794 results for "DMT"
Emotion regulation effects of Ayahuasca in experienced subjects during implicit aversive stimulation: An fMRI study.
Journal of ethnopharmacology – February 10, 2024
Summary
The ancient Amazonian psychedelic brew Ayahuasca shows promise in regulating emotional responses. Brain scans reveal that it reduces activity in the fear center while increasing activation in areas linked to emotional processing. Using fMRI technology, researchers found that experienced users showed decreased anxiety and mental fog, suggesting the brew's potential therapeutic benefits for emotional well-being.
Abstract
Ayahuasca is a beverage used in Amazonian traditional medicine and it has been part of the human experience for millennia as well as other differen...
Commentary: Evidence-Informed Recommendation to Achieve Approximate Parity in the Allowed Number of Doses for Common Psychedelics.
Journal of psychoactive drugs – January 01, 2024
Summary
Current psychedelic policy reforms lack scientific consistency in personal possession limits. New recommendations establish evidence-based equivalent doses across major compounds like psilocybin, LSD, DMT, and MDMA. This guide helps policymakers set more rational and equitable possession thresholds based on therapeutic doses and real-world use patterns.
Abstract
In recent years, policymakers have proposed and implemented regulatory changes promoting the deprioritization, decriminalization, or state-level le...
Corrigendum: Three naturally-occurring psychedelics and their significance in the treatment of mental health disorders.
Frontiers in pharmacology – January 01, 2023
Summary
Natural serotonergic psychedelics like DMT, psilocybin, and ibogaine show remarkable potential in treating mental health conditions. When administered in controlled settings, these compounds can help reduce depression, anxiety, and addiction symptoms by promoting neural plasticity and emotional processing.
Abstract
[This corrects the article DOI: 10.3389/fphar.2022.927984.].
Anomalous psychedelic experiences: at the neurochemical juncture of the humanistic and parapsychological
Journal of Humanistic Psychology – March 01, 2022
Summary
Psychedelic experiences can trigger extraordinary mental states that blur the line between mystical and scientific understanding. Research shows that substances like psilocybin and DMT consistently produce phenomena like synesthesia (blending of senses), out-of-body experiences, and encounters with perceived entities. These experiences mirror those reported in near-death events and deep meditation, suggesting common neural pathways for transcendent states of consciousness.
Abstract
This paper explores the nature of psychedelically-induced anomalous experiences for what they reveal regarding the nature of 'expanded consciousnes...
Editorial: Beyond psilocybin: exploring the clinical potential of alternative and novel psychedelics.
Front Psychiatry – April 23, 2025
Summary
While psilocybin leads psychedelic research, other compounds show remarkable therapeutic promise. Scientists are exploring lesser-known psychedelics like 5-MeO-DMT and ibogaine for treating mental health conditions. Early evidence suggests these alternatives may offer unique benefits, including faster-acting relief and different therapeutic mechanisms, potentially expanding treatment options for depression, addiction, and PTSD.
Abstract
Editorial: Beyond psilocybin: exploring the clinical potential of alternative and novel psychedelics.
Psychedelics and disorders of consciousness: the current landscape and the path forward.
Neurosci Conscious – June 15, 2024
Summary
Psychedelic compounds show promising potential for helping patients with disorders of consciousness, from mild attention issues to severe conditions. Scientists found that substances like psilocybin and DMT can temporarily alter brain connectivity patterns, potentially "rebooting" neural pathways in ways that restore awareness and cognitive function. Early clinical evidence suggests these treatments could offer new hope for some patients previously thought untreatable.
Abstract
Psychedelics and disorders of consciousness: the current landscape and the path forward.
Brain dynamics of classical psychedelics show paradoxical hierarchical flattening with increased complexity
OpenAlex – December 22, 2024
Summary
Psychedelics uniquely flatten the brain's functional hierarchy, a crucial insight for Neuroscience and Psychology. Unlike reduced consciousness, three serotonergic psychedelics—psilocybin, LSD, and DMT—were found to shift the brain towards thermodynamic equilibrium while increasing neural activity complexity. This discovery, vital for Cognitive science and Cognitive psychology, and Psychedelics and Drug Studies, suggests a distinct mechanism. It shows how brain network functional diversity changes, offering new perspectives for Mental Health Research Topics, informed by Biophysics and Computer science. This work refines our understanding of consciousness.
Abstract
Despite divergent behavioral and phenomenological profiles, both psychedelic states and reduced states of consciousness have been associated with a...
PolDrugs 2025: results of the third edition of the nationwide study on psychoactive substance use in the context of psychiatry and harm reduction.
Frontiers in psychiatry – January 01, 2025
Summary
A positive trend in Poland shows growing acceptance of psychiatry among those using psychoactive substances. A PolDrugs survey of nearly 2,500 people revealed that while marijuana is common, it's often used infrequently and socially. Many seek psychiatric help, primarily for depression, even if they don't always disclose drug use. Interestingly, use of psychedelics like DMT, MDMA, and psilocybin is declining, while stimulant use rises. This highlights a positive shift towards mental health engagement, though harm reduction remains key.
Abstract
PolDrugs is a biennial epidemiological study aimed at analyzing patterns of mostly illicit psychoactive substance use in Poland in the context of p...
Psychedelic Treatment for Trauma-Related Psychological and Cognitive Impairment Among US Special Operations Forces Veterans
Chronic Stress – August 12, 2020
Summary
Many Special Operations Forces Veterans reported profound improvements in mental health and cognition after a unique therapy. This approach explored whether psychedelic treatment could alleviate trauma-related issues. Researchers surveyed 51 Veterans who received ibogaine and 5-MeO-DMT. Participants reported significant reductions in PTSD, depression, anxiety, suicidal ideation, and cognitive impairment. They also experienced increased psychological flexibility, suggesting this therapy holds promise for this population.
Abstract
Background U.S. Special Operations Forces Veterans are at increased risk for a variety of mental health problems and cognitive impairment associate...
Survey of entity encounter experiences occasioned by inhaled N,N-dimethyltryptamine: Phenomenology, interpretation, and enduring effects.
Journal of psychopharmacology (Oxford, England) – September 01, 2020
Summary
Over half of atheists surveyed no longer identified as such after a profound entity encounter occasioned by N,N-dimethyltryptamine. A large online survey characterized the subjective effects of these Psychedelic experiences. Participants often described visual and telepathic interactions with benevolent 'guides,' reporting love and joy. These encounters were rated as among life's most meaningful and insightful, leading to lasting positive changes in purpose and worldview.
Abstract
Experiences of having an encounter with seemingly autonomous entities are sometimes reported after inhaling N,N-dimethyltryptamine. The study chara...
Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings.
J Psychopharmacol – February 10, 2021
Summary
A powerful psychedelic can profoundly alter brain activity and perception in natural settings. Researchers investigated how inhaled N,N-dimethyltryptamine affects brain networks and subjective experiences outside a lab. Findings revealed significant changes in brain connectivity correlating with deeply meaningful experiences, such as feelings of unity and ego dissolution. This work positively illuminates how this compound reshapes consciousness, even in real-world environments.
Abstract
Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings.
Microcrystalloptic tests for lysergic acid diethylamide and other hallucinogens
Journal of Pharmacy and Pharmacology – November 01, 1970
Summary
Accurately identifying illicit hallucinogens like Psilocybin and Lysergic acid diethylamide (LSD) presents a persistent challenge in forensic toxicology. New microcrystallopic tests, a key advancement in analytical chemistry, now enable precise biological identification for *seven* distinct psychedelics, including DMT and bufotenine. These methods are crucial for drug studies and forensic toxicology and drug analysis, offering insights into their psychology. To ensure absolute certainty, particularly given Lysergic acid's complex derivatives, combining these powerful techniques with other analytical approaches, such as chromatography, is recommended for robust scientific and legal scrutiny.
Abstract
Abstract Microcrystallopic tests for LSD, NN-diethyltryptamine, NN-dimethyltryptamine, bufotenine, psilocin, psilocybin and STP are described. The ...
The 3D-ASCr scale: A revalidation of the core dimensions of the Altered States of Consciousness Rating Scale 5D(11)-ASC for psychedelic research.
Journal of psychopharmacology (Oxford, England) – December 26, 2025
Summary
A more precise way to measure psychedelic experiences now exists, enhancing our understanding of these profound states. Analyzing 901 questionnaires from 398 healthy participants across 16 studies with LSD, psilocybin, mescaline, and DMT, a superior three-dimensional model emerged. Ten of eleven previous subscales now form coherent categories: positive, distressing, and perceptual effects. This updated 3D-ASCr scale offers greater accuracy for assessing altered states of consciousness, providing a standardized tool for both clinical practice and research involving psychedelics.
Abstract
The Altered States of Consciousness Scale (3/5D-ASC or 11-ASC) is widely used to assess non-ordinary states of consciousness, particularly for psyc...
Determination and Confirmation of Psychedelic and Psychoactive Compounds in Botanical Materials by UPLC-ESI-MS/MS: Single-Laboratory Validation.
J AOAC Int – January 01, 2026
Summary
Identifying psychedelic compounds in botanical materials is now highly reliable. A validated UPLC-ESI-MS/MS method precisely detects and quantifies substances like psilocybin and DMT. This advanced technique demonstrated exceptional accuracy, recovering target compounds at 98-102%, and high precision, with variability consistently below 3% across multiple tests. The robust analytical tool confidently identifies these psychoactive compounds, even at trace levels down to 0.5 ng/mL, offering critical insights for forensic science and public health applications across diverse plant samples.
Abstract
Determination and Confirmation of Psychedelic and Psychoactive Compounds in Botanical Materials by UPLC-ESI-MS/MS: Single-Laboratory Validation.