NOVEL MANAGEMENT OF DEPRESSION USING KETAMINE IN THE INTENSIVE CARE UNIT
Nirmaljot Kaur, Siva Naga S. Yarrarapu, Abhishek R. Giri, Kathleen A. Rottman Pietrzak, Christan Santos, Philip E. Lowman, Shehzad Niaz, Pablo Moreno Franco, Devang K. Sanghavi
medRxiv Preprint Server September 23, 2021 preprint DOI: 10.1101/2021.09.23.21262316 via medRxiv
Summary
AI-generated from the abstractKetamine, a dissociative anesthetic that blocks glutaminergic NMDA receptors, can rapidly relieve depression. While previously used in outpatient settings for treatment-resistant depression, this work demonstrates its usefulness for managing depression in the intensive care unit (ICU), expanding the settings where this rapid antidepressant effect can be applied.
Study at a glance
| Characteristics | Case study Case report |
|---|---|
| Intervention | Ketamine |
| Keywords | Ketamine depression treatment Intensive care psychiatry Rapid antidepressant effect Novel therapies |
| Key finding | Ketamine can be effectively used for depression management in the intensive care unit. |
Abstract
Background Ketamine, a dissociative anesthetic, induces remission of depression by antagonizing glutaminergic NMDA receptors. Ketamine has been used previously in outpatient setting for treatment-resistant depression, but we showcase its utility in depression management at the Intensive Care Unit (ICU).