Psychedelic-Assisted Psychotherapy for TRD: An Umbrella Review [Clinical Psychology Topic 331]

An umbrella review of meta-analyses and systematic reviews finds that psilocybin, particularly when paired with psychological support, shows consistent efficacy for depression and anxiety, with moderate to large effect sizes. The evidence supports a Neural-Connectivity Re-set Model (NCRM) as a plausible mechanism, wherein psilocybin disrupts rigid neural networks, allowing for reorganization. The review notes that while results are promising, limitations include small sample sizes, short follow-up periods, and potential expectancy biases. The authors suggest that psilocybin-assisted therapy represents a significant advance, but call for larger, more rigorous trials to confirm long-term safety and effectiveness.

Study at a glance

Abstract

A high-rigor Umbrella Review (v7.0) on the Neural-Connectivity Re-set Model (NCRM) and psilocybin efficacy