Psychedelic fungi

Various fungi across multiple phyla produce psychoactive compounds like psilocybin, ibotenic acid, muscimol, and lysergic acid amides, which affect human neurotransmitter receptors to cause profound psychological effects. These substances appear in mushroom-forming genera such as Psilocybe and Amanita, as well as ergot-producing Claviceps and insect-pathogenic Massospora. Ecologically, psychedelics may deter predators or aid spore dispersal. Biosynthetic enzymes are encoded in metabolic gene clusters that can spread via horizontal gene transfer, leading to a patchy distribution among species. The renewed study of these compounds presents both opportunities and challenges for science and society.

Study at a glance

Abstract

Several species of fungi, collectively known as 'psychedelic fungi', produce a range of psychoactive substances, such as psilocybin, ibotenic acid, muscimol and lysergic acid amides. These substances interact with neurotransmitter receptors in the human brain to induce profound psychological effects. These substances are found across multiple fungal phyla, in the mushroom-forming genera Psilocybe, Amanita, and others, and also the ergot-producing Claviceps and insect-pathogenic Massospora. The ecological roles of these psychedelics may include deterring predators or facilitating spore dispersal. Enzymes for psychedelic compound biosynthesis are encoded in metabolic gene clusters that are sometimes dispersed by horizontal gene transfer, resulting in a patchy distribution of psychedelics among species. The (re-)emerging science of these strange substances creates new opportunities and challenges for science and humanity at large.