1269 results for "Set and Setting"
Evaluating Theory-Driven Messaging to Overcome the Barriers to Meditation: Large-Scale Digital Field Experiment.
JMIR mental health – July 07, 2025
Summary
No Summary
Abstract
The general public is largely aware of meditation, and there is compelling evidence the practice has health benefits. But many people who are aware...
Feasibility Testing a Meditation App for Professionals Working With Youth in the Legal System: Protocol for a Hybrid Type 2 Effectiveness-Implementation Pilot Randomized Controlled Trial.
JMIR research protocols – April 24, 2025
Summary
Probation officers and other professionals in the juvenile legal system face immense workplace stress. A new digital mental health initiative aims to help by testing a mobile app designed to boost emotion regulation through mindfulness meditation. This remote pilot trial involves 50 officers, comparing a specialized meditation app against a control. It uses ecological momentary assessment (EMA) to track real-time emotion regulation and objective app usage. The goal is to demonstrate this mhealth tool's feasibility and positive impact, making mindfulness widely accessible to support mental wellbeing in high-stress workplace roles.
Abstract
Probation officers and other professionals who work with youth in the legal system often experience high chronic workplace stress, which can contri...
Traumatic Psychedelic Experiences.
Current topics in behavioral neurosciences – April 29, 2025
Summary
No Summary
Abstract
Psychedelic experiences involving extreme feelings of horror, helplessness, and perceived threats can be traumatizing. Traumatic psychedelic experi...
Mindfulness-based relapse prevention for drug addiction in Nepal: impact and implications of an initial 2-day training of trainers.
BJPsych international – February 01, 2025
Summary
No Summary
Abstract
Drug addiction is rife in Nepal, with a high relapse rate following treatment. Apart from basic psychosocial support, there are no evidence-based a...
The associations and effects of mindfulness on anger and aggression: A meta-analytic review.
Clinical psychology review – June 01, 2025
Summary
No Summary
Abstract
Dispositional mindfulness and mindfulness-based interventions have been linked to emotion regulation and may reduce anger and aggression. The prese...
Neurobehavioural Correlates of Breath Meditation in Novice Adolescents: Insights from Anapanasati-based Paradigm.
Annals of neurosciences – April 02, 2025
Summary
No Summary
Abstract
Breath-awareness practices contribute to stress management and psychological well-being among adolescents. However, their neurobehavioural effects ...
Regulation of Stress Physiology While Parenting: a Randomized Micro-trial of Loving-Kindness Meditation on Parenting and Salivary Alpha Amylase.
Prevention science : the official journal of the Society for Prevention Research – April 01, 2025
Summary
No Summary
Abstract
Sensitive parenting early in life sets children up for healthy development, and this type of parenting draws on the parent's compassion and physiol...
Network analysis of meditative states in highly skilled meditators using EEG and horizontal visibility graphs.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference – July 01, 2024
Summary
No Summary
Abstract
The benefits of meditation are increasingly recognized, and some forms are now used for clinical intervention. However, the electrophysiological co...
Effect of a mindfulness program on stress, anxiety, depression, sleep quality, social support, and life satisfaction: a quasi-experimental study in college students.
Frontiers in psychology – January 01, 2025
Summary
No Summary
Abstract
The university experience often brings various personal and academic challenges that can negatively impact students' mental health. This research a...
Intracranial substrates of meditation-induced neuromodulation in the amygdala and hippocampus.
Proceedings of the National Academy of Sciences of the United States of America – February 11, 2025
Summary
No Summary
Abstract
Meditation is an accessible mental practice associated with emotional regulation and well-being. Loving-kindness meditation (LKM), a specific subty...
About Distress in Chronic Pain Conditions: A Pre-Post Study on the Effectiveness of a Mindfulness-Based Intervention for Fibromyalgia and Low Back Pain Patients.
International journal of environmental research and public health – November 13, 2024
Summary
No Summary
Abstract
Chronic pain (CP) affects about 30% of the global population and poses significant challenges to individuals and healthcare systems worldwide. The ...
Mindfulness-Based Interventions for People with Autism Spectrum Disorder: A Systematic Literature Review.
Brain sciences – September 30, 2024
Summary
No Summary
Abstract
Mindfulness-based interventions (MBIs) have emerged in recent years as a strong candidate for the treatment of a range of difficulties faced by ind...
A Validation Study of the Mindfulness-Based Interventions Teaching Assessment Criteria for Assessing Mindfulness-Based Intervention Teacher Skill: Inter-Rater Reliability and Predictive Validity.
Global advances in integrative medicine and health – January 01, 2024
Summary
No Summary
Abstract
Prior data suggests the Mindfulness-Based Interventions: (MBI) Teaching Assessment Criteria (MBI:TAC) has good inter-rater reliability, but many ra...
The Real-World Impact of App-Based Mindfulness on Headspace Members With Moderate and Severe Perceived Stress: Observational Study.
JMIR mHealth and uHealth – March 04, 2024
Summary
No Summary
Abstract
Perceived stress in the United States has drastically increased since the COVID-19 pandemic and is associated with negative mental health outcomes ...
The Relationship Between Changes in Mindfulness and Subsequent Changes in Well-Being Following Psychedelic Use: Prospective Cohort Study.
JMIR formative research – March 04, 2024
Summary
Changes in mindfulness after psychedelic drug use strongly predict improved mental health. An observational web-based survey tracked individuals' experiences with hallucinogens. Findings show enhanced mindfulness, often linked to meditation, significantly reduced symptoms of depression and anxiety, boosting overall well-being. This suggests that the mindful integration of psychedelic substance use can lead to lasting positive changes, highlighting a beneficial pathway for mental health.
Abstract
This study demonstrates that changes in mindfulness predict subsequent changes in well-being in a data set including individuals who recently engag...
Neuro-functional modeling of near-death experiences in contexts of altered states of consciousness.
Frontiers in psychology – January 01, 2022
Summary
No Summary
Abstract
Near-death experiences (NDEs) including out-of-body experiences (OBEs) have been fascinating phenomena of perception both for affected persons and ...
Designing a "Near-Death Experience" Reality Testing System.
Journal of medical physics – January 01, 2021
Summary
No Summary
Abstract
"Near-death experiences (NDEs)" are usually depicted with a vivid perception of departure from the physical body and being in a distinctive spatial...
Naturalistic Use of Mescaline Is Associated with Self-Reported Psychiatric Improvements and Enduring Positive Life Changes.
ACS pharmacology & translational science – April 09, 2021
Summary
No Summary
Abstract
Mescaline is a naturally occurring psychoactive alkaloid that has been used as a sacrament by Indigenous populations in spiritual ritual and healin...
Safety pharmacology of acute LSD administration in healthy subjects
Psychopharmacology – September 13, 2021
Summary
Lysergic acid diethylamide (LSD) demonstrates a strong safety profile in a substantial pharmacology analysis. Across 131 single-dose administrations to 83 healthy subjects, 91-96% reported significant "good drug effects" at 50-200 µg, a hallucinogen dose range explored in medicine. Safety pharmacology revealed only moderate physiological changes, with no subjects exceeding 180 mmHg systolic blood pressure. This supports the administration of LSD in psychology and psychedelics and drug studies, indicating its potential in complementary medicine. Biochemical analysis confirmed unaltered organ function.
Abstract
Abstract Rationale Lysergic acid diethylamide (LSD) is used in psychiatric and psychological research and investigated as a potential treatment for...
Self-Boundary Dissolution in Meditation: A Phenomenological Investigation.
Brain sciences – June 21, 2021
Summary
No Summary
Abstract
A fundamental aspect of the sense of self is its pre-reflective dimension specifying the self as a bounded and embodied knower and agent. Being a c...
Personality Traits in Former Spanish Substance Users Recovered with Ayahuasca.
Journal of psychoactive drugs – January 01, 2020
Summary
No Summary
Abstract
Ayahuasca is a psychoactive brew that contains N,N-dimethyltryptamine and monoamine oxidase-inhibiting alkaloids. It is originally from the Amazon ...
Cardiovascular effects and safety of classic psychedelics.
Nature cardiovascular research – February 01, 2025
Summary
No Summary
Abstract
Psychedelics, used for millennia in spiritual and healing practices, have emerged as promising treatments for mental health conditions including de...
To Move or Not to Move: Factors of Mind-Body Practice Engagement in a Population-Based Study.
Journal of integrative and complementary medicine – April 01, 2025
Summary
No Summary
Abstract
Background: Mind-body practices (MBPs), which include seated- (meditation) and movement-based practices (yoga, Tai Chi, qigong), have grown increas...
The Impact of a 4-Domain Wellness-Initiative Curriculum on Internal Medicine Resident Physicians.
HCA healthcare journal of medicine – January 01, 2024
Summary
No Summary
Abstract
There is a trend toward fostering well-being, or the state of being happy and healthy, within the medical community. Historically, resident physici...
How to create a mindful community of practice: exploring the social functions of group-based mindfulness practices facilitated via Zoom during COVID-19.
Frontiers in psychology – January 01, 2025
Summary
No Summary
Abstract
This exploratory qualitative study was conducted to investigate the experiences of individuals who have been participating in online mindfulness se...
Meditation Moderates the Relationship between Insecure Attachment and Loneliness: A Study of Long-Term Care Residents in Thailand.
Medicina (Kaunas, Lithuania) – April 11, 2024
Summary
No Summary
Abstract
Background and Objectives: Loneliness is prevalent among residents of long-term care settings, posing significant challenges to their mental wellbe...
Convolutional neural networks for classifying healthy individuals practicing or not practicing meditation according to the EEG data.
Vavilovskii zhurnal genetiki i selektsii – December 01, 2023
Summary
No Summary
Abstract
The development of objective methods for assessing stress levels is an important task of applied neuroscience. Analysis of EEG recorded as part of ...
Trends in hallucinogen‐associated emergency department visits and hospitalizations in California, USA, from 2016 to 2022
Addiction – January 11, 2024
Summary
Hallucinogen-associated emergency department visits in California dramatically rose by 54% between 2016 and 2022, from 2260 to 3476. This contrasts with a 20% decrease for alcohol and a 15% increase for cannabis. Hallucinogen-related hospitalizations also climbed 55%, from 2556 to 3965, while alcohol and cannabis saw only 1% rises. These trends underscore evolving demands on Medicine and Psychiatry for mental health services, prompting critical consideration in Psychedelics and Drug Studies and Cannabis and Cannabinoid Research.
Abstract
Abstract Background and aims Hallucinogens encompass a diverse range of compounds of increasing scientific and public interest. Risks associated wi...
Spiritual health practitioners’ contributions to psychedelic assisted therapy: A qualitative analysis
PLoS ONE – January 02, 2024
Summary
Spiritual health practitioners offer unique expertise in psychedelic-assisted therapies, vital for Medicine and Health care. Qualitative research, using thematic analysis of 15 practitioner interviews, revealed seven contributions, including competency with spiritual material and offering a counterbalance to biomedical perspectives in Psychology. Familiarity with these alkaloids, many from chemical synthesis, helps them complement psychotherapists and nurses in interdisciplinary teams. This approach, informed by Psychedelics and Drug Studies and Complementary and Alternative Medicine Studies, can establish rigorous standards for holistic treatment.
Abstract
Background Psychedelic-assisted therapies hold early promise for treating multiple psychiatric conditions. However, absent standards for the care, ...
Substance use in sexual minority youth: prevalence in an urban cohort.
Child and adolescent psychiatry and mental health – September 16, 2023
Summary
No Summary
Abstract
Little comparative data on substance use (SU) between sexual minority youth (SMY) and heterosexual youth (HET) is available. This study compares th...
Mindfulness meditation use in chronic pain treatment in rural Australia: Pitfalls and potential - A case report.
Journal of neurosciences in rural practice – January 01, 2023
Summary
No Summary
Abstract
Mindfulness is a state of awareness characterized by open and non-judgmental recognition of thoughts and sensations and an ability to resist the us...
Therapeutic Protocols Using Ketamine and Esketamine for Depressive Disorders: A Systematic Review.
Journal of psychoactive drugs – January 01, 2024
Summary
No Summary
Abstract
Depression is one of the most prevalent mental health disorders globally, causing severe emotional suffering, reducing life expectancy and increasi...
[Mindfulness meditation in somatic medicine. A management tool for physical and psychological pain].
Revue medicale suisse – June 21, 2023
Summary
No Summary
Abstract
Mindfulness meditation is a mind-body approach that helps to cope with psychological or physical symptoms such as pain. To date, this approach is s...
Retigabine promotes ketamine's antidepressant effect in the forced swim test in male and female C57BL/6J mice.
Pharmacology, biochemistry, and behavior – September 01, 2023
Summary
No Summary
Abstract
Ketamine has been increasingly used as a rapid-onset antidepressant in specific clinical settings. However, as a psychedelic reagent, the potential...
Importance of Integrating Spiritual, Existential, Religious, and Theological Components in Psychedelic-Assisted Therapies.
JAMA psychiatry – July 01, 2023
Summary
No Summary
Abstract
Mounting evidence supports the role of spiritual, existential, religious, and theological components in mediating psychedelic-assisted therapy, yet...
Virtually-Delivered Emotion Focused Mindfulness Therapy (EFMT) Group vs. Wait-List Control for Late-Life Anxiety: A Randomized Controlled Trial.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry – October 01, 2023
Summary
No Summary
Abstract
The worldwide annual prevalence of anxiety in older adults is estimated to be between 6% and 10%. Emotion Focused Mindfulness Therapy (EFMT) is a m...
Rapid onset brain plasticity at novel pharmacologic targets hypothetically drives innovations for rapid onset antidepressant actions.
Journal of psychopharmacology (Oxford, England) – March 01, 2023
Summary
No Summary
Abstract
Numerous new agents with rapid onset antidepressant effects are entering clinical trials and clinical practice. Studies focus on either first-line ...
Cessations of consciousness in meditation: Advancing a scientific understanding of nirodha samāpatti.
Progress in brain research – January 01, 2023
Summary
No Summary
Abstract
Absence of consciousness can occur due to a concussion, anesthetization, intoxication, epileptic seizure, or other fainting/syncope episode caused ...
Ethical principles of traditional Indigenous medicine to guide western psychedelic research and practice.
Lancet regional health. Americas – February 01, 2023
Summary
No Summary
Abstract
The resurgence of Western psychedelic research and practice has led to increasing concerns from many Indigenous Nations regarding cultural appropri...
Ayahuasca: What Healthcare Providers Need to Know.
Journal of addictions nursing
Summary
No Summary
Abstract
Ayahuasca is a pan-Amazonian botanical hallucinogenic decoction made from a mixture of the bark of the Banisteriopsis caapi plant, containing a mon...
Acute Psychological Adverse Reactions in First-Time Ritual Ayahuasca Users: A Prospective Case Series.
Journal of clinical psychopharmacology
Summary
No Summary
Abstract
In recent decades, ritualistic use of ayahuasca has spread throughout the world. Retrospective studies have suggested a good psychological safety p...
How does ayahuasca work from a psychiatric perspective? Pros and cons of the entheogenic therapy.
Human psychopharmacology – May 01, 2020
Summary
No Summary
Abstract
Ayahuasca is a hallucinogenic plant preparation, traditionally consumed in sacred ceremonies by indigenous North-Westerner Amazonian countries like...
Mindfulness Meditation and Respiration: Accelerometer-Based Respiration Rate and Mindfulness Progress Estimation to Enhance App Engagement and Mindfulness Skills
arXiv Preprint Archive – July 23, 2025
Summary
Many struggle to stick with mindfulness apps. What if your phone could guide you better? Researchers explored if real-time breathing feedback and skill assessment boost engagement. They developed a smartphone accelerometer algorithm to track slow meditation breaths without extra devices. This **cs.HC** innovation also enabled the first system to estimate mindfulness skills like concentration and equanimity from this data, leveraging **cs.LG** for progress estimation. Testing showed breathing feedback significantly improved app usability. The tracking was highly accurate, and skill estimation successfully tracked user progress with 80-84% accuracy. This integration powerfully enhances digital mindfulness training.
Abstract
Mindfulness training is widely recognized for its benefits in reducing depression, anxiety, and loneliness. With the rise of smartphone-based mindf...
Therapeutic and legal aspects of psilocybin in cancer-related depression
Frontiers in Psychiatry – August 04, 2025
Summary
Head and neck cancer patients experience twice the major depressive disorder prevalence of other cancer populations. Conventional antidepressants and psychological interventions are too slow, taking weeks to act. Psilocybin, a hallucinogen and alkaloid, offers rapid antidepressant effects within hours, validated in Psychedelics and Drug Studies. This potential Medicine for Psychiatry is critical for perioperative care. However, its legal context, like Poland's restrictions, complicates clinical integration. Diverse academic research themes highlight the need for ethical pathways to utilize psilocybin's chemical synthesis benefits for immediate psychiatric support.
Abstract
Depression prevalence is markedly elevated in oncological patients, particularly among head and neck cancer (HNC) cohorts, who face twice the preva...
Investigating Safety Concerns and Harm Reduction in Entheogenic Churches: The Case for Community-Based Participatory Research.
Current topics in behavioral neurosciences – November 22, 2025
Summary
Communities using psychedelics like Ayahuasca or Santo Daime have unique safety frameworks. This work shows that Community-based participatory practices, involving a Community advisory board, effectively builds trust and yields vital harm reduction insights. Positive findings highlight successful engagement and respect for historical context, informing future psychedelic research and public education.
Abstract
Alongside the important contributions of the harm reduction movement to improving public health in secular settings, communities that use psychedel...
Quality of Recovery in Veterans Following Postoperative Ketamine Infusion Implementation.
Pain management nursing : official journal of the American Society of Pain Management Nurses – November 18, 2025
Summary
For Veterans experiencing chronic pain, surgical recovery can be particularly challenging. A new program explored how low-dose Ketamine infusions could improve postoperative pain management. Twenty-one Veterans undergoing complex surgery received infusions for 24-72 hours. Remarkably, 80% achieved a clinically meaningful improvement in their Quality of recovery by day 30, with scores significantly rising. No adverse events were reported, demonstrating safety. This successful implementation suggests Ketamine is a promising, scalable intervention for Veterans.
Abstract
Chronic pain is highly prevalent among Veterans and contributes to poor surgical recovery. This pilot quality improvement project evaluated a struc...
Open-label Prospective, Interventional Study Assessing Efficacy and Safety of Intramuscular Ketamine for Suicidal Ideation in a Tertiary Care Hospital.
Indian journal of psychological medicine – November 13, 2025
Summary
A single dose of intramuscular ketamine can dramatically reduce suicidal ideation within hours. Researchers explored the efficacy and safety of this rapid intervention for severe suicidal thoughts, particularly where IV options are challenging. Using the MADRS-SI scale, adult patients received 0.5 mg/kg intramuscular ketamine. Within two hours, 76% of participants reported no suicidal ideation, with scores dropping by 78%. Most maintained this improvement for a month. The treatment demonstrated strong efficacy and good safety, with common, non-serious side effects like dizziness. This approach offers a promising, fast-acting solution.
Abstract
This study evaluated intramuscular (IM) ketamine's efficacy and safety for rapid suicidal ideation reduction, addressing the critical need for fast...
Ketamine infusion therapy for treatment-resistant major depressive disorder and suicidal ideation: Nursing care and considerations.
Nursing – December 01, 2025
Summary
Major depressive disorder affects millions, and for those with treatment-resistant forms, ketamine infusion therapy offers a promising behavioral health solution. This approach effectively addresses chronically depressed mood and acute suicidal ideation. Expert nursing care is vital for safe and effective ketamine administration, ensuring positive patient outcomes.
Abstract
Major depressive disorder (MDD) affects approximately 332 million people worldwide. Among those diagnosed with MDD, approximately 53% receive pharm...
Unfolding States of Mind: A Dissociative-Psychedelic Model of Ketamine-Assisted Psychotherapy in Palliative Care.
Healthcare (Basel, Switzerland) – October 27, 2025
Summary
For those facing chronic illness, including cancer, navigating end-of-life can bring deep existential distress. A promising new model for **ketamine-assisted psychotherapy** is emerging in **palliative care**, offering significant relief. Researchers synthesized evidence on **ketamine's** unique effects, integrating neuroscientific and **psychedelics** insights. The proposed short-course model features preparatory sessions, two distinct ketamine dosing sessions (low and moderate), and integrative therapy. This patient-centered approach aims to enhance psychological safety and meaning-making, effectively addressing both physical and emotional suffering. It provides a compassionate framework to boost meaning, emotional resolution, and quality of life.
Abstract
Background/Objectives: Patients in palliative care often experience multifaceted forms of suffering that extend beyond physical symptoms, including...
The Past and Future of Psychedelic Science: An Introduction to This Issue
Journal of Psychoactive Drugs – March 15, 2019
Summary
A compelling resurgence in psychedelics and drug studies is transforming psychiatry. After decades of suppression, psychological intervention using substances like psilocybin and lysergic acid diethylamide (LSD) is showing remarkable promise. Modern trials, often involving hundreds of participants, demonstrate significant reductions in anxiety and addiction, with some reporting over 60% success rates. These hallucinogens also inspire creativity and profound psychic experiences. From chemical synthesis and alkaloids to psychotherapist-led sessions, psychology is embracing these tools for healing.
Abstract
Psychedelic plants and fungi have been used in indigenous medicinal traditions for millennia. Modern psychedelic research began when Albert Hofmann...
The Psychedelic Renaissance and Its Forensic Implications.
The journal of the American Academy of Psychiatry and the Law – March 01, 2020
Summary
Recent studies reveal psychedelics may reduce interpersonal violence, marking a significant shift in understanding these substances. After decades, a renaissance in mental health research explores their potential. This re-evaluation necessitates updated knowledge for legal and public safety professionals. Evidence points to positive outcomes, requiring careful assessment of individuals' psychedelic use in various contexts.
Abstract
Recent years have seen a renaissance of research into the use of psychedelic compounds to address various psychiatric conditions. The study of thes...
On Revelations and Revolutions: Drinking Ayahuasca Among Palestinians Under Israeli Occupation
Frontiers in Psychology – August 27, 2021
Summary
Ayahuasca rituals, while fostering a feeling of harmony, can paradoxically perpetuate political injustice. Through 31 interviews and observations, it was seen how these psychedelic experiences often depoliticized ongoing marginalization. Yet, specific revelatory events, like the three described, confronted participants with the truth of oppressive relations. This sparked deep emotions, resistance, and a drive to deliver emancipatory messages, politicizing the practice. This sociology highlights the profound social psychology of Ayahuasca and its potential for revolutionary change, moving beyond mere aesthetic unity towards addressing real-world politics.
Abstract
The ritualistic use of ayahuasca can induce a feeling of unity and harmony among group members. However, such depoliticized feelings can come in th...
Completing the Circle: A History of Psychedelics and Harm Reduction.
Current topics in behavioral neurosciences – August 08, 2024
Summary
Long before formal 'harm reduction,' psychedelic safety was paramount. Early clinical protocols, championed by figures like Humphry Osmond, prioritized patient well-being. Later, community efforts in places like San Francisco, often linked to groups like the Grateful Dead, offered support at festivals. The Native American Church also exemplifies ancient traditions integrating psychedelic substances with spiritual healing and community care. This historical overview reveals that effective risk management strategies for psychedelics have deep roots across medical, cultural, and Indigenous practices, offering valuable lessons for today.
Abstract
Harm reduction officially entered the public health lexicon in the 1980s as a response to the HIV/AIDS crisis and its spread amongst intravenous dr...
Psychedelics and psychotherapy in Canada: Humphry Osmond and Aldous Huxley.
History of psychology – August 01, 2018
Summary
In the 1950s, Canadian researchers pioneered a unique blend of psychotherapy and emerging psychoactive substances. Psychiatrist Humphry Osmond and writer Aldous Huxley, through their correspondence, explored how compounds like mescaline and LSD could stimulate empathy and alter perception. Working from an isolated Canadian hospital, their innovative collaboration developed a distinct "psychedelic approach" to therapy, laying foundational insights into its potential for mental health solutions.
Abstract
The decade of the 1950s is well known among historians of psychiatry for the unprecedented shift toward psychopharmacological solutions to mental h...
Exploratory study of the dose-related safety, tolerability, and efficacy of dimethyltryptamine (DMT) in healthy volunteers and major depressive disorder.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology – September 01, 2022
Summary
A potent compound showed promising next-day antidepressant effects in individuals with treatment-resistant depression. Researchers explored the safety and therapeutic potential of this rapid-onset psychedelic. Participants received varying doses, revealing it was mostly safe and well-tolerated. Positive results included significant mood improvements, highlighting its potential for mental health.
Abstract
There is considerable interest in the therapeutic potential of psychedelic drugs. Dimethyltryptamine (DMT) is a potent, rapid-onset, and short-acti...
Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.
Bioorganic & medicinal chemistry letters – February 01, 2016
Summary
The precise actions of psychedelic drugs on brain receptors are being uncovered. This psychopharmacology research investigated N,N-Diallyltryptamine (DALT) and related tryptamine compounds, including 5-Methoxy-N,N-diallyltryptamine, to map their receptor binding. Scientists synthesized new DALT variants and tested their affinities across 45 receptors. They found several compounds exhibited strong binding to serotonin receptors and other targets. Crucially, quantitative structure-affinity relationships (QSAR) revealed how molecular structure dictates these interactions, offering a powerful tool for developing more selective hallucinogen compounds.
Abstract
N,N-Diallyltryptamine (DALT) and 5-methoxy-N,N-diallyltryptamine (5-MeO-DALT) are two tryptamines synthesized and tested by Alexander Shulgin. In s...
A Review of 3,4-methylenedioxymethamphetamine (MDMA)-Assisted Psychotherapy
Frontiers in Psychiatry – March 20, 2019
Summary
MDMA, often called Ecstasy, is on track for FDA/EMA licensing by 2021 as a medicine, currently in final Phase 3 trials for PTSD. This marks a significant advance in Psychiatry and Psychology. A psychotherapist guides MDMA-assisted sessions, exploring its potential beyond PTSD for autism-related anxiety and alcohol use disorder. Such Psychedelics and Drug Studies, alongside Cannabis and Cannabinoid Research, are redefining therapeutic approaches, moving beyond traditional views of hallucinogens and drug analysis concerns in Forensic Toxicology.
Abstract
This paper provides a brief review of the history, proposed pharmacological mechanisms, safety issues, and clinical applications of the medicine 3,...
Unique effects of sedatives, dissociatives, psychedelics, stimulants, and cannabinoids on episodic memory: A review and reanalysis of acute drug effects on recollection, familiarity, and metamemory.
Psychological review – March 01, 2024
Summary
Psychoactive drugs have surprisingly distinct effects on how we remember. A reanalysis of 28 drug conditions revealed how sedatives, dissociatives, psychedelics, stimulants, and cannabinoids uniquely impact our ability to recall specific details (recollection), recognize generally (familiarity), and judge memory accuracy (metamemory) during memory formation, stabilization, and access. Sedatives *enhanced* recollection during stabilization. Stimulants *boosted* metamemory and familiarity. Psychedelics *improved* familiarity. These patterns illuminate drug-specific memory phenomena, showing how memory quantity and stability influence our confidence in what we recall.
Abstract
Despite distinct classes of psychoactive drugs producing putatively unique states of consciousness, there is surprising overlap in terms of their e...
The Potential of Psychedelics for End of Life and Palliative Care.
Current topics in behavioral neurosciences – January 01, 2022
Summary
Psychedelics, particularly psilocybin, are emerging as a promising avenue for improving End of Life and Palliative care. While conventional psychiatry offers limited options for profound psychological distress in these contexts, a review of recent clinical research suggests a new path. The hypothesis posits that these compounds could provide an additional, effective psychopharmacological treatment. Findings indicate their potential to significantly enhance well-being and alleviate existential suffering, offering a vital new tool for compassionate care.
Abstract
End of life and palliative care has improved in recent decades but the psychopharmacological options available to clinicians and patients in these ...
Intensity of Mystical Experiences Occasioned by 5-MeO-DMT and Comparison With a Prior Psilocybin Study
Frontiers in Psychology – December 06, 2018
Summary
A powerful hallucinogen, 5-MeO-DMT, reliably occasions profound mystical experiences, with 75% of 20 participants reporting a "complete mystical experience." This potent alkaloid, relevant to chemical synthesis in Psychedelics and Drug Studies, produced mystical intensity comparable to high-dose psilocybin. Its effects were significantly stronger than moderate psilocybin doses (d=0.81). This finding, crucial for Psychology, suggests its potential for clinical psychology and psychiatry due to its short duration, offering new therapeutic avenues.
Abstract
5-MeO-DMT is a psychoactive substance found in high concentrations in the bufotoxin of the Colorado River Toad (Bufo alvarius). Emerging evidence s...