Improvement of depressive symptoms, after a suicide attempt, with dextromethorphan/bupropion combination treatment in a patient with treatment-resistant depression and psychiatric comorbidities.
Bruno Pedraz-Petrozzi, Michael Deuschle, Maria Gilles
Clinical case reports March 1, 2023 DOI: 10.1002/ccr3.7045 via PubMed
Summary
AI-generated from the abstractA 42-year-old patient with severe treatment-resistant depression and psychiatric comorbidities attempted suicide five weeks after hospital admission. After starting dextromethorphan/bupropion, her mood improved and suicide risk decreased, allowing discharge.
Study at a glance
| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | 42-year-old patient with severe treatment-resistant depression and psychiatric comorbidities |
| Intervention | Dextromethorphan/bupropion |
| Topics | Depression |
| Keywords | Bupropion Comorbidity Dextromethorphan Suicidal ideation |
| Key finding | Dextromethorphan/bupropion was associated with improved mood and reduced suicide risk in a patient with treatment-resistant depression. |
Abstract
We admitted a 42-year-old patient with severe treatment-resistant depression and with psychiatric comorbidities. The patient attempted suicide 5 weeks after admission. Subsequently, we initiated dextromethorphan/bupropion based on prior evidence. As a result, the patient demonstrated an improvement in mood symptoms and a reduction in suicide risk, leading to her discharge.