Effects of marijuana history on the subjective, psychomotor, and reinforcing effects of nitrous oxide in humans.
S Yajnik, P Thapar, J L Lichtor, T Patterson, J P Zacny
Drug and alcohol dependence December 1, 1994 DOI: 10.1016/0376-8716(94)90149-x via PubMed
Summary
AI-generated from the abstractAn experiment compared marijuana users and non-users to see if their history with cannabis affected how they responded to nitrous oxide. Participants first sampled both 40% nitrous oxide in oxygen and a placebo (100% oxygen), then chose which to inhale in later sessions. Both groups chose nitrous oxide less than half the time, and the choice patterns did not differ significantly between marijuana users and non-users. However, marijuana users reported stronger subjective effects from nitrous oxide, suggesting a history of marijuana use may intensify some of the drug's subjective experiences.
Study at a glance
| Characteristics | Experiment Peer reviewed |
|---|---|
| Population | Marijuana users and non-users |
| Interventions | 40% nitrous oxide in oxygen 100% oxygen (placebo) |
| Dose | 40% nitrous oxide in oxygen |
| Key finding | Marijuana users and non-users did not differ in their choice to inhale nitrous oxide, but marijuana users reported intensified subjective effects from nitrous oxide. |
Abstract
An experiment using marijuana users and non-users was conducted to assess whether the reinforcing, subjective, or psychomotor effects of nitrous oxide were influenced by a subject's drug history. Subjects in the first four sessions sampled 40% nitrous oxide in oxygen and 100% oxygen (placebo), and then over the next three sessions, chose which agent they wished to inhale. Choice distributions between the two groups did not differ significantly, and nitrous oxide choice rates were less than 50% in both groups. However, a history of marijuana use appeared to intensify some of the subjective effects induced by nitrous oxide inhalation.