A Multi-Site, Randomized, Parallel-Group, Controlled Trial of Virtually-Delivered Sahaj Samadhi Meditation for the Management of Moderate Depressive Symptoms in Chronic Pain.
Darren K Cheng, Robert Simpson, Rahim Moineddin, Joel Katz, Benoit H Mulsant, Akshya Vasudev, Michelle Greiver, Fardous Hosseiny, Marco Inzitari, Ronnie I Newman, Leon Rivlin, Kirk D Foat, Andrea D Furlan, John Francis Flannery, Deanna Telner, Rachael Bosma, Michelle Naimer, Chadwick Chung, Andrew D Pinto, Michelle L A Nelson, Ross Upshur, Abhimanyu Sud
Journal of pain research January 1, 2025 DOI: 10.2147/JPR.S515229 via PubMed
Summary
AI-generated from the abstractA virtual Sahaj Samadhi Meditation program did not significantly outperform an active control (Health Enhancement Program) in reducing depressive symptoms among people with chronic pain and moderate depression. Within the meditation group, depressive symptoms decreased by an average of 3.97 points on the PHQ-9 at 12 weeks and 4.96 points at 24 weeks, both exceeding the minimal clinically important difference, while the control group showed no significant change. The trial enrolled 108 participants, with 89 randomized. The findings suggest potential benefits of the meditation program, but larger trials under non-pandemic conditions are needed to confirm effectiveness.
Study at a glance
| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 89 |
| Population | People with chronic pain and moderate depressive symptoms |
| Interventions | Sahaj Samadhi Meditation Health Enhancement Program |
| Duration | 12-week intervention, 24-week follow-up |
| Topics | Depression Meditation |
| Keywords | Chronic pain Clinical trial Mind-body therapies Meditation meditation |
| Registration | NCT04039568 |
| Key finding | Sahaj Samadhi Meditation did not significantly reduce depressive symptoms compared to an active control, but showed significant within-group improvements exceeding the minimal clinically important difference. |
Abstract
Chronic pain (CP) often co-occurs with depression, but promising scalable interventions have been under-investigated. We assessed the effectiveness of the virtually-delivered Sahaj Samadhi Meditation (SSM) program in reducing depressive symptoms in people with CP and moderate depressive symptoms. We conducted a randomized controlled trial comparing SSM to the Health Enhancement Program (HEP), an active control. Participants were recruited from multiple sites in the Greater Toronto Area and virtually. Both 12-week programs were delivered virtually in groups by appropriately trained facilitators. Depressive symptoms were assessed using the Patient Health Questionnaire (PHQ-9) at baseline, 12 weeks, and 24 weeks. ClinicalTrials.gov registration number: NCT04039568. Of 108 participants enrolled, 89 were randomized to SSM (n=43) or HEP (n=46). Between-group differences for the PHQ-9 were not significant. Within-group mean differences for SSM were significant and greater than the minimal clinically important difference at both 12 weeks and 24 weeks (-3.97 (95% CI -6.69 to -1.24) and -4.96 (-8.36 to -1.56), respectively), while within-group mean differences were not significant for HEP. This study suggests potential benefits of SSM for individuals with comorbid CP and depression. Future trials should include larger sample sizes in non-pandemic conditions to better evaluate the effectiveness of SSM. Further research should also explore pragmatic trial designs and the integration of mind-body interventions in clinical settings.