3D Microfluidic Channel Development for a Microdosing System
Ana C. Romo-Cardenas, Carlos A. Ruiz-Delgado, Paulo C. Calvo, Luis Jesús Villarreal-Gómez, Faruk Fonthal
Summary
AI-generated from the abstractA passively operated microfluidic device fabricated using 3D-printed templates enables insulin microdosing. The system includes a microvalve with a spiral trajectory and four outlet channels that align with a 10 mm x 15 mm matrix of 25 microchannels, each 770 µm in internal diameter. It delivers a dose of 2.3 mL in 6 minutes. The design enhances fluid dynamics without affecting insulin stability and allows the use of Humalog insulin in tropical climates up to 30°C without refrigeration for 28 days. The approach can be adapted for microdosing other drugs.
Study at a glance
| Key finding | A 3D-printed microfluidic device with a spiral microvalve and 25 microchannels delivers a 2.3 mL dose of insulin in 6 minutes and maintains insulin stability for 28 days at up to 30°C. |
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Abstract
In the last decade, three-dimensional (3D) printing has allowed the field of complex microfluidic channels to expand rapidly towards channels with variable cross-sections (i.e., beyond simple rounded media with a constant diameter) and channels. Whose trajectory can be outside a single plane and has gained numerous macro- and nanoscale manufacturing advances. Three-dimensional printing is being explored for various biomedical applications and the fabrication of nanomedicines using additive manufacturing techniques. Employing 3D-printed templates for macro-to-micro interfacing, a passively operated microfluidic device was designed. The research seeks to fabricate a biodevice that enables insulin microdosing, creating a subsystem like a microvalve and a microchannel matrix using additive manufacturing techniques. Our systems feature designs that enhance fluid dynamics without affecting the stability of the insulin. We propose using Humalog insulin in tropical climates (up to 30°C) without refrigeration for 28 days. The microvalve has a spiral trajectory with four outlet channels distributed along it. These channels align with the microchannels organized in a 10 mm x 15 mm matrix with 25 microchannels, each with a 770 µm internal diameter. The system delivers a dose of 2,3 mL in 6 minutes. We designed these systems for insulin micro-dosing, but they can also serve similar devices for other drugs.