N,N-Diisopropyltryptamine and diptogenia: proposed mechanisms for a frequency-selective pitch-distorting psychedelic.

N,N-Diisopropyltryptamine (DiPT) is a psychedelic drug that selectively distorts pitch perception, making sounds seem lower in pitch than they actually are. Hurst and Bajo propose specific neural mechanisms that could explain this frequency-selective effect. They suggest that this property might be harnessed as a potential therapeutic intervention for tinnitus, a condition characterized by phantom sounds or ringing in the ears. The paper outlines a theoretical framework linking the drug's auditory effects to possible clinical applications.

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Abstract

N,N-Diisopropyltryptamine (DiPT) is a frequency-selective pitch-distorting psychedelic drug that induces a downward shift in perception where the auditory world of the subject sounds lower in pitch than in a sober state of consciousness. Hurst and Bajo propose the neural mechanisms for this effect and its use as potential therapeutic for tinnitus.