Towards an animal model of consciousness based on the platform theory.

Brain pathologies and mental diseases impair conscious cognition and behavior, but valid animal models of consciousness for preclinical research are lacking. The platform theory proposes that the brain enters a conscious operation mode when mental representations are actively maintained and manipulated in working memory. Using this theory as a framework, behavioral paradigms are categorized by the level of consciousness involved. A consciousness behavioral test battery for rodents is proposed, including tests of working memory, episodic-like memory, prospective memory, detour tests, and operant conditioning with concurrent schedules. Performance on these tests can be contrasted with tasks requiring lower consciousness levels. A second comprehensive battery controls for non-conscious behavioral phenotypes. This framework may guide deciphering the neurobiological basis of consciousness.

Study at a glance

Abstract

The evolution of intellectual capacities has brought forth a continuum of consciousness levels subserved by neuronal networks of varying complexity. Brain pathologies, neurodegenerative, and mental diseases affect conscious cognition and behavior. Although impairments in consciousness are among the most devastating consequences of neurological and mental diseases, valid and reliable animal models of consciousness, that could be used for preclinical research are missing. The platform theory holds that the brain enters a conscious operation mode, whenever mental representations of stimuli, associations, concepts, memories, and experiences are effortfully maintained (in working memory) and actively manipulated. We used the platform theory as a framework and evaluation standard to categorize behavioral paradigms with respect to the level of consciousness involved in task performance. According to the platform theory, a behavioral paradigm involves conscious cognitive operations, when the problem posed is unexpected, novel or requires the maintenance and manipulation of a large amount of information to perform cognitive operations on them. Conscious cognitive operations are associated with a relocation of processing resources and the redirection of attentional focus. A consciousness behavioral test battery is proposed that is composed of tests which are assumed to require higher levels of consciousness as compared to other tasks and paradigms. The consciousness test battery for rodents includes the following tests: Working memory in the radial arm maze, episodic-like memory, prospective memory, detour test, and operant conditioning with concurrent variable-interval variable-ratio schedules. Performance in this test battery can be contrasted with the performance in paradigms and tests that require lower levels of consciousness. Additionally, a second more comprehensive behavioral test battery is proposed to control for behavioral phenotypes not related to consciousness. Our theory could serve as a guidance for the decryption of the neurobiological basis of consciousness.