Case report: Maintaining altered states of consciousness over repeated ketamine infusions may be key to facilitate long-lasting antidepressant effects: some initial lessons from a personalized-dosing single-case study.
Steffen Reissmann, Matthias Hartmann, Andreas Kist, Matthias E. Liechti, Kurt Stocker
Front Psychiatry October 25, 2023 DOI: 10.3389/fpsyt.2023.1197697 via PubMed Central
Summary
AI-generated from the abstractIn a single patient with treatment-resistant depression, personalized dosing of ketamine infusions that consistently maintained an altered state of consciousness was associated with sustained antidepressant relief over repeated sessions. The patient received six infusions over three weeks, with doses adjusted to keep the altered state at a moderate-to-strong level. Depressive symptoms dropped by more than 50% after the first infusion and remained low for at least four weeks after the final infusion. The case suggests that maintaining a non-ordinary state of consciousness across infusions may be important for long-lasting antidepressant effects.
Study at a glance
| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | Single patient with treatment-resistant depression |
| Intervention | Ketamine infusions |
| Topics | Altered states of consciousness |
| Keywords | Ketamine therapy Ketamine treatment Ketamine infusion Ketamine-assisted therapy Depression treatment |
| Key finding | Personalized dosing that consistently maintains an altered state of consciousness across repeated ketamine infusions may facilitate long-lasting antidepressant effects. |
Abstract
Case report: Maintaining altered states of consciousness over repeated ketamine infusions may be key to facilitate long-lasting antidepressant effects: some initial lessons from a personalized-dosing single-case study.