Nitrous oxide therapy-induced changes in brain modules of treatment-resistant depression: a randomized controlled study
Na Li, Ziyi Wang, Jun Huang, Shuting Sun, Jing Zhu, Xiaowei Li, Bin Hu
IEEE International Conference on Bioinformatics and Biomedicine December 3, 2024 DOI: 10.1109/bibm62325.2024.10822512 via Semantic Scholar
Summary
AI-generated from the abstractIn a randomized controlled trial, 44 patients with treatment-resistant depression received either a one-hour inhalation of 50% nitrous oxide with 50% oxygen or a placebo of 50% oxygen with 50% air. Nitrous oxide treatment significantly altered the segregation of interconnected brain functional modules, as measured by EEG. The treatment showed superior antidepressant efficacy compared to placebo, with reductions in both the participation coefficient and connector hub after treatment. Changes in these modular metrics moderately correlated with reductions in depressive symptoms, offering insights into the neurophysiological mechanisms underlying nitrous oxide's rapid antidepressant effects.
Study at a glance
| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 44 |
| Population | Patients with treatment-resistant depression (TRD) |
| Intervention | Nitrous oxide |
| Dose | 1-hour inhalation of 50% nitrous oxide/50% oxygen |
| Duration | 1-hour intervention |
| Keywords | Computer science Medicine |
| Key finding | Nitrous oxide treatment significantly altered brain functional module segregation and showed superior antidepressant efficacy compared to placebo. |
Abstract
Currently, treatment options for patients with treatment-resistant depression (TRD) are extremely limited. Although the rapid antidepressant effects of nitrous oxide have been preliminarily validated, the underlying neurophysiological mechanisms remain unclear. In this study, we intended to explore impact on brain modules induced by nitrous oxide through a randomized controlled study. A total of 44 patients with TRD were recruited. Subjects were randomly allocated to nitrous oxide-intervention group (1-hour inhalation of 50% nitrous oxide/50% oxygen) or placebo-control group (1-hour inhalation of 50% oxygen/50% air). The eye-closed resting state EEG signals were recorded. Our findings reveal that nitrous oxide treatment significantly altered the segregation of interconnected brain functional modules. The result of General Linear Model (repeated measurements) demonstrates superior antidepressant efficacy of nitrous oxide compared to placebo, as evidenced by reductions in both the participation coefficient and connector hub after treatment. Furthermore, changes in modular metrics moderately correlated with reductions in depressive symptoms. These findings offer valuable insights into mechanism underlying the treatment of TRD using nitrous oxide from a modular perspective.