Lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers.
S Yajnik, J P Zacny, C J Young, J L Lichtor, G Rupani, J M Klafta, D W Coalson, J L Apfelbaum
Pharmacology, biochemistry, and behavior June 1, 1996 DOI: 10.1016/0091-3057(95)02278-3 via PubMed
Summary
AI-generated from the abstractA crossover, double-blind trial with eleven healthy volunteers tested whether acute drug tolerance develops to the subjective, cognitive, and psychomotor effects of subanesthetic nitrous oxide at doses of 0, 10, 20, 30, and 40%. Over a 120-minute inhalation period, there was little evidence of acute tolerance to the subjective or impairing effects at any concentration.
Study at a glance
| Characteristics | Crossover, double-blind trial Peer reviewed |
|---|---|
| Sample size | 11 |
| Population | Healthy volunteers |
| Intervention | Nitrous oxide |
| Dose | 0, 10, 20, 30, and 40% |
| Duration | 120-min inhalation |
| Key finding | Little evidence of acute drug tolerance to the subjective, cognitive, or psychomotor effects of nitrous oxide at any concentration tested over 120 minutes. |
Abstract
A crossover, double-blind trial was conducted using eleven healthy volunteers to determine whether and the degree to which acute drug tolerance occurred to the subjective, cognitive, and psychomotor effects of a range of subanesthetic nitrous oxide doses (0, 10, 20, 30, and 40%). There was little evidence of acute drug tolerance to the subjective measures or to the cognitive/psychomotor impairing effects of nitrous oxide at any of the concentrations tested over the course of the 120-min inhalation.