The Kappa Opioid Receptor Agonist 16-Bromo Salvinorin A Has Anti-Cocaine Effects without Significant Effects on Locomotion, Food Reward, Learning and Memory, or Anxiety and Depressive-like Behaviors.

A kappa opioid receptor agonist called 16-Bromo Salvinorin A reduces cocaine-related effects without causing major side effects. In animal tests, it blocked cocaine's rewarding properties and prevented cocaine-induced seizures, while not affecting movement, food reward, learning, memory, or anxiety- and depression-like behaviors. This suggests the compound may have potential as a treatment for cocaine use disorder with fewer adverse effects than other kappa opioid receptor agonists.

Study at a glance

Abstract

The Kappa Opioid Receptor Agonist 16-Bromo Salvinorin A Has Anti-Cocaine Effects without Significant Effects on Locomotion, Food Reward, Learning and Memory, or Anxiety and Depressive-like Behaviors.