25I-NBOH: a new potent serotonin 5-HT2A receptor agonist identified in blotter paper seizures in Brazil.
Luciano Chaves Arantes, Ettore Ferrari Júnior, Luciano Figueiredo De Souza, Andriele Costa Cardoso, Thaynara Lino Fernandes Alcântara, Luciano Morais Lião, Yuri Machado, Rogério Araújo Lordeiro, José Coelho Neto, Ana Flávia B Andrade
Forensic toxicology January 1, 2017 DOI: 10.1007/s11419-017-0357-x via PubMed
Summary
AI-generated from the abstractA new potent serotonin 5-HT2A receptor agonist, 25I-NBOH, was identified in blotter papers by several state-level forensic laboratories in Brazil. The molecule is labile and fragments into 2C-I during routine GC screening, requiring GC-MS, LC-QTOF-MS, FTIR, and NMR for full characterization. Individual doses range from 300 to 1000 μg. Although it is a potent 5-HT2A receptor agonist, 25I-NBOH is not registered with the UNODC and is controlled only in Sweden and Brazil. This is the first scientific report of 25I-NBOH identification in actual seizures.
Study at a glance
| Characteristics | Scientific report Peer reviewed |
|---|---|
| Population | Blotter papers seized in Brazil |
| Dose | 300 to 1000 μg |
| Keywords | 25i-nboh 5-ht2a receptor agonist Nps Phenethylamine derivatives Phenethylamine derivatives |
| Citations | 50 |
| Key finding | 25I-NBOH, a potent 5-HT2A receptor agonist, was identified in seized blotter papers in Brazil and is not controlled in most countries. |
Abstract
A new potent serotonin 5-HT2A receptor agonist was identified in blotter papers by several state level forensic laboratories in Brazil. The 25I-NBOH is a labile molecule, which fragments into 2C-I when analyzed by routine seized material screening gas chromatography (GC) methods. GC-mass spectrometry (MS), liquid chromatography-quadrupole time-of-flight-MS, and Fourier transform infrared and nuclear magnetic resonance analyses were performed to complete molecular characterization. Individual doses range from 300 to 1000 μg. Despite its being a potent 5-HT2A receptor agonist, 25I-NBOH is neither registered in the United Nations Office on Drugs and Crime (UNODC) nor classified as a scheduled substance in most countries. Sweden and Brazil seem to be the only countries to control 25I-NBOH. To our knowledge, this is the first scientific report dealing with identification of 25I-NBOH in actual seizures.