Acute pharmacological effects of α-PVP in humans: a naturalistic observational study.
Georgina De la Rosa, Esther Papaseit, Olga Hladun, Lourdes Poyatos, Dolly Andrea Caicedo, Martha Catalina Argote, Soraya Martín, Mireia Ventura, Nunzia La Maida, Annagiulia Di Trana, Silvia Graziano, Simona Pichini, Magí Farré, Clara Pérez-mañá
Frontiers in pharmacology January 1, 2025 DOI: 10.3389/fphar.2025.1626692 via PubMed
Summary
AI-generated from the abstractAlpha-pyrrolidinopentiophenone (α-PVP), a synthetic cathinone similar to MDPV and cocaine, produces rapid-onset psychostimulant and empathogenic effects after a single intranasal dose. In nine participants with prior psychostimulant use, 10 mg or 20 mg of α-PVP caused an acute increase in blood pressure and heart rate that peaked 40 minutes after administration. Subjective effects appeared quickly and resolved within 3 to 5 hours. The drug's psychostimulant properties resembled those of cocaine, and its empathogenic effects were similar to those of MDMA and other cathinones like methylone.
Study at a glance
| Characteristics | Non-controlled observational study Peer reviewed |
|---|---|
| Sample size | 9 |
| Population | Participants with a previous history of psychostimulant use |
| Intervention | α-PVP |
| Dose | 10mg or 20mg |
| Duration | 5 hours post-administration |
| Keywords | Cathinones New psychoactive substances Alpha-pyrrolidinopentiophenone α-pvp α-pvp Synthetic cathinone Pharmacology acute pharmacology |
| Citations | 7 |
| Key finding | Intranasal α-PVP produces rapid-onset psychostimulant and empathogenic effects similar to cocaine and MDMA, with acute cardiovascular changes peaking 40 minutes after administration and subjective effects lasting 3 to 5 hours. |
Abstract
Alpha-pyrrolidinopentiophenone (α-PVP) is a commonly consumed analogue of pyrovalerone, a synthetic cathinone with psychostimulant properties similar to those of 3,4-Methylenedioxypyrovalerone (MDPV) and cocaine. Since the pharmacology of α-PVP remains scarcely studied, we aimed to evaluate the acute pharmacological effects and its abuse potential in humans after intranasal administration. We carried out a non-controlled observational study in a naturalistic environment in nine participants (3 women and six men) with a previous history of psychostimulant use. Participants self-administered a single intranasal dose of 10mg or 20mg of α-PVP. The outcomes included physiological effects (systolic and diastolic blood pressure, heart rate, and temperature) and subjective effects (Evaluation of Subjective Effects of Substances with Abuse Potential questionnaire_VESSPA-SSE, the short form of the Addiction Research Center Inventory questionnaire_ARCI and visual analog scales_VASs) and were measured at different time points (0, 20 and 40 minutes and 1, 1.5, 2, 2.5, 3, 4 and 5 hours). An acute increase in blood pressure and heart rate was observed that peaked 40 minutes after administration. Subjective effects also showed a rapid onset and disappeared 3 to 5 hours after administration. α-PVP showed psychostimulant properties similar to those displayed by cocaine and empathogenic effects commonly associated with MDMA and other cathinones (eg. methylone) consumption.