Multidimensional Personality Changes Following Psilocybin-Assisted Therapy in Patients With Alcohol Use Disorder: Results From a Double-Blind, Placebo-Controlled Clinical Trial
Noam Goldway, Snehal Bhatt, Stephen Ross, Broc A. Pagni, Richard J. Zeifman, Sarah E. Mennenga, Brennan M. Carrithers, Kelley C. O’donnell, Michael P. Bogenschutz
American Journal of Psychiatry January 1, 2025 DOI: 10.1176/appi.ajp.20230887 via OpenAlex
Summary
AI-generated from the abstractPsilocybin-assisted therapy (PAT) produced lasting changes in personality, indicating a normalization of abnormal personality trait expression in people with alcohol use disorder. The findings suggest that PAT may reduce impulsiveness, or that impulsive individuals may inherently respond better to the therapy. Further research is needed to clarify the mechanism.
Study at a glance
| Characteristics | Randomized controlled trial Placebo-controlled Double-blind Peer reviewed |
|---|---|
| Population | People with alcohol use disorder |
| Intervention | Psilocybin-assisted therapy |
| Topics | Addiction Psilocybin |
| Keywords | Alcohol dependence Placebo Psychiatry |
| Citations | 23 |
| Key finding | Psilocybin-assisted therapy produced durable shifts in personality, suggesting normalization of abnormal personality trait expression in alcohol use disorder. |
Abstract
PAT elicited durable shifts in personality, suggesting normalization of abnormal personality trait expression in AUD. Further study is needed to clarify whether PAT exerts its beneficial effects by reducing impulsiveness or whether impulsive individuals inherently respond better to PAT.