Hyperlocomotion Test for Assessing Behavioral Disorders.
Methods in molecular biology (Clifton, N.J.) January 1, 2018 DOI: 10.1007/978-1-4939-7614-0_29 via PubMed
Summary
AI-generated from the abstractNutrition during pregnancy can affect offspring behavior later in life. This paper describes a protocol for the hyperlocomotion test, which measures behavioral symptoms resembling psychosis or mania. The example uses rats given an acute injection of phencyclidine (PCP), which causes hyperlocomotion and stereotypic behaviors similar to positive symptoms of schizophrenia.
Study at a glance
| Characteristics | Protocol Peer reviewed |
|---|---|
| Population | Rats |
| Keywords | Behavioral deficits Hyperlocomotion test Nutritional programming Pcp Psychosis |
| Key finding | The hyperlocomotion test can assess behavioral symptoms such as psychosis or mania in rats using an acute PCP-injection model. |
Abstract
Under- or overfeeding during pregnancy can lead to behavioral deficits in the offspring in later life. Here, we present a protocol for setting up and carrying out the hyperlocomotion test for assessing behavioral symptoms such as psychosis or mania. As an example, we use the acute rat phencyclidine-injection model which exhibits hyperlocomotion and stereotypic behaviors, resembling the positive symptoms of schizophrenia.