Fatal cold medication poisoning in an adolescent.
The American journal of emergency medicine February 1, 2022 DOI: 10.1016/j.ajem.2021.08.043 via PubMed
Summary
AI-generated from the abstractMortality from intentional misuse of over-the-counter combination cold products is rare, but co-formulated ingredients such as antihistamines can potentiate dangerous effects. A case is reported of an adolescent decedent with markedly elevated postmortem chlorpheniramine and dextromethorphan blood concentrations and no other identifiable cause of death.
Study at a glance
| Characteristics | Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | Adolescent decedent |
| Keywords | Chlorpheniramine Dextromethorphan Fatal Poisoning |
| Key finding | Markedly elevated postmortem chlorpheniramine and dextromethorphan blood concentrations were found in an adolescent decedent with no other identifiable cause of death. |
Abstract
Toxicity from the intentional misuse of over-the-counter (OTC) combination cold products has been widely recognized. Adolescents are most frequently involved and dextromethorphan containing products are the most popular. Desired symptoms include stimulatory effects, euphoria, hallucinations, and dissociation. Potential adverse effects include tachycardia, agitation, hyperthermia, acidosis, and coma. However, mortality is rare [ 1-3]. Co-formulated ingredients such as acetaminophen, pseudoephedrine, and antihistamines may also be present and potentiate dangerous effects. We report a case of an adolescent decedent with markedly elevated postmortem chlorpheniramine (CPA) and dextromethorphan (DXM) blood concentrations and no other identifiable cause of death.