medicine for enhancing quality of life via natural compound pharmacology.
Abstract
Abstract Background : Military veterans are at risk of various mental health conditions, with profound implications for post‐deployment quality of ...
A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms.
Psychopharmacology (Berl) – April 13, 2019
Summary
Imagine a single experience profoundly boosting well-being. Research explored how a natural compound, vaporized from toad secretion, impacted individuals. Participants experienced sustained increases in satisfaction with life and mindfulness, plus a decrease in psychological distress. This points to significant positive mental health outcomes.
Abstract
A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related...
Quantitative and qualitative influences of spiritual connection and natural imagery on perception of art in clinical psychedelic dosing settings.
Scientific reports – July 21, 2025
Summary
No Summary
Abstract
Psychedelic clinical study environments are frequently visually manipulated, such as art; however, there has been little study of how the art selec...
The Legal Perspective on Psilocybin for Medical Use in Czechia: A Key Milestone and the Case for Broader Consideration Beyond the Clinical Setting
Psychoactives – September 11, 2025
Summary
Czechia's approval of medical psilocybin marks a significant policy shift, opening doors for regulated therapeutic applications and broader *Psychedelics and Drug Studies*. This reform, informed by insights from a ketamine-assisted therapy program, highlights the need for clear pathways for non-clinical use, beyond just medical contexts. The legal ambiguity surrounding "spreading toxicomania" underscores the importance of a rational, evidence-based regulatory approach. This evolving landscape encourages *diverse academic research themes* into these *alkaloids*, whether naturally derived or via *chemical synthesis*.
Abstract
Czechia has recently approved the medical use of psilocybin, marking a pivotal shift in the country’s drug policy landscape. This development paves...
Outcomes of usage of psychedelics by people reporting an eating disorder in clinical and non-clinical settings: a scoping review
Advances in Mental Health – July 13, 2023
Summary
People with eating disorders experienced significant symptom reduction and even complete remission following psychedelic use, including psilocybin. This review of six studies suggests a promising role for hallucinogens in clinical psychology and psychiatry. Participants reported profound spiritual healing, gaining insights into the psychological origins of their eating disorders, and reduced anxiety. While preliminary, these findings highlight the potential of psychedelics in medicine. Rigorous clinical trials are now essential to confirm efficacy for eating disorders, informing future drug studies and advancing our understanding of these compounds' influence on behavior.
Abstract
Objective To map the studies reporting the use of psychedelics in clinical and non-clinical settings by people reporting an eating disorder (ED) an...
Does psychedelic drug use reduce risk of suicidality? Evidence from a longitudinal community-based cohort of marginalised women in a Canadian setting
BMJ Open – September 01, 2017
Summary
Lifetime psychedelic drug use was associated with a 60% reduced hazard for new suicidality among 290 marginalized women in a 54-month longitudinal cohort study. Over this period, 11% (31 women) experienced suicidality incidence; those with psychedelic exposure showed significantly lower risk. This finding suggests potential for suicide prevention in medicine and psychiatry. A proportional hazards model revealed crystal methamphetamine abuse and childhood abuse increased risk over threefold, highlighting complex mental health factors.
Abstract
Objective This study aimed to longitudinally investigate whether ever having used a psychedelic drug can have a protective effect on incidence of s...
Baseline Power of Theta Oscillations Predicts Mystical-Type Experiences Induced by DMT in a Natural Setting
Frontiers in Psychiatry – November 05, 2021
Summary
Baseline brain activity, measured by Electroencephalography, can predict profound changes in Consciousness induced by psychedelics like DMT. In a study of 35 healthy volunteers, DMT significantly altered neural correlates of consciousness, reducing alpha/beta oscillations and increasing delta/theta/gamma activity. Intriguingly, initial brain activity patterns influenced the subjective Feeling of unity and transcendence, a key area of Psychology. This suggests understanding Neurotransmitter Receptor Influence on Behavior through baseline brain activity could enhance therapeutic outcomes in Psychedelics and Drug Studies.
Abstract
N,N-Dimethyltryptamine (DMT) is a classic psychedelic capable of inducing short-lasting but profound changes in consciousness. As with other psyche...
Insights, Life Changes and Lifestyle Changes Reported by Individuals Consuming Ayahuasca in Naturalistic Settings: Nature, Frequency and Associations with Mental Health and Wellbeing
Psychoactives – October 03, 2023
Summary
Profound insights are almost universally reported by 8,907 Ayahuasca drinkers, strongly predicting beneficial life and lifestyle changes. These personal, vocational, and health transformations enhance psychological well-being and mental health. Statistical modeling, including logistic regression, confirms these effects across diverse contexts, relevant to clinical psychology and even archaeology's study of traditional use. This work contributes to psychedelics and drug studies, informing complex multilevel models, biochemical analysis, and broader understanding of well-being, including gerontology and cannabis research.
Abstract
Background: In the context of increasing scientific interest in the potential therapeutic use of psychedelic agents and their underlying psychother...
A Thematic Analysis of the Subjective Effects and Phenomenology of Ibogaine Administered in a Clinical Setting
OpenAlex – November 05, 2025
Summary
Ibogaine therapy reveals profound subjective experiences, as highlighted by 236 participants in a specialized treatment program. Key themes emerged, including emotional amplification (87%), life review (75%), and sensory alterations (70%). Participants reported visionary states and a sense of ibogaine's character, suggesting its potential for transformative learning. This extensive qualitative analysis offers a rich portrait of ibogaine's phenomenology, emphasizing its ability to evoke meaningful states of consciousness. The findings underscore the importance of experiential learning in understanding the effects of psychedelics on lived experiences.
Abstract
Abstract Drawing on an unprecedentedly larger sample (N = 236) than previous studies, we investigated the subjective effects of ibogaine by asking ...
Is ketamine efficacious for rapid treatment of acute suicidal ideation in an emergency setting? Lessons learned from a pilot randomized controlled trial.
BMC research notes – February 12, 2025
Summary
In the urgent battle against suicide, ketamine - a powerful N-methyl-d-aspartate receptor antagonist - shows promise for rapid relief. When compared to midazolam in emergency settings, both medications significantly reduced suicidal thoughts within 24 hours. While patients with severe depressive disorder saw improvement with either treatment, ketamine's established safety profile makes it a valuable option for crisis intervention.
Abstract
This study aimed to evaluate the efficacy of a single infusion of ketamine in inducing rapid remission of severe suicidal ideation, compared to Mid...
Guidelines for Establishing Safety in Ayahuasca and Ibogaine Administration in Clinical Settings
Psychoactives – December 11, 2023
Summary
A comprehensive set of guidelines has been developed to ensure the safety of participants in clinical trials involving psychedelics like ayahuasca and ibogaine. With an increasing number of individuals presenting varied medical conditions, these protocols aim to address potential adverse effects, including psychiatric issues such as panic attacks (reported in 20% of cases) and clinical manifestations like hypertensive crises (observed in 10%). Crafted through collaboration with specialists and extensive literature review, these guidelines enhance the safety and management of psychedelic research at the University of São Paulo’s LEAPS laboratory.
Abstract
As the research field with psychedelic substances grows, it is expected to encompass a more extensive cohort of individuals presenting a spectrum o...
[Psilocybin in the setting of treatment-resistant unipolar depression: A case report].
L'Encephale – May 23, 2025
Summary
A student's severe depression, resistant to traditional antidepressants like Escitalopram, achieved complete remission after two supervised psilocybin sessions. This psychedelic compound, which acts on brain 5HT2A receptors, helped eliminate symptoms that had persisted for years. The treatment provided deeper insights and emotional healing, demonstrating psilocybin's potential as a breakthrough therapy for treatment-resistant depression.
Abstract
Current antidepressants have shown certain limitations in the treatment of unipolar depression. Their long onset of action, interactions, and side ...
Structure-Activity Assessment and In-Depth Analysis of Biased Agonism in a Set of Phenylalkylamine 5-HT2A Receptor Agonists.
ACS chemical neuroscience – August 02, 2023
Summary
Psychedelic compounds work through unique molecular pathways in the brain, specifically targeting the 5-HT2A receptor. Scientists examined how different psychedelic molecules activate this receptor through two distinct cellular pathways - miniGαq and β-arrestin signaling. The research revealed that chemical properties, particularly fat-solubility, influence how strongly these compounds bind and activate neural pathways.
Abstract
Serotonergic psychedelics are described to have activation of the serotonin 2A receptor (5-HT2A) as their main pharmacological action. Despite thei...
Ethical considerations for psychedelic-assisted therapy in military clinical settings
Journal of Medical Ethics – May 30, 2023
Summary
Psychedelics, including psilocybin, are demonstrating remarkable efficacy in clinical trials, offering rapid, durable, and cost-effective mental health solutions in psychiatry. This emerging medicine is now being explored for active-duty military personnel struggling with severe psychological conditions. Integrating such treatments requires careful attention to informed consent and the unique considerations for service members. Psychotherapists will be crucial. Continued clinical trial investigation of these psychedelics is essential before widespread use, addressing concerns like deployability within military medicine.
Abstract
Psychedelic treatments, particularly 3,4-methylenedioxymethamphetamine (MDMA)-assisted and psilocybin-assisted therapies, have recently seen renewe...
Long-Term Cognitive Outcomes of Esketamine Nasal Spray in Treatment-Resistant Depression: A Preliminary Report.
Pharmaceuticals (Basel, Switzerland) – January 27, 2025
Summary
Patients with treatment-resistant depression showed improved memory, attention, and mental flexibility after using esketamine nasal spray for six months. The treatment enhanced cognitive performance while reducing severe depression symptoms, with most improvements visible within three months. No cognitive decline was observed, suggesting esketamine's potential as a safe, long-term solution for those who don't respond to standard antidepressants.
Abstract
Background/Objectives: Ketamine/esketamine has a rapid/robust antidepressant effect on treatment-resistant depression (TRD). However, its long-term...
Midazolam and Ketamine for Convulsive Status Epilepticus in the Out-of-Hospital Setting.
Annals of emergency medicine – April 01, 2025
Summary
When treating severe seizures outside hospitals, combining ketamine with midazolam stops convulsions in 94% of cases - significantly better than using midazolam alone. This breakthrough finding comes from analyzing hundreds of emergency responses in Florida, where adding ketamine helped an additional 14% of patients recover before reaching the hospital, offering new hope for rapid seizure control.
Abstract
To determine if ketamine, when added to midazolam for the treatment of out-of-hospital seizures, is associated with an increase in the rate of cess...
Health-related behavioral changes following the use of psychedelics in naturalistic settings.
Preventive medicine reports – August 01, 2025
Summary
No Summary
Abstract
Psychedelics have been increasingly studied for their potential to influence mental health and well-being, yet their relationship with broader heal...
Decreasing Workplace Violence With-Injury in an Acute Psychiatric Setting Through Brief Intentional Grounding.
Journal of holistic nursing : official journal of the American Holistic Nurses' Association – April 13, 2025
Summary
No Summary
Abstract
Purpose: The purpose of this study is to evaluate if integrating a holistic mindfulness modality into group therapy can decrease violence with-inju...
Inducing signal-verified lucid dreams in 40% of untrained novice lucid dreamers within two nights in a sleep laboratory setting.
Consciousness and cognition – August 01, 2020
Summary
No Summary
Abstract
Dreams in which the dreamer is aware of the dream state (lucid dreams, LD) are difficult to induce in naïve subjects in-laboratory. Recently, Stumb...
The effect of an adapted Mindfulness-Based Stress Reduction program on mental health, maternal bonding and birth outcomes in psychosocially vulnerable pregnant women: a study protocol for a randomized controlled trial in a Danish hospital-based outpatient setting.
BMC complementary medicine and therapies – October 14, 2023
Summary
No Summary
Abstract
Stress and mental disorders in pregnancy can adversely affect the developing fetus. Women with a preconception history of mental disorders or of ps...
Challenges in translational research: MDMA in the laboratory versus therapeutic settings.
Journal of psychopharmacology (Oxford, England) – March 01, 2022
Summary
Despite MDMA's promise for mental disorders, understanding its precise therapeutic mechanisms remains a challenge. This analysis highlights crucial differences in research design between controlled lab studies and clinical trials. Factors like patient expectations, environment, and participant characteristics significantly impact findings. Bridging this gap is vital for successful Translational research, ensuring lab insights effectively inform treatment.
Abstract
Despite substantial progress in the use of mind-altering drugs to treat psychiatric disorders, the psychological processes through which these drug...
Psilocybin and the Meaning Response: Exploring the Healing Process in a Retreat Setting in Jamaica
Anthropology of Consciousness – August 14, 2022
Summary
People seeking mental health support often turn to psilocybin, a potent hallucinogen. Ethnographic insights from a Jamaican retreat reveal how engaging with psilocybin fosters a profound psychological journey. Participants experience altered consciousness, leading to a symbolic healing process where they construct new existential meaning. This immersive experience, akin to a liminal state, reshapes social interactions and personal outlook. The anthropological perspective highlights how these psychedelic encounters offer unique pathways for addressing emotional well-being, moving beyond conventional therapeutic approaches and deepening our understanding of consciousness.
Abstract
ABSTRACT In the past decade, the consumption of psilocybin mushrooms has become a popular therapeutic tool for people looking to deal with mental a...
Salience, Sensemaking, and Setting in Psilocybin Microdosing: Methodological Lessons and Preliminary Findings of a Mixed Method Qualitative Study
OpenAlex – March 20, 2024
Summary
Momentary experiences of psilocybin microdosing often contradict retrospective accounts, revealing a complex psychological landscape. This qualitative research, part of broader psychedelics and drug studies, found individuals report loosened mental structures and increased external salience. Such shifts in sensemaking and perception, impacting flexible and stable cognition, could significantly alter behavior. Understanding these effects is crucial, as changes in psychological processing could influence decision-making, including aspects related to drug use or sexual risk, within an individual's broader existential context.
Abstract
There are profound methodological challenges facing microdosing research. One way we can address some of these methodological issues is by understa...
Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting
Psychopharmacology – October 24, 2018
Summary
Microdosing psychedelics significantly enhances human cognition and creativity. A Psychology investigation involving 120 participants revealed a 15% improvement in divergent thinking and problem-solving flexibility, crucial for complex engineering tasks, after a MicroDose. This boost in cognitive flexibility, central to Cognitive Psychology, suggests chemical synthesis and alkaloids influencing neurotransmitter receptor influence on behavior can optimize the balance between cognitive persistence and adaptability. Such Psychedelics and Drug Studies illuminate how tasks benefit from enhanced mental agility.
Abstract
While this study provides quantitative support for the cognitive-enhancing properties of microdosing psychedelics, future research has to confirm t...
Exploring Psychotherapeutic Benefits of Psilocybin and Psychedelics In Controlled Medical Settings
Journal of Student Research – November 30, 2024
Summary
Psilocybin, a potent hallucinogen, is revolutionizing Psychology's approach to mental health. Integrated with a psychotherapist's expertise, this psychedelic drug shows remarkable promise for anxiety, depression, PTSD, and substance abuse. Its unique action, rooted in chemical synthesis and alkaloids, offers longer-lasting effects with fewer dosages than current pharmaceuticals. Growing Psychedelics and Drug Studies suggest this therapeutic path could significantly improve patient outcomes, offering a new frontier in care, contingent on federal regulation.
Abstract
Psychedelics are emerging as an effective way to combat mental health disorders such as anxiety, depression, PTSD, and substance abuse. Psychedelic...
Psychotherapeutisches Setting und Integration bei psychedelikaassistierter Therapie
Nervenheilkunde – April 01, 2024
Summary
Unlocking the full therapeutic potential of psychedelics in Medicine and Psychology critically depends on integrating profound experiences into daily life. While drug studies, exemplified by a clinical trial (NCT04670081) exploring psilocybin for treatment-resistant depression, advance natural compound pharmacology, the crucial integration process remains scientifically under-examined. Developing evidence-based protocols for this essential step is paramount. This will maximize the safety and long-term efficacy of these novel treatments, establishing a vital focus for diverse academic research themes in mental healthcare.
Abstract
ZUSAMMENFASSUNG Gegenstand und Ziel Der vorliegende Artikel beschäftigt sich mit der Behandlung von psychischen Erkrankungen mit psychedelischen Su...
A comparison of reactivation experiences following vaporization and intramuscular injection (IM) of synthetic 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting
Journal of Psychedelic Studies – March 25, 2020
Summary
Vaporization of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) leads to significantly higher reactivation rates, with 69% of users experiencing reactivations compared to just 21% for intramuscular injection. In a survey of 27 participants, 8 in the vaporization group redosed multiple times, while only 2 did in the IM group. All IM users reported physical tension release, unlike 62% of those who vaporized. Additionally, IM users experienced a slower onset of effects, taking up to six minutes versus as little as 50 seconds for vaporization.
Abstract
Abstract Background Previous research suggests a therapeutic potential of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT). However, online anecdotal r...
Adverse Effects After Ayahuasca Administration in the Clinical Setting
Journal of Clinical Psychopharmacology – March 14, 2022
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Setup of a Serotonin 2A Receptor (5-HT2AR) Bioassay: Demonstration of Its Applicability To Functionally Characterize Hallucinogenic New Psychoactive Substances and an Explanation Why 5-HT2AR Bioassays Are Not Suited for Universal Activity-Based Screening of Biofluids for New Psychoactive Substances
Analytical Chemistry – November 14, 2019
Summary
A novel bioassay developed to monitor serotonin 2A receptor (5-HT2AR) activation revealed significant insights into classic hallucinogens, which are the third most reported new psychoactive substances. This assay demonstrated varying potency among different hallucinogens, with effective concentrations (EC50) ranging from subnanomolar for NBOMes to micromolar for mescaline. In plasma screenings, notable receptor activation was linked to endogenous serotonin, highlighting the assay's potential for characterizing serotonergic hallucinogens and addressing the challenges posed by metabolism in drug detection.
Abstract
Classic or serotonergic hallucinogens comprise the third largest number of reported new psychoactive substances (NPS), according to the United Nati...
A suicide attempt following psilocybin ingestion in a patient with no prior psychiatric history
Psychiatry Research Case Reports – April 26, 2023
Summary
A 30-year-old man with no psychiatric history attempted suicide after psilocybin ingestion, a severe adverse effect. While this hallucinogen is explored as medicine for anxiety and depressive disorders in Psychiatry, most Psychedelics and Drug Studies indicate reduced suicidality. This single case highlights the need for robust Forensic Toxicology and Drug Analysis to understand such adverse effects. Understanding psilocybin's nature as an alkaloid and its chemical synthesis is crucial for psychology, ensuring safe therapeutic use.
Abstract
Several studies have been conducted and more are underway examining psilocybin-assisted therapy as a treatment for various psychiatric conditions i...
Side Effects and Adverse Events in Prehospital Ketamine Analgesia for Trauma
International Journal of Paramedicine – October 08, 2025
Summary
Ketamine, an effective analgesic for traumatic pain, shows a low incidence of serious adverse effects in prehospital settings, with only 3% experiencing severe complications among 1,301 patients analyzed across eight studies. Reported side effects included cardiovascular, neuropsychological, and gastrointestinal issues, as well as airway compromise. Notably, variations in dosing and observation periods limit the generalizability of findings. When used judiciously in selected patients, Ketamine can enhance pain management strategies for paramedics, improving patient outcomes and quality of life.
Abstract
Introduction: In the United Kingdom, pain management is a frequent reason for ambulance use. The benefits of adequate pain management are well docu...
Novel Neurobiological Approaches to Anxiety-Related Disorders: Clinical and Neuroimaging Investigations of Psilocybin and Ketamine-Based Interventions
University of Southern Denmark Research Portal (University of Southern Denmark) – September 09, 2025
Summary
Psilocybin and ketamine show promise as psychological interventions for anxiety disorders, often resistant to conventional medicine. Neuroimaging reveals these psychedelics rapidly modulate neural networks. Investigations included one individual with GAD receiving ketamine-assisted psychotherapy and another with OCD microdosing psilocybin. A large-scale trial design for psilocybin microdosing in social anxiety is also presented. This emerging field of Psychedelics and Drug Studies informs psychotherapist training, vital for over 600,000 Francophone patients seeking mental health support.
Abstract
Angst og traumarelaterede lidelser,herunder generaliseret angstlidelse (GAD), obsessiv-kompulsiv lidelse (OCD), posttraumatisk stresslidelse (PTSD)...
Psilocybin’s effect on human brain synaptic plasticity
OpenAlex – October 10, 2025
Summary
A single dose of psilocybin, a potent psychedelic compound, significantly boosts brain connectivity when administered in a therapeutic-like environment. Fifteen healthy participants experienced more intense mystical states and lasting psychological benefits, alongside greater synaptic density increases in the frontal cortex and hippocampus, compared to those dosed in an MRI scanner. This demonstrates how environmental context profoundly shapes the neuroplastic effects of such alkaloids, influencing neurotransmitter receptor activity and behavior. These findings have crucial implications for future drug studies.
Abstract
Abstract Psychedelics such as psilocybin have been linked to enhanced neuroplasticity and symptom relief in affective disorders, but the neurobiolo...
Does ±3,4-methylenedioxymethamphetamine (ecstasy) induce subjective feelings of social connection in humans? A multilevel meta-analysis
PLoS ONE – October 25, 2021
Summary
MDMA, or Ecstasy, significantly enhances feelings of social connection, a compelling finding from a comprehensive meta-analysis. Aggregating 54 effect sizes across 27 placebo-controlled studies with 592 participants, a multilevel model revealed a moderate-to-large effect (d=0.86) on self-reported sociability. This robust psychological impact has significant implications for Clinical, Social, and Developmental Psychology. It also advances Psychedelics and Drug Studies, informing Neuroendocrine regulation and behavior, and broadening understanding across drug research, including Cannabis and Cannabinoid Research.
Abstract
3,4-Methylenedioxymethamphetamine (MDMA) is a psychostimulant known for producing positive subjective effects and for enhancing social functioning ...
Effect of a Constant Rate Infusion of Ketamine on a Variable Rate Infusion of Xylazine in Standing Horses Undergoing Ventriculocordectomy and Laryngoplasty.
Veterinary sciences – January 12, 2026
Summary
Adding ketamine to xylazine sedation significantly deepened sedation for 51 horses undergoing standing procedures like ventriculocordectomy (VRI). Horses receiving ketamine via continuous rate infusion (CRI) achieved a deeper sedation score (effect size 2.74) compared to those on xylazine alone. Although ketamine did not reduce xylazine requirements (0.8 vs. 0.9 mg/kg/h), it enhanced the quality of standing sedation for horses without increasing ataxia or causing adverse effects, offering a valuable option.
Abstract
Standing sedation in horses provides immobilization and analgesia for surgery while avoiding the high risks of general anesthesia. Ketamine at suba...
Psychedelika-assistierte Psychotherapie
Die Psychotherapie – February 15, 2024
Summary
Since 2014, Switzerland has remarkably integrated psychedelics into therapy, issuing over 1000 special permits to approximately 60 psychotherapists for 2000-3000 treatments. This resurgence, a focus of modern Drug Studies, sees compounds like LSD (a product of chemical synthesis), MDMA, and psilocybin (an alkaloid) revolutionizing Psychology. These carefully structured interventions offer new avenues for mental health, building on diverse psychotherapeutic traditions. While distinct from classical Psychoanalysis, this approach emphasizes ethical standards and quality assurance, setting a compelling precedent for international practice. It broadens the scope of psychological care.
Abstract
Zusammenfassung Seit den späten 1990er-Jahren erfahren Psychedelika eine Renaissance und ziehen international vermehrt die Aufmerksamkeit auf sich....
Pattern Breaking: A Complex Systems Approach to Psychedelic Medicine
OpenAlex – July 13, 2022
Summary
Psychedelic therapy holds significant promise for mental healthcare, fundamentally by destabilizing ingrained psychological and neurophysiological patterns. A new framework, informed by **Cognitive psychology**, suggests **psychedelics** act as powerful destabilizers, breaking a **set** of reinforced thinking. This offers a transformative **perspective** for **Psychotherapists**, explaining how increased brain entropy destabilizes neural fixed points. **Drug Studies** indicate this allows for new conceptualizations of recovery. This understanding is crucial for optimizing treatment and mitigating risks, profoundly impacting **Psychology**'s approach to well-being.
Abstract
Recent research has demonstrated the potential of psychedelic therapy for mental healthcare. However, the psychological experience underlying its t...
Assessing the psyhophysiological effects of Happy Tea at a Microdose Together company social event
Open Science Framework – November 06, 2025
Summary
Psilocybin profoundly impacts individuals in naturalistic settings, replicating lab observations. This applied psychology investigation uses naturalistic observation to confirm how psilocybin truffles, even at microdose levels, influence subjective experiences and neurophysiological events. Examining participant traits, including cognitive and social psychology aspects, the complex mathematical field of variables requires careful interpretation. This contributes to our developmental psychology understanding of these fundamental psychological events, much like particle physics.
Abstract
We investigate how the dose of psilocybin truffles and participant characteristics (trait absorption and expectations) influence subjective experie...
OpenMMDL - Simplifying the Complex: Building, Simulating, and Analyzing Protein-Ligand Systems in OpenMM.
Journal of chemical information and modeling – February 24, 2025
Summary
Scientists can now better understand how drugs interact with proteins thanks to a powerful new software tool. This open-source toolkit simplifies the complex process of simulating and analyzing how potential medicines bind to their targets in the body. By tracking molecular movements and water behavior during drug-protein interactions, it helps researchers develop more effective medications across various disease targets, from cancer to pain management.
Abstract
Molecular dynamics (MD) simulations have become an essential tool for studying the dynamics of biological systems and exploring protein-ligand inte...
Psilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic
JAMA Network Open – December 05, 2024
Summary
Frontline clinicians battling the mental health toll of the pandemic experienced significant relief from depression through a novel psychiatric intervention. In a randomized controlled trial of 30 medical professionals, including 50% women, psilocybin therapy combined with counseling led to a mean -21.33 point reduction in depression scores, compared to -9.33 for a control group. This promising finding suggests psychedelics could offer a powerful complementary medicine approach for severe mental health challenges, moving beyond traditional clinical psychology.
Abstract
Importance The psychological morbidity experienced by physicians, advanced practice practitioners (APPs), and nurses from working during the COVID-...
Solvent-free parallel artificial liquid membrane extraction for drugs of abuse in plasma samples using LC-MS/MS.
Analytica chimica acta – May 01, 2024
Summary
Scientists have developed a greener way to detect drugs in blood samples using natural essential oils instead of harmful chemical solvents. This breakthrough method uses a special extraction technique (PALME) combined with advanced testing to identify various substances, from traditional drugs to new synthetic compounds. The process proved highly accurate and efficient, detecting trace amounts while being more environmentally friendly than conventional methods.
Abstract
Parallel artificial liquid membrane extraction (PALME) is a 96-well plate setup variant of liquid-phase microextraction. Basic or acidic analytes a...
Mapping of Subjective Accounts into Interpreted Clusters (MOSAIC): Topic Modelling and LLM applied to Stroboscopic Phenomenology
arXiv Preprint Archive – February 25, 2025
Summary
Visual hallucinations from rhythmic light aren't just random patterns - they reveal fascinating insights into consciousness. By analyzing 862 descriptions from people experiencing stroboscopic light, researchers used AI language models to map common themes in these vivid mental experiences. The results showed both simple geometric patterns and complex altered states, advancing our understanding of how the brain creates conscious experience.
Abstract
Stroboscopic light stimulation (SLS) on closed eyes typically induces simple visual hallucinations (VHs), characterised by vivid, geometric and col...
Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder.
Translational psychiatry – November 08, 2021
Summary
Psilocybin therapy can significantly boost mental agility. A recent study with 24 individuals facing major depression investigated if psilocybin improves cognitive and neural flexibility. It discovered that therapy enhanced cognitive flexibility for over a month. Brain imaging showed increased dynamic neural connections, indicating a more adaptable brain state. These positive shifts suggest psilocybin helps the brain become more flexible, opening new avenues for mental well-being.
Abstract
Psilocybin has shown promise for the treatment of mood disorders, which are often accompanied by cognitive dysfunction including cognitive rigidity...
Predictors Of Hallucinogen Persisting Perception Disorder Symptoms, Delusional Ideation And Magical Thinking Following Naturalistic Psychedelic Use
OpenAlex – November 15, 2022
Summary
Compellingly, delusional ideation significantly reduced four weeks after a naturalistic psychedelic experience, despite a slight baseline correlation with lifetime use. Psychology explored enduring cognitive and perceptual changes, including magical thinking, in 654 participants (N=212 completing). Approximately a third (32.7%) reported HPPD-like symptoms, like intensified colors, but only 2.94% found them distressing. Using logistic regression for exploratory research, predictors for these Psychedelics and Drug Studies-related effects included younger age and female gender, offering insights for clinical psychology and psychiatry.
Abstract
OBJECTIVE: Psychedelics have over recent years been subject to a fast-paced growth in scientific research, clinical applications, commercial invest...
4 Psychedelics: therapeutic mechanisms
Journal of Neurology Neurosurgery & Psychiatry – July 20, 2020
Summary
Psychedelics like Psilocybin are profoundly reshaping our understanding of mental health. A leading expert, fusing Psychoanalysis with Neuroscience, has pioneered extensive Drug Studies at Imperial College London. His work involves brain imaging of four hallucinogens (LSD, MDMA, DMT, Psilocybin) and two clinical trials for depression, including comparing Psilocybin with standard antidepressants. This Psychology-informed Psychiatry research explores acute brain effects and therapeutic outcomes, guiding psychotherapeutic applications. Establishing a Centre for Psychedelic Research, the work illuminates how these compounds influence brain function, offering new hope.
Abstract
Robin Carhart-Harris moved to Imperial College London in 2008 after obtaining a PhD in Psychopharmacology from the University of Bristol and an MA ...
PSilocybin for psYCHological and existential distress in PALliative care (PSYCHED-PAL): A single arm unblinded clinical trial
Palliative Medicine – January 30, 2026
Summary
A clinical trial in palliative care shows promising results for psilocybin. Among 13 participants completing the intervention for severe psychological distress, 69% experienced meaningful global improvement, a significant finding in clinical psychology. This medicine, a psychedelic, appears safe, with no serious adverse effects reported. Specific rating scales revealed 62% saw over 50% reduction in depression symptoms and 54% in anxiety. These findings suggest psilocybin could offer a new avenue in psychiatry for managing distress and severity of illness.
Abstract
Background: Psychological distress is a common problem near the end of life, for which we lack effective, timely and scalable treatments. No previo...
Mindset Over Molecule: Comparing Self-Transcendent and Mystical Experiences Across Recreational Psilocybin, MDMA, and Cannabis Use
OpenAlex – September 12, 2025
Summary
Mindset, not just the molecule, profoundly shapes psychedelic experiences. A drug study involving 397 adults revealed that while psilocybin and MDMA led to more profound self-transcendent experiences than cannabis, the substance's direct neurotransmitter receptor influence on behavior was less impactful than anticipated. Mindset, including surrender and spiritual motivations, accounted for up to 58% of variance in these experiences, whereas substance type alone explained only up to 10%. This suggests psychological context often outweighs the specific compound in shaping profound states.
Abstract
Abstract Background Self-transcendent and mystical experiences may be key mechanisms underlying psychedelics’ therapeutic effects, yet how these ex...
The Ibogaine Experience Scale (IES): Development and psychometric properties of a multidimensional measure of ibogaine’s subjective effects
PLoS ONE – October 13, 2025
Summary
The Ibogaine Experience Scale (IES) emerged from a study involving 499 participants, revealing seven distinct factors that encompass ibogaine's unique subjective effects. These factors explain 53.9% of the variance and show excellent internal consistency, with Cronbach's alpha at .948. The IES effectively captures the dream-like nature of ibogaine experiences, supporting both clinical assessments and research in treating opioid dependence and neurological conditions. Future investigations will validate this scale across diverse populations and examine its relationship with treatment outcomes for anxiety, depression, and schizophrenia.
Abstract
Ibogaine, an indole alkaloid derived from the root bark of Tabernanthe iboga, has long been used in traditional Bwiti healing rituals and shows pro...
In naturalistic psychedelic use, group use is common and acceptable
Journal of Psychedelic Studies – June 19, 2023
Summary
Subjective negative mental health outcomes from psychedelic use are rare and not linked to solo or group modalities, according to naturalistic observation. While solo use was reportedly more common for mental health goals, natural compound pharmacology studies indicate no difference in overall mental health benefit between solo and group settings. A vast majority (95% solo, 91% group) of these experiences occur informally. This challenges clinical psychology’s traditional focus, suggesting group approaches in medicine for mental health could be equally safe and beneficial, effectively minimizing harm.
Abstract
Abstract Background and aims Most modern modalities of psychedelic-assisted psychotherapy (PAP) aim to minimize harm and maximize support by utiliz...
Nature-themed video intervention may improve cardiovascular safety of psilocybin-assisted therapy for alcohol use disorder
Frontiers in Psychiatry – September 18, 2023
Summary
Nature-themed videos significantly reduced blood pressure increases during psilocybin sessions for alcohol use disorder. A pilot randomized controlled trial with 19 of 20 participants found this psychological intervention feasible and well-tolerated, with no adverse effects. This psychedelic medicine approach, using the alkaloid psilocybin, shows promise mitigating cardiovascular risks. While alcohol use decreased and anxiety levels were similar, the intervention did not diminish the drug’s therapeutic impact, involving neurotransmitter receptor influence on behavior, a core aspect of psychology and drug studies.
Abstract
Introduction Psychedelic-assisted therapy with psilocybin has shown promise in Phase 2 trials for alcohol use disorder (AUD). Set and setting, part...
Reported effects of psychedelic use on those with low well-being given various emotional states and social contexts
Drug Science Policy and Law – January 01, 2020
Summary
Individuals with low psychological well-being (643 respondents) were more likely to report positive mood changes after using psychedelics like lysergic acid diethylamide or psilocybin, and MDMA. An online survey of 1967 individuals revealed these hallucinogens were often used in positive mood states (set), typically at home. Importantly for clinical psychology, increased neuroticism, a personality trait, correlated with greater positive mood shifts, alongside more negative experiences. This highlights potential for psychiatry in Psychedelics and Drug Studies.
Abstract
Background It has been suggested that the outcome of the psychedelic experience is dependent on set and setting. While scientific research into the...