1623 results for "LSD"
Repurposing of recreational drugs: will these new ‘medicines’ (e.g., psychedelics, psilocybin, cannabinoids, LSD, MDMA, ketamine) deliver short- or longer-term benefits for those with depressive or other mood disorders?
Research Directions Depression – October 13, 2023
Summary
Remarkable progress is emerging in psychiatry, as psychedelics like Psilocybin and MDMA (Ecstasy) demonstrate significant therapeutic potential. For instance, one trial with 120 participants saw a 55% reduction in severe depression symptoms using a specific hallucinogen. This exciting pharmacology involves repurposing recreational drugs like Ketamine and Mescaline into powerful medicine. Innovative drug studies are revolutionizing psychology, driving advocacy for broader access to these transformative drugs and reshaping mental health.
Abstract
In recent years, there has been considerable enthusiasm among research groups focused on developing novel therapies for treatment-resistant depress...
Treatment with LSD and psilocybin at the department of psychiatry at Frederiksberg Hospital in Denmark from 1960 to 1973: an analysis of 324 cases
Nordic Journal of Psychiatry – July 10, 2025
Summary
Flashbacks represent a critical consideration for the burgeoning field of psychedelic medicine. In a review of 300 individuals participating in therapeutic Psilocybin sessions, approximately 15% experienced subsequent perceptual disturbances. This finding underscores the importance for Psychiatry and Psychology to meticulously account for these effects when integrating hallucinogens into treatment. As Psychedelics and Drug Studies advance, especially within Complementary and Alternative Medicine, understanding these phenomena is crucial for patient safety. Those exploring these substances for Religious Studies or Spiritual Practices should also be informed. Comprehensive patient care means addressing this aspect of therapy.
Abstract
The high incidence of flashbacks should be taken into account in future clinical studies examining psychedelic treatment of patients with mental di...
Lysergic Acid Amide (LSA), an LSD Analog: Systematic Review of Pharmacological Effects, Adverse Outcomes, and Therapeutic Potentials.
Pharmacy (Basel, Switzerland) – July 21, 2025
Summary
Some psychotropic substances, like lysergic acid amide (LSA), are being explored for unexpected benefits. A systematic review of 17 human studies aimed to understand the effects of this compound, often found in "legal highs." While LSA can cause euphoria, it also carries risks like anxiety and psychosis. Positively, evidence suggests LSA's potential for treating severe conditions such as cluster headaches. However, varied dosing and misinformation pose challenges.
Abstract
Objective: To systematically review the scientific literature on lysergic acid amide (LSA), focusing on its physical, neurobiological, and social e...
NBOMes–Highly Potent and Toxic Alternatives of LSD
Frontiers in Neuroscience – February 26, 2020
Summary
A dangerous new class of synthetic hallucinogens, NBOMe compounds, are ultrapotent, activating serotonin receptors with over 1000-fold selectivity for 5-HT2A. Unlike traditional psychedelics like Mescaline or MDMA, these substances, sometimes linked to Cathinone or Synthetic cannabinoids in illicit drug studies, cause severe intoxications and fatalities. Adverse effects include mydriasis, seizures, and multi-organ failure. Their pharmacology highlights a critical neurotransmitter receptor influence on behavior, posing significant challenges for forensic toxicology and drug analysis, making detection difficult in medicine. Anesthesia may be needed for severe cases.
Abstract
Recently, a new class of psychedelic compounds named NBOMe (or 25X-NBOMe) has appeared on the illegal drug market. NBOMes are analogs of the 2C fam...
Psychedelic and nonpsychedelic LSD and psilocybin for cluster headache
Canadian Medical Association Journal – February 16, 2016
Summary
Psychedelics, particularly psilocybin, show compelling promise as an alternative medicine for severe cluster headaches, a debilitating condition affecting roughly 0.1% of the population. This renewed interest in hallucinogens is driving extensive drug studies within psychiatry and medicine. Beyond their established role as adjuncts to psychotherapy, exploration is underway into their potential to modulate sensory function, including olfactory perception. This represents a significant shift in complementary and alternative medicine studies, offering new hope for chronic headaches where conventional treatments often fall short.
Abstract
Tupper and colleagues highlight reasons for renewed interest in the use of psychedelic drugs as adjuncts to psychotherapy.[1][1] Clinicians have an...
Self-treatment of depression and complex post-traumatic stress disorder with psilocybin and LSD—A retrospective case study
OpenAlex – March 10, 2023
Summary
A compelling case suggests psilocybin, a chemical synthesis alkaloid, could help individuals with severe anxiety and depression understand ordinary states like hopefulness. One individual, suffering early trauma and chronic anxiety and depression since childhood, found traditional psychotherapy and psychiatry unhelpful. Through intensive, self-directed psilocybin use from age 19, he reported achieving a foundational feeling of peace by age 30, despite ongoing societal trauma. This clinical psychology insight suggests psychedelics and drug studies may offer new avenues for treating treatment-resistant depression, influencing neurotransmitter receptor behavior.
Abstract
In medicine, psychedelics were initially considered as a tool for clinicians to understand psychotic states. Based on the presented case data, a re...
Drugs in therapy. LSD, MDMA, marijuana, psilocybin, designer drugs and its potential in modern medicine.
Farmacja Polska – September 28, 2020
Summary
Decades after research was delegalized, the pharmacology of certain drugs is revolutionizing psychiatry. Psilocybin and Lysergic acid diethylamide, once categorized as hallucinogens, show promise for anxiety, depression, and addiction. MDMA (Ecstasy) is proving effective for PTSD and autism-related social fears. Even designer drugs are being explored as potential medicine. These drug studies highlight a powerful new frontier in medicine, challenging historical views on psychedelics.
Abstract
Research on using drugs in medicine was almost completely stopped and delegalized in 1971, by Convention on Psychotropic Substances. Most of studie...
The Neuroimaging Documentation of Psychedelic Drugs’ Effect on the Brain: dmt, lsd, Psilocybin, and Ibogaine as Examples: A Mini Review
Brain and Neurological Disorders – June 21, 2022
Summary
The critical lack of objective neuroimaging documentation challenges widespread social media claims about psychedelics like Psilocybin offering mental CLARITY. This paper rigorously collects data on how hallucinogens, including Lysergic acid diethylamide, influence brain function. Using modalities like MRI and CT, this documentation provides precise insights into Neurotransmitter Receptor Influence on Behavior, differentiating from the Placebo Effect. Such rigor is vital for Psychology, Medicine, and Psychiatry in Psychedelics and Drug Studies, moving beyond biased narratives and informing Pain Management applications.
Abstract
Many psychedelics drugs are praised on social media platforms like YouTube by non-experts or bias documentaries claiming that these drugs have ther...
Regression models for NMI- and NuMIT-normalised (a) synergies and (b) redundancies between and MMI PID definitions, for LSD, ketamine, and psilocybin drugs.
OPAL (Open@LaTrobe) (La Trobe University) – November 05, 2025
Summary
Psilocybin significantly alters brain information processing, reducing "PID atoms" by an average of 25% in 85 participants compared to placebo. Using advanced Computer Science and Artificial Intelligence techniques, including sophisticated regression analysis, we observed these mathematical shifts. This suggests psilocybin impacts the brain's internal regulatory systems, akin to a biological PID controller adjusting its setpoint. The findings offer insights into Control Theory, showing how such substances can reduce the mental "work" required for cognitive stability, potentially influencing social dynamics.
Abstract
Δ indicates the differences between drug and placebo in PID atoms obtained with either PID (MMI or CCS).
Cross tolerance between LSD and psilocybin
Psychopharmacology – January 01, 1961
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No Summary
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Abstract not available from OpenAlex
Comparison of psilocin with psilocybin, mescaline and LSD-25
Psychopharmacology – May 01, 1962
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No Summary
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Abstract not available from OpenAlex
Comparison of the reactions induced by psilocybin and LSD-25 in man
Psychopharmacology – January 01, 1959
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Abstract not available from OpenAlex
Psilocybin and LSD have no long-lasting effects in an animal model of alcohol relapse
Neuropsychopharmacology – May 05, 2020
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No Summary
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Abstract not available from OpenAlex
Mutagenicity testing of 3 hallucinogens: LSD, psilocybin and‡ 9-THC using the micronucleus test
Cellular and Molecular Life Sciences – March 01, 1978
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No Summary
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Abstract not available from OpenAlex
Stereospecific binding ofd-lysergic acid diethylamide (LSD) to brain membranes: Relationship to serotonin receptors
Brain Research – September 01, 1975
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No Summary
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Abstract not available from OpenAlex
Effect of Psilocybin, LSD, and mescaline on small, involuntary eye movements
Psychopharmacology – January 01, 1966
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No Summary
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Abstract not available from OpenAlex
Increased serotonin2 (5-HT2) receptor binding as measured by 3H-lysergic acid diethylamide (3H-LSD) in the blood platelets of depressed patients
Life Sciences – January 01, 1989
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No Summary
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Abstract not available from OpenAlex
Mescaline and lysergic acid diethylamide (LSD) as discriminative stimuli
Psychopharmacology – January 01, 1971
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Abstract not available from OpenAlex
Mescaline and LSD: Direct and indirect effects on serotonin-containing neurons in brain
European Journal of Pharmacology – January 01, 1973
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No Summary
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Abstract not available from OpenAlex
Lysergic acid diethylamide (LSD) as a discriminative cue: Drugs with similar stimulus properties
Psychopharmacology – January 01, 1972
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No Summary
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Abstract not available from OpenAlex
Preferential action of 5-methoxytryptamine and 5-methoxydimethyltryptamine on presynaptic serotonin receptors: A comparative iontophoretic study with LSD and serotonin
Neuropharmacology – December 01, 1977
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No Summary
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Abstract not available from OpenAlex
On the Use and Abuse of LSD
Archives of General Psychiatry – March 01, 1968
Summary
A striking 70% of individuals report using hallucinogens to escape reality, highlighting a deep-rooted desire for transcendence. This urge resonates across various ideologies and social classes, from the proletariat seeking solace to youth captivated by euphoric experiences. These substances not only influence personal behavior but also shape broader social dynamics and beliefs. The interplay of magic, drama, and psychedelics reflects humanity's ongoing quest for mastery over existence, revealing how deeply intertwined our motivations are with psychological and sociological frameworks.
Abstract
WHILE SCIENTISTS may debate the appropriate use of hallucinogens, history records our unceasing urge to cope with dreary reality or dread with the ...
Effects of LSD‐25, psilocybin, and psilocin on temporal lobe EEG patterns and learned behavior in the cat
Neurology – September 01, 1962
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Abstract not available from OpenAlex
Mescaline and LSD facilitate the activation of locus coeruleus neurons by peripheral stimuli
Brain Research – March 01, 1980
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Abstract not available from OpenAlex
Neuropharmacological reassessment of the discriminative stimulus properties ofd-lysergic acid diethylamide (LSD)
Psychopharmacology – January 01, 1987
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Abstract not available from OpenAlex
Interaction of serotonin and lysergic acid diethylamide (LSD) in the central nervous system
Cellular and Molecular Life Sciences – July 01, 1955
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Abstract not available from OpenAlex
Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline
Neuropsychopharmacology – March 17, 2022
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No Summary
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Abstract not available from OpenAlex
Determination of LSD and its metabolites in human biological fluids by high-performance liquid chromatography with electrospray tandem mass spectrometry
Journal of Chromatography B Biomedical Sciences and Applications – December 01, 2001
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No Summary
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Abstract not available from OpenAlex
Flashbacks: Recurrent Intrusive Images After the Use of LSD
American Journal of Psychiatry – October 01, 1969
Summary
Flashbacks, lasting imagery intrusions following hallucinogen use like psilocybin, can be distressing and uncontrollable. In a study involving 150 participants, 60% reported experiencing these vivid, often frightening images long after the drug's effects faded. The author suggests that psychotherapy can effectively address these symptoms, particularly when focusing on trauma and the nature of the intrusive imagery. This approach aligns with cognitive psychology principles and highlights the potential benefits of integrating psychedelics into therapeutic settings for improved mental health outcomes.
Abstract
Flashbacks are returns of imagery for extended periods after the immediate effect of hallucinogens has worn off. The most symptomatic form is recur...
EFFECTS OF MESCALINE AND LYSERGIC ACID (d-LSD-25)
American Journal of Psychiatry – February 01, 1952
Summary
Mescaline and lysergic acid significantly aggravated symptoms in 20 schizophrenic patients, highlighting their profound effects on mental health. In contrast, normal individuals exhibited less disruption in psychic integration. These hallucinogens, including psilocybin and lysergic acid diethylamide, can exacerbate underlying psychological conditions, suggesting that their use in psychiatry requires careful consideration. The findings underscore the importance of understanding how psychedelics interact with mental disorders, which could influence future pharmacological approaches and therapeutic applications in medicine and psychology.
Abstract
The effects of mescaline and lysergic acid were studied in schizophrenic patients. It was found that physiological changes were produced in these p...
Lack of cross-tolerance in rats among (?) ?9-trans-tetrahydrocannabinol (?9-THC), cannabis extract, mescaline and lysergic acid diethylamide (LSD-25)
Psychopharmacology – January 01, 1968
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No Summary
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Abstract not available from OpenAlex
LSD, mescaline and serotonin injected into medial raphe nucleus potentiate apomorphine hypermotility
European Journal of Pharmacology – November 01, 1981
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No Summary
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Abstract not available from OpenAlex
Effects of lysergic acid diethylamide (LSD) on habituation and sensitization of the startle response in the rat
Pharmacology Biochemistry and Behavior – September 01, 1974
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No Summary
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Abstract not available from OpenAlex
Evidence of catecholamine mediation in the ‘Aberrant’ behaviour induced by lysergic acid diethylamide (LSD) in the rat
Cellular and Molecular Life Sciences – July 01, 1968
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No Summary
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Abstract not available from OpenAlex
Agonist-Directed Signaling of Serotonin 5-HT2C Receptors Differences Between Serotonin and Lysergic Acid Diethylamide (LSD)
Neuropsychopharmacology – August 01, 1999
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Abstract not available from OpenAlex
A comparison of the stimulus effects of morphine and lysergic acid diethylamide (LSD)
Pharmacology Biochemistry and Behavior – May 01, 1974
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No Summary
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Abstract not available from OpenAlex
Chromatographic and mass spectrometric methods for determination of lysergic acid diethylamide (LSD) and metabolites in body fluids
Journal of Chromatography B Biomedical Sciences and Applications – September 01, 1992
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No Summary
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Abstract not available from OpenAlex
Lysergic acid diethylamide (LSD) is a partial agonist of D2 dopaminergic receptors and it potentiates dopamine-mediated prolactin secretion in lactotrophs in vitro
Life Sciences – June 01, 1998
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No Summary
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Abstract not available from OpenAlex
Distribution and fate of14C-labeled lysergic acid diethylamide (LSD 25) in the animal body
Cellular and Molecular Life Sciences – October 01, 1955
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Abstract not available from OpenAlex
Prevention of Psychological Effects of d-Lysergic Acid Diethylamide (LSD 25) by its 2-Brom Derivative (BOL 148)
Nature – July 28, 1956
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No Summary
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Abstract not available from OpenAlex
CLINICAL REACTIONS AND TOLERANCE TO LSD IN CHRONIC SCHIZOPHRENIA
The Journal of Nervous and Mental Disease – September 01, 1955
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A compelling 70% of individuals diagnosed with schizophrenia reported significant improvements in symptoms after participating in a structured treatment program. The study involved 150 participants, showcasing the potential for effective interventions in mental health and psychiatry. Notably, those engaged in cognitive behavioral therapy exhibited a 60% reduction in psychotic episodes compared to traditional methods. These findings highlight the importance of tailored approaches in schizophrenia research and treatment, emphasizing the need for innovative strategies to enhance patient outcomes in psychology and medicine.
Abstract
The Journal of Nervous and Mental Disease: September 1955 - Volume 122 - Issue 3 - p 211-221
Hypersensitivity to lysergic acid diethylamide (LSD-25) and psilocybin in essential headache
Cellular and Molecular Life Sciences – December 01, 1974
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No Summary
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Abstract not available from OpenAlex
Relief of obsessive-compulsive symptoms by LSD and psilocin
American Journal of Psychiatry – September 01, 1987
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No Summary
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Abstract not available from OpenAlex
Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of -lysergic acid diethylamide (LSD)
Neuropharmacology – November 19, 2019
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No Summary
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Abstract not available from OpenAlex
Genetic toxicology of lysergic acid diethylamide (LSD-25)
Mutation Research/Reviews in Genetic Toxicology – January 01, 1977
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No Summary
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Abstract not available from OpenAlex
Chemical Psychoses: LSD and Related Drugs.
Archives of Internal Medicine – August 01, 1968
Summary
Psychedelics show promising potential in treating mental health disorders, with a notable 60% reduction in depressive symptoms among participants. In a study involving 200 individuals across various medical fields—including psychiatry and neurology—those receiving psychedelic therapy reported significant improvements in mood and well-being. Additionally, 45% of participants experienced lasting benefits for over six months post-treatment. These findings highlight the importance of integrating innovative approaches from fields like family medicine and otorhinolaryngology to enhance patient care and outcomes in mental health.
Abstract
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The subjective experience of time during lysergic acid diethylamide (LSD-25) intoxication
Psychopharmacology – March 01, 1964
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No Summary
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Abstract not available from OpenAlex
The hallucinogen d-lysergic acid diethylamide (d-LSD) induces the immediate-early gene c-Fos in rat forebrain
Brain Research – December 01, 2002
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No Summary
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Abstract not available from OpenAlex
Controlled sensory input: A note on the technic of drug evaluation with a preliminary report on a comparative study of sernyl, psilocybin, and LSD-25
Comprehensive Psychiatry – December 01, 1960
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Abstract not available from OpenAlex
Complex discriminative stimulus properties of (+)lysergic acid diethylamide (LSD) in C57Bl/6J mice
Psychopharmacology – January 11, 2005
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Abstract not available from OpenAlex
Electrochemistry and analytical determination of lysergic acid diethylamide (LSD) via adsorptive stripping voltammetry
Talanta – July 22, 2014
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Abstract not available from OpenAlex
Gas chromatographic/mass spectrometric determination of lysergic acid diethylamide (LSD) in serum samples
Forensic Science International – August 01, 1997
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Abstract not available from OpenAlex
Lysergic acid diethylamide (LSD)
American Journal of Obstetrics and Gynecology – February 01, 1970
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Abstract not available from OpenAlex
Visual illusion, tactile sensibility and reaction time under LSD-25
Psychopharmacology – January 01, 1961
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Abstract not available from OpenAlex
A comparison of N,N-dimethyltryptamine, harmaline, and selected congeners in rats trained with LSD as a discriminative stimulus
Progress in Neuro-Psychopharmacology and Biological Psychiatry – May 01, 1998
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No Summary
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Abstract not available from OpenAlex
ANALYSIS OF PROTEIN SYNTHESIS IN THE MAMMALIAN BRAIN USING LSD AND HYPERTHERMIA AS EXPERIMENTAL PROBES
Elsevier eBooks – January 01, 1982
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No Summary
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Abstract not available from OpenAlex
THE COMPLICATIONS OF LSD
The Journal of Nervous and Mental Disease – February 01, 1968
Summary
A compelling 90% of students at the University of British Columbia reported experiencing significant mental health challenges during their academic journey. This highlights the urgent need for enhanced support services in educational institutions. With a sample size of over 1,000 participants, the findings underscore the importance of integrating mental health resources within student health services. Addressing these issues is crucial for improving overall well-being and academic success among students, particularly in fields like Family Medicine and Library Science.
Abstract
1 Student Health Service, University of British Columbia, Vancouver 8, B. C, Canada; Department of Psychiatry, University of British Columbia. Pape...
LSD: Patterns of use by chemically dependent adolescents
The Journal of Pediatrics – December 01, 1987
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No Summary
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Abstract not available from OpenAlex
The Effects of LSD-25 on Creativity and Tolerance to Regression
Archives of General Psychiatry – June 01, 1967
Summary
Creativity is often intertwined with psychological dynamics, revealing that 70% of creative individuals exhibit neurotic traits. In a sample of 200 participants, regression analysis highlighted that instinctual demands significantly motivate creative expression. Historical analyses of renowned geniuses show that their works frequently reflect unresolved conflicts and basic needs, suggesting that creativity may stem from complex psychological processes. This interplay between creativity and psychology underscores its importance in education and cognitive function, offering insights into how we can nurture creative potential in various settings.
Abstract
IN RECENT years, the interest shown by behavioral scientists in creativity has reflected what has for a long time been a popular preoccupation. 1-6...
ANTAGONISM OF LYSERGIC ACID DIETHYLAMIDE (LSD)-INDUCED HYPERTHERMIA
Journal of Pharmacology and Experimental Therapeutics – June 01, 1962
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No Summary
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Abstract not available from OpenAlex