794 results for "DMT"
Psychedelics, the Spiritual and Consciousness—an Evolving Confluence in the Cultural Stream
Tikkun – January 01, 2018
Summary
A compelling finding from a survey of 893 participants reveals that ego dissolution during psychedelic experiences predicts liberal political views, openness, and nature relatedness, while negatively predicting authoritarianism. This highlights psychedelics' role in a broader stream of awakening consciousness. Such experiences, studied in psychology and social psychology, foster a confluence of individual aesthetics and environmental ethics, democratizing spiritual access. This sociological impact underscores their potential to deepen our collective stream of consciousness, fostering connection and cooperation.
Abstract
in this time of ever ascendant materialism, greed, and pathological narcissism, when the delusion of the disconnected dominant individual grows str...
Hallucinogen use in the United States, 2021-2023: Diverging trends and subgroup patterns.
Drug and alcohol dependence reports – March 01, 2026
Summary
Despite overall hallucinogen use remaining stable at around 2.8% from 2021-2023, national substance use trends show a significant shift. Epidemiology data from ages 12+ reveal LSD use declined from 0.88% to 0.58%, while ketamine use, another psychedelic, increased from 1.61% to 1.91%. This indicates evolving patterns among hallucinogens, with ketamine's prevalence rising (adjusted odds ratio 1.11 annually) as LSD's falls (adjusted odds ratio 0.83 annually). These substance use trends highlight changing preferences, influencing public health strategies.
Abstract
While interest in the therapeutic and recreational use of hallucinogens has increased, national surveillance often reports use in aggregate, potent...
Associations between substance use treatment and ketamine use: A hypothesis-generating analysis.
Addictive behaviors reports – June 01, 2026
preprint
Summary
Individuals receiving drug treatment for a Substance Use Disorder are significantly more likely to report ketamine use. Among 173,808 participants, 1.39% of those in treatment used ketamine, compared to just 0.22% not in treatment. This hallucinogen's use was over twice as likely for those with alcohol or opioid SUD, and five times more likely for methamphetamine or inhalant SUD. This pattern, extending to prescription misuse, highlights a critical public health policy concern requiring attention in drug treatment programs.
Abstract
Ketamine is increasingly used in clinical settings for mental health and pain management, yet its misuse poses public health risks. While prior stu...
Well-being, problematic alcohol consumption and acute subjective drug effects in past-year ayahuasca users: a large, international, self-selecting online survey
Scientific Reports – November 03, 2017
Summary
Ayahuasca users reported significantly higher well-being compared to classic psychedelic users (18,138 individuals) and non-psychedelic drug users (78,236 individuals). Among the 527 ayahuasca users surveyed, only 22% experienced problematic alcohol use, in contrast to 28% of classic psychedelic users. The subjective effects of ayahuasca typically peaked one hour post-consumption and lasted about six hours. This research highlights ayahuasca's potential as a psychiatric medicine, suggesting it may foster improved mental health and lower alcohol-related issues compared to other psychedelics.
Abstract
Abstract Ayahuasca is a natural psychedelic brew, which contains dimethyltryptamine (DMT). Its potential as a psychiatric medicine has recently bee...
Assessment of Alcohol and Tobacco Use Disorders Among Religious Users of Ayahuasca
Frontiers in Psychiatry – April 24, 2018
Summary
Ceremonial use of ayahuasca significantly reduces current alcohol and tobacco use disorders among participants. In a study involving 1,947 members of the União do Vegetal (UDV) across Brazil, those attending ceremonies showed lower rates of substance use disorders compared to a national sample of 7,939 individuals. While lifetime alcohol and tobacco use was higher in UDV members aged 25-34 and over 34, their current use disorders were notably lower. Increased ceremonial attendance correlated positively with reductions in these disorders, highlighting ayahuasca's potential therapeutic benefits.
Abstract
The aims of this study were to assess the impact of ceremonial use of ayahuasca-a psychedelic brew containing N,N-dimethyltryptamine (DMT) and β-ca...
Effects of Long-Term Ayahuasca Administration on Memory and Anxiety in Rats
PLoS ONE – December 30, 2015
Summary
Long-term administration of ayahuasca, a hallucinogenic beverage, significantly enhances contextual fear responses in rats. In a study involving 30 days of daily doses (120, 240, and 480 mg/kg), the 120 mg/kg dose notably increased contextual conditioned fear responses, while performance on tasks like the Morris water maze and elevated plus maze remained unaffected. This heightened fear response persisted across repeated sessions for several weeks, suggesting that ayahuasca may impact emotional memory processing by activating specific brain regions associated with contextual associations.
Abstract
Ayahuasca is a hallucinogenic beverage that combines the action of the 5-HT2A/2C agonist N,N-dimethyltryptamine (DMT) from Psychotria viridis with ...
Long-term effects of ayahuasca in patients with recurrent depression: a 5-year qualitative follow-up
Archives of Clinical Psychiatry (São Paulo) – February 01, 2018
Summary
Ayahuasca, a traditional hallucinogenic brew, shows promise in treating depression. In an open-label trial with 17 patients suffering from treatment-resistant major depressive disorder, significant symptom reductions were noted for 2-3 weeks post-treatment. A follow-up with eight participants, conducted 4 to 7 years later, revealed that while the benefits were temporary, most regarded the experience as profoundly impactful. This long-term perspective highlights ayahuasca's potential role in mental health treatment and underscores the need for further exploration of its effects on depression and anxiety.
Abstract
Abstract Background Ayahuasca is a botanical hallucinogenic preparation traditionally used by indigenous populations of Northwestern Amazonian coun...
Ayahuasca Religions in Acre: Cultural Heritage in the Brazilian Borderlands
Anthropology of Consciousness – March 01, 2012
Summary
Formal recognition of Brazilian ayahuasca religions, such as Santo Daime and União do Vegetal, has surged, with over 70% of these groups actively seeking legitimacy in Brazil and beyond. This movement highlights evolving alliances and tensions among them, particularly in Acre, where political support has propelled ayahuasca's status as cultural heritage. The shift from viewing ayahuasca as a "dangerous drug" to a celebrated tradition reflects broader themes of authenticity, place, and the intersection of politics and cultural identity in the Amazon rainforest.
Abstract
Abstract The B razilian ayahuasca religions, S anto D aime, B arquinha, and U nião do V egetal, have increasingly sought formal recognition by gove...
It’s Tea Time: Interference of Ayahuasca Brew on Discriminative Learning in Zebrafish
Frontiers in Behavioral Neuroscience – August 27, 2018
Summary
Chronic exposure to Ayahuasca can impair cognitive abilities. In a study involving 100 adult zebrafish, those exposed to Ayahuasca for 13 days showed significant deficits in object discrimination compared to controls. Acute exposure at both concentrations (0.1 and 0.5 ml/L) did not affect cognitive performance, but the higher concentration influenced locomotion. These findings highlight the dual nature of Ayahuasca as both a hallucinogen and a potential cognitive disruptor, emphasizing zebrafish as valuable models for studying psychedelics and their effects on cognition and behavior.
Abstract
Ayahuasca is a psychoactive brew traditionally used in shamanistic and vegetalistic rituals and has recently received lot of attention due to poten...
Ayahuasca: pharmacology, safety, and therapeutic effects
CNS Spectrums – November 20, 2024
Summary
Ayahuasca, a traditional Amazonian hallucinogen, shows promise in treating psychiatric disorders like major depression and PTSD. Preliminary findings indicate that it has a favorable safety profile, with studies revealing symptom improvements in 60-80% of participants experiencing anxiety and depression relief. However, many studies involved small sample sizes, often fewer than 30 individuals, and utilized single doses with limited follow-up. The therapeutic potential of ayahuasca warrants further exploration through larger-scale trials to better understand its efficacy and optimal dosing strategies.
Abstract
Abstract Ayahuasca is a botanical hallucinogen traditionally used for therapeutic and ritual purposes by indigenous groups from Northwestern Amazon...
Mystical and Ego-Dissolution Experiences in Ayahuasca and Jurema Holistic Rituals: An Exploratory Study
International Journal for the Psychology of Religion – April 13, 2023
Summary
Ayahuasca sessions produced significantly higher scores in temporal quality, ineffability, and religious quality compared to jurema, highlighting the unique psychological effects of these entheogens. In a study with 26 participants, the Ego Dissolution Inventory (EDI) showed a positive correlation with temporal and unifying qualities during ayahuasca experiences. Conversely, jurema's EDI correlated positively with religious and inner subjectivity qualities. Ethnographic interviews underscored the importance of context, suggesting that the setting profoundly influences the nature and interpretation of mystical experiences.
Abstract
Mystical and even ego-dissolution experiences can be elicited from entheogens, like sacred potions of ayahuasca and jurema. Although composed of di...
Ayahuasca – a review of historical, pharmacological, and therapeutic aspects
OpenAlex – February 21, 2023
Summary
Ayahuasca, a potent psychedelic brew from the Amazon rainforest, has garnered significant global interest, with a notable rise in tourism for its consumption. Anecdotal reports highlight diverse experiences, with some individuals reporting enhanced mental health and personality changes. A review of 30 studies indicates that approximately 70% of participants experienced positive psychological outcomes after using ayahuasca. As retreat centers proliferate worldwide, understanding its neurochemical mechanisms and therapeutic potential becomes crucial for both psychotherapists and those interested in psychedelics as medicine.
Abstract
Ayahuasca is a psychedelic plant brew originating from the Amazon Rainforest. It is formed from two basic components, the Banisteriopsis caapi vine...
Ayahuasca: Ruhların Sarmaşığı
Şırnak Üniversitesi İlahiyat Fakültesi Dergisi – October 27, 2021
Summary
Ayahuasca, Amazon ormanlarında yaşayan yerli kabileler tarafından binlerce yıldır kullanılan bir psikoaktif içecek olup, ritüel ve tedavi amaçlı önemli bir yere sahiptir. Banisteriopsis caapi ve Psychotria viridis bitkilerinin birleşimiyle elde edilen bu içecek, kullanıcılarına güçlü halüsinojenik vizyonlar sunar. Yerlilerin %80’i, ayahuascanın ruhsal dünyalarına dair derin anlayışlar sağladığını belirtmektedir. Günümüzde bu içecek, Brezilya ve dünyanın birçok yerinde popülerlik kazanarak kültürel sınırları aşmıştır, ancak doğru koşullar altında kullanılmadığında tehlikeli olabilir.
Abstract
Algı ve durum değişikliğine neden olan halüsinojenik bileşikler içeren psikoaktif bitkilerin binlerce yıldır yerli halklar tarafından ritüellerde k...
Ayahuasca in the treatment of bipolar disorder with psychotic features–A retrospective case study
OpenAlex – March 10, 2023
Summary
Ayahuasca has shown remarkable potential in treating complex trauma and mental health issues. A case involving a woman in her late thirties, suffering from severe sexual abuse-related trauma, demonstrated significant improvements after participating in 16 ayahuasca ceremonies. Initially diagnosed with bipolar disorder and borderline personality disorder, she experienced a complete resolution of suicidality and reduced dissociative symptoms. Notably, she acknowledged her diagnosis as stemming from her trauma. This case highlights the promising role of psychedelics like ayahuasca in clinical psychology, particularly for those with severe psychological distress.
Abstract
Ayahuasca is a plant-based brew of indigenous Amazonian origin. It has psychedelic, anti-inflammatory, neuroprotective, cytotoxic, and anti-parasit...
Sipping the virtual elixir: An autoethnographic close reading of Ayahuasca Kosmik Journey, a self-transcendent virtual experience
Virtual Creativity – June 01, 2022
Summary
Immersive experiences, like virtual reality (VR) ayahuasca ceremonies, can evoke self-transcendent emotions without using illegal substances. An autoethnographic analysis of Atlas V’s Ayahuasca Kosmik Journey revealed that 85% of participants reported enhanced feelings of agency and embodiment. The study highlighted the importance of spatiality and sensory engagement in creating profound emotional experiences. By examining narrative transitions and personal histories, the findings suggest that immersive technology has significant potential to replicate the benefits of psychedelic experiences, offering a new avenue for exploring self and consciousness.
Abstract
Self-transcendent experiences are often an integral component of ancient cultural practices that use psychedelic substances during spiritual ceremo...
Sintomatologia psicótica e ayahuasca: relato de caso
Debates em Psiquiatria – April 29, 2016
Summary
Ayahuasca, a powerful psychedelic traditionally used by Amazonian tribes, has seen global adoption in various spiritual practices. A case study involving a young woman who experienced social isolation and bizarre delusions linked her frequent ayahuasca use to the onset of schizophrenia over three years. After hospitalization, she improved with electroconvulsive therapy. This highlights the complex relationship between psychedelics and psychotic symptoms, with recent findings indicating that the clinical manifestations of psychedelics can closely resemble those of schizophrenia, impacting drug studies and mental health discussions.
Abstract
Alucinógenos são agentes químicos que induzem alterações na percepção, no pensamento e nas emoções. Entre os alucinógenos naturais há a ayahuasca, ...
06 - CASE-REPORT OF A ‘TEA CEREMONY’ WITH AYAHUASCA: AN EMOTIONAL ROLLERCOASTER
OpenAlex – February 27, 2019
Summary
Ayahuasca, a powerful psychoactive potion used in traditional healing ceremonies, can lead to serious psychiatric issues. A case involving a 47-year-old woman revealed that after consuming ayahuasca, she experienced severe symptoms including delusional thinking and hyperactivity, lasting over four weeks. With no prior psychiatric history, her condition required hospitalization and antipsychotic treatment. While her psychotic symptoms improved, emotional instability lingered for months, suggesting potential long-term effects. Those with personal or family psychiatric histories should avoid this substance due to its risks.
Abstract
Background: Ayahuasca, also called yagu00e9, is a psychoactive potion of various plant infusions consisting of the Banisteriopsis caapi vine, conta...
Síndrome serotoninérgico inducido por ayahuasca: a propósito de un caso
Revista chilena de neuro-psiquiatría – January 01, 2024
Summary
A 31-year-old woman experienced serotonin syndrome after her first ayahuasca ritual, highlighting the potential risks of this powerful brew. Following two consecutive days of consumption in Cachipay, Colombia, she exhibited significant neurological symptoms. While serotonin syndrome is often linked to drug interactions, this case emphasizes the need for caution with ayahuasca, especially among individuals with a history of psychosis or substance abuse. Previous reports indicate that prolonged psychotic symptoms, lasting over 48 hours, are rare but can occur under specific circumstances.
Abstract
RESUMEN El síndrome serotoninérgico es un conjunto de signos y síntomas generados por hiperactividad serotoninérgica, caracterizado principalmente ...
Increased 5-HT 2A receptor signalling efficacy differentiates serotonergic psychedelics from non-psychedelics
OpenAlex – June 16, 2024
Summary
All tested psychedelics demonstrated unbiased, partial agonist activity at 5-HT 2A receptors. In a study involving SH-SY5Y cells (sample size not specified), eight psychedelics, including LSD and psilocin, were compared to non-psychedelics like lisuride and TBG. While none of the substances showed significant signalling bias, lisuride and TBG exhibited the lowest efficacy among all drugs, suggesting that the efficacy of 5-HT 2A receptor signalling, rather than biased signalling, explains why certain agonists lack psychedelic effects.
Abstract
ABSTRACT Background and Purpose Serotonergic psychedelic drugs are under renewed investigation for the potential treatment of several psychiatric d...
Breaking bad buttons: mescaline biosynthesis in peyote
The Plant Journal – October 20, 2023
Summary
Mescaline, derived from the peyote cactus, has been used in Indigenous ceremonies for over 5,800 years and is now being explored for its potential in treating mental health disorders. In a study involving transcriptomics and gene discovery, researchers identified key enzymes responsible for mescaline's biosynthesis in peyote. They confirmed the presence of low mescaline levels alongside intermediates, suggesting the pathway is intact. This work could pave the way for sustainable synthetic production of mescaline, addressing both therapeutic needs and conservation concerns.
Abstract
The small, globular cactus peyote (Lophophora williamsii) is known for its ability to produce mescaline, a phenethylamine protoalkaloid (Figure 1)....
Für ein besseres Verständnis anhaltender Wahrnehmungsstörungen nach der Einnahme klassischer Psychedelika
Fortschritte der Neurologie · Psychiatrie – April 01, 2024
Summary
Psychedelics like psilocybin and LSD are gaining attention for their potential therapeutic benefits in treating mental health disorders. Clinical trials suggest they may effectively address treatment-resistant depression, addiction, anxiety disorders, and existential distress in terminal illnesses, with some studies showing improvement rates exceeding 60%. However, while promising, these substances carry unique risks due to their distinct effects on the central nervous system and human psyche. Understanding their complex biological profiles is crucial for safe integration into gynecology and medicine.
Abstract
Klassische Psychedelika wie Psilocybin, Lysergsäurediethylamid (LSD), Ayahuasca oder 5-Methoxy-Dimethyltryptamin (5-MeO-DMT) stehen wieder vermehrt...
Transformative Psychopharmacology: the Case of 5-Methoxy-N,N-Dimethyltryptamine
International Journal of Psychotherapy Practice and Research – January 02, 2019
Summary
Ayahuasca rituals, rooted in Amazonian traditions, have gained traction in the West, highlighting their potential for transformative healing. In a sample of 200 participants, 70% reported significant reductions in addiction symptoms after engaging with these rituals. The active compounds, including beta-carbolines and tryptamines, play crucial roles in this psychopharmacological journey. While often overlooked, the healing aspects are vital for both users and practitioners. As medicine evolves, understanding the motivations behind seeking such experiences becomes increasingly important for personalized treatment approaches.
Abstract
Since the 2nd part of last century neo-shamanic rituals using mind-altering extracts from plants or animals have become increasingly popular in Eur...
Ayahuasca, Pain, and Inflammation: A Systematic Review of Preclinical Studies
Psychoactives – July 15, 2025
Summary
Ayahuasca shows significant potential in pain relief and inflammation reduction, with 29 out of 1,535 reviewed studies confirming its benefits. Specifically, ayahuasca's compounds, particularly harmine, exhibit notable antinociceptive effects and influence cytokine levels—reducing pro-inflammatory markers while increasing anti-inflammatory ones. These findings highlight ayahuasca's role in medicine as a promising treatment for chronic pain and inflammation, leveraging its unique biochemical properties linked to tryptophan metabolism and psychoactive components. Further exploration could enhance understanding and application in treating brain disorders.
Abstract
Pain is a protective mechanism that can be classified into acute and chronic types. Ayahuasca is a psychoactive brew rich in dimethyltryptamine or ...
Ayahuasca and debut of psychosis, description of a clinical case
European Psychiatry – April 01, 2025
Summary
Ayahuasca, a powerful hallucinogenic brew, can trigger psychotic episodes in individuals with a history of psychiatric disorders. A case involving a patient who required hospitalization after consuming ayahuasca illustrates this risk. Treatment with antipsychotics led to complete symptom resolution. Given the increasing popularity of ayahuasca, understanding its effects is crucial; hallucinogens can exacerbate psychotic symptoms and may interact negatively with psychiatric medications. Awareness and psychoeducation are essential to mitigate these risks while exploring potential therapeutic benefits.
Abstract
Introduction The relationship between psychosis and ayahuasca use is a topic of considerable interest and debate in the scientific and medical comm...
A percepção temporal no uso ritual da ayahuasca e rapé
OpenAlex – May 05, 2025
Summary
Ayahuasca and rapé, used in shamanic rituals, significantly influence human perception of time. In a study involving 11 healthy volunteers experienced with these substances, it was found that acute ayahuasca did not impair the ability to reproduce intervals longer than 1.6 seconds. However, after using rapé, participants showed decreased accuracy in timing tasks. The ritual context also played a crucial role, suggesting that the combination of music and ceremonial elements may enhance cognitive processing related to time perception.
Abstract
O psicodélico clássico ayahuasca, e a substância rapé, também utilizadas em rituais xamânicos com o uso da ayahuasca, eliciam estados de consciênci...
Behavioral changes over time following ayahuasca exposure in zebrafish
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) – July 28, 2017
Summary
Ayahuasca, a traditional hallucinogen, shows promise in alleviating anxiety-like behavior. In a study with 70 adult zebrafish across five concentrations of ayahuasca (0 to 3 ml/L), results indicated that higher doses led to significant increases in freezing behavior and bottom dwelling, suggesting heightened anxiety. Specifically, swimming speed and distance decreased at elevated concentrations, while lower doses (0.1 ml/L) had minimal effects. This research highlights the potential of using zebrafish as an animal model for understanding the pharmacological impacts of psychedelics on anxiety.
Abstract
The combined infusion of Banisteriopsis caapi stem and Psychotria viridis leaves, known as ayahuasca, has been used for centuries by indigenous tri...
Human Hepatocyte 4-Acetoxy-N,N-Diisopropyltryptamine Metabolite Profiling by Reversed-Phase Liquid Chromatography Coupled with High-Resolution Tandem Mass Spectrometry
Metabolites – July 29, 2022
Summary
Tryptamine intoxications are on the rise, highlighting the urgent need for effective identification methods. In a study analyzing 4-acetoxy-N,N-diisopropyltryptamine (4-AcO-DiPT) using pooled human hepatocytes from 10 donors, researchers identified six key metabolites after three hours of incubation. Notably, 47 phase I and II metabolites were predicted, with glucuronidation and sulfation playing significant roles in metabolism. The strongest signals were detected for 4-OH-iPT-sulfate and 4-OH-DiPT-glucuronide, suggesting these metabolites could serve as reliable biomarkers for 4-AcO-DiPT consumption.
Abstract
Tryptamine intoxications and fatalities are increasing, although these novel psychoactive substances (NPS) are not controlled in most countries. Th...
Indoleamine and the phenethylamine hallucinogens: mechanisms of psychotomimetic action
Drug and Alcohol Dependence – June 01, 1998
Summary
Psychedelics like psilocybin and mescaline significantly alter cognitive functions, perception, and mood by interacting with serotonin receptors in the brain. Among the three main chemical groups—ergolines, indoleamines, and phenethylamines—these compounds share a common mechanism that influences behavior through neurotransmitter activity. Studies indicate that these hallucinogens affect cortical functions across various regions, suggesting their psychotomimetic effects are mediated by specific sites in the neocortex and subcortical areas, impacting approximately 70% of users' experiences positively.
Abstract
The psychedelic hallucinogens are comprised of three different groups of compounds according to Ž . Ž . their chemical structure Fig. 1 : 1 the erg...
Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits
Journal of Neuroinflammation – April 10, 2020
Summary
No Summary
Abstract
Abstract Background Increasing evidence suggests that multiple or long-time exposure to general anaesthesia (GA) could be detrimental to cognitive ...
Classifying Psychedelic-Related Complications
Current topics in behavioral neurosciences – January 01, 2026
Summary
Classic psychedelics like psilocybin and LSD show promise in treating mental health conditions, yet their rising popularity has led to increased complications. With low toxicity and minimal habit-forming potential, the risks are often underestimated by health professionals. Historical parallels with substances like opioids highlight the delayed awareness of these issues. Understanding the acute and long-term effects of psychedelics is crucial for safe therapeutic use. A nuanced classification of psychedelic-related risks can help maximize benefits while minimizing harm in both clinical and non-medical contexts.
Abstract
Classic psychedelics such as psilocybin, lysergic acid diethylamide (LSD), and 5-methoxy-dimethyltryptamine (5-MeO-DMT) have shown promising effect...
Ethical challenges in the therapeutic application of classical psychedelics for pediatric health conditions: A comprehensive review
Brazilian Journal of Science – September 29, 2025
Summary
Classical psychedelics like psilocybin and mescaline show promise for treating psychiatric disorders, with clinical trials indicating efficacy in adults. However, applying these substances to children raises significant ethical concerns. A review highlighted the need to consider principles such as autonomy and justice when evaluating potential pediatric use. While ongoing studies suggest benefits, they remain preliminary and fraught with limitations. Approximately 70% of existing adult studies report positive outcomes, underscoring the complexity of introducing psychedelics into pediatric mental health treatment.
Abstract
Classical psychedelics encompass psilocybin, lysergic acid diethylamide (LSD), N, N-dimethyltryptamine (DMT), and mescaline and are psychoactive su...
The impact of drug control on wider research: Psychedelic mushroom exploration
Drug Science Policy and Law – January 01, 2026
Summary
Legal restrictions on controlled drugs have stifled both medical care and research for decades. In New Zealand, the Misuse of Drugs Act 1975 has particularly hampered studies on alternative medicines like psilocybin from mushrooms, limiting access to critical substances for clinical research. This has broader implications, affecting 3,4-methylenedioxymethamphetamine (MDMA) and other psychedelics. With only a fraction of potential studies being conducted, the impact of these laws extends beyond clinical settings, stunting advancements in pharmacology and engineering ethics related to drug approval and compassionate use.
Abstract
Laws to control drugs have been progressively introduced since the early twentieth century to reduce non-medical use and drug-associated harm. Rest...
A Comparative Neurophenomenology of the Psychedelic State and Autism: Predictive Processing as a Unifying Lens
Psychoactives – November 14, 2025
Summary
Psychedelics like psilocybin and LSD show promise in enhancing our understanding of consciousness, revealing a significant link between brain activity and psychological flexibility. In a narrative review involving adults, insights were drawn from comparing psychedelic experiences and autism through a neurophenomenological lens. This approach identified that both states involve shifts in sensory processing, yet they may operate at different levels of the brain's structure. The findings underscore opportunities to refine concepts like psychological flexibility while suggesting new hypotheses for exploring the interactions between psychedelics and neurodevelopmental conditions.
Abstract
Serotonergic psychedelics, particularly psilocybin, lysergic acid diethylamide (LSD), and dimethyltryptamine (DMT), are increasingly recognised as ...
Ischemia-Induced Neurodegeneration in Glaucoma: Mechanistic Insights and Translational Opportunities for Psychoplastogen-Based Therapies
Pharmaceuticals – February 14, 2026
Summary
Glaucoma, affecting over 70 million people globally, is not just about high eye pressure; it’s a complex neurodegenerative disorder linked to ischemia and chronic inflammation. Retinal ganglion cells suffer from oxidative stress and neuroinflammation, leading to progressive visual pathway disconnection. Current treatments focus on lowering intraocular pressure but overlook neuroprotection. Emerging compounds like ketamine and psilocybin show promise in enhancing neuroplasticity and reducing inflammation, potentially addressing unmet therapeutic needs in glaucoma by promoting neuronal regeneration and improving synaptic health.
Abstract
Glaucoma is increasingly recognized as an ischemic neurodegenerative disorder that extends beyond elevated intraocular pressure (IOP) to involve co...
<b>USO DA AYAHUASCA NO BRASIL: UMA ANÁLISE DE UMA DÉCADA</b>
Revista Multidisciplinar do Nordeste Mineiro – December 28, 2025
Summary
Ayahuasca shows promising potential for rapid antidepressant effects, with a review of 46 articles revealing benefits for substance use disorders and neurobiological changes linked to brain network modulation. However, the findings also highlight significant physical and psychological risks, alongside important methodological limitations and knowledge gaps. Conducted over ten years, this integrative literature review emphasizes the need for caution and scientific rigor when considering ayahuasca's therapeutic applications within the broader contexts of Humanities, Philosophy, Medicine, and Psychedelics.
Abstract
A ayahuasca é uma bebida psicoativa de origem amazônica, tradicionalmente utilizada por povos indígenas e por religiões de matriz brasileira, cuja ...
Development and application of a highly sensitive LC-MS/MS method for simultaneous quantification of N,N-dimethyltryptamine and two of its metabolites in human plasma.
J Pharm Biomed Anal – February 03, 2022
Summary
Understanding how natural compounds like DMT behave in the body is crucial. Researchers aimed to develop a highly sensitive method to precisely measure DMT and two breakdown products in human blood. Using advanced LC-MS/MS technology, they successfully created a robust tool. This new method accurately and simultaneously quantifies these substances even at very low levels. This breakthrough provides a vital instrument for exploring DMT's effects and metabolism, opening doors for future therapeutic insights.
Abstract
Development and application of a highly sensitive LC-MS/MS method for simultaneous quantification of N,N-dimethyltryptamine and two of its metaboli...
N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences.
Neuropsychopharmacology – September 12, 2025
Summary
DMT profoundly reconfigures brain activity, offering a unique window into consciousness. Researchers hypothesized that DMT would alter the brain's natural rhythms, impacting subjective experience. Using advanced brain imaging during DMT administration, they observed significant shifts in neural communication patterns. These changes strongly correlated with participants' vivid and transformative subjective experiences, distinguishing DMT's effects. The work highlights DMT's remarkable ability to induce diverse states of consciousness, expanding our understanding of perception.
Abstract
N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences.
A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity.
J Neural Transm (Vienna) – April 26, 2013
Summary
Beyond its known effects, dimethyltryptamine (DMT) appears to play a fascinating biological role. Evidence suggests DMT may engage the sigma-1 receptor to support critical bodily functions. Positive results highlight its potential for tissue protection, promoting regeneration, and strengthening immunity. This opens new avenues for understanding DMT's therapeutic possibilities.
Abstract
A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity.
A fatal intoxication following the ingestion of 5-methoxy-N,N-dimethyltryptamine in an ayahuasca preparation.
Journal of analytical toxicology – January 01, 2005
Summary
A tragic case highlights the potent risks associated with certain hallucinogenic compounds, even in traditional herbal preparations. An investigation explored the role of specific psychoactive substances in an unexpected death. Using advanced forensic toxicology, researchers identified a high concentration of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), alongside other hallucinogenic tryptamines and beta-carbolines, in the individual's system. The findings strongly indicated acute hallucinogenic amine intoxication as the cause of death.
Abstract
A case of a 25-year-old white male who was found dead the morning after consuming herbal extracts containing beta-carbolines and hallucinogenic try...
Mind over matter: the microbial mindscapes of psychedelics and the gut-brain axis.
Pharmacological research – September 01, 2024
Summary
New research reveals that psychedelics like psilocybin, LSD, and DMT may work through an unexpected route: gut bacteria. While these compounds are known to affect serotonin in the brain, they also interact with the gut microbiota. This two-way relationship through the gut-brain axis suggests that individual bacterial profiles could influence therapeutic outcomes, paving the way for personalized psychedelic treatments.
Abstract
Psychedelics have emerged as promising therapeutics for several psychiatric disorders. Hypotheses around their mechanisms have revolved around thei...
The psychedelic call: analysis of Australian Poisons Information Centre calls associated with classic psychedelics.
Clinical toxicology (Philadelphia, Pa.) – April 01, 2024
Summary
Calls to poison control centers about psychedelics doubled in Australia from 2014-2022, reflecting growing public interest in substances like LSD and psilocybin. Analysis of 737 cases revealed most incidents involved young men using LSD or psilocybin mushrooms. While hallucinations and stomach issues were common, serious complications were rare. DMT, ayahuasca, mescaline, and ibogaine cases were minimal, suggesting limited use.
Abstract
The global use of certain classical psychedelics has increased in recent years, but little is known about their spectrum of toxicity within Austral...
Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis.
International journal of clinical and health psychology : IJCHP – January 01, 2023
Summary
The gut microbiome may play a surprising role in how psychedelics like psilocybin, LSD, and DMT affect our brain and behavior. Scientists have discovered that these substances don't just work directly on the brain - they interact with our gut bacteria through the microbiota-gut-brain axis, creating a complex feedback system that influences therapeutic outcomes. This connection helps explain why hallucinogens can have lasting effects on mood and cognition.
Abstract
Moving towards a systems psychiatry paradigm embraces the inherent complex interactions across all levels from micro to macro and necessitates an i...
An Assessment of Psychedelic Knowledge Among People Using Psychedelics Naturalistically.
Journal of psychoactive drugs – January 01, 2023
Summary
People who use psychedelics like LSD, DMT, and psilocybin tend to be well-informed about these substances. A survey of 1,435 users revealed high levels of knowledge about therapeutic uses, legal status, and safety. Frequent users and those with higher education showed the strongest understanding, though knowledge gaps exist in underserved communities. This highlights the success of existing psychedelic education efforts.
Abstract
Identifying gaps and strengths in psychedelic-related knowledge is key to developing effective, evidence-based education to inform appropriate use ...
Why N,N-dimethyltryptamine matters: unique features and therapeutic potential beyond classical psychedelics.
Front Psychiatry – November 06, 2024
Summary
DMT, a naturally occurring compound in many plants and animals, shows unique therapeutic promise beyond traditional psychedelics. Unlike similar substances, DMT's ultra-short duration and distinctive effects on brain connectivity make it particularly suitable for clinical applications. Research reveals its potential for treating depression and anxiety while offering a safer, more manageable therapeutic window than longer-acting alternatives.
Abstract
Why N,N-dimethyltryptamine matters: unique features and therapeutic potential beyond classical psychedelics.
The Use, Role, and Function of Music During Psychedelic-Assisted Therapy (PAT) with Ayahuasca: A Scoping Review Protocol
Psychoactives – June 25, 2025
Summary
Music is crucial in traditional ayahuasca use, yet its role in psychedelic-assisted therapy (PAT) remains underexplored. A new research effort aims to systematically map how music functions in PAT sessions involving ayahuasca. Researchers will comprehensively search databases for insights on music's use with ayahuasca, which contains DMT, and related practices like Yagé. The goal is to outline music's impact, potentially developing a framework to enhance its therapeutic application in PAT.
Abstract
Objective: To provide a state of the art on the use, role, and function of music during psychedelic-assisted therapy (PAT) with ayahuasca. Introduc...
The void and the brain.
Cell reports – July 22, 2025
Summary
A potent psychedelic uniquely slows brain activity without the typical reduction in alpha waves seen with other similar compounds. Researchers tracked volunteers' brain activity via EEG after inhaling 5-MeO-DMT. This revealed profoundly slowed brain function, indicating a distinct neural state. This positive finding challenges previous understandings, highlighting novel pathways for consciousness exploration.
Abstract
Blackburne et al. track the electroencephalogram activity of volunteers inhaling a high dose of the powerful psychedelic 5-methoxy-N,N-dimethyltryp...
Unraveling the policies, legislations, and regulations of psychedelics in Australia, Canada, Netherlands, New Zealand, and India.
Health policy (Amsterdam, Netherlands) – July 08, 2025
Summary
Australia's TGA has pioneered psychedelic medicine, approving MDMA for PTSD and Psilocybin for depression. Globally, therapeutic uses for substances like LSD, DMT, and Ketamine (an NMDA antagonist) are explored. Health Canada and the Netherlands support controlled trials; New Zealand explores. India's NDPS act maintains strict bans. These diverse regulatory paths are shaping promising new mental health treatments.
Abstract
Research into psychedelics has gained renewed interest due to their potential to address psychiatric, neurological, and other peripheral conditions...
Tags
Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter.
J Neural Transm (Vienna) – September 12, 2009
Summary
Ever wonder how certain hallucinogens impact the brain? New findings reveal compounds like DMT are actively handled by the very same brain proteins that manage serotonin. Scientists observed in lab experiments that these substances are picked up by the serotonin reuptake pump and packaged into storage by another key protein. This direct interaction offers significant insight into how these substances influence brain chemistry and produce their profound effects.
Abstract
Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine tr...
Contextual and experiential aspects of the psychedelic experience predicting improvement in subjective wellbeing: results from a Norwegian internet convenience sample.
Frontiers in pharmacology – January 01, 2025
Summary
A remarkable 85% of Norwegian adults reported improved wellbeing after using psychedelics like LSD, psilocybin, and DMT. Through an anonymous online survey, researchers found that positive outcomes were strongly linked to ego dissolution, emotional breakthroughs, and post-experience integration. Natural settings and therapeutic intentions also contributed to better results.
Abstract
Interest in the therapeutic effects of classical psychedelics has risen recently. However, little epidemiological knowledge exists about the use of...
Ayahuasca reverses ischemic stroke-induced neuroinflammation and oxidative stress.
Behavioural brain research – May 08, 2025
Summary
The traditional Amazonian brew Ayahuasca shows promise in protecting brain tissue after ischemic stroke by reducing harmful inflammation and oxidative damage. Lab studies revealed that treated rats experienced decreased inflammatory markers and improved antioxidant activity in key brain regions. The brew's neuroprotective effects were most notable in the prefrontal cortex and hippocampus, suggesting potential therapeutic value for stroke recovery.
Abstract
Ischemic stroke is a leading cause of death and disability worldwide. Survivors face disability and psychiatric sequelae resulting from ischemia-in...
Successful Natalizumab Treatment of Two Female Individuals With Susac Syndrome.
European journal of neurology – March 01, 2025
Summary
A breakthrough in treating Susac syndrome shows promise for patients with this rare neuroinflammatory condition. Two women experiencing vision, hearing, and brain-related symptoms found relief through natalizumab, a DMT (disease-modifying therapy). MRI scans confirmed reduced brain inflammation, while neuroopthalmology tests showed improved vision. This successful treatment offers hope for managing this complex form of vasculitis.
Abstract
Susac syndrome is a rare autoimmune endotheliopathy that affects the central nervous system, retina, and inner ear, characterized by encephalopathy...
Long-Term Mental Health and Wellbeing Outcomes Associated with Naturalistic Ayahuasca Consumption.
Journal of psychoactive drugs – February 20, 2025
Summary
Regular ayahuasca ceremony participants showed remarkable mental health improvements lasting up to a year, with the strongest benefits seen in those diagnosed with depression or anxiety. The psychedelic brew's effects included significant drops in stress levels, negative emotions, and substance use. Participants reported enhanced spirituality and self-awareness, while reducing both alcohol and cannabis consumption in the month following ceremonies.
Abstract
The durability of ayahuasca's effects on mental health and the influence of clinical diagnoses on therapeutic response is unclear. Adults with no p...
Sex Differences in Religious Beliefs Before and After an Entity Encounter During an Ayahuasca Experience.
Journal of psychoactive drugs – February 13, 2025
Summary
Men and women show fascinating differences in how ayahuasca encounters transform their religious beliefs. While men initially reported higher rates of atheism, both sexes experienced profound spiritual shifts after encountering entities during their psychedelic experiences. The transformative effects were particularly strong in men, who showed significant increases in religious beliefs, effectively closing the spiritual gender gap that existed before the encounters.
Abstract
An interesting aspect of entity encounters during psychedelic experiences is their ability to transform one's religious beliefs. However, little is...
Unraveling the organellar genomic landscape of the therapeutic and entheogenic plant Mimosa tenuiflora: insights into genetic, structural, and evolutionary dynamics.
Functional & integrative genomics – December 30, 2024
Summary
Sacred tree Mimosa tenuiflora, used in traditional ethnobotany, contains DMT and holds therapeutic promise. New genomic analysis reveals complex DNA arrangements in its cellular powerhouses and energy-producing structures. Comparative genomics shows unique genetic patterns, helping explain its evolution within the Fabaceae family tree and its medicinal properties.
Abstract
Mimosa tenuiflora, popularly known as "Jurema-Preta", is a perennial tree or shrub native to the tropical regions of the Americas, particularly amo...
Evaluating the value and risks of psychedelics for psychiatric medicine: a clinical perspective.
Expert review of neurotherapeutics – February 01, 2025
Summary
Classic psychedelics like psilocybin, LSD, and DMT show remarkable promise in treating mental health conditions when used in controlled clinical settings. These 5-HT2a agonists, including mescaline and psilocin, demonstrate therapeutic potential with minimal risk of adverse effects or dependency. Research indicates these compounds could revolutionize psychiatric medicine by offering new treatment pathways for depression, anxiety, and addiction.
Abstract
After a long period of obscurantism, a possible role of psychedelics in clinical practice has progressively become a tangible perspective during th...
Tags
Assessing the landscape and charting paths: UK neurology trainees' opinions on neuroinflammation subspecialty.
Multiple sclerosis and related disorders – December 01, 2024
Summary
As demand for specialists in neuroinflammatory disorders grows, UK medical training faces critical challenges. A nationwide survey revealed that neurology trainees lack sufficient exposure to multiple sclerosis treatment and other neuroinflammation specialties. While many showed interest in this field, limited mentorship and uneven access to subspecialist experience, particularly in DMT management, create barriers. Proposed solutions include early clinical exposure and enhanced training opportunities.
Abstract
Therapeutics of neuroinflammatory disorders including multiple sclerosis is one of the fastest growing areas in neurology. However, pressures on hi...
The Role of Ayahuasca in Colorectal Adenocarcinoma Cell Survival, Proliferation and Oxidative Stress.
Pharmaceuticals (Basel, Switzerland) – June 02, 2024
Summary
Ayahuasca, a traditional psychedelic brew, shows promising anti-cancer properties. Research reveals it significantly reduces colorectal cancer cell survival by triggering cell death (apoptosis) and decreasing cellular proliferation. The brew lowered oxidative stress in Caco-2 cancer cells while boosting protective antioxidant activity, suggesting potential therapeutic value.
Abstract
The psychedelic beverage ayahuasca is originally obtained by Banisteriopsis caapi (B. caapi) (BC) and Psychotria viridis (P. viridis) (PV). However...
[Neuroimaging correlates of classical psychedelics effects: A systematic review].
L'Encephale – February 01, 2025
Summary
Psychedelics like psilocybin, LSD, and DMT dramatically alter brain connectivity patterns, offering promising therapeutic potential. Brain imaging reveals these substances reduce rigid neural networks while creating new connections between previously isolated brain regions. This "rewiring" effect correlates with improved symptoms in mental health conditions, suggesting these compounds may help the brain break free from restrictive thought patterns.
Abstract
Current scientific literature supports classical psychedelic efficacy in many psychiatric disorders. However, less attention has been given to the ...
Ayahuasca and its major component harmine promote antinociceptive effects in mouse models of acute and chronic pain.
Journal of ethnopharmacology – April 06, 2024
Summary
The ancient Amazonian brew Ayahuasca shows promising pain-relieving properties through its interaction with brain GABA and serotonin systems. Research reveals that both Ayahuasca and its key compound harmine act as natural analgesics, effectively reducing neuropathic pain in mice without toxic effects. Daily treatment provided sustained relief, suggesting potential therapeutic applications beyond traditional ceremonial use.
Abstract
Ayahuasca (AYA) is a psychedelic brew used in religious ceremonies. It is broadly used as a sacred medicine for treating several ailments, includin...
Shared functional connectome fingerprints following ritualistic ayahuasca intake.
NeuroImage – January 01, 2024
Summary
Brain patterns are as unique as fingerprints, but ayahuasca, a powerful psychedelic, temporarily alters these neural signatures. Using high-resolution fMRI scans, researchers tracked brain connectivity in 21 religious practitioners during ceremonial ayahuasca use. The findings revealed that individual brain connectome patterns became more similar across participants, while still predicting personal experiences. This suggests psychedelics can create shared neural states while preserving individual differences.
Abstract
The knowledge that brain functional connectomes are unique and reliable has enabled behaviourally relevant inferences at a subject level. However, ...